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The map label for this gene is merA [H]

Identifier: 110632713

GI number: 110632713

Start: 394240

End: 395667

Strand: Reverse

Name: merA [H]

Synonym: Meso_0352

Alternate gene names: 110632713

Gene position: 395667-394240 (Counterclockwise)

Preceding gene: 110632714

Following gene: 110632712

Centisome position: 8.97

GC content: 59.8

Gene sequence:

>1428_bases
ATGACCACCATCCTCAAACCTGACATTTGCGTGATCGGCGCAGGCTCGGGCGGATTGACCGTCGCGGCCGCGGCAGCGTC
CCTTGGTGCTTCCGTCGTTCTTATCGAGCGGGGGAAGATGGGCGGAGATTGCCTCAACTATGGCTGCGTTCCTTCCAAAG
CGCTGATCGCGTCCGCCAGACAGGCGCACCGGCTATCCCACGGAGGGAGTTTGGGAATTGCTGCTGTGGAACCTTCAATC
GACTTCGCCCGCGTGGCTGGCCATATCGAGCAGGCAATCGCTGCGATTGCGCCCAACGATTCGAAAGAGCGCTTCACAGC
GCTCGGCGTTGAGGTCATTTCAGCCCAAGGCCATTTCAAGGACCCACGGACCGTCGTGGCCGGAGGCAGTGAAATCCGCG
CCCGTCGTTTCGTAATCGCAACCGGCTCCTCACCTGCCATTCCTCCGATCCCTGGGCTTTCTGATGTTCCCTTTCTCACG
AACGAGACGACTTTCGGGCTGAAGCAAAGTCCGGCACACCTGATCATCGTCGGAGGAGGCCCCATAGGCATGGAGCGGGC
GCAGGCGCACCGCCGGCTTGGCGCAGATGTTACGGTGCTCGAGGCCGATACCGTGCTCGGCAAGGAAGACCCTGAACTGG
CCCTTGGGGTCAAGCAGGCTCTTTTGAAGGAAGGAGTCGCGATACTGGAACATGCGCGCGCCGAGCGCGTGGAGCGCTAC
AAAGGAACCGGCATACGGGTTCATGTGGCGGATGAGAAGGGCGCACACAGCATCGACGGCTCGCACTTACTGATCGCCAC
CGGGCGCAGACCGAATGTCGAGGCTCTGGCACTTGAAAATGCGGGCGTTGCCTATGGGCCGGGCGGTATCACGATTTCCC
CTAAGCTCAGGACAACCAACCGACGCATTTTCGCCATTGGCGATGTGGCTGGCGGCCCGCAGTTCACGCATGTCGCGAAT
TATCATGCGGGGCTGGTTATCCGCGCCATTCTTTTCCGCCTGCCTGTAAAGGCGAATCACGAACACATTCCCAGGGTGAC
ATTCACCGACCCCGAACTCGCCCAAATCGGACTGACGGAAAACGAAGCCCGGAGGAGAGGCTTGCAGGTGAAGGTGCTGC
GCTCCTCATTTTCCGAAAACGATCGGGCGCATGCCGAAGGACACACGGACGGTTTCATCAAGCTCATCGTGGGTCGGCGC
GGACGCATTCTCGGCGTCTCGATTCTAGGCCGAGGCGCCGGTGAAATGATGCATTTCTGGTCCCTCGCACTCTCTCGACG
CATGAGGGTGCACGATATTTCGCAATATGTTGCGCCCTACCCCACGCTTGGAGAAATCGGAAAGCGTGCCGCCCTCTCTT
ATTTCGCCGAAGCGGCGCGCAGCTCATCCGTGCGTGGAATATTAGGCTTTTTGCGGCTATTTGGCTAA

Upstream 100 bases:

>100_bases
TCCCTCGGCGGGCTTGCGGTGGTCGCAGCCCTTGCGGTCGTCGTAAAACGAAGGTTGAAAAGCAAGGCCACCGGGAGGGG
CGAAGTGCCAATGGCGGGAA

Downstream 100 bases:

>100_bases
GTAGGGTGATCATTGTGGGAACCACCACCTGTGCAGCAGCGGAACAGGAATGGCCGAGGAGAAGCGTCAGGAAGGAACCA
AGACCGAATTAGACGCGAGT

Product: pyridine nucleotide-disulphide oxidoreductase dimerisation region

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MTTILKPDICVIGAGSGGLTVAAAAASLGASVVLIERGKMGGDCLNYGCVPSKALIASARQAHRLSHGGSLGIAAVEPSI
DFARVAGHIEQAIAAIAPNDSKERFTALGVEVISAQGHFKDPRTVVAGGSEIRARRFVIATGSSPAIPPIPGLSDVPFLT
NETTFGLKQSPAHLIIVGGGPIGMERAQAHRRLGADVTVLEADTVLGKEDPELALGVKQALLKEGVAILEHARAERVERY
KGTGIRVHVADEKGAHSIDGSHLLIATGRRPNVEALALENAGVAYGPGGITISPKLRTTNRRIFAIGDVAGGPQFTHVAN
YHAGLVIRAILFRLPVKANHEHIPRVTFTDPELAQIGLTENEARRRGLQVKVLRSSFSENDRAHAEGHTDGFIKLIVGRR
GRILGVSILGRGAGEMMHFWSLALSRRMRVHDISQYVAPYPTLGEIGKRAALSYFAEAARSSSVRGILGFLRLFG

Sequences:

>Translated_475_residues
MTTILKPDICVIGAGSGGLTVAAAAASLGASVVLIERGKMGGDCLNYGCVPSKALIASARQAHRLSHGGSLGIAAVEPSI
DFARVAGHIEQAIAAIAPNDSKERFTALGVEVISAQGHFKDPRTVVAGGSEIRARRFVIATGSSPAIPPIPGLSDVPFLT
NETTFGLKQSPAHLIIVGGGPIGMERAQAHRRLGADVTVLEADTVLGKEDPELALGVKQALLKEGVAILEHARAERVERY
KGTGIRVHVADEKGAHSIDGSHLLIATGRRPNVEALALENAGVAYGPGGITISPKLRTTNRRIFAIGDVAGGPQFTHVAN
YHAGLVIRAILFRLPVKANHEHIPRVTFTDPELAQIGLTENEARRRGLQVKVLRSSFSENDRAHAEGHTDGFIKLIVGRR
GRILGVSILGRGAGEMMHFWSLALSRRMRVHDISQYVAPYPTLGEIGKRAALSYFAEAARSSSVRGILGFLRLFG
>Mature_474_residues
TTILKPDICVIGAGSGGLTVAAAAASLGASVVLIERGKMGGDCLNYGCVPSKALIASARQAHRLSHGGSLGIAAVEPSID
FARVAGHIEQAIAAIAPNDSKERFTALGVEVISAQGHFKDPRTVVAGGSEIRARRFVIATGSSPAIPPIPGLSDVPFLTN
ETTFGLKQSPAHLIIVGGGPIGMERAQAHRRLGADVTVLEADTVLGKEDPELALGVKQALLKEGVAILEHARAERVERYK
GTGIRVHVADEKGAHSIDGSHLLIATGRRPNVEALALENAGVAYGPGGITISPKLRTTNRRIFAIGDVAGGPQFTHVANY
HAGLVIRAILFRLPVKANHEHIPRVTFTDPELAQIGLTENEARRRGLQVKVLRSSFSENDRAHAEGHTDGFIKLIVGRRG
RILGVSILGRGAGEMMHFWSLALSRRMRVHDISQYVAPYPTLGEIGKRAALSYFAEAARSSSVRGILGFLRLFG

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=467, Percent_Identity=31.6916488222698, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI50301238, Length=456, Percent_Identity=30.0438596491228, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI22035672, Length=465, Percent_Identity=25.5913978494624, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI148277065, Length=453, Percent_Identity=23.6203090507726, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI33519430, Length=453, Percent_Identity=23.6203090507726, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI33519428, Length=453, Percent_Identity=23.6203090507726, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI33519426, Length=453, Percent_Identity=23.6203090507726, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI148277071, Length=453, Percent_Identity=23.6203090507726, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI291045266, Length=455, Percent_Identity=23.5164835164835, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI291045268, Length=449, Percent_Identity=22.71714922049, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI87081717, Length=450, Percent_Identity=30, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1786307, Length=457, Percent_Identity=30.8533916849015, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI87082354, Length=462, Percent_Identity=26.4069264069264, Blast_Score=138, Evalue=8e-34,
Organism=Escherichia coli, GI1789915, Length=431, Percent_Identity=29.2343387470998, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1789065, Length=194, Percent_Identity=28.3505154639175, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=467, Percent_Identity=29.9785867237687, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17557007, Length=475, Percent_Identity=27.7894736842105, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71983419, Length=430, Percent_Identity=28.3720930232558, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71983429, Length=430, Percent_Identity=28.3720930232558, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71982272, Length=486, Percent_Identity=24.4855967078189, Blast_Score=101, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6321091, Length=482, Percent_Identity=29.8755186721992, Blast_Score=170, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=27.8969957081545, Blast_Score=130, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6325240, Length=468, Percent_Identity=26.7094017094017, Blast_Score=126, Evalue=7e-30,
Organism=Drosophila melanogaster, GI21358499, Length=464, Percent_Identity=32.1120689655172, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=26.4392324093817, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=26.4392324093817, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=26.4392324093817, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI17737741, Length=479, Percent_Identity=25.4697286012526, Blast_Score=115, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 50283; Mature: 50151

Theoretical pI: Translated: 10.36; Mature: 10.36

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTILKPDICVIGAGSGGLTVAAAAASLGASVVLIERGKMGGDCLNYGCVPSKALIASAR
CCCEECCCEEEEECCCCCCCHHHHHHHCCCEEEEEECCCCCCCHHCCCCCCHHHHHHHHH
QAHRLSHGGSLGIAAVEPSIDFARVAGHIEQAIAAIAPNDSKERFTALGVEVISAQGHFK
HHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCEEEEECCCCCC
DPRTVVAGGSEIRARRFVIATGSSPAIPPIPGLSDVPFLTNETTFGLKQSPAHLIIVGGG
CCCEEEECCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCC
PIGMERAQAHRRLGADVTVLEADTVLGKEDPELALGVKQALLKEGVAILEHARAERVERY
CCCHHHHHHHHHCCCCEEEEECCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGTGIRVHVADEKGAHSIDGSHLLIATGRRPNVEALALENAGVAYGPGGITISPKLRTTN
CCCCEEEEEECCCCCCCCCCCEEEEEECCCCCEEEEEEECCCEEECCCCEEECCCEEECC
RRIFAIGDVAGGPQFTHVANYHAGLVIRAILFRLPVKANHEHIPRVTFTDPELAQIGLTE
CEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHEECCCC
NEARRRGLQVKVLRSSFSENDRAHAEGHTDGFIKLIVGRRGRILGVSILGRGAGEMMHFW
CHHHHCCCEEEEEHHHCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCHHHHHHH
SLALSRRMRVHDISQYVAPYPTLGEIGKRAALSYFAEAARSSSVRGILGFLRLFG
HHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TTILKPDICVIGAGSGGLTVAAAAASLGASVVLIERGKMGGDCLNYGCVPSKALIASAR
CCEECCCEEEEECCCCCCCHHHHHHHCCCEEEEEECCCCCCCHHCCCCCCHHHHHHHHH
QAHRLSHGGSLGIAAVEPSIDFARVAGHIEQAIAAIAPNDSKERFTALGVEVISAQGHFK
HHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCEEEEECCCCCC
DPRTVVAGGSEIRARRFVIATGSSPAIPPIPGLSDVPFLTNETTFGLKQSPAHLIIVGGG
CCCEEEECCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCC
PIGMERAQAHRRLGADVTVLEADTVLGKEDPELALGVKQALLKEGVAILEHARAERVERY
CCCHHHHHHHHHCCCCEEEEECCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGTGIRVHVADEKGAHSIDGSHLLIATGRRPNVEALALENAGVAYGPGGITISPKLRTTN
CCCCEEEEEECCCCCCCCCCCEEEEEECCCCCEEEEEEECCCEEECCCCEEECCCEEECC
RRIFAIGDVAGGPQFTHVANYHAGLVIRAILFRLPVKANHEHIPRVTFTDPELAQIGLTE
CEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHEECCCC
NEARRRGLQVKVLRSSFSENDRAHAEGHTDGFIKLIVGRRGRILGVSILGRGAGEMMHFW
CHHHHCCCEEEEEHHHCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCHHHHHHH
SLALSRRMRVHDISQYVAPYPTLGEIGKRAALSYFAEAARSSSVRGILGFLRLFG
HHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2067577 [H]