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The map label for this gene is ccmE

Identifier: 108812370

GI number: 108812370

Start: 2496218

End: 2496712

Strand: Reverse

Name: ccmE

Synonym: YPN_2209

Alternate gene names: 108812370

Gene position: 2496712-2496218 (Counterclockwise)

Preceding gene: 108812371

Following gene: 108812369

Centisome position: 55.06

GC content: 51.11

Gene sequence:

>495_bases
GTGAACCCACGTAGAAAAAGTCGGCTCTATCTGGCGATGGTGGTTCTGATCGGCATCTCTTTGACCACCACGTTGGTGCT
GTATGCGCTGCGTTCAAATATCGATCTATTTTATACCCCCGGCGAAATTTTACAGGGCAAAGGCGAACGCCATGAGAAAC
CAGCAATAGGCCAACGTTTACGTATTGGCGGCATGGTGATGCCGGGATCCGTGCAACGCGATGCAAAGACTTTGGAAATG
AGTTTTCAAGTTTATGATGCGCGTGGCGCTGTCACCGTGACATACACCGGTATTCTGCCGGATCTGTTTAGGGAAGGGCA
GGGGGTCGTGGCGCAAGGGGTATTTGCTGAAGGTAATACCGTCCATGCCAAAGAAGTGCTGGCAAAGCATGATGAAAAAT
ACACGCCACCTGAAGTTGAAGAGGCAATGAAAGAGAACCACTCTCGCCCGGCGGCCGCTTATCGTGGCACTAATACGACG
GGTAATGCCTTATGA

Upstream 100 bases:

>100_bases
AGACATCGATGCATCAAGTACCGTTGCATCAAGCACCATTACATCAAGCACCGTTACAACAAGCACCCCAGCACATCGCC
AATTTACAGGAGAAGCGACC

Downstream 100 bases:

>100_bases
TCCCTGAAATTGGCAGTTTTTTATTATGTTTGGCGTTGGCGATTTCACTGCTGCTGAGTCTGTATCCACAATGGGGAGCC
GCGCGTCAGGATGCCCGTAT

Product: cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MNPRRKSRLYLAMVVLIGISLTTTLVLYALRSNIDLFYTPGEILQGKGERHEKPAIGQRLRIGGMVMPGSVQRDAKTLEM
SFQVYDARGAVTVTYTGILPDLFREGQGVVAQGVFAEGNTVHAKEVLAKHDEKYTPPEVEEAMKENHSRPAAAYRGTNTT
GNAL

Sequences:

>Translated_164_residues
MNPRRKSRLYLAMVVLIGISLTTTLVLYALRSNIDLFYTPGEILQGKGERHEKPAIGQRLRIGGMVMPGSVQRDAKTLEM
SFQVYDARGAVTVTYTGILPDLFREGQGVVAQGVFAEGNTVHAKEVLAKHDEKYTPPEVEEAMKENHSRPAAAYRGTNTT
GNAL
>Mature_164_residues
MNPRRKSRLYLAMVVLIGISLTTTLVLYALRSNIDLFYTPGEILQGKGERHEKPAIGQRLRIGGMVMPGSVQRDAKTLEM
SFQVYDARGAVTVTYTGILPDLFREGQGVVAQGVFAEGNTVHAKEVLAKHDEKYTPPEVEEAMKENHSRPAAAYRGTNTT
GNAL

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=155, Percent_Identity=68.3870967741936, Blast_Score=227, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_YERP3 (A7FGJ2)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001400370.1
- ProteinModelPortal:   A7FGJ2
- SMR:   A7FGJ2
- STRING:   A7FGJ2
- GeneID:   5386717
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_1391
- eggNOG:   COG2332
- HOGENOM:   HBG296631
- OMA:   HVEFAVH
- ProtClustDB:   PRK13165
- BioCyc:   YPSE349747:YPSIP31758_1391-MONOMER
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 18033; Mature: 18033

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: BINDING 130-130

Signals:

None

Transmembrane regions:

HASH(0x1144a800)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPRRKSRLYLAMVVLIGISLTTTLVLYALRSNIDLFYTPGEILQGKGERHEKPAIGQRL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCCCCCCCCEE
RIGGMVMPGSVQRDAKTLEMSFQVYDARGAVTVTYTGILPDLFREGQGVVAQGVFAEGNT
EECCEECCCCCCCCHHEEEEEEEEEECCCCEEEEECCCCHHHHHCCCCEEEEEEECCCCE
VHAKEVLAKHDEKYTPPEVEEAMKENHSRPAAAYRGTNTTGNAL
EHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHCCCCCCCCCCH
>Mature Secondary Structure
MNPRRKSRLYLAMVVLIGISLTTTLVLYALRSNIDLFYTPGEILQGKGERHEKPAIGQRL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCCCCCCCCEE
RIGGMVMPGSVQRDAKTLEMSFQVYDARGAVTVTYTGILPDLFREGQGVVAQGVFAEGNT
EECCEECCCCCCCCHHEEEEEEEEEECCCCEEEEECCCCHHHHHCCCCEEEEEEECCCCE
VHAKEVLAKHDEKYTPPEVEEAMKENHSRPAAAYRGTNTTGNAL
EHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA