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The map label for this gene is cobQ

Identifier: 110835226

GI number: 110835226

Start: 2688822

End: 2690267

Strand: Reverse

Name: cobQ

Synonym: ABO_2365

Alternate gene names: 110835226

Gene position: 2690267-2688822 (Counterclockwise)

Preceding gene: 110835227

Following gene: 110835223

Centisome position: 86.22

GC content: 55.88

Gene sequence:

>1446_bases
GTGGCGACTCTGATGGTGCAAGGCTGCACATCGGATGCGGGAAAGAGCACGGTGGTCGCGGCGTTGTGCCGCTGGTTTGC
CCGGCGTGGATATTCGGTGGCGCCGTTTAAACCGCAGAACATGGCACTGAACAGTGCTGTGACCGTGGATGGGGGTGAGA
TTGGTCGTTCTACCGCGTTGCAGGCGTTGGCTTGCGGGGTCGCGCCGCACAGTGACATGAACCCTGTATTGCTCAAGCCA
CAAACGGATATGGGCGCCCAGGTTATTATTCGCGGCAAGGTGTTGGGCAATATGCAGGCACTGGATTATCACGCCTACAA
GAACACCGCCAGTGAGGCGGTGCTGGCGGCCTGGCAGGACTTGTCTTCCCGGTTTGATGTGATCATCGCTGAAGGCGCTG
GCAGCCCGGCGGAGATTAATCTGCGAGATAACGACATCGCTAACATGGGGTTTGCCGAAAGGGTGGACTGCCCGGTGATT
GTGGTGGCGGATATTGATCGCGGCGGTGTCTTTGCGCATCTTACCGGTACCCTGGATTTACTGTCTGAAAGTGAACAAAA
ACGAACCCTGGGGTTTGTGATTAATCGTTTTCGTGGCGACCTGTCTTTATTGCAGGGTGGGCTGGATTGGTTGGAGGAGC
GTACTGGCAAGCCAGTGTTTGGGGTGTTGCCTTATTTGCATGGCCTGACTCTGGATGCGGAAGATGCGGTGGATGAACAG
GGCGCGCATGACGTGGGTGCTTTCAATGTGGTGGTGCCTCTGTTGCCGCGTATGAGTAACCACAACGACTTTGACCCTCT
GCGATTACATCCGCAGGTGAATTTGCAATTCGTAAAGATGGGGGAGGCTTGGCCGTCGGCAGACCTGATCATTCTGCCGG
GCAGCAAGGCTACCCGTGCGGATTTGGCTTTCCTGCGCCAGCAGGGCTGGGACAAGCAGATCGAAAAGCACCTGCGTTAC
GGCGGCAAAGTGCTAGGCATTTGTGGTGGCTTTCAAATGTTGGGAGAGCGCATCGACGACCCGGAGGGGTTAGAAAGTGA
TGCGGGAAGTAGTGCCGGGCTTGGCTGGTTATCCATGACCACTCGATTGATTTCCGGTAAACAGCTACGAAATGTCGAAG
GCCGTTTTGTTGCCGCTGACACCCTGATTCGCGGGTATGAAATCCACAATGGCCTTACTCAGGGCGAAGCATTAAAGCAT
CCTATGCTGGTTCTGGAGGGTAGGGATGATGGCGCCATGAGCGAGGATGGGCGGGTGATGGGGTGTTACCTGCATGGCCT
GTTTGATGTTCCCGACAGTTGCAATACCATACTCGAATGGGCGGGCCTGAAAAGCCAGCGCAGTGTGGATTATGCGGTCC
ATCGAGAGCAACAGCTGGATCGCCTGGCCGATATGCTGGAGGAACACTTGGATATGACGCGGTTAAAGCAATGCATGGGG
AGCTAG

Upstream 100 bases:

>100_bases
GTTCGGAAAAAATACGGGGCGAGTGGGCCGGCAAGGTCACTGTAGGTGCTGGGTTGCGCTTCAAGTTTGAGATTGTAACG
TTCAAGGTAAGGTTTTCTCC

Downstream 100 bases:

>100_bases
CTCGAATAGCGTGCCTGACTTTTTCTCAGCGCCAAACCGGGCGCCCTGTATTTTTTCAGTAACGTTTCGTTGCCTAAAGA
TTCGAGCAATACACCGATTA

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MATLMVQGCTSDAGKSTVVAALCRWFARRGYSVAPFKPQNMALNSAVTVDGGEIGRSTALQALACGVAPHSDMNPVLLKP
QTDMGAQVIIRGKVLGNMQALDYHAYKNTASEAVLAAWQDLSSRFDVIIAEGAGSPAEINLRDNDIANMGFAERVDCPVI
VVADIDRGGVFAHLTGTLDLLSESEQKRTLGFVINRFRGDLSLLQGGLDWLEERTGKPVFGVLPYLHGLTLDAEDAVDEQ
GAHDVGAFNVVVPLLPRMSNHNDFDPLRLHPQVNLQFVKMGEAWPSADLIILPGSKATRADLAFLRQQGWDKQIEKHLRY
GGKVLGICGGFQMLGERIDDPEGLESDAGSSAGLGWLSMTTRLISGKQLRNVEGRFVAADTLIRGYEIHNGLTQGEALKH
PMLVLEGRDDGAMSEDGRVMGCYLHGLFDVPDSCNTILEWAGLKSQRSVDYAVHREQQLDRLADMLEEHLDMTRLKQCMG
S

Sequences:

>Translated_481_residues
MATLMVQGCTSDAGKSTVVAALCRWFARRGYSVAPFKPQNMALNSAVTVDGGEIGRSTALQALACGVAPHSDMNPVLLKP
QTDMGAQVIIRGKVLGNMQALDYHAYKNTASEAVLAAWQDLSSRFDVIIAEGAGSPAEINLRDNDIANMGFAERVDCPVI
VVADIDRGGVFAHLTGTLDLLSESEQKRTLGFVINRFRGDLSLLQGGLDWLEERTGKPVFGVLPYLHGLTLDAEDAVDEQ
GAHDVGAFNVVVPLLPRMSNHNDFDPLRLHPQVNLQFVKMGEAWPSADLIILPGSKATRADLAFLRQQGWDKQIEKHLRY
GGKVLGICGGFQMLGERIDDPEGLESDAGSSAGLGWLSMTTRLISGKQLRNVEGRFVAADTLIRGYEIHNGLTQGEALKH
PMLVLEGRDDGAMSEDGRVMGCYLHGLFDVPDSCNTILEWAGLKSQRSVDYAVHREQQLDRLADMLEEHLDMTRLKQCMG
S
>Mature_480_residues
ATLMVQGCTSDAGKSTVVAALCRWFARRGYSVAPFKPQNMALNSAVTVDGGEIGRSTALQALACGVAPHSDMNPVLLKPQ
TDMGAQVIIRGKVLGNMQALDYHAYKNTASEAVLAAWQDLSSRFDVIIAEGAGSPAEINLRDNDIANMGFAERVDCPVIV
VADIDRGGVFAHLTGTLDLLSESEQKRTLGFVINRFRGDLSLLQGGLDWLEERTGKPVFGVLPYLHGLTLDAEDAVDEQG
AHDVGAFNVVVPLLPRMSNHNDFDPLRLHPQVNLQFVKMGEAWPSADLIILPGSKATRADLAFLRQQGWDKQIEKHLRYG
GKVLGICGGFQMLGERIDDPEGLESDAGSSAGLGWLSMTTRLISGKQLRNVEGRFVAADTLIRGYEIHNGLTQGEALKHP
MLVLEGRDDGAMSEDGRVMGCYLHGLFDVPDSCNTILEWAGLKSQRSVDYAVHREQQLDRLADMLEEHLDMTRLKQCMGS

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_ALCBS (Q0VLY5)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_694085.1
- ProteinModelPortal:   Q0VLY5
- STRING:   Q0VLY5
- GeneID:   4212341
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_2365
- NMPDR:   fig|393595.12.peg.2367
- eggNOG:   COG1492
- HOGENOM:   HBG302271
- OMA:   RGDIANM
- ProtClustDB:   PRK00784
- BioCyc:   ABOR393595:ABO_2365-MONOMER
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: 6.3.5.10

Molecular weight: Translated: 52367; Mature: 52236

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 328-328 ACT_SITE 425-425

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLMVQGCTSDAGKSTVVAALCRWFARRGYSVAPFKPQNMALNSAVTVDGGEIGRSTAL
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCEEEECCHHCCHHHHH
QALACGVAPHSDMNPVLLKPQTDMGAQVIIRGKVLGNMQALDYHAYKNTASEAVLAAWQD
HHHHHCCCCCCCCCCEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHCHHHHHHHHHHHH
LSSRFDVIIAEGAGSPAEINLRDNDIANMGFAERVDCPVIVVADIDRGGVFAHLTGTLDL
HCCCCCEEEECCCCCCEEEEECCCCCCCCCCHHHCCCCEEEEEECCCCCEEEEECHHHHH
LSESEQKRTLGFVINRFRGDLSLLQGGLDWLEERTGKPVFGVLPYLHGLTLDAEDAVDEQ
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHCC
GAHDVGAFNVVVPLLPRMSNHNDFDPLRLHPQVNLQFVKMGEAWPSADLIILPGSKATRA
CCCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEEEECCCCCCCCEEEECCCCCHHH
DLAFLRQQGWDKQIEKHLRYGGKVLGICGGFQMLGERIDDPEGLESDAGSSAGLGWLSMT
HHHHHHHCCCHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
TRLISGKQLRNVEGRFVAADTLIRGYEIHNGLTQGEALKHPMLVLEGRDDGAMSEDGRVM
HHHHCCCHHCCCCCCEEEHHHHHHCCHHHCCCCCCHHHCCCEEEEECCCCCCCCCCCCEE
GCYLHGLFDVPDSCNTILEWAGLKSQRSVDYAVHREQQLDRLADMLEEHLDMTRLKQCMG
EEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
S
C
>Mature Secondary Structure 
ATLMVQGCTSDAGKSTVVAALCRWFARRGYSVAPFKPQNMALNSAVTVDGGEIGRSTAL
CEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCEEEECCHHCCHHHHH
QALACGVAPHSDMNPVLLKPQTDMGAQVIIRGKVLGNMQALDYHAYKNTASEAVLAAWQD
HHHHHCCCCCCCCCCEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHCHHHHHHHHHHHH
LSSRFDVIIAEGAGSPAEINLRDNDIANMGFAERVDCPVIVVADIDRGGVFAHLTGTLDL
HCCCCCEEEECCCCCCEEEEECCCCCCCCCCHHHCCCCEEEEEECCCCCEEEEECHHHHH
LSESEQKRTLGFVINRFRGDLSLLQGGLDWLEERTGKPVFGVLPYLHGLTLDAEDAVDEQ
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHCC
GAHDVGAFNVVVPLLPRMSNHNDFDPLRLHPQVNLQFVKMGEAWPSADLIILPGSKATRA
CCCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEEEECCCCCCCCEEEECCCCCHHH
DLAFLRQQGWDKQIEKHLRYGGKVLGICGGFQMLGERIDDPEGLESDAGSSAGLGWLSMT
HHHHHHHCCCHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
TRLISGKQLRNVEGRFVAADTLIRGYEIHNGLTQGEALKHPMLVLEGRDDGAMSEDGRVM
HHHHCCCHHCCCCCCEEEHHHHHHCCHHHCCCCCCHHHCCCEEEEECCCCCCCCCCCCEE
GCYLHGLFDVPDSCNTILEWAGLKSQRSVDYAVHREQQLDRLADMLEEHLDMTRLKQCMG
EEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA