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The map label for this gene is waaA [H]

Identifier: 110835362

GI number: 110835362

Start: 2836868

End: 2838148

Strand: Reverse

Name: waaA [H]

Synonym: ABO_2501

Alternate gene names: 110835362

Gene position: 2838148-2836868 (Counterclockwise)

Preceding gene: 110835366

Following gene: 110835360

Centisome position: 90.96

GC content: 58.31

Gene sequence:

>1281_bases
ATGCGAACTATTTATTCCGCCCTTTGGTATTTGCTGCTTCCCGCTCTTTTTCTGCGCTTGTGGCTGAGAGGTAGAAAAGC
ACCGGCTTATCGTTTGCGGTGGAAGGAGCGCATGGCGTGGGGGTACCGGTCCGGGATCTTGAAAAAAAGCCTTTGGGTGC
ATGCGGTGTCGGTGGGGGAAACATTGGCGGCGGCGCCGTTAATTGAGCGGTTGCTGGAAGACTACCCGGATGTGCCTTTA
CTGGTCACCACCACTACGCCCACTGGCTCAGAGCGGGTGCAGGCGTTGTTCGGGGGCCGGGTGACTCACGTTTATTGTCC
TTGGGAATTGCCCACGGCGTTGAACCGTTTTATGCGCGCCTTTGATCCGCAACTGGTAATCGTGCTGGAAACCGAGCTGT
GGCCGAATCTGTGTGCGGCGGTAAAGCGCCATGGCGCTAAACTGATGCTAATGAATGGGCGATTGTCGGAAAAAAGTTAT
CAGGGTTACGGCAAGTTGCCGCGGTTGATTCGCCCAATGATGGCACGCTTTGACGCGCTGGCAGTGCAGACACAAGTGGA
AGCCGAGCGTTACATGGCGCTAGGGGCTTGGCCGGAACGGGTATATCCCATTGGCAGTGTGAAATTCGATATGACACTGG
ATGCAGCAGTGAAACAGGCTGCGGCGGCACTGCGCTCGTCGTTCGGTAACCGGCCGGTGTGGATCGCTGCCAGCACCCAT
CCCGGAGAGGACGCTCTGGTTTTGGCTGCCCATAAAGCATTGCGTGAACAGAGGCCCGAGGCGCTGTTAATCCTGGTGCC
TCGACACCCGGAACGGTTTGCTGCAGTGGCCGATCAGATCCGTGAGGCAGGCTTGTCGGTGGCTCGGCGCAGCCAGCAGG
AGTCGGCCGCCGGCGTGGATGTGTACTTGGCCGATACCATGGGTGAGCTGTTGATGTTGTTTGGCACCTGCGATGTGGCT
TTTGTGGGCGGCTCTCTGGTGCCGGTAGGTGGGCATAATTTGTTGGAGCCGGCGGCTTGGCAGAAGCCGGTGCTCACCGG
GCCGCATTTACATAATTTTACTGCTATTGGGCAGTTGCTTGATGATGCTGGCGGGCTCAGTGTGGTGGAGGATGCGCAAT
CGTTGGGGGCGACCTTGCTGGCCTTGCTGGATGACCCGGCACAATGCGCTCGGCAAGGCAAAGCTGCTGCCGGCGTGGTG
GAAGCTAATCGAGGGGCGCTGGAAAAAGGGCTGCGGTTGGTTGCCATGGAGCTGAATACTGGACTTGGCCCTTCGGGTTA
A

Upstream 100 bases:

>100_bases
GCTGGCACGCGCATCGGCGCTGACACAGACAAGATGGATCATGTGTTTTGGGCTGTGCGCGTTGCCCGTGTATTGCCTCT
ACATTGAGATAAGAGCCCCT

Downstream 100 bases:

>100_bases
TGCGATCTGCTGTTTAGGTTGTGTACCTGCGCATGAATTTTTAGTGTGAAGGGCTGAACATCAACCGTCGGATTTTTCTC
GCAAGTAAATATAAAAAAAC

Product: 3-deoxy-D-manno-octulosonic-acid transferase

Products: NA

Alternate protein names: KDO transferase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MRTIYSALWYLLLPALFLRLWLRGRKAPAYRLRWKERMAWGYRSGILKKSLWVHAVSVGETLAAAPLIERLLEDYPDVPL
LVTTTTPTGSERVQALFGGRVTHVYCPWELPTALNRFMRAFDPQLVIVLETELWPNLCAAVKRHGAKLMLMNGRLSEKSY
QGYGKLPRLIRPMMARFDALAVQTQVEAERYMALGAWPERVYPIGSVKFDMTLDAAVKQAAAALRSSFGNRPVWIAASTH
PGEDALVLAAHKALREQRPEALLILVPRHPERFAAVADQIREAGLSVARRSQQESAAGVDVYLADTMGELLMLFGTCDVA
FVGGSLVPVGGHNLLEPAAWQKPVLTGPHLHNFTAIGQLLDDAGGLSVVEDAQSLGATLLALLDDPAQCARQGKAAAGVV
EANRGALEKGLRLVAMELNTGLGPSG

Sequences:

>Translated_426_residues
MRTIYSALWYLLLPALFLRLWLRGRKAPAYRLRWKERMAWGYRSGILKKSLWVHAVSVGETLAAAPLIERLLEDYPDVPL
LVTTTTPTGSERVQALFGGRVTHVYCPWELPTALNRFMRAFDPQLVIVLETELWPNLCAAVKRHGAKLMLMNGRLSEKSY
QGYGKLPRLIRPMMARFDALAVQTQVEAERYMALGAWPERVYPIGSVKFDMTLDAAVKQAAAALRSSFGNRPVWIAASTH
PGEDALVLAAHKALREQRPEALLILVPRHPERFAAVADQIREAGLSVARRSQQESAAGVDVYLADTMGELLMLFGTCDVA
FVGGSLVPVGGHNLLEPAAWQKPVLTGPHLHNFTAIGQLLDDAGGLSVVEDAQSLGATLLALLDDPAQCARQGKAAAGVV
EANRGALEKGLRLVAMELNTGLGPSG
>Mature_426_residues
MRTIYSALWYLLLPALFLRLWLRGRKAPAYRLRWKERMAWGYRSGILKKSLWVHAVSVGETLAAAPLIERLLEDYPDVPL
LVTTTTPTGSERVQALFGGRVTHVYCPWELPTALNRFMRAFDPQLVIVLETELWPNLCAAVKRHGAKLMLMNGRLSEKSY
QGYGKLPRLIRPMMARFDALAVQTQVEAERYMALGAWPERVYPIGSVKFDMTLDAAVKQAAAALRSSFGNRPVWIAASTH
PGEDALVLAAHKALREQRPEALLILVPRHPERFAAVADQIREAGLSVARRSQQESAAGVDVYLADTMGELLMLFGTCDVA
FVGGSLVPVGGHNLLEPAAWQKPVLTGPHLHNFTAIGQLLDDAGGLSVVEDAQSLGATLLALLDDPAQCARQGKAAAGVV
EANRGALEKGLRLVAMELNTGLGPSG

Specific function: Essential step in lipopolysaccharides biosynthesis. Acts at transfer of 3-deoxy-D-mono octulonic acid (KDO) from CMP-KDO to a tetraacyldisaccharide 1,4'-bisphosphate precursor of lipid A (lipid IVA). Transfers two molecules of KDO to lipid IVA [H]

COG id: COG1519

COG function: function code M; 3-deoxy-D-manno-octulosonic-acid transferase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 1 family [H]

Homologues:

Organism=Escherichia coli, GI1790064, Length=416, Percent_Identity=48.7980769230769, Blast_Score=388, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001296
- InterPro:   IPR007507 [H]

Pfam domain/function: PF00534 Glycos_transf_1; PF04413 Glycos_transf_N [H]

EC number: 2.-.-.-

Molecular weight: Translated: 46538; Mature: 46538

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTIYSALWYLLLPALFLRLWLRGRKAPAYRLRWKERMAWGYRSGILKKSLWVHAVSVGE
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHH
TLAAAPLIERLLEDYPDVPLLVTTTTPTGSERVQALFGGRVTHVYCPWELPTALNRFMRA
HHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHH
FDPQLVIVLETELWPNLCAAVKRHGAKLMLMNGRLSEKSYQGYGKLPRLIRPMMARFDAL
CCCCEEEEEECCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AVQTQVEAERYMALGAWPERVYPIGSVKFDMTLDAAVKQAAAALRSSFGNRPVWIAASTH
HHHHHHHHHHHHEECCCHHHCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEECCC
PGEDALVLAAHKALREQRPEALLILVPRHPERFAAVADQIREAGLSVARRSQQESAAGVD
CCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VYLADTMGELLMLFGTCDVAFVGGSLVPVGGHNLLEPAAWQKPVLTGPHLHNFTAIGQLL
EEEHHHHHHHHHHHHCCCEEEECCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
DDAGGLSVVEDAQSLGATLLALLDDPAQCARQGKAAAGVVEANRGALEKGLRLVAMELNT
HCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCEEECCCHHHHHCCEEEEEEECC
GLGPSG
CCCCCC
>Mature Secondary Structure
MRTIYSALWYLLLPALFLRLWLRGRKAPAYRLRWKERMAWGYRSGILKKSLWVHAVSVGE
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHH
TLAAAPLIERLLEDYPDVPLLVTTTTPTGSERVQALFGGRVTHVYCPWELPTALNRFMRA
HHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHH
FDPQLVIVLETELWPNLCAAVKRHGAKLMLMNGRLSEKSYQGYGKLPRLIRPMMARFDAL
CCCCEEEEEECCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AVQTQVEAERYMALGAWPERVYPIGSVKFDMTLDAAVKQAAAALRSSFGNRPVWIAASTH
HHHHHHHHHHHHEECCCHHHCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEECCC
PGEDALVLAAHKALREQRPEALLILVPRHPERFAAVADQIREAGLSVARRSQQESAAGVD
CCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VYLADTMGELLMLFGTCDVAFVGGSLVPVGGHNLLEPAAWQKPVLTGPHLHNFTAIGQLL
EEEHHHHHHHHHHHHCCCEEEECCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
DDAGGLSVVEDAQSLGATLLALLDDPAQCARQGKAAAGVVEANRGALEKGLRLVAMELNT
HCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCEEECCCHHHHHCCEEEEEEECC
GLGPSG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]