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The map label for this gene is moaA [H]

Identifier: 110835223

GI number: 110835223

Start: 2686086

End: 2687099

Strand: Reverse

Name: moaA [H]

Synonym: ABO_2362

Alternate gene names: 110835223

Gene position: 2687099-2686086 (Counterclockwise)

Preceding gene: 110835226

Following gene: 110835222

Centisome position: 86.12

GC content: 58.19

Gene sequence:

>1014_bases
ATGAATGCTGATGTTTCCACCGACAATCCAGTCCTGCAGGACCGCTTCGGGCGCGCCATTGATTATGTGCGGCTGTCGGT
GACGGACCGCTGTGATTTTCGCTGTGTGTACTGTATGGCGGAGGATATGACCTTTGTGCCCCGCGATCAGGTGCTGACTC
TGGAGGAGATGAGTCGGTTGGCCCGGGTGCTAGTGCGGTTGGGGGTCAAGCGTATTCGGTTAACTGGCGGCGAGCCGTTA
GTGCGCCGTGATGTGGCGCATTTGGTGCGCGATATTGGTGCCATCGAGGGCCTGCGTGAACTGAATATGACCACCAATGG
GGCTGGGCTGACTCGGCACGCGGTGGCCCTGAAGGCTGCCGGGCTCAATCGGCTGAATATCAGCCTGGATTCGCTGGATC
CGGAGCGATTCAAGGCGCTTACCCGTACCGGGAATTTGGTTCAAGTGCTGGCAGGAATCGATGCGGCCAGGGCCGCCGGT
TTTGAACGCATCAAACTCAACAGCGTGATCATGCGAGGCCGTAATCACGACGAGGTGCCGGCGCTGGTAGATTTCGCTCT
AGCGCGGGGCTTGGATATTTCCTTTATTGAGGAGATGCCTCTCGGGCAGATCACCGAACACGACCGGGAACTGGCCTTTG
TGTCCTCGGCGGAGCTGCGTGAACAGCTGTCTGCACGGCTTGAATTGGTGCCGCTGGCAGAAAAAACGGGAGGGCCGTCA
CGCTACTGGCAAGCGCCCGGGAGTAACAGTCGCATCGGCTTTATTTCACCCCACTCACAAAACTTTTGCCATTTGTGTAA
TCGAGTGCGGATTACGGCCGAGGGGCGTATGCTTTTGTGCCTAGGCCATGAGCACAGTGTGGATTTACGCGCGGTGCTGC
GCGCCTATCCGGATGACGATACTCCTCTTCGCGAAGCCATTGTGGATGCCATGGCCATCAAGCCCGAGCGCCACGACTTC
AGCCTGGAGCCGGGTGAGCAGTTGGTACGGTTTATGAATATGACAGGGGGCTAG

Upstream 100 bases:

>100_bases
AAGACCGGCAAGGGCCTGACCAACTGGAGCTAGCCTGGCCCGACGGGCGTTAGGAGGAGTCGCTTGCCCAGGTTGGCCCC
GCATTTGCTACAGTAGCGGC

Downstream 100 bases:

>100_bases
CGCGCCGATAGGTTGCGGGCTGCCTGTAGAGTGAATGCGCAAAAAAGCGAGGAACGATGAAATCCCTACCTGATTTGTTT
TCCAACAACGAAAAATGGCG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MNADVSTDNPVLQDRFGRAIDYVRLSVTDRCDFRCVYCMAEDMTFVPRDQVLTLEEMSRLARVLVRLGVKRIRLTGGEPL
VRRDVAHLVRDIGAIEGLRELNMTTNGAGLTRHAVALKAAGLNRLNISLDSLDPERFKALTRTGNLVQVLAGIDAARAAG
FERIKLNSVIMRGRNHDEVPALVDFALARGLDISFIEEMPLGQITEHDRELAFVSSAELREQLSARLELVPLAEKTGGPS
RYWQAPGSNSRIGFISPHSQNFCHLCNRVRITAEGRMLLCLGHEHSVDLRAVLRAYPDDDTPLREAIVDAMAIKPERHDF
SLEPGEQLVRFMNMTGG

Sequences:

>Translated_337_residues
MNADVSTDNPVLQDRFGRAIDYVRLSVTDRCDFRCVYCMAEDMTFVPRDQVLTLEEMSRLARVLVRLGVKRIRLTGGEPL
VRRDVAHLVRDIGAIEGLRELNMTTNGAGLTRHAVALKAAGLNRLNISLDSLDPERFKALTRTGNLVQVLAGIDAARAAG
FERIKLNSVIMRGRNHDEVPALVDFALARGLDISFIEEMPLGQITEHDRELAFVSSAELREQLSARLELVPLAEKTGGPS
RYWQAPGSNSRIGFISPHSQNFCHLCNRVRITAEGRMLLCLGHEHSVDLRAVLRAYPDDDTPLREAIVDAMAIKPERHDF
SLEPGEQLVRFMNMTGG
>Mature_337_residues
MNADVSTDNPVLQDRFGRAIDYVRLSVTDRCDFRCVYCMAEDMTFVPRDQVLTLEEMSRLARVLVRLGVKRIRLTGGEPL
VRRDVAHLVRDIGAIEGLRELNMTTNGAGLTRHAVALKAAGLNRLNISLDSLDPERFKALTRTGNLVQVLAGIDAARAAG
FERIKLNSVIMRGRNHDEVPALVDFALARGLDISFIEEMPLGQITEHDRELAFVSSAELREQLSARLELVPLAEKTGGPS
RYWQAPGSNSRIGFISPHSQNFCHLCNRVRITAEGRMLLCLGHEHSVDLRAVLRAYPDDDTPLREAIVDAMAIKPERHDF
SLEPGEQLVRFMNMTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=331, Percent_Identity=39.2749244712991, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI22027536, Length=331, Percent_Identity=39.2749244712991, Blast_Score=216, Evalue=3e-56,
Organism=Escherichia coli, GI1786999, Length=330, Percent_Identity=35.7575757575758, Blast_Score=214, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI32566331, Length=315, Percent_Identity=36.8253968253968, Blast_Score=211, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI32566329, Length=315, Percent_Identity=36.8253968253968, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17561210, Length=308, Percent_Identity=37.3376623376623, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI28574488, Length=334, Percent_Identity=38.622754491018, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI28574490, Length=314, Percent_Identity=39.4904458598726, Blast_Score=214, Evalue=7e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37550; Mature: 37550

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNADVSTDNPVLQDRFGRAIDYVRLSVTDRCDFRCVYCMAEDMTFVPRDQVLTLEEMSRL
CCCCCCCCCCHHHHHHCCHHHEEEEEECCCCCCEEEEEEECCCEECCCCCEECHHHHHHH
ARVLVRLGVKRIRLTGGEPLVRRDVAHLVRDIGAIEGLRELNMTTNGAGLTRHAVALKAA
HHHHHHHCHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHC
GLNRLNISLDSLDPERFKALTRTGNLVQVLAGIDAARAAGFERIKLNSVIMRGRNHDEVP
CCCEEEEEECCCCHHHHHHHHHCCCHHHHHHCCCHHHHCCCHHEEHHHHHCCCCCCCCHH
ALVDFALARGLDISFIEEMPLGQITEHDRELAFVSSAELREQLSARLELVPLAEKTGGPS
HHHHHHHHCCCCHHHHHCCCCCCHHHCCHHEEEHHHHHHHHHHHHHEEEEEEHHCCCCCC
RYWQAPGSNSRIGFISPHSQNFCHLCNRVRITAEGRMLLCLGHEHSVDLRAVLRAYPDDD
CEECCCCCCCEEEEECCCCCCHHHHHCCEEEEECCCEEEEECCCCCCHHHHHHHHCCCCC
TPLREAIVDAMAIKPERHDFSLEPGEQLVRFMNMTGG
CHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MNADVSTDNPVLQDRFGRAIDYVRLSVTDRCDFRCVYCMAEDMTFVPRDQVLTLEEMSRL
CCCCCCCCCCHHHHHHCCHHHEEEEEECCCCCCEEEEEEECCCEECCCCCEECHHHHHHH
ARVLVRLGVKRIRLTGGEPLVRRDVAHLVRDIGAIEGLRELNMTTNGAGLTRHAVALKAA
HHHHHHHCHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHC
GLNRLNISLDSLDPERFKALTRTGNLVQVLAGIDAARAAGFERIKLNSVIMRGRNHDEVP
CCCEEEEEECCCCHHHHHHHHHCCCHHHHHHCCCHHHHCCCHHEEHHHHHCCCCCCCCHH
ALVDFALARGLDISFIEEMPLGQITEHDRELAFVSSAELREQLSARLELVPLAEKTGGPS
HHHHHHHHCCCCHHHHHCCCCCCHHHCCHHEEEHHHHHHHHHHHHHEEEEEEHHCCCCCC
RYWQAPGSNSRIGFISPHSQNFCHLCNRVRITAEGRMLLCLGHEHSVDLRAVLRAYPDDD
CEECCCCCCCEEEEECCCCCCHHHHHCCEEEEECCCEEEEECCCCCCHHHHHHHHCCCCC
TPLREAIVDAMAIKPERHDFSLEPGEQLVRFMNMTGG
CHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA