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The map label for this gene is hemC

Identifier: 110835183

GI number: 110835183

Start: 2649558

End: 2650490

Strand: Reverse

Name: hemC

Synonym: ABO_2322

Alternate gene names: 110835183

Gene position: 2650490-2649558 (Counterclockwise)

Preceding gene: 110835184

Following gene: 110835182

Centisome position: 84.95

GC content: 58.31

Gene sequence:

>933_bases
ATGTCCCGCGAAATCTTGCGTATCGCTACCCGTTCCAGCCCGTTGGCTATTTGGCAGGCCGAGTATGTTCAGCAGCGCCT
GGAAAGCCTGCATGAGGGATTGCGCGTGGAGCTGGTGCGGATTAAGACTCAGGGCGACAAGATTCTCGATACCCCGCTGG
CAAAGATTGGTGGCAAAGGATTATTCGTCAAAGAGCTGGAAGAGGCGATGATGGATGGGCGCGCGGATATTGCCGTGCAT
TCCATGAAAGATGTGCCAATGGAATTGCCACCGGGTTTTGCGTTGCCAGTGATTTGTGAGCGTGAAGATCCCCGGGATGC
CTTTGTCTCCAACACGTTCGACGGCCTATCTTCGCTGCCCCATGGTGCCTGCGTGGGGACCTCCAGCCTGCGTCGCCAGG
CTCAGGTAAAAGCCAATCGCCCGGATTTGGTCGTCAACAGTCTCCGCGGTAATGTGCAGACCCGGCTGGGCAAGCTGGAT
GCGGGTAACTTCGATGCCATTATCCTTGCCGCCGCGGGCCTTAAGCGCCTGGAAATGCACGATCGCATTCGTTACGAAAT
GCCTCCGGAAGAATCGCTCCCCGCAGTGGGGCAAGGCGCCGTGGGTATCGAGTGTCGTGAGGGTGATGAGAGCACCATTG
AGTTGCTGTCACCGCTGAGTGACGTGGATACTTGGGATCGGGTGGTGGCCGAACGGGCCATGAACCGGCGCCTCGAAGGG
GGGTGTCAGGTGCCGATCGCGGGTTTTGCTCTGCTTGAAGATGGCCAGTTGTGGCTACGTGGCTTGGTGGCAGAAGAAGA
TGGTAGCCGGGTATTGCGCGCAGAAGGAACCGCTCCCCGCGGCCAAGGCGCGGAACTGGGTATCGATATTGCTGAGCAGT
TATTGGCCCAGGGCGCGGATGAAATTTTGAAGGCCTTGTACGCTCGCCAATGA

Upstream 100 bases:

>100_bases
TTTAAATGGCATCCGCTTTTCTATGCCGCTGTGGCTTGAGGCTTGAAGCTTGTTAAACTGATAGACTGTCGATCTAAATT
CACAACCCTTAGAGTGCCCC

Downstream 100 bases:

>100_bases
ACGATCAAGGCCGACAGCAACGGGTTGTCGTCACCCGCCCTGAAGGTCAGCAGCAGCGGCTGATGGGCCTGTTGGTTGAG
GCAGGGTATCAGCCGCTTCA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MSREILRIATRSSPLAIWQAEYVQQRLESLHEGLRVELVRIKTQGDKILDTPLAKIGGKGLFVKELEEAMMDGRADIAVH
SMKDVPMELPPGFALPVICEREDPRDAFVSNTFDGLSSLPHGACVGTSSLRRQAQVKANRPDLVVNSLRGNVQTRLGKLD
AGNFDAIILAAAGLKRLEMHDRIRYEMPPEESLPAVGQGAVGIECREGDESTIELLSPLSDVDTWDRVVAERAMNRRLEG
GCQVPIAGFALLEDGQLWLRGLVAEEDGSRVLRAEGTAPRGQGAELGIDIAEQLLAQGADEILKALYARQ

Sequences:

>Translated_310_residues
MSREILRIATRSSPLAIWQAEYVQQRLESLHEGLRVELVRIKTQGDKILDTPLAKIGGKGLFVKELEEAMMDGRADIAVH
SMKDVPMELPPGFALPVICEREDPRDAFVSNTFDGLSSLPHGACVGTSSLRRQAQVKANRPDLVVNSLRGNVQTRLGKLD
AGNFDAIILAAAGLKRLEMHDRIRYEMPPEESLPAVGQGAVGIECREGDESTIELLSPLSDVDTWDRVVAERAMNRRLEG
GCQVPIAGFALLEDGQLWLRGLVAEEDGSRVLRAEGTAPRGQGAELGIDIAEQLLAQGADEILKALYARQ
>Mature_309_residues
SREILRIATRSSPLAIWQAEYVQQRLESLHEGLRVELVRIKTQGDKILDTPLAKIGGKGLFVKELEEAMMDGRADIAVHS
MKDVPMELPPGFALPVICEREDPRDAFVSNTFDGLSSLPHGACVGTSSLRRQAQVKANRPDLVVNSLRGNVQTRLGKLDA
GNFDAIILAAAGLKRLEMHDRIRYEMPPEESLPAVGQGAVGIECREGDESTIELLSPLSDVDTWDRVVAERAMNRRLEGG
CQVPIAGFALLEDGQLWLRGLVAEEDGSRVLRAEGTAPRGQGAELGIDIAEQLLAQGADEILKALYARQ

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI20149500, Length=339, Percent_Identity=43.952802359882, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI66933009, Length=339, Percent_Identity=43.952802359882, Blast_Score=246, Evalue=2e-65,
Organism=Escherichia coli, GI48994974, Length=307, Percent_Identity=63.1921824104234, Blast_Score=380, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6319996, Length=318, Percent_Identity=37.7358490566038, Blast_Score=192, Evalue=4e-50,
Organism=Drosophila melanogaster, GI20130425, Length=255, Percent_Identity=43.1372549019608, Blast_Score=205, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_ALCBS (Q0VM28)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_694042.1
- ProteinModelPortal:   Q0VM28
- SMR:   Q0VM28
- STRING:   Q0VM28
- GeneID:   4212667
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_2322
- NMPDR:   fig|393595.12.peg.2323
- eggNOG:   COG0181
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- PhylomeDB:   Q0VM28
- ProtClustDB:   PRK00072
- BioCyc:   ABOR393595:ABO_2322-MONOMER
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 33849; Mature: 33718

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSREILRIATRSSPLAIWQAEYVQQRLESLHEGLRVELVRIKTQGDKILDTPLAKIGGKG
CCCCCEEHCCCCCCEEHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHCHHHHHCCCC
LFVKELEEAMMDGRADIAVHSMKDVPMELPPGFALPVICEREDPRDAFVSNTFDGLSSLP
CHHHHHHHHHHCCCCCEEEEHHCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCC
HGACVGTSSLRRQAQVKANRPDLVVNSLRGNVQTRLGKLDAGNFDAIILAAAGLKRLEMH
CCCCCCCHHHHHHHHHCCCCCCHHHHHHCCCHHHHHCCCCCCCCCEEEEEHHCHHHHHHH
DRIRYEMPPEESLPAVGQGAVGIECREGDESTIELLSPLSDVDTWDRVVAERAMNRRLEG
HHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
GCQVPIAGFALLEDGQLWLRGLVAEEDGSRVLRAEGTAPRGQGAELGIDIAEQLLAQGAD
CCCCCCCCEEEEECCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHCCHH
EILKALYARQ
HHHHHHHCCC
>Mature Secondary Structure 
SREILRIATRSSPLAIWQAEYVQQRLESLHEGLRVELVRIKTQGDKILDTPLAKIGGKG
CCCCEEHCCCCCCEEHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHCHHHHHCCCC
LFVKELEEAMMDGRADIAVHSMKDVPMELPPGFALPVICEREDPRDAFVSNTFDGLSSLP
CHHHHHHHHHHCCCCCEEEEHHCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCC
HGACVGTSSLRRQAQVKANRPDLVVNSLRGNVQTRLGKLDAGNFDAIILAAAGLKRLEMH
CCCCCCCHHHHHHHHHCCCCCCHHHHHHCCCHHHHHCCCCCCCCCEEEEEHHCHHHHHHH
DRIRYEMPPEESLPAVGQGAVGIECREGDESTIELLSPLSDVDTWDRVVAERAMNRRLEG
HHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
GCQVPIAGFALLEDGQLWLRGLVAEEDGSRVLRAEGTAPRGQGAELGIDIAEQLLAQGAD
CCCCCCCCEEEEECCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHCCHH
EILKALYARQ
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA