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The map label for this gene is mscS [H]

Identifier: 110835246

GI number: 110835246

Start: 2709418

End: 2710260

Strand: Reverse

Name: mscS [H]

Synonym: ABO_2385

Alternate gene names: 110835246

Gene position: 2710260-2709418 (Counterclockwise)

Preceding gene: 110835251

Following gene: 110835244

Centisome position: 86.86

GC content: 49.94

Gene sequence:

>843_bases
ATGGATATGGAGCAAATACAGCCGTATCTGGACAAGGGAATTGAGCTAAGCATGGCCTATTTGCCTAAGGTGCTGCTAGC
GGTGATTACATTGATTGTGGGCTTCTGGATCATCAAGAGGGTGATCAAGGGCATGAACCGGCTGCTGGGCTTCAAGGCCG
TGGACGATACCTTACAGAAGTTTATGACCAGCCTTGTTGATGTGCTGCTTAAAATTTTGTTGCTGGTGGCGGTGGCAGGA
ATGGTTGGCGTACAAACGACGTCCTTTATTGCCATGCTGGGTGCCATGGGGTTGGCGGTGGGGCTGGCGTTGCAAGGAAG
CCTGGGCAACTTTGCTGGCGGTGTGCTTATCCTGCTCTTCAAACCGTACCGGGTGGGGGACATTATTGAAGCCCAGGGGC
ATACCGGAAAAGTATGGGATATTCAGATTTTCAATACCATCCTCACGACCTACGACAACCAGCGCATCGTGATTCCCAAC
GGACTCATGTCCAATGGCTGTATCAAAAATATTTTTGTGGAGCCGCAACGGCGCATAGATATTGAATTTGGTATTGGCTA
TGGCGATAGCATTGAGCAGGCTCGGGCCGCGATTCAATCGGTGATTGATAACGATGATCGCATTCTGGATGGTGGTAGTT
TCGACGCCGATATTTTTGTTTCGGCCCATGCGGATAGCAGCATTACAATGTTGACTCGGGCGTGGGTGAATTCGGAAGAT
TATTGGCCGGTGTATTTTGGTTTGTTCGAGCAGGTGAAATACGCCTTTGATAAAGCCGGTATTACCATTCCGTTCCCCCA
GCGGGATGTGCATTTATTTCAGCAGAGCGGAGGCGAAAGTTAG

Upstream 100 bases:

>100_bases
CGAAAGGATAAATAGTGGCAGATTCAGACGCAGTTAAGGTTTGCGGTTGGCCTCTTAGTGGTACTTTAAGTGTCTACATA
ACTCATAAAGGAAGGGAATC

Downstream 100 bases:

>100_bases
ACGCTAAAACGCGAGGTGAATTGGTGATACCAAAAAGAGGGGCCGTGATCAGTGATGATCGCGGCCCCTTTTTTTGGCGT
GGAAAGGGTGTGGTTGCGTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MDMEQIQPYLDKGIELSMAYLPKVLLAVITLIVGFWIIKRVIKGMNRLLGFKAVDDTLQKFMTSLVDVLLKILLLVAVAG
MVGVQTTSFIAMLGAMGLAVGLALQGSLGNFAGGVLILLFKPYRVGDIIEAQGHTGKVWDIQIFNTILTTYDNQRIVIPN
GLMSNGCIKNIFVEPQRRIDIEFGIGYGDSIEQARAAIQSVIDNDDRILDGGSFDADIFVSAHADSSITMLTRAWVNSED
YWPVYFGLFEQVKYAFDKAGITIPFPQRDVHLFQQSGGES

Sequences:

>Translated_280_residues
MDMEQIQPYLDKGIELSMAYLPKVLLAVITLIVGFWIIKRVIKGMNRLLGFKAVDDTLQKFMTSLVDVLLKILLLVAVAG
MVGVQTTSFIAMLGAMGLAVGLALQGSLGNFAGGVLILLFKPYRVGDIIEAQGHTGKVWDIQIFNTILTTYDNQRIVIPN
GLMSNGCIKNIFVEPQRRIDIEFGIGYGDSIEQARAAIQSVIDNDDRILDGGSFDADIFVSAHADSSITMLTRAWVNSED
YWPVYFGLFEQVKYAFDKAGITIPFPQRDVHLFQQSGGES
>Mature_280_residues
MDMEQIQPYLDKGIELSMAYLPKVLLAVITLIVGFWIIKRVIKGMNRLLGFKAVDDTLQKFMTSLVDVLLKILLLVAVAG
MVGVQTTSFIAMLGAMGLAVGLALQGSLGNFAGGVLILLFKPYRVGDIIEAQGHTGKVWDIQIFNTILTTYDNQRIVIPN
GLMSNGCIKNIFVEPQRRIDIEFGIGYGDSIEQARAAIQSVIDNDDRILDGGSFDADIFVSAHADSSITMLTRAWVNSED
YWPVYFGLFEQVKYAFDKAGITIPFPQRDVHLFQQSGGES

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=256, Percent_Identity=40.234375, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI1786670, Length=206, Percent_Identity=25.7281553398058, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787591, Length=229, Percent_Identity=24.8908296943231, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 30890; Mature: 30890

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMEQIQPYLDKGIELSMAYLPKVLLAVITLIVGFWIIKRVIKGMNRLLGFKAVDDTLQK
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
FMTSLVDVLLKILLLVAVAGMVGVQTTSFIAMLGAMGLAVGLALQGSLGNFAGGVLILLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCEEEEEE
KPYRVGDIIEAQGHTGKVWDIQIFNTILTTYDNQRIVIPNGLMSNGCIKNIFVEPQRRID
CCCCCCCEEECCCCCCCEEEHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHEECCCCEEE
IEFGIGYGDSIEQARAAIQSVIDNDDRILDGGSFDADIFVSAHADSSITMLTRAWVNSED
EEEECCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCEEEEEECCCCCHHHHHHHHCCCCC
YWPVYFGLFEQVKYAFDKAGITIPFPQRDVHLFQQSGGES
CCHHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MDMEQIQPYLDKGIELSMAYLPKVLLAVITLIVGFWIIKRVIKGMNRLLGFKAVDDTLQK
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
FMTSLVDVLLKILLLVAVAGMVGVQTTSFIAMLGAMGLAVGLALQGSLGNFAGGVLILLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCEEEEEE
KPYRVGDIIEAQGHTGKVWDIQIFNTILTTYDNQRIVIPNGLMSNGCIKNIFVEPQRRID
CCCCCCCEEECCCCCCCEEEHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHEECCCCEEE
IEFGIGYGDSIEQARAAIQSVIDNDDRILDGGSFDADIFVSAHADSSITMLTRAWVNSED
EEEECCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCEEEEEECCCCCHHHHHHHHCCCCC
YWPVYFGLFEQVKYAFDKAGITIPFPQRDVHLFQQSGGES
CCHHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]