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The map label for this gene is hemD [H]

Identifier: 110835182

GI number: 110835182

Start: 2648830

End: 2649561

Strand: Reverse

Name: hemD [H]

Synonym: ABO_2321

Alternate gene names: 110835182

Gene position: 2649561-2648830 (Counterclockwise)

Preceding gene: 110835183

Following gene: 110835181

Centisome position: 84.92

GC content: 60.93

Gene sequence:

>732_bases
ATGAACGATCAAGGCCGACAGCAACGGGTTGTCGTCACCCGCCCTGAAGGTCAGCAGCAGCGGCTGATGGGCCTGTTGGT
TGAGGCAGGGTATCAGCCGCTTCACCAGCCGGCACTGGTTATCGAACCGATAACGGTGGATGACACCATGCAGCGTACCC
TGATGGAGCTGGATGGTTATCATGCGGTGTTTTTCGCCAGTGTAAATGCTGCCCGCCTGGCCCTGTCGGCCATGGCTGAC
CTGTGGCCCCAGTGGCCCGTTGGGGTGCACTGGCTAGCGGTGGGTCGTGCTACTGCAGCAGAGCTGGAAAGCTGGCACTT
GCCTGCCACCGTGCCGCAGCAAGGGTTTAATACCGAAGCGGTGCTGGCGTTGCCTTGCCTGCAGCAGCTGGTTGAAAAAC
AGATTCTGATTTGCCGGGGTGACAGCGGCCGGGAACTGTTGGCGCAAACGCTGCAGTCCCGAGGGGCGAGAGTGGATGCG
TTGGCTTTTTATCGCCGAAAGGCCGCAAGCCCAGTTCTAATCCCGGCAGAGACCGACTGGGTTATGATTACCAGCGTACA
GGGGTGGCAAGCAATCGGCGGCTCGGTGCCGCCGTGCTGTGGCGTGGTGGCTGCGGGGGAGCGAGTGGCTGACGTGGTGC
GCGCTGAGCATTCCGGGGATGTGTCTGTAGCCGCTAGCGCCCACGATGAAGACATGTTGTCTGCCCTTGTTGCGGTCGCC
ACGAAAGATTAA

Upstream 100 bases:

>100_bases
CCGCTCCCCGCGGCCAAGGCGCGGAACTGGGTATCGATATTGCTGAGCAGTTATTGGCCCAGGGCGCGGATGAAATTTTG
AAGGCCTTGTACGCTCGCCA

Downstream 100 bases:

>100_bases
GAAGAAGATATAAACATTTACCAAAAGGTAAAATAGTGTGCAGGCCTTTTTTTCCTTGCCGGTAACGGTAATGATTGGAC
AGCAATGGGCGGTCACTTTA

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MNDQGRQQRVVVTRPEGQQQRLMGLLVEAGYQPLHQPALVIEPITVDDTMQRTLMELDGYHAVFFASVNAARLALSAMAD
LWPQWPVGVHWLAVGRATAAELESWHLPATVPQQGFNTEAVLALPCLQQLVEKQILICRGDSGRELLAQTLQSRGARVDA
LAFYRRKAASPVLIPAETDWVMITSVQGWQAIGGSVPPCCGVVAAGERVADVVRAEHSGDVSVAASAHDEDMLSALVAVA
TKD

Sequences:

>Translated_243_residues
MNDQGRQQRVVVTRPEGQQQRLMGLLVEAGYQPLHQPALVIEPITVDDTMQRTLMELDGYHAVFFASVNAARLALSAMAD
LWPQWPVGVHWLAVGRATAAELESWHLPATVPQQGFNTEAVLALPCLQQLVEKQILICRGDSGRELLAQTLQSRGARVDA
LAFYRRKAASPVLIPAETDWVMITSVQGWQAIGGSVPPCCGVVAAGERVADVVRAEHSGDVSVAASAHDEDMLSALVAVA
TKD
>Mature_243_residues
MNDQGRQQRVVVTRPEGQQQRLMGLLVEAGYQPLHQPALVIEPITVDDTMQRTLMELDGYHAVFFASVNAARLALSAMAD
LWPQWPVGVHWLAVGRATAAELESWHLPATVPQQGFNTEAVLALPCLQQLVEKQILICRGDSGRELLAQTLQSRGARVDA
LAFYRRKAASPVLIPAETDWVMITSVQGWQAIGGSVPPCCGVVAAGERVADVVRAEHSGDVSVAASAHDEDMLSALVAVA
TKD

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=243, Percent_Identity=28.3950617283951, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 26249; Mature: 26249

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDQGRQQRVVVTRPEGQQQRLMGLLVEAGYQPLHQPALVIEPITVDDTMQRTLMELDGY
CCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHCCC
HAVFFASVNAARLALSAMADLWPQWPVGVHWLAVGRATAAELESWHLPATVPQQGFNTEA
EEEEEEECHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCH
VLALPCLQQLVEKQILICRGDSGRELLAQTLQSRGARVDALAFYRRKAASPVLIPAETDW
HHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCCE
VMITSVQGWQAIGGSVPPCCGVVAAGERVADVVRAEHSGDVSVAASAHDEDMLSALVAVA
EEEEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHH
TKD
CCC
>Mature Secondary Structure
MNDQGRQQRVVVTRPEGQQQRLMGLLVEAGYQPLHQPALVIEPITVDDTMQRTLMELDGY
CCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHCCC
HAVFFASVNAARLALSAMADLWPQWPVGVHWLAVGRATAAELESWHLPATVPQQGFNTEA
EEEEEEECHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCH
VLALPCLQQLVEKQILICRGDSGRELLAQTLQSRGARVDALAFYRRKAASPVLIPAETDW
HHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCCE
VMITSVQGWQAIGGSVPPCCGVVAAGERVADVVRAEHSGDVSVAASAHDEDMLSALVAVA
EEEEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHH
TKD
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8159168; 10984043 [H]