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The map label for this gene is thiC [H]

Identifier: 110835360

GI number: 110835360

Start: 2833192

End: 2835066

Strand: Reverse

Name: thiC [H]

Synonym: ABO_2499

Alternate gene names: 110835360

Gene position: 2835066-2833192 (Counterclockwise)

Preceding gene: 110835362

Following gene: 110835359

Centisome position: 90.86

GC content: 56.85

Gene sequence:

>1875_bases
GTGCCAGACGATCAGCGCCCCATCGCCAACGCCATTGACGAATCTTGTCAGCCTATCGCCGGTTCACGAAAAATCTATGT
CACGGGGTCGCGCCCGGATATTCGTGTGCCCATGCGGGAAATCCAGCAGCATCCGACCCCTTTGGCGGACGGAAAGTTCG
AGGATAACCCACCGCTGTCGGTTTATGATACCTCTGGTCCTTATACCGACCCAGATACCTATATCGACATCCGTAAAGGG
CTGAACCCAATTCGGGATGCCTGGATTGCTGAGCGTGATGACACCGAACAGCTGGCCGGGTTGACCAGTGAGTATGGTCG
CAAGCGAGCCAATGATGTTGCCAAGGCAGGGCTACGCTTTGAGCACACTCGCATTCCTCGTCGTGCCCGTGCGGGCAAGA
ATGTTACCCAGATGCACTACGCGCGCCAGGGGATCATCACCCCGGAGATGGAATATATCGCCATCCGCGAGAATCAGCGC
TTGCGTGAACATCGCGAAGCGGGCCTGCCTGTGAACCAGCATCCCGGCCAGAGTTTTGGTGCGGCGATTCCGGCGGAAAT
TACGCCGGAATTCGTCCGTGATGAAGTGGCCCGTGGTCGAGCAGTGATTCCGGTGAATATCAACCATCCGGAAATTGAGC
CGATGATTATCGGCCGCAACTTTCTCACCAAGATCAACGCCAATATCGGCAACTCGGCGGTGACGTCCTCCATCGAGGAA
GAGGTGTCGAAGATGACCTGGGCCACCCGTTGGGGCGGCGACACGGTGATGGACCTGTCCACCGGTGACAACATTCACGA
AACCCGCGAGTGGATTCTGCGTAACTCGCCGGTGCCCATCGGTACGGTGCCGATCTATCAGGCGTTAGAAAAGGTTAACG
GCGTAGCCGAAGACCTGACGTGGGAAATTTTCCGCGACACCTTAATCGAGCAGGCGGAGCAGGGGGTGAGCTACTTCACC
ATTCACGCGGGTGTGCTGCTGCGTTATGTGCCGATGACCGCTAATCGCGTTACCGGTATCGTCTCTCGGGGTGGTTCGAT
TATGGCTAAGTGGTGCCTGGCGCACCATGAAGAAAGCTTCCTCTACACCCATTTCGAAGATATCTGCGAAATCATGAAGG
CCTACGACGTGACCTTCAGCCTGGGTGATGGTTTGCGTCCGGGTTCTTTGGCAGATGCCAACGATGAAGCCCAATTCAGC
GAACTGCGCACTTTGGGCGAGCTGACCAAAATTGCCTGGAAGCATGATGTGCAGGTGATGATCGAAGGGCCGGGCCATGT
GCCCATGCACATGATCAAAGCCAACATGGACGAGCAGCTGAAGCACTGCGGGGAAGCGCCGTTTTACACCCTTGGCCCGC
TGACCATTGATATTTCTCCGGGTTATGACCACATTTCCAGTGCCATTGGCGCGGCCATGATCGGTTGGTATGGCACTGCC
ATGCTGTGCTACGTGACGCCCAAGGAGCACCTAGGGCTGCCGAACCGTGAAGACGTGAAAGAAGGCATCATCGCCTACAA
GATTGCAGCCCATGCGGCGGATTTGGCGAAGGGTCACCCGGGAGCCCAGTTGCGCGATAATGCGCTGTCCAAGGCCCGCT
TTGAGTTCCGCTGGGAAGACCAGTTCAACCTGGGGCTGGATCCGGATCGTGCCCGCGAGTATCACGATGAGACTCTGCCA
AAGCAGGCCCACAAGGTGGCGCATTTCTGTTCCATGTGCGGGCCCAAGTTCTGTTCCATGAAGATCAGCCAAGAAGTCCG
CGAGATCTATGGTGACGGCACCGCCCAGGTGGCTCAGGCTGAAGCGGGCATGGAAGAAAAATCTAAGGAGTTTCGAGAGC
AGGGCTCCGCGCTATATCATGAGGCCCATGAGTAA

Upstream 100 bases:

>100_bases
CTGCCTGTTTGGGCCAGTTCCGCGGTTGTTTGGCTGCTGGGCGCTGACGTATAGTGTCGCAATTCCTGAATTTCCTTTAT
TTTAGCCTCTGGAGGCCGAC

Downstream 100 bases:

>100_bases
TCATTCGTTAACACCGCCATTTGGCCCTCAGGACGTGGAAGTGTTGGCGCGGGAGACCCCGTTCCAAGGCTTTTTCCGGG
TGGATACCCTGACCCTGCGC

Product: thiamine biosynthesis protein ThiC

Products: @AMIN06.txt*4-amino-2-methyl-5-hydroxymethylpyrimidine!; 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate [C]

Alternate protein names: Hydroxymethylpyrimidine phosphate synthase; HMP-P synthase; HMP-phosphate synthase; HMPP synthase; Thiamine biosynthesis protein thiC [H]

Number of amino acids: Translated: 624; Mature: 623

Protein sequence:

>624_residues
MPDDQRPIANAIDESCQPIAGSRKIYVTGSRPDIRVPMREIQQHPTPLADGKFEDNPPLSVYDTSGPYTDPDTYIDIRKG
LNPIRDAWIAERDDTEQLAGLTSEYGRKRANDVAKAGLRFEHTRIPRRARAGKNVTQMHYARQGIITPEMEYIAIRENQR
LREHREAGLPVNQHPGQSFGAAIPAEITPEFVRDEVARGRAVIPVNINHPEIEPMIIGRNFLTKINANIGNSAVTSSIEE
EVSKMTWATRWGGDTVMDLSTGDNIHETREWILRNSPVPIGTVPIYQALEKVNGVAEDLTWEIFRDTLIEQAEQGVSYFT
IHAGVLLRYVPMTANRVTGIVSRGGSIMAKWCLAHHEESFLYTHFEDICEIMKAYDVTFSLGDGLRPGSLADANDEAQFS
ELRTLGELTKIAWKHDVQVMIEGPGHVPMHMIKANMDEQLKHCGEAPFYTLGPLTIDISPGYDHISSAIGAAMIGWYGTA
MLCYVTPKEHLGLPNREDVKEGIIAYKIAAHAADLAKGHPGAQLRDNALSKARFEFRWEDQFNLGLDPDRAREYHDETLP
KQAHKVAHFCSMCGPKFCSMKISQEVREIYGDGTAQVAQAEAGMEEKSKEFREQGSALYHEAHE

Sequences:

>Translated_624_residues
MPDDQRPIANAIDESCQPIAGSRKIYVTGSRPDIRVPMREIQQHPTPLADGKFEDNPPLSVYDTSGPYTDPDTYIDIRKG
LNPIRDAWIAERDDTEQLAGLTSEYGRKRANDVAKAGLRFEHTRIPRRARAGKNVTQMHYARQGIITPEMEYIAIRENQR
LREHREAGLPVNQHPGQSFGAAIPAEITPEFVRDEVARGRAVIPVNINHPEIEPMIIGRNFLTKINANIGNSAVTSSIEE
EVSKMTWATRWGGDTVMDLSTGDNIHETREWILRNSPVPIGTVPIYQALEKVNGVAEDLTWEIFRDTLIEQAEQGVSYFT
IHAGVLLRYVPMTANRVTGIVSRGGSIMAKWCLAHHEESFLYTHFEDICEIMKAYDVTFSLGDGLRPGSLADANDEAQFS
ELRTLGELTKIAWKHDVQVMIEGPGHVPMHMIKANMDEQLKHCGEAPFYTLGPLTIDISPGYDHISSAIGAAMIGWYGTA
MLCYVTPKEHLGLPNREDVKEGIIAYKIAAHAADLAKGHPGAQLRDNALSKARFEFRWEDQFNLGLDPDRAREYHDETLP
KQAHKVAHFCSMCGPKFCSMKISQEVREIYGDGTAQVAQAEAGMEEKSKEFREQGSALYHEAHE
>Mature_623_residues
PDDQRPIANAIDESCQPIAGSRKIYVTGSRPDIRVPMREIQQHPTPLADGKFEDNPPLSVYDTSGPYTDPDTYIDIRKGL
NPIRDAWIAERDDTEQLAGLTSEYGRKRANDVAKAGLRFEHTRIPRRARAGKNVTQMHYARQGIITPEMEYIAIRENQRL
REHREAGLPVNQHPGQSFGAAIPAEITPEFVRDEVARGRAVIPVNINHPEIEPMIIGRNFLTKINANIGNSAVTSSIEEE
VSKMTWATRWGGDTVMDLSTGDNIHETREWILRNSPVPIGTVPIYQALEKVNGVAEDLTWEIFRDTLIEQAEQGVSYFTI
HAGVLLRYVPMTANRVTGIVSRGGSIMAKWCLAHHEESFLYTHFEDICEIMKAYDVTFSLGDGLRPGSLADANDEAQFSE
LRTLGELTKIAWKHDVQVMIEGPGHVPMHMIKANMDEQLKHCGEAPFYTLGPLTIDISPGYDHISSAIGAAMIGWYGTAM
LCYVTPKEHLGLPNREDVKEGIIAYKIAAHAADLAKGHPGAQLRDNALSKARFEFRWEDQFNLGLDPDRAREYHDETLPK
QAHKVAHFCSMCGPKFCSMKISQEVREIYGDGTAQVAQAEAGMEEKSKEFREQGSALYHEAHE

Specific function: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction [H]

COG id: COG0422

COG function: function code H; Thiamine biosynthesis protein ThiC

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiC family [H]

Homologues:

Organism=Escherichia coli, GI1790427, Length=607, Percent_Identity=71.169686985173, Blast_Score=906, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002817 [H]

Pfam domain/function: PF01964 ThiC [H]

EC number: NA

Molecular weight: Translated: 69805; Mature: 69673

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDDQRPIANAIDESCQPIAGSRKIYVTGSRPDIRVPMREIQQHPTPLADGKFEDNPPLS
CCCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCEE
VYDTSGPYTDPDTYIDIRKGLNPIRDAWIAERDDTEQLAGLTSEYGRKRANDVAKAGLRF
EEECCCCCCCCCCCHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
EHTRIPRRARAGKNVTQMHYARQGIITPEMEYIAIRENQRLREHREAGLPVNQHPGQSFG
HHHCCCHHHHCCCCHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCC
AAIPAEITPEFVRDEVARGRAVIPVNINHPEIEPMIIGRNFLTKINANIGNSAVTSSIEE
CCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCEEEECCHHHHHCCCCCCCHHHHHHHHH
EVSKMTWATRWGGDTVMDLSTGDNIHETREWILRNSPVPIGTVPIYQALEKVNGVAEDLT
HHHHHHHHEECCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHH
WEIFRDTLIEQAEQGVSYFTIHAGVLLRYVPMTANRVTGIVSRGGSIMAKWCLAHHEESF
HHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCCCH
LYTHFEDICEIMKAYDVTFSLGDGLRPGSLADANDEAQFSELRTLGELTKIAWKHDVQVM
HHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEE
IEGPGHVPMHMIKANMDEQLKHCGEAPFYTLGPLTIDISPGYDHISSAIGAAMIGWYGTA
EECCCCCCHHHHHCCHHHHHHHCCCCCCEEECCEEEEECCCHHHHHHHHHHHHHHHHHHE
MLCYVTPKEHLGLPNREDVKEGIIAYKIAAHAADLAKGHPGAQLRDNALSKARFEFRWED
EEEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCEEEEEECC
QFNLGLDPDRAREYHDETLPKQAHKVAHFCSMCGPKFCSMKISQEVREIYGDGTAQVAQA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHH
EAGMEEKSKEFREQGSALYHEAHE
HCCHHHHHHHHHHHCHHHHHHCCC
>Mature Secondary Structure 
PDDQRPIANAIDESCQPIAGSRKIYVTGSRPDIRVPMREIQQHPTPLADGKFEDNPPLS
CCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCEE
VYDTSGPYTDPDTYIDIRKGLNPIRDAWIAERDDTEQLAGLTSEYGRKRANDVAKAGLRF
EEECCCCCCCCCCCHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
EHTRIPRRARAGKNVTQMHYARQGIITPEMEYIAIRENQRLREHREAGLPVNQHPGQSFG
HHHCCCHHHHCCCCHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCC
AAIPAEITPEFVRDEVARGRAVIPVNINHPEIEPMIIGRNFLTKINANIGNSAVTSSIEE
CCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCEEEECCHHHHHCCCCCCCHHHHHHHHH
EVSKMTWATRWGGDTVMDLSTGDNIHETREWILRNSPVPIGTVPIYQALEKVNGVAEDLT
HHHHHHHHEECCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHH
WEIFRDTLIEQAEQGVSYFTIHAGVLLRYVPMTANRVTGIVSRGGSIMAKWCLAHHEESF
HHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCCCH
LYTHFEDICEIMKAYDVTFSLGDGLRPGSLADANDEAQFSELRTLGELTKIAWKHDVQVM
HHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEE
IEGPGHVPMHMIKANMDEQLKHCGEAPFYTLGPLTIDISPGYDHISSAIGAAMIGWYGTA
EECCCCCCHHHHHCCHHHHHHHCCCCCCEEECCEEEEECCCHHHHHHHHHHHHHHHHHHE
MLCYVTPKEHLGLPNREDVKEGIIAYKIAAHAADLAKGHPGAQLRDNALSKARFEFRWED
EEEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCEEEEEECC
QFNLGLDPDRAREYHDETLPKQAHKVAHFCSMCGPKFCSMKISQEVREIYGDGTAQVAQA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHH
EAGMEEKSKEFREQGSALYHEAHE
HCCHHHHHHHHHHHCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ?; ?; 5'-phosphoribosyl-5-aminoimidazole [C]

Specific reaction: Synthesis of @AMIN06.txt*4-amino-2-methyl-5-hydroxymethylpyrimidine! 5'-phosphoribosyl-5-aminoimidazole = 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA