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The map label for this gene is thrS [H]

Identifier: 110834994

GI number: 110834994

Start: 2436008

End: 2437924

Strand: Direct

Name: thrS [H]

Synonym: ABO_2133

Alternate gene names: 110834994

Gene position: 2436008-2437924 (Clockwise)

Preceding gene: 110834991

Following gene: 110834995

Centisome position: 78.07

GC content: 56.44

Gene sequence:

>1917_bases
ATGAGTGTGAGCTATCAACTGCCCGATGGGGCAAATATGGAGTTTGAGCAGCCGGTCTCCGCCTTGGAAATTGCCGGTCG
CATCAGTAAAAAACTCGCCAAGCAAGCTTTGGCCGCTAAAGCCAACGGCAACCTGATTGATGTCTATCTGCCCATCGACG
ACGGCGCCACGGTGGAAATCATCACCCGAGATACCGACGAAGCCCTAGAGCTTATTCGTCACGATGCCGCCCATGTTATG
GCCCAAGCCGTGCAGGAGCTGTTTCCAGACACCCAGGTGACTATTGGCCCAACCATTGCCAACGGCTTCTATTATGACTT
CCATCGGGACATACCGTTCACACCGGATGACCTGAAAACCATTGAAAAGCGCATGCTAGAGATTGTGCGCCGCAATGAGG
AAATAAGGCGTGAAATATGGGATCGAGATGAGGCTGTCGCTTTTTTCCTGGAAAAAGGTGAAGAATTTAAGGCCGAAATC
ATCCGTGACCTGCCCGCCGATCAAGAAGTGAGCCTCTATCGCCAGGGCGATTTCATCGACCTGTGTCGTGGCCCGCACCT
GCCCAGCACCAGCAAACTGGGCGATGGCTTCAAACTGACTAAGGTCGCTGGCGCTTACTGGCGTGGCGATGCTGACAAGG
CGCAACTACAGCGCATCTACGGCACCGCCTGGCGCGACAAGAAAGAGTTGAACGCTTACCTCAAACAGCTTGAAGAAGCG
GAAAAACGCGATCACCGTAAACTGGCCAAGGAAATGGGTCTATTCCATATCCAACAAGAAGCGGTAGGCAGCATGTTCTG
GCACCCTAAGGGCTGGCGCATGCGCAAAAACCTGGAAAATTACATCCGCGGAAAAATGGAAAAAGGAGGCTATGAAGAAG
TCTCCACTCCGCAAATGATGGATCGTATTCTCTGGGAACAATCCGGCCATTGGGACAAATACGGCGAAGACATGTTCACC
GTCTGCACCCACGACCACAAAGAAATGGCCGTGAAGCCGATGAACTGCCCCGGCCACGTACAGATCTTCAAACAGGGGAT
CACCAGCTACCGAGACTTGCCCATTCGCTTGGGAGAGTTCACCACCCTGTTCCGTAACGAAGCCCACGGCGCCCTACATG
GCCTGATGCGAGCCCGCTCGTTCAGCCAGGACGATGCTCACATCTTCTGTACCGAAGAGCAGGTTAACGAAGAAACCGCC
GGCTTCATCAAGATGCTGCGCGAAGTCTACGCAGATTTTGGATTCGACTCGTTCCGTATCAAATTCTCGGACCGCCCGGA
TAACCGCGCCGGCTCCGACGAAACCTGGGACAAAGCCGAAGGCGCACTGCGCTCGGCGGTGGAATCCCTGGGCCTGGAAT
GCGAGCTTAACCCGGGTGAAGGGGCCTTCTACGGCCCAAAACTGGAGTTCGTGCTCCGTGACGCCATTGGCCGTGACTGG
CAGTGCGGCACCCTGCAGGTGGACTTTGTGCTGCCCGATCGCCTGGATGCCGAATACGTGGCCGAGGACGGCTCCCGCCA
GCGCCCAGTCATGTTGCACCGTGCTGTTCTGGGCTCTTTGGAACGCTTCCTCGGCATCCTGATCGAGTCCACCGCCGGTC
ACCTACCCCTGTGGCTAGCGCCGCGGCCGGTGGCGGTTTGCACCATTACCAACTCCGCCGACGAGTATGCCACCACCGTG
CAGCAGAAACTGGTTGCCGCCGGGATACCGGCAGAGCTGGATATTCGTAACGAGAAGATTGGCTTCAAGGTCCGTGAGCA
CTCCCGCGCCAAAACCCCGCGTATCTGGGTAATTGGCGAGCAGGAAGCACAACACAACCAAGTCGCTATTCGTACCCTTG
GCTCCCAAGCCACCGAAACCGTAGATCTGGACGAAGCCGTGGCGGCCTTGGCCGAAGCAACACGCTTACCGATCTGA

Upstream 100 bases:

>100_bases
AAATCGAGCCCTGTTTAATAGTCGCCGCACCTTGATGCGGAGGGCCTGATTGCCTACCATCTTCCGGTTCTGAGCCAACC
ACCTGGATCCCTTGTCACTC

Downstream 100 bases:

>100_bases
CCCGGCGCCACTGGTAAGAGTACCCCTCAAGGTGCGAACTGTGCTCGGGAAAGCTTTCGCAAGCAGGTTCGCCCCTCAAG
AGGGGCGCCTACATCCTGAA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 638; Mature: 637

Protein sequence:

>638_residues
MSVSYQLPDGANMEFEQPVSALEIAGRISKKLAKQALAAKANGNLIDVYLPIDDGATVEIITRDTDEALELIRHDAAHVM
AQAVQELFPDTQVTIGPTIANGFYYDFHRDIPFTPDDLKTIEKRMLEIVRRNEEIRREIWDRDEAVAFFLEKGEEFKAEI
IRDLPADQEVSLYRQGDFIDLCRGPHLPSTSKLGDGFKLTKVAGAYWRGDADKAQLQRIYGTAWRDKKELNAYLKQLEEA
EKRDHRKLAKEMGLFHIQQEAVGSMFWHPKGWRMRKNLENYIRGKMEKGGYEEVSTPQMMDRILWEQSGHWDKYGEDMFT
VCTHDHKEMAVKPMNCPGHVQIFKQGITSYRDLPIRLGEFTTLFRNEAHGALHGLMRARSFSQDDAHIFCTEEQVNEETA
GFIKMLREVYADFGFDSFRIKFSDRPDNRAGSDETWDKAEGALRSAVESLGLECELNPGEGAFYGPKLEFVLRDAIGRDW
QCGTLQVDFVLPDRLDAEYVAEDGSRQRPVMLHRAVLGSLERFLGILIESTAGHLPLWLAPRPVAVCTITNSADEYATTV
QQKLVAAGIPAELDIRNEKIGFKVREHSRAKTPRIWVIGEQEAQHNQVAIRTLGSQATETVDLDEAVAALAEATRLPI

Sequences:

>Translated_638_residues
MSVSYQLPDGANMEFEQPVSALEIAGRISKKLAKQALAAKANGNLIDVYLPIDDGATVEIITRDTDEALELIRHDAAHVM
AQAVQELFPDTQVTIGPTIANGFYYDFHRDIPFTPDDLKTIEKRMLEIVRRNEEIRREIWDRDEAVAFFLEKGEEFKAEI
IRDLPADQEVSLYRQGDFIDLCRGPHLPSTSKLGDGFKLTKVAGAYWRGDADKAQLQRIYGTAWRDKKELNAYLKQLEEA
EKRDHRKLAKEMGLFHIQQEAVGSMFWHPKGWRMRKNLENYIRGKMEKGGYEEVSTPQMMDRILWEQSGHWDKYGEDMFT
VCTHDHKEMAVKPMNCPGHVQIFKQGITSYRDLPIRLGEFTTLFRNEAHGALHGLMRARSFSQDDAHIFCTEEQVNEETA
GFIKMLREVYADFGFDSFRIKFSDRPDNRAGSDETWDKAEGALRSAVESLGLECELNPGEGAFYGPKLEFVLRDAIGRDW
QCGTLQVDFVLPDRLDAEYVAEDGSRQRPVMLHRAVLGSLERFLGILIESTAGHLPLWLAPRPVAVCTITNSADEYATTV
QQKLVAAGIPAELDIRNEKIGFKVREHSRAKTPRIWVIGEQEAQHNQVAIRTLGSQATETVDLDEAVAALAEATRLPI
>Mature_637_residues
SVSYQLPDGANMEFEQPVSALEIAGRISKKLAKQALAAKANGNLIDVYLPIDDGATVEIITRDTDEALELIRHDAAHVMA
QAVQELFPDTQVTIGPTIANGFYYDFHRDIPFTPDDLKTIEKRMLEIVRRNEEIRREIWDRDEAVAFFLEKGEEFKAEII
RDLPADQEVSLYRQGDFIDLCRGPHLPSTSKLGDGFKLTKVAGAYWRGDADKAQLQRIYGTAWRDKKELNAYLKQLEEAE
KRDHRKLAKEMGLFHIQQEAVGSMFWHPKGWRMRKNLENYIRGKMEKGGYEEVSTPQMMDRILWEQSGHWDKYGEDMFTV
CTHDHKEMAVKPMNCPGHVQIFKQGITSYRDLPIRLGEFTTLFRNEAHGALHGLMRARSFSQDDAHIFCTEEQVNEETAG
FIKMLREVYADFGFDSFRIKFSDRPDNRAGSDETWDKAEGALRSAVESLGLECELNPGEGAFYGPKLEFVLRDAIGRDWQ
CGTLQVDFVLPDRLDAEYVAEDGSRQRPVMLHRAVLGSLERFLGILIESTAGHLPLWLAPRPVAVCTITNSADEYATTVQ
QKLVAAGIPAELDIRNEKIGFKVREHSRAKTPRIWVIGEQEAQHNQVAIRTLGSQATETVDLDEAVAALAEATRLPI

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=635, Percent_Identity=38.5826771653543, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI38570111, Length=632, Percent_Identity=37.8164556962025, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI20070344, Length=658, Percent_Identity=37.3860182370821, Blast_Score=411, Evalue=1e-114,
Organism=Escherichia coli, GI1788013, Length=630, Percent_Identity=48.5714285714286, Blast_Score=659, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=162, Percent_Identity=29.6296296296296, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71984192, Length=632, Percent_Identity=40.6645569620253, Blast_Score=481, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI71984184, Length=632, Percent_Identity=40.6645569620253, Blast_Score=480, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6322112, Length=642, Percent_Identity=38.6292834890966, Blast_Score=443, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6322654, Length=393, Percent_Identity=37.6590330788804, Blast_Score=282, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24583842, Length=631, Percent_Identity=38.351822503962, Blast_Score=463, Evalue=1e-130,
Organism=Drosophila melanogaster, GI28574141, Length=631, Percent_Identity=38.351822503962, Blast_Score=463, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24583839, Length=631, Percent_Identity=38.351822503962, Blast_Score=462, Evalue=1e-130,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 72374; Mature: 72243

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSYQLPDGANMEFEQPVSALEIAGRISKKLAKQALAAKANGNLIDVYLPIDDGATVEI
CCCEEECCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEE
ITRDTDEALELIRHDAAHVMAQAVQELFPDTQVTIGPTIANGFYYDFHRDIPFTPDDLKT
EECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEECCCEEEEECCCCCCCCHHHHH
IEKRMLEIVRRNEEIRREIWDRDEAVAFFLEKGEEFKAEIIRDLPADQEVSLYRQGDFID
HHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHEECCCCHH
LCRGPHLPSTSKLGDGFKLTKVAGAYWRGDADKAQLQRIYGTAWRDKKELNAYLKQLEEA
HCCCCCCCCCCCCCCCEEEHHHHCHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
EKRDHRKLAKEMGLFHIQQEAVGSMFWHPKGWRMRKNLENYIRGKMEKGGYEEVSTPQMM
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHH
DRILWEQSGHWDKYGEDMFTVCTHDHKEMAVKPMNCPGHVQIFKQGITSYRDLPIRLGEF
HHHHHHCCCCCCHHCCCEEEEECCCCHHHEEECCCCCCHHHHHHHHHHHHCCCCEEHHHH
TTLFRNEAHGALHGLMRARSFSQDDAHIFCTEEQVNEETAGFIKMLREVYADFGFDSFRI
HHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEHHHHCHHHHHHHHHHHHHHHHCCCCEEEE
KFSDRPDNRAGSDETWDKAEGALRSAVESLGLECELNPGEGAFYGPKLEFVLRDAIGRDW
EECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCEECCHHHHHHHHHCCCCC
QCGTLQVDFVLPDRLDAEYVAEDGSRQRPVMLHRAVLGSLERFLGILIESTAGHLPLWLA
CCCEEEEEEECCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEC
PRPVAVCTITNSADEYATTVQQKLVAAGIPAELDIRNEKIGFKVREHSRAKTPRIWVIGE
CCCEEEEEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEECCCCCCCCCEEEEEEC
QEAQHNQVAIRTLGSQATETVDLDEAVAALAEATRLPI
CCCCCCHHHEEECCCCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SVSYQLPDGANMEFEQPVSALEIAGRISKKLAKQALAAKANGNLIDVYLPIDDGATVEI
CCEEECCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEE
ITRDTDEALELIRHDAAHVMAQAVQELFPDTQVTIGPTIANGFYYDFHRDIPFTPDDLKT
EECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEECCCEEEEECCCCCCCCHHHHH
IEKRMLEIVRRNEEIRREIWDRDEAVAFFLEKGEEFKAEIIRDLPADQEVSLYRQGDFID
HHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHEECCCCHH
LCRGPHLPSTSKLGDGFKLTKVAGAYWRGDADKAQLQRIYGTAWRDKKELNAYLKQLEEA
HCCCCCCCCCCCCCCCEEEHHHHCHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
EKRDHRKLAKEMGLFHIQQEAVGSMFWHPKGWRMRKNLENYIRGKMEKGGYEEVSTPQMM
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHH
DRILWEQSGHWDKYGEDMFTVCTHDHKEMAVKPMNCPGHVQIFKQGITSYRDLPIRLGEF
HHHHHHCCCCCCHHCCCEEEEECCCCHHHEEECCCCCCHHHHHHHHHHHHCCCCEEHHHH
TTLFRNEAHGALHGLMRARSFSQDDAHIFCTEEQVNEETAGFIKMLREVYADFGFDSFRI
HHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEHHHHCHHHHHHHHHHHHHHHHCCCCEEEE
KFSDRPDNRAGSDETWDKAEGALRSAVESLGLECELNPGEGAFYGPKLEFVLRDAIGRDW
EECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCEECCHHHHHHHHHCCCCC
QCGTLQVDFVLPDRLDAEYVAEDGSRQRPVMLHRAVLGSLERFLGILIESTAGHLPLWLA
CCCEEEEEEECCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEC
PRPVAVCTITNSADEYATTVQQKLVAAGIPAELDIRNEKIGFKVREHSRAKTPRIWVIGE
CCCEEEEEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEECCCCCCCCCEEEEEEC
QEAQHNQVAIRTLGSQATETVDLDEAVAALAEATRLPI
CCCCCCHHHEEECCCCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA