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The map label for this gene is hisI

Identifier: 110834995

GI number: 110834995

Start: 2438046

End: 2438474

Strand: Direct

Name: hisI

Synonym: ABO_2134

Alternate gene names: 110834995

Gene position: 2438046-2438474 (Clockwise)

Preceding gene: 110834994

Following gene: 110834996

Centisome position: 78.14

GC content: 55.24

Gene sequence:

>429_bases
ATGTTCAAACACAACGAACAACAGCCCGAAGGCTTTCAGATTTCCCTCAAAGAAGCCCTCGACAACTTGGCGTTCAACGA
CGCCGGGCTAGTGGCAGCCATTGCTCAGCAGCACGATAGTGGCGAAGTATTGATGATGGCATGGATGAATCGCGAGGCCA
TTGAAGAGACTCTGGCCACGGGACGCGTTTGCTATTTTTCCCGCTCGCGAGGGAAGTTATGGCGTAAAGGCGAATCCTCC
GGCCAAGTACAAACGCTGAAAGAACTGCGCATTGATTGCGACGGCGACGCCTTGCTAGTGAAAGTGGACCAGACCGGCTC
CGCTTGCCACACCGGCCGCCGCGACTGCTTCTACTGGAAAGCCGACGCCAACAACGTGACCATCGACAAAGCCCCCATCA
AAGACCCCAAAGAGCTGTACGGCAAATGA

Upstream 100 bases:

>100_bases
ACCCCTCAAGGTGCGAACTGTGCTCGGGAAAGCTTTCGCAAGCAGGTTCGCCCCTCAAGAGGGGCGCCTACATCCTGAAT
AGAAACGCCCTGGAGGCGTC

Downstream 100 bases:

>100_bases
CCTTACGATTGCAGAACACCCTCACCGGCAAAAAGGACGACTTCATTCCGCTGGACCCTAACCGCATCACCCTTTACGTG
TGCGGCCCCACGGTTTACAA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 142; Mature: 142

Protein sequence:

>142_residues
MFKHNEQQPEGFQISLKEALDNLAFNDAGLVAAIAQQHDSGEVLMMAWMNREAIEETLATGRVCYFSRSRGKLWRKGESS
GQVQTLKELRIDCDGDALLVKVDQTGSACHTGRRDCFYWKADANNVTIDKAPIKDPKELYGK

Sequences:

>Translated_142_residues
MFKHNEQQPEGFQISLKEALDNLAFNDAGLVAAIAQQHDSGEVLMMAWMNREAIEETLATGRVCYFSRSRGKLWRKGESS
GQVQTLKELRIDCDGDALLVKVDQTGSACHTGRRDCFYWKADANNVTIDKAPIKDPKELYGK
>Mature_142_residues
MFKHNEQQPEGFQISLKEALDNLAFNDAGLVAAIAQQHDSGEVLMMAWMNREAIEETLATGRVCYFSRSRGKLWRKGESS
GQVQTLKELRIDCDGDALLVKVDQTGSACHTGRRDCFYWKADANNVTIDKAPIKDPKELYGK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=89, Percent_Identity=46.0674157303371, Blast_Score=94, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_ALCBS (Q0VML6)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_693854.1
- ProteinModelPortal:   Q0VML6
- SMR:   Q0VML6
- STRING:   Q0VML6
- GeneID:   4211473
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_2134
- NMPDR:   fig|393595.12.peg.2132
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   TQYVHEV
- ProtClustDB:   PRK00051
- BioCyc:   ABOR393595:ABO_2134-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 15938; Mature: 15938

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKHNEQQPEGFQISLKEALDNLAFNDAGLVAAIAQQHDSGEVLMMAWMNREAIEETLAT
CCCCCCCCCCCEEEEHHHHHHHCCCCCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHC
GRVCYFSRSRGKLWRKGESSGQVQTLKELRIDCDGDALLVKVDQTGSACHTGRRDCFYWK
CEEEEEECCCCCEECCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCEEEEE
ADANNVTIDKAPIKDPKELYGK
CCCCEEEECCCCCCCHHHHHCC
>Mature Secondary Structure
MFKHNEQQPEGFQISLKEALDNLAFNDAGLVAAIAQQHDSGEVLMMAWMNREAIEETLAT
CCCCCCCCCCCEEEEHHHHHHHCCCCCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHC
GRVCYFSRSRGKLWRKGESSGQVQTLKELRIDCDGDALLVKVDQTGSACHTGRRDCFYWK
CEEEEEECCCCCEECCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCEEEEE
ADANNVTIDKAPIKDPKELYGK
CCCCEEEECCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA