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The map label for this gene is pdhR [H]

Identifier: 110632727

GI number: 110632727

Start: 409674

End: 410540

Strand: Direct

Name: pdhR [H]

Synonym: Meso_0366

Alternate gene names: 110632727

Gene position: 409674-410540 (Clockwise)

Preceding gene: 110632721

Following gene: 110632728

Centisome position: 9.28

GC content: 63.9

Gene sequence:

>867_bases
GTGAAGCGGCAGGGGCCTGTGACGAACGTTTTTTCCAGGATAGAGCATACCCGCACGGCAGACTCCGTCGTGTACCAGAT
CGAGGCATTGATCCTCGAGGGTGTGCTGCGCGATGGCGATCGCCTCCCCGGTGAGCGCGAATTGGCGACCCAGATGGATG
TGTCGCGGCCGATCCTGCGTGATGCGCTCAAGGTCTTGGAGGGGCGCGGGCTTCTGGCGACGCGGCCCGGCGGCGGCACG
CATGTGGCCAATGTGGTGGGCGAGGTGTTCGCGAAACCCATGCGCGAGCTTATAGCTAGCCATCCCAAGGCCACGGCCGA
TTATCTGGAATACCGGCGGGAGATCGAAGCCGTGGCGGCGGAACTGGCGGCAACGCGCGCGACGGAGGCCGACAAGGCGC
TGCTTTCCAGAATCGTGACGCGCATGGAGGAGGCGCATGCCTCTCGCGATCCCGCGATAGAAGCCGAAATCGATGTTGAA
TTCCACAACGCGGTAGGTGAGTGCGCGCACAACTTCATCCTGCTTCATACGCTGCGCTCCTGTTATCGCCTGTTGGCGGA
AGGCGTGTTCTACAGCCGTGCCCGCATTTACCACCTGCCGGGCGCGCGCGAGGAACTGCTCGTGCAGCACCGCGCGATTT
TCACGGCCATCCACGAGGGTGACCCGGCCGCCGCGCGAAAGGCGGCGGTGGACCATATTTCCTATGTTCAGAAGGCGAGC
GCGGAAGCCGAGCTCACCGATGAAAGAGAGCGTGTAGCCGGCCTTCGCCTGCTCCATCGGTCCGACGCGCAGGCTCTTGC
CCGGCAAACCGGACCGAAAACCTCCCGCACAAAGCGCTCGGCCGCTGCTGACCGTGAGATAGGGTGA

Upstream 100 bases:

>100_bases
GGAAAGCGCAATGCGCTGATCTGAAGCAGATCGTTGTTCCTGCATTGGACAAATAAGTTGACCAGTTGTACGCGGCGCCT
TACCCTACGCAAGAACGCTG

Downstream 100 bases:

>100_bases
TCTATTGCAAGAAGATGTGAAGAAGAAGAACCCCCGCGTGGGCCTGTTTGTGACCTGCCTTGTCGATCTCTTCCGGCCGA
CGGTGGGGTTCGCATCCGTC

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MKRQGPVTNVFSRIEHTRTADSVVYQIEALILEGVLRDGDRLPGERELATQMDVSRPILRDALKVLEGRGLLATRPGGGT
HVANVVGEVFAKPMRELIASHPKATADYLEYRREIEAVAAELAATRATEADKALLSRIVTRMEEAHASRDPAIEAEIDVE
FHNAVGECAHNFILLHTLRSCYRLLAEGVFYSRARIYHLPGAREELLVQHRAIFTAIHEGDPAAARKAAVDHISYVQKAS
AEAELTDERERVAGLRLLHRSDAQALARQTGPKTSRTKRSAAADREIG

Sequences:

>Translated_288_residues
MKRQGPVTNVFSRIEHTRTADSVVYQIEALILEGVLRDGDRLPGERELATQMDVSRPILRDALKVLEGRGLLATRPGGGT
HVANVVGEVFAKPMRELIASHPKATADYLEYRREIEAVAAELAATRATEADKALLSRIVTRMEEAHASRDPAIEAEIDVE
FHNAVGECAHNFILLHTLRSCYRLLAEGVFYSRARIYHLPGAREELLVQHRAIFTAIHEGDPAAARKAAVDHISYVQKAS
AEAELTDERERVAGLRLLHRSDAQALARQTGPKTSRTKRSAAADREIG
>Mature_288_residues
MKRQGPVTNVFSRIEHTRTADSVVYQIEALILEGVLRDGDRLPGERELATQMDVSRPILRDALKVLEGRGLLATRPGGGT
HVANVVGEVFAKPMRELIASHPKATADYLEYRREIEAVAAELAATRATEADKALLSRIVTRMEEAHASRDPAIEAEIDVE
FHNAVGECAHNFILLHTLRSCYRLLAEGVFYSRARIYHLPGAREELLVQHRAIFTAIHEGDPAAARKAAVDHISYVQKAS
AEAELTDERERVAGLRLLHRSDAQALARQTGPKTSRTKRSAAADREIG

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=235, Percent_Identity=40.8510638297872, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1790032, Length=228, Percent_Identity=40.3508771929825, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI1789353, Length=229, Percent_Identity=34.9344978165939, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1790780, Length=224, Percent_Identity=29.0178571428571, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI87082208, Length=208, Percent_Identity=28.3653846153846, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789621, Length=226, Percent_Identity=26.5486725663717, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 31819; Mature: 31819

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRQGPVTNVFSRIEHTRTADSVVYQIEALILEGVLRDGDRLPGERELATQMDVSRPILR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
DALKVLEGRGLLATRPGGGTHVANVVGEVFAKPMRELIASHPKATADYLEYRREIEAVAA
HHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
ELAATRATEADKALLSRIVTRMEEAHASRDPAIEAEIDVEFHNAVGECAHNFILLHTLRS
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
CYRLLAEGVFYSRARIYHLPGAREELLVQHRAIFTAIHEGDPAAARKAAVDHISYVQKAS
HHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
AEAELTDERERVAGLRLLHRSDAQALARQTGPKTSRTKRSAAADREIG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MKRQGPVTNVFSRIEHTRTADSVVYQIEALILEGVLRDGDRLPGERELATQMDVSRPILR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
DALKVLEGRGLLATRPGGGTHVANVVGEVFAKPMRELIASHPKATADYLEYRREIEAVAA
HHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
ELAATRATEADKALLSRIVTRMEEAHASRDPAIEAEIDVEFHNAVGECAHNFILLHTLRS
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
CYRLLAEGVFYSRARIYHLPGAREELLVQHRAIFTAIHEGDPAAARKAAVDHISYVQKAS
HHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
AEAELTDERERVAGLRLLHRSDAQALARQTGPKTSRTKRSAAADREIG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]