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The map label for this gene is adpP [H]

Identifier: 110835359

GI number: 110835359

Start: 2832564

End: 2833208

Strand: Reverse

Name: adpP [H]

Synonym: ABO_2498

Alternate gene names: 110835359

Gene position: 2833208-2832564 (Counterclockwise)

Preceding gene: 110835360

Following gene: 110835358

Centisome position: 90.8

GC content: 59.69

Gene sequence:

>645_bases
ATGAGGCCCATGAGTAATCATTCGTTAACACCGCCATTTGGCCCTCAGGACGTGGAAGTGTTGGCGCGGGAGACCCCGTT
CCAAGGCTTTTTCCGGGTGGATACCCTGACCCTGCGCCACAAGCACTATAACGGGGGCTGGGGCGAGCCTGTCCGCCGGG
AATTGTTTGTGCGCCCACCGGCAGCGGCCGTGTTGCCCTATGACCCGGTGCGTGGCGAGATTTTGCTGGTGGAGCAGTTT
CGAGTCGGCGCGCTGGAGTGGCGAGATACCCCTTGGTGCCTGGAGTTGATCGCGGGCATTGCAGACAAGGATGGCGAGAG
CGCTGCCGACCTGATTCGTCGCGAAGCGGTGGAAGAGGCGGGGCTGACCTTGGGCACCCTGGAACCGATTGCCGCTTACA
TGCCCAGCCCGGGTGGTACCAATGAGCGCTTGCAGTTGTTTGTGGGCCATGCGGACTTGGCTGGTGCGGGTGGTATTTTT
GGTTGTCCAGACGAAGGTGAAGACATTCGTGCCGTGACAATGAGTGCTGATGACATTCCTGCGTTATTGAATGGTGGCCA
GGTAGATAACGCGGCCTCGCTGATTGCCCTGCAATGGTTGCTGTTGAATCGTGCCCGGTTGGATGCGGGTTGGGGAGGTA
AGTGA

Upstream 100 bases:

>100_bases
CGCGAGATCTATGGTGACGGCACCGCCCAGGTGGCTCAGGCTGAAGCGGGCATGGAAGAAAAATCTAAGGAGTTTCGAGA
GCAGGGCTCCGCGCTATATC

Downstream 100 bases:

>100_bases
GTCGCCGCGATCGCTACCAGCTGGATTTCCGTGCGCTGATGACTCAGTGCGAGGAAAACTATGCGCGGCTGTTGCCCTTG
ATGAAAGCGTTGGGGGAGCG

Product: ADPribose pyrophosphatase

Products: NA

Alternate protein names: ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ASPPase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRPMSNHSLTPPFGPQDVEVLARETPFQGFFRVDTLTLRHKHYNGGWGEPVRRELFVRPPAAAVLPYDPVRGEILLVEQF
RVGALEWRDTPWCLELIAGIADKDGESAADLIRREAVEEAGLTLGTLEPIAAYMPSPGGTNERLQLFVGHADLAGAGGIF
GCPDEGEDIRAVTMSADDIPALLNGGQVDNAASLIALQWLLLNRARLDAGWGGK

Sequences:

>Translated_214_residues
MRPMSNHSLTPPFGPQDVEVLARETPFQGFFRVDTLTLRHKHYNGGWGEPVRRELFVRPPAAAVLPYDPVRGEILLVEQF
RVGALEWRDTPWCLELIAGIADKDGESAADLIRREAVEEAGLTLGTLEPIAAYMPSPGGTNERLQLFVGHADLAGAGGIF
GCPDEGEDIRAVTMSADDIPALLNGGQVDNAASLIALQWLLLNRARLDAGWGGK
>Mature_214_residues
MRPMSNHSLTPPFGPQDVEVLARETPFQGFFRVDTLTLRHKHYNGGWGEPVRRELFVRPPAAAVLPYDPVRGEILLVEQF
RVGALEWRDTPWCLELIAGIADKDGESAADLIRREAVEEAGLTLGTLEPIAAYMPSPGGTNERLQLFVGHADLAGAGGIF
GCPDEGEDIRAVTMSADDIPALLNGGQVDNAASLIALQWLLLNRARLDAGWGGK

Specific function: Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789412, Length=205, Percent_Identity=46.3414634146341, Blast_Score=198, Evalue=2e-52,
Organism=Escherichia coli, GI1788810, Length=159, Percent_Identity=28.9308176100629, Blast_Score=66, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004385
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: =3.6.1.13 [H]

Molecular weight: Translated: 23221; Mature: 23221

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPMSNHSLTPPFGPQDVEVLARETPFQGFFRVDTLTLRHKHYNGGWGEPVRRELFVRPP
CCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEEEEEEEECCCCCCCCCHHHHEEECCC
AAAVLPYDPVRGEILLVEQFRVGALEWRDTPWCLELIAGIADKDGESAADLIRREAVEEA
CCEECCCCCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GLTLGTLEPIAAYMPSPGGTNERLQLFVGHADLAGAGGIFGCPDEGEDIRAVTMSADDIP
CCEECCHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCH
ALLNGGQVDNAASLIALQWLLLNRARLDAGWGGK
HHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRPMSNHSLTPPFGPQDVEVLARETPFQGFFRVDTLTLRHKHYNGGWGEPVRRELFVRPP
CCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEEEEEEEECCCCCCCCCHHHHEEECCC
AAAVLPYDPVRGEILLVEQFRVGALEWRDTPWCLELIAGIADKDGESAADLIRREAVEEA
CCEECCCCCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GLTLGTLEPIAAYMPSPGGTNERLQLFVGHADLAGAGGIFGCPDEGEDIRAVTMSADDIP
CCEECCHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCH
ALLNGGQVDNAASLIALQWLLLNRARLDAGWGGK
HHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]