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The map label for this gene is gcvP-2

Identifier: 110835453

GI number: 110835453

Start: 2932175

End: 2933533

Strand: Reverse

Name: gcvP-2

Synonym: ABO_2592

Alternate gene names: 110835453

Gene position: 2933533-2932175 (Counterclockwise)

Preceding gene: 110835454

Following gene: 110835452

Centisome position: 94.02

GC content: 59.75

Gene sequence:

>1359_bases
ATGCCCTATATCCCCCATACCCCCGATGACGTGCGCGCCATGCTCGACGCCATTGGCGCCGATAGCATCGAAGATTTGTT
CGATGAAATTCCTTCGCACCTGAAAGCCGCTGGCAAGCTCGATGCTCTGCCTGAAGGGCTGAGCGAAATGGACGTCACTC
GGCTGATGAGCGACCGTGCTGCCCAGGATGCAGGCGCGGTCAGTTTCATCGGTGCCGGTGCCTACCAGCACCACGTGCCG
GCGGCGGTATGGGAAATTGCTACCCGGGGGGAGTTCTACACCGCTTACACCCCGTATCAGGCGGAGGCGAGCCAGGGCAC
CCTGCAGGTGATCTACGAATTCCAAACCCTGATGACCCGCCTCACCGGCATGGACGTGAGCAACGCTTCTGTCTACGACG
GTGCCTCTGGTTTGGCCGAGGCGGTGTTGATGAGCCTGCGAGCCAACCGCAAGAGCAAGTCCCGCAAGGTGCTGGTGCCC
ACCGCGGTGAACCCGCGCTACACCAGCGCGACCCAGGCCATCGTGGAAAATCAGGACGTGGCCCTGGAAAGGGTGGGCTT
CGATGCCGCTAGCGGGCAGACCCCACTAGATGCACTCAAACCCTATGAAGGTGAAGATTATGCCGCGCTGGTGATTAGCC
AGCCCAACTTCTTCGGTTCTCTGGAAGAAGTCGATGCGCTCACCGACTGGGCCCATGCCAACAAAATGTTGGTCATTGGT
GTGGTTAACCCCACCTCCCTGGCGCTGCTGACGCCTCCTGGCGAATGGGGCGCAGACGGTGCAGATATCGTTGTGGGTGA
AGGCCAGCCGCTGGGTGTGCCGCTATCCTCCGGTGGGCCGTACTTTGGCTTTATGTGCTGTAAACAGAAACACGTTCGGC
AAATGCCGGGTCGAATCATCGGCCGCACCGTGGACATGGAAGGCAAACAAGGTTTCACCCTGACATTGCAGGCCCGTGAA
CAACATATTCGTCGTTCCAAGGCCACCAGTAATATTTGTACCAACCAGGGCTTGGCCATGACCGCGGCGACCATTTACAC
CTCGCTGCTGGGGCCGGATGGCCTGGGTAATGTGGCGGCTCATTGCCACGCCAACACTCAGGCACTGGCGGACAAGCTCA
CCGCTATCGATGGCGTTGAGCGAGCCTTCACCGCGCCGACTTTCCACGAAGTGGTACTGACGCTGCCCAAGCCTGCGGAT
CAGGTGCTGGCGGCGCTGGCCGAGAAAGACGTGCTGGGCGGCGTGAGCCTGGCCGGCGACTATGACATGAATAATGCGAT
TCTGGTAAATGCTACCGAAGTCCATTCCGAGCAGGATTTGCAGCTGTTCGAACAAGCCCTGAAGGAGGTGCTGGCATGA

Upstream 100 bases:

>100_bases
CCCCGCCCGGTTTTCTTGGCTGCTTGACGCTTGCAGCTAATCCCCGTCGTTTTTAATGATGAGGGATTCAACGCCAACAC
CAACACCATCAGGTACCTCC

Downstream 100 bases:

>100_bases
GCGAGACACAACTGATTTTCCAACTGTCTCATCCAGGTCGTAGCGCCACCTCCCAAGCGCCCAAGGCGCTGGCGGAAGAC
AAGCTGTCCGCGATTCCAGC

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MPYIPHTPDDVRAMLDAIGADSIEDLFDEIPSHLKAAGKLDALPEGLSEMDVTRLMSDRAAQDAGAVSFIGAGAYQHHVP
AAVWEIATRGEFYTAYTPYQAEASQGTLQVIYEFQTLMTRLTGMDVSNASVYDGASGLAEAVLMSLRANRKSKSRKVLVP
TAVNPRYTSATQAIVENQDVALERVGFDAASGQTPLDALKPYEGEDYAALVISQPNFFGSLEEVDALTDWAHANKMLVIG
VVNPTSLALLTPPGEWGADGADIVVGEGQPLGVPLSSGGPYFGFMCCKQKHVRQMPGRIIGRTVDMEGKQGFTLTLQARE
QHIRRSKATSNICTNQGLAMTAATIYTSLLGPDGLGNVAAHCHANTQALADKLTAIDGVERAFTAPTFHEVVLTLPKPAD
QVLAALAEKDVLGGVSLAGDYDMNNAILVNATEVHSEQDLQLFEQALKEVLA

Sequences:

>Translated_452_residues
MPYIPHTPDDVRAMLDAIGADSIEDLFDEIPSHLKAAGKLDALPEGLSEMDVTRLMSDRAAQDAGAVSFIGAGAYQHHVP
AAVWEIATRGEFYTAYTPYQAEASQGTLQVIYEFQTLMTRLTGMDVSNASVYDGASGLAEAVLMSLRANRKSKSRKVLVP
TAVNPRYTSATQAIVENQDVALERVGFDAASGQTPLDALKPYEGEDYAALVISQPNFFGSLEEVDALTDWAHANKMLVIG
VVNPTSLALLTPPGEWGADGADIVVGEGQPLGVPLSSGGPYFGFMCCKQKHVRQMPGRIIGRTVDMEGKQGFTLTLQARE
QHIRRSKATSNICTNQGLAMTAATIYTSLLGPDGLGNVAAHCHANTQALADKLTAIDGVERAFTAPTFHEVVLTLPKPAD
QVLAALAEKDVLGGVSLAGDYDMNNAILVNATEVHSEQDLQLFEQALKEVLA
>Mature_451_residues
PYIPHTPDDVRAMLDAIGADSIEDLFDEIPSHLKAAGKLDALPEGLSEMDVTRLMSDRAAQDAGAVSFIGAGAYQHHVPA
AVWEIATRGEFYTAYTPYQAEASQGTLQVIYEFQTLMTRLTGMDVSNASVYDGASGLAEAVLMSLRANRKSKSRKVLVPT
AVNPRYTSATQAIVENQDVALERVGFDAASGQTPLDALKPYEGEDYAALVISQPNFFGSLEEVDALTDWAHANKMLVIGV
VNPTSLALLTPPGEWGADGADIVVGEGQPLGVPLSSGGPYFGFMCCKQKHVRQMPGRIIGRTVDMEGKQGFTLTLQAREQ
HIRRSKATSNICTNQGLAMTAATIYTSLLGPDGLGNVAAHCHANTQALADKLTAIDGVERAFTAPTFHEVVLTLPKPADQ
VLAALAEKDVLGGVSLAGDYDMNNAILVNATEVHSEQDLQLFEQALKEVLA

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=366, Percent_Identity=33.3333333333333, Blast_Score=201, Evalue=1e-51,
Organism=Escherichia coli, GI1789269, Length=367, Percent_Identity=34.0599455040872, Blast_Score=171, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI17535605, Length=371, Percent_Identity=38.8140161725067, Blast_Score=204, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6323843, Length=377, Percent_Identity=33.9522546419098, Blast_Score=203, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24645648, Length=362, Percent_Identity=37.8453038674033, Blast_Score=224, Evalue=9e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_ALCBS (Q0VLA8)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_694312.1
- ProteinModelPortal:   Q0VLA8
- SMR:   Q0VLA8
- STRING:   Q0VLA8
- GeneID:   4211691
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_2592
- NMPDR:   fig|393595.12.peg.2596
- eggNOG:   COG0403
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- BioCyc:   ABOR393595:ABO_2592-MONOMER
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 48258; Mature: 48127

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYIPHTPDDVRAMLDAIGADSIEDLFDEIPSHLKAAGKLDALPEGLSEMDVTRLMSDRA
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHH
AQDAGAVSFIGAGAYQHHVPAAVWEIATRGEFYTAYTPYQAEASQGTLQVIYEFQTLMTR
HHCCCCEEEEECCCHHHCCCHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHH
LTGMDVSNASVYDGASGLAEAVLMSLRANRKSKSRKVLVPTAVNPRYTSATQAIVENQDV
HHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCH
ALERVGFDAASGQTPLDALKPYEGEDYAALVISQPNFFGSLEEVDALTDWAHANKMLVIG
HHHHCCCCCCCCCCCHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEE
VVNPTSLALLTPPGEWGADGADIVVGEGQPLGVPLSSGGPYFGFMCCKQKHVRQMPGRII
EECCCEEEEECCCCCCCCCCCEEEEECCCCCEEEECCCCCEEEHHHHHHHHHHHCCHHHH
GRTVDMEGKQGFTLTLQAREQHIRRSKATSNICTNQGLAMTAATIYTSLLGPDGLGNVAA
CEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHH
HCHANTQALADKLTAIDGVERAFTAPTFHEVVLTLPKPADQVLAALAEKDVLGGVSLAGD
HHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCHHHHHHHHHHHHHHCCEEEECC
YDMNNAILVNATEVHSEQDLQLFEQALKEVLA
CCCCCEEEEEEHHHCCHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
PYIPHTPDDVRAMLDAIGADSIEDLFDEIPSHLKAAGKLDALPEGLSEMDVTRLMSDRA
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHH
AQDAGAVSFIGAGAYQHHVPAAVWEIATRGEFYTAYTPYQAEASQGTLQVIYEFQTLMTR
HHCCCCEEEEECCCHHHCCCHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHH
LTGMDVSNASVYDGASGLAEAVLMSLRANRKSKSRKVLVPTAVNPRYTSATQAIVENQDV
HHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCH
ALERVGFDAASGQTPLDALKPYEGEDYAALVISQPNFFGSLEEVDALTDWAHANKMLVIG
HHHHCCCCCCCCCCCHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEE
VVNPTSLALLTPPGEWGADGADIVVGEGQPLGVPLSSGGPYFGFMCCKQKHVRQMPGRII
EECCCEEEEECCCCCCCCCCCEEEEECCCCCEEEECCCCCEEEHHHHHHHHHHHCCHHHH
GRTVDMEGKQGFTLTLQAREQHIRRSKATSNICTNQGLAMTAATIYTSLLGPDGLGNVAA
CEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHH
HCHANTQALADKLTAIDGVERAFTAPTFHEVVLTLPKPADQVLAALAEKDVLGGVSLAGD
HHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCHHHHHHHHHHHHHHCCEEEECC
YDMNNAILVNATEVHSEQDLQLFEQALKEVLA
CCCCCEEEEEEHHHCCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA