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The map label for this gene is cysS

Identifier: 110834996

GI number: 110834996

Start: 2438471

End: 2439853

Strand: Direct

Name: cysS

Synonym: ABO_2135

Alternate gene names: 110834996

Gene position: 2438471-2439853 (Clockwise)

Preceding gene: 110834995

Following gene: 110834998

Centisome position: 78.15

GC content: 56.69

Gene sequence:

>1383_bases
ATGACCTTACGATTGCAGAACACCCTCACCGGCAAAAAGGACGACTTCATTCCGCTGGACCCTAACCGCATCACCCTTTA
CGTGTGCGGCCCCACGGTTTACAACTTCGTCCACATTGGCAACGCTCGCCCGGTGGTGGTCTTTGATGTTCTGTACCGGT
TACTGCAACGGCTCTACCCGAACGTGGTCTACGCCCGTAACATCACCGACATTGATGACAAGATCATCAAGGCGGCAGCG
GATAACGGCGAAGCGATCAGCACCCTCACCGAACGCTTTACCCAAGCTTTTGCCGACGACATGGCATCATTGAATGCCAA
AACCCCAAGCATCATTCCCAAGGCTACCGATCACATCCCCGAGATGATCCAGATGATCGCTATCTTGGTAGAAAAAGGGC
ACGCCTACGAAGCCGATGGCCAAGTGCTGTTCGCGGTGGAATCCATGCCCGACTACGGCAAGCTCTCCGGTCGCAAACTG
GAAGACATGCTTGCTGGCGCTCGGGTGGAAGTGGCGGACTACAAACGCCACCCCGGCGATTTCATTCTTTGGAAACCGTC
CACCGATGAACAGCCCGGCTGGGACTCCCCTTGGGGACGTGGCCGCCCTGGCTGGCACATCGAGTGTTCCGCCATGATCC
ACAAGCACCTGGGTGATGTAATTGATATCCACGGTGGTGGCCAGGATCTAATCTTCCCGCACCACGAAAACGAAATTGCC
CAAGGCTGCTGCGCCCACGGAACCGACTACGTGCGTTACTGGCTGCACAACGGCTACATCAACATCGACGGCGAAAAGAT
GTCCAAGTCCTTGGGCAACTTCCGTTTGGTCCGCGACTTGCTCACCCAGTACCACGGCGAAACGCTGCGCTTCGCGTTAC
TATCGAGCCACTACCGCTCGCCGCTGAATTTCTCTGCCGATGTACTGGATAATGCAGAAAAAGGCTTGGATACGCTCTAT
TACGCCTTGCTCGGTCGCGGTGAAACCGTTGCACCAGAAGCGGGCTATCAACTGCCGGACAACCATCCGGTACTCGACGC
TCTTAAGGACGATCTGAACACCTCCGAAGCGGTCAGCGCCTTGCACGCTATTGCCGGTGAACTGAACAAGGCCGAGCTTG
ACGACAAGCCCAAGCTGAAAGCCGAACTACTGGCCGCCGCCGACCTGCTCGGCCTGCTCACCGTAGAGCCCACCGCCTGG
TTCCAGAACAAGAACGTGAGCGAAGATGGCCTCAGCAACGATGCCATCGACGCCCTGGTGGAAGAACGCACCCAAGCCAA
GAAAGACAAAAACTTCGCTCGCGCCGATGAAATCCGCCAGCAACTCACCAAAGCAGGTATTCAACTGGAAGATACCCGCG
AAGGCACCCGCTGGAGTCGATGA

Upstream 100 bases:

>100_bases
GCCACACCGGCCGCCGCGACTGCTTCTACTGGAAAGCCGACGCCAACAACGTGACCATCGACAAAGCCCCCATCAAAGAC
CCCAAAGAGCTGTACGGCAA

Downstream 100 bases:

>100_bases
AAGATAGCGCCAAGCGGCTTGCTCTTAGCCAACGAGAAAAACAGATTTTTATTATCTGAAACGAAAGAGGCCGCGCCTAG
AGCATAGCTTGGGCGCAGCC

Product: cysteinyl-tRNA synthetase

Products: NA

Alternate protein names: Cysteine--tRNA ligase; CysRS

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MTLRLQNTLTGKKDDFIPLDPNRITLYVCGPTVYNFVHIGNARPVVVFDVLYRLLQRLYPNVVYARNITDIDDKIIKAAA
DNGEAISTLTERFTQAFADDMASLNAKTPSIIPKATDHIPEMIQMIAILVEKGHAYEADGQVLFAVESMPDYGKLSGRKL
EDMLAGARVEVADYKRHPGDFILWKPSTDEQPGWDSPWGRGRPGWHIECSAMIHKHLGDVIDIHGGGQDLIFPHHENEIA
QGCCAHGTDYVRYWLHNGYINIDGEKMSKSLGNFRLVRDLLTQYHGETLRFALLSSHYRSPLNFSADVLDNAEKGLDTLY
YALLGRGETVAPEAGYQLPDNHPVLDALKDDLNTSEAVSALHAIAGELNKAELDDKPKLKAELLAAADLLGLLTVEPTAW
FQNKNVSEDGLSNDAIDALVEERTQAKKDKNFARADEIRQQLTKAGIQLEDTREGTRWSR

Sequences:

>Translated_460_residues
MTLRLQNTLTGKKDDFIPLDPNRITLYVCGPTVYNFVHIGNARPVVVFDVLYRLLQRLYPNVVYARNITDIDDKIIKAAA
DNGEAISTLTERFTQAFADDMASLNAKTPSIIPKATDHIPEMIQMIAILVEKGHAYEADGQVLFAVESMPDYGKLSGRKL
EDMLAGARVEVADYKRHPGDFILWKPSTDEQPGWDSPWGRGRPGWHIECSAMIHKHLGDVIDIHGGGQDLIFPHHENEIA
QGCCAHGTDYVRYWLHNGYINIDGEKMSKSLGNFRLVRDLLTQYHGETLRFALLSSHYRSPLNFSADVLDNAEKGLDTLY
YALLGRGETVAPEAGYQLPDNHPVLDALKDDLNTSEAVSALHAIAGELNKAELDDKPKLKAELLAAADLLGLLTVEPTAW
FQNKNVSEDGLSNDAIDALVEERTQAKKDKNFARADEIRQQLTKAGIQLEDTREGTRWSR
>Mature_459_residues
TLRLQNTLTGKKDDFIPLDPNRITLYVCGPTVYNFVHIGNARPVVVFDVLYRLLQRLYPNVVYARNITDIDDKIIKAAAD
NGEAISTLTERFTQAFADDMASLNAKTPSIIPKATDHIPEMIQMIAILVEKGHAYEADGQVLFAVESMPDYGKLSGRKLE
DMLAGARVEVADYKRHPGDFILWKPSTDEQPGWDSPWGRGRPGWHIECSAMIHKHLGDVIDIHGGGQDLIFPHHENEIAQ
GCCAHGTDYVRYWLHNGYINIDGEKMSKSLGNFRLVRDLLTQYHGETLRFALLSSHYRSPLNFSADVLDNAEKGLDTLYY
ALLGRGETVAPEAGYQLPDNHPVLDALKDDLNTSEAVSALHAIAGELNKAELDDKPKLKAELLAAADLLGLLTVEPTAWF
QNKNVSEDGLSNDAIDALVEERTQAKKDKNFARADEIRQQLTKAGIQLEDTREGTRWSR

Specific function: Unknown

COG id: COG0215

COG function: function code J; Cysteinyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI13375695, Length=310, Percent_Identity=41.2903225806452, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI10835051, Length=270, Percent_Identity=37.4074074074074, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI21269877, Length=270, Percent_Identity=37.4074074074074, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI62240992, Length=270, Percent_Identity=37.4074074074074, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI303304987, Length=270, Percent_Identity=37.4074074074074, Blast_Score=184, Evalue=1e-46,
Organism=Escherichia coli, GI1786737, Length=462, Percent_Identity=48.0519480519481, Blast_Score=415, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17509795, Length=245, Percent_Identity=39.5918367346939, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17509797, Length=245, Percent_Identity=39.5918367346939, Blast_Score=166, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6324082, Length=300, Percent_Identity=33.3333333333333, Blast_Score=180, Evalue=3e-46,
Organism=Drosophila melanogaster, GI19922218, Length=491, Percent_Identity=35.030549898167, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI19922364, Length=351, Percent_Identity=32.1937321937322, Blast_Score=179, Evalue=4e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYC_ALCBS (Q0VML5)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_693855.1
- ProteinModelPortal:   Q0VML5
- SMR:   Q0VML5
- STRING:   Q0VML5
- GeneID:   4212582
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_2135
- NMPDR:   fig|393595.12.peg.2133
- eggNOG:   COG0215
- HOGENOM:   HBG327651
- OMA:   INARAAC
- PhylomeDB:   Q0VML5
- ProtClustDB:   PRK00260
- BioCyc:   ABOR393595:ABO_2135-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00041_B
- InterPro:   IPR015803
- InterPro:   IPR015273
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10890
- PRINTS:   PR00983
- SMART:   SM00840
- TIGRFAMs:   TIGR00435

Pfam domain/function: PF09190 DALR_2; PF01406 tRNA-synt_1e; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.16

Molecular weight: Translated: 51329; Mature: 51197

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 269-269

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRLQNTLTGKKDDFIPLDPNRITLYVCGPTVYNFVHIGNARPVVVFDVLYRLLQRLYP
CEEEECCCCCCCCCCCEECCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHCC
NVVYARNITDIDDKIIKAAADNGEAISTLTERFTQAFADDMASLNAKTPSIIPKATDHIP
CEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
EMIQMIAILVEKGHAYEADGQVLFAVESMPDYGKLSGRKLEDMLAGARVEVADYKRHPGD
HHHHHHHHHHHCCCCEECCCCEEEEEECCCCCCCCCCCHHHHHHCCCEEEEHHHCCCCCC
FILWKPSTDEQPGWDSPWGRGRPGWHIECSAMIHKHLGDVIDIHGGGQDLIFPHHENEIA
EEEECCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCEEEECCCCCCEECCCCCCHHH
QGCCAHGTDYVRYWLHNGYINIDGEKMSKSLGNFRLVRDLLTQYHGETLRFALLSSHYRS
HHHHHCCHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
PLNFSADVLDNAEKGLDTLYYALLGRGETVAPEAGYQLPDNHPVLDALKDDLNTSEAVSA
CCCCCHHHHCCHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCHHHHHHHCCCHHHHHHH
LHAIAGELNKAELDDKPKLKAELLAAADLLGLLTVEPTAWFQNKNVSEDGLSNDAIDALV
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEEECCHHHHCCCCCCCCCCCHHHHHHHH
EERTQAKKDKNFARADEIRQQLTKAGIQLEDTREGTRWSR
HHHHHHHHHCCHHHHHHHHHHHHHCCCEEECCCCCCCCCC
>Mature Secondary Structure 
TLRLQNTLTGKKDDFIPLDPNRITLYVCGPTVYNFVHIGNARPVVVFDVLYRLLQRLYP
EEEECCCCCCCCCCCEECCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHCC
NVVYARNITDIDDKIIKAAADNGEAISTLTERFTQAFADDMASLNAKTPSIIPKATDHIP
CEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
EMIQMIAILVEKGHAYEADGQVLFAVESMPDYGKLSGRKLEDMLAGARVEVADYKRHPGD
HHHHHHHHHHHCCCCEECCCCEEEEEECCCCCCCCCCCHHHHHHCCCEEEEHHHCCCCCC
FILWKPSTDEQPGWDSPWGRGRPGWHIECSAMIHKHLGDVIDIHGGGQDLIFPHHENEIA
EEEECCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCEEEECCCCCCEECCCCCCHHH
QGCCAHGTDYVRYWLHNGYINIDGEKMSKSLGNFRLVRDLLTQYHGETLRFALLSSHYRS
HHHHHCCHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
PLNFSADVLDNAEKGLDTLYYALLGRGETVAPEAGYQLPDNHPVLDALKDDLNTSEAVSA
CCCCCHHHHCCHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCHHHHHHHCCCHHHHHHH
LHAIAGELNKAELDDKPKLKAELLAAADLLGLLTVEPTAWFQNKNVSEDGLSNDAIDALV
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEEECCHHHHCCCCCCCCCCCHHHHHHHH
EERTQAKKDKNFARADEIRQQLTKAGIQLEDTREGTRWSR
HHHHHHHHHCCHHHHHHHHHHHHHCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA