| Definition | Yersinia pestis Nepal516, complete genome. |
|---|---|
| Accession | NC_008149 |
| Length | 4,534,590 |
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The map label for this gene is menD [H]
Identifier: 108812284
GI number: 108812284
Start: 2397737
End: 2399440
Strand: Reverse
Name: menD [H]
Synonym: YPN_2122
Alternate gene names: 108812284
Gene position: 2399440-2397737 (Counterclockwise)
Preceding gene: 108812285
Following gene: 108812283
Centisome position: 52.91
GC content: 56.98
Gene sequence:
>1704_bases ATGTCGACAAGTGTTTTTAACCGTCGTTGGGCGGCACTGCTACTGGAGGCTTTGACCCGCCACGGTGTGCGTCATATCTG TATTGCCCCAGGGTCTCGCTCTACACCGTTAACGTTAGCGGCTGCCGCTAATCCGTCGTTGGTTTGCCATACCCATTTTG ATGAGCGCGGTCTGGGCCATCTGGCTCTGGGGCTGGCGAAGGCCTCAACAGAACCGGTGGCGGTCATTGTCACCTCGGGT ACGGCGGTGGCGAATCTTTATCCTGCGCTAATCGAAGCGGGGTTAACGGGTGAGCGGCTGATATTATTGACCGCTGATCG CCCACCGGAGTTAATCGATTGCGGTGCCAATCAGGCTATCCGCCAGCAGGGGCTGTTTGCCAGCCATCCAACCCTAAGTG TTAATCTCCCCAGACCGACGCCCGATATCTCTGCCCGTTGGTTGGTTTCCACACTCGACAGCGCGATGGCGCAATTGCAA CATGGCGCTTTGCACATTAATTGTCCCTTTGCTGAACCACTGTATGGGGGGGATGAGCAACAGTATGCCGACTGGTCTGC CTCGCTGGGCGATTGGTGGCAGGATTGTCACCCATGGCTGCGTCAAACCTGTTACCCGCCCTCTCTTTATCAACCACCAG CACAGCAAGCTGACTGGTTTTTCTGGCGGCAAAAACGTGGCGTCGTGATTGCCGGACGGATGGGCGCGCAAGAGGGTAGG CAACTGACCGCATGGGCTGCAATGCTGGGCTGGCCACTGATTGGCGATGTATTGTCACAAACCGGTCAGCCATTGCCTTG TGCTGACTTATGGCTGGCGCACCCACGGGCGCAAGAAACCCTCGCTCAAGCACAGATGGTGTTGCAATTTGGCAGCAGTC TGACCAGTAAGCGCCTTTTACAATGGCAGACCGCATGTCAGCCACAGGAATACTGGCTGGTGGATAGCGCCCCAGGCCGC CTTGATCCTGCTAACCATCGTGGCCGACGTATTATTTGCCCGGTGGGCGAGTGGTTGAGTCGGCACCCCGCGCAGCGGCG TACACCTTGGGCCACGGAACTGGCGGCATATTCGGAAAGTGCGCAAGCACAGGTGATCGAGACGCTGGCCGGCCAATTCA GTGAGGCCGCCGTGGCACATCAGCTCGCGGAATTATTACCGGATAACGGCCAGCTATTTGTTGGCAACAGTTTGATTGTC CGGTTGATTGATGCGCTGGGGCAGCTACCCGCAGGCTATCCGGTTTACAGCAATCGGGGGGCCAGCGGTATCGATGGTTT GCTGTCAACCGCCGCCGGTGTACAGCGCGCGACGGCGAAACCGACATTAGCTATCGTCGGTGATTTGTCTGCCTTATATG ACCTTAATGCGCTGGCACTTTTGCGCCAGAGCTCGGCACCGATGGTGCTACTGGTGATCAATAACAATGGGGGGCAGATT TTCTCTTTATTGCCAACGCCAGAGGCCGAGCGCCAGCGTTTCTACTGTATGCCGCAGGATGTGAACTTCGAACACGCGGC GGTTATGTTCAGCTTAGGTTATGCTCGCCCTAATAGCTGGCCTCAGCTACGGGAGCTAGCGCATCAATGCTGGCTACGGG GGGGAACCACGCTGATTGAAGTCCAGGTGCCACCAAGTCAGGGGGCAGAAACACTGCAACAGTTAGTACAACAGGTGACA TTAATACCGCAGGTGGCCCCATGA
Upstream 100 bases:
>100_bases TTAACCATAAAGCGGTCGCTGCGGATTTTTCAAAGGTAACGTTTCTCTTTATCTTAATTATCACGGCCGTAGCGTCTGTT AACTGACTTTTGAGCAAACC
Downstream 100 bases:
>100_bases CGACACTGGCTTGCCGAAAACTGGCCCCTCATCCGGAATCGCCCCGCCATCAACACGCTGGGCCTTGGTTGGTTTGGTTA CATGGTTTGTTGGGCAGCGG
Product: 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase
Products: NA
Alternate protein names: SEPHCHC synthase; Menaquinone biosynthesis protein menD [H]
Number of amino acids: Translated: 567; Mature: 566
Protein sequence:
>567_residues MSTSVFNRRWAALLLEALTRHGVRHICIAPGSRSTPLTLAAAANPSLVCHTHFDERGLGHLALGLAKASTEPVAVIVTSG TAVANLYPALIEAGLTGERLILLTADRPPELIDCGANQAIRQQGLFASHPTLSVNLPRPTPDISARWLVSTLDSAMAQLQ HGALHINCPFAEPLYGGDEQQYADWSASLGDWWQDCHPWLRQTCYPPSLYQPPAQQADWFFWRQKRGVVIAGRMGAQEGR QLTAWAAMLGWPLIGDVLSQTGQPLPCADLWLAHPRAQETLAQAQMVLQFGSSLTSKRLLQWQTACQPQEYWLVDSAPGR LDPANHRGRRIICPVGEWLSRHPAQRRTPWATELAAYSESAQAQVIETLAGQFSEAAVAHQLAELLPDNGQLFVGNSLIV RLIDALGQLPAGYPVYSNRGASGIDGLLSTAAGVQRATAKPTLAIVGDLSALYDLNALALLRQSSAPMVLLVINNNGGQI FSLLPTPEAERQRFYCMPQDVNFEHAAVMFSLGYARPNSWPQLRELAHQCWLRGGTTLIEVQVPPSQGAETLQQLVQQVT LIPQVAP
Sequences:
>Translated_567_residues MSTSVFNRRWAALLLEALTRHGVRHICIAPGSRSTPLTLAAAANPSLVCHTHFDERGLGHLALGLAKASTEPVAVIVTSG TAVANLYPALIEAGLTGERLILLTADRPPELIDCGANQAIRQQGLFASHPTLSVNLPRPTPDISARWLVSTLDSAMAQLQ HGALHINCPFAEPLYGGDEQQYADWSASLGDWWQDCHPWLRQTCYPPSLYQPPAQQADWFFWRQKRGVVIAGRMGAQEGR QLTAWAAMLGWPLIGDVLSQTGQPLPCADLWLAHPRAQETLAQAQMVLQFGSSLTSKRLLQWQTACQPQEYWLVDSAPGR LDPANHRGRRIICPVGEWLSRHPAQRRTPWATELAAYSESAQAQVIETLAGQFSEAAVAHQLAELLPDNGQLFVGNSLIV RLIDALGQLPAGYPVYSNRGASGIDGLLSTAAGVQRATAKPTLAIVGDLSALYDLNALALLRQSSAPMVLLVINNNGGQI FSLLPTPEAERQRFYCMPQDVNFEHAAVMFSLGYARPNSWPQLRELAHQCWLRGGTTLIEVQVPPSQGAETLQQLVQQVT LIPQVAP >Mature_566_residues STSVFNRRWAALLLEALTRHGVRHICIAPGSRSTPLTLAAAANPSLVCHTHFDERGLGHLALGLAKASTEPVAVIVTSGT AVANLYPALIEAGLTGERLILLTADRPPELIDCGANQAIRQQGLFASHPTLSVNLPRPTPDISARWLVSTLDSAMAQLQH GALHINCPFAEPLYGGDEQQYADWSASLGDWWQDCHPWLRQTCYPPSLYQPPAQQADWFFWRQKRGVVIAGRMGAQEGRQ LTAWAAMLGWPLIGDVLSQTGQPLPCADLWLAHPRAQETLAQAQMVLQFGSSLTSKRLLQWQTACQPQEYWLVDSAPGRL DPANHRGRRIICPVGEWLSRHPAQRRTPWATELAAYSESAQAQVIETLAGQFSEAAVAHQLAELLPDNGQLFVGNSLIVR LIDALGQLPAGYPVYSNRGASGIDGLLSTAAGVQRATAKPTLAIVGDLSALYDLNALALLRQSSAPMVLLVINNNGGQIF SLLPTPEAERQRFYCMPQDVNFEHAAVMFSLGYARPNSWPQLRELAHQCWLRGGTTLIEVQVPPSQGAETLQQLVQQVTL IPQVAP
Specific function: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-ca
COG id: COG1165
COG function: function code H; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the TPP enzyme family. MenD subfamily [H]
Homologues:
Organism=Escherichia coli, GI1788599, Length=560, Percent_Identity=69.8214285714286, Blast_Score=798, Evalue=0.0,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004433 - InterPro: IPR012001 - InterPro: IPR011766 [H]
Pfam domain/function: PF02775 TPP_enzyme_C; PF02776 TPP_enzyme_N [H]
EC number: =2.2.1.9 [H]
Molecular weight: Translated: 61777; Mature: 61646
Theoretical pI: Translated: 6.78; Mature: 6.78
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.9 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 3.4 %Cys+Met (Translated Protein) 1.9 %Cys (Mature Protein) 1.2 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSTSVFNRRWAALLLEALTRHGVRHICIAPGSRSTPLTLAAAANPSLVCHTHFDERGLGH CCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCEEEEECCCCCCCCH LALGLAKASTEPVAVIVTSGTAVANLYPALIEAGLTGERLILLTADRPPELIDCGANQAI HHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHEECCCCHHH RQQGLFASHPTLSVNLPRPTPDISARWLVSTLDSAMAQLQHGALHINCPFAEPLYGGDEQ HHCCCEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCH QYADWSASLGDWWQDCHPWLRQTCYPPSLYQPPAQQADWFFWRQKRGVVIAGRMGAQEGR HHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCCCCC QLTAWAAMLGWPLIGDVLSQTGQPLPCADLWLAHPRAQETLAQAQMVLQFGSSLTSKRLL HHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH QWQTACQPQEYWLVDSAPGRLDPANHRGRRIICPVGEWLSRHPAQRRTPWATELAAYSES HHHHCCCCCCEEEEECCCCCCCCCCCCCCEEEECHHHHHHCCCCCCCCCCHHHHHHHCCH AQAQVIETLAGQFSEAAVAHQLAELLPDNGQLFVGNSLIVRLIDALGQLPAGYPVYSNRG HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCCCC ASGIDGLLSTAAGVQRATAKPTLAIVGDLSALYDLNALALLRQSSAPMVLLVINNNGGQI CCHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEE FSLLPTPEAERQRFYCMPQDVNFEHAAVMFSLGYARPNSWPQLRELAHQCWLRGGTTLIE EEECCCCCHHCCEEEECCCCCCCHHHHHEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEE VQVPPSQGAETLQQLVQQVTLIPQVAP EECCCCCCHHHHHHHHHHHHHCCCCCC >Mature Secondary Structure STSVFNRRWAALLLEALTRHGVRHICIAPGSRSTPLTLAAAANPSLVCHTHFDERGLGH CCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCEEEEECCCCCCCCH LALGLAKASTEPVAVIVTSGTAVANLYPALIEAGLTGERLILLTADRPPELIDCGANQAI HHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHEECCCCHHH RQQGLFASHPTLSVNLPRPTPDISARWLVSTLDSAMAQLQHGALHINCPFAEPLYGGDEQ HHCCCEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCH QYADWSASLGDWWQDCHPWLRQTCYPPSLYQPPAQQADWFFWRQKRGVVIAGRMGAQEGR HHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCCCCC QLTAWAAMLGWPLIGDVLSQTGQPLPCADLWLAHPRAQETLAQAQMVLQFGSSLTSKRLL HHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH QWQTACQPQEYWLVDSAPGRLDPANHRGRRIICPVGEWLSRHPAQRRTPWATELAAYSES HHHHCCCCCCEEEEECCCCCCCCCCCCCCEEEECHHHHHHCCCCCCCCCCHHHHHHHCCH AQAQVIETLAGQFSEAAVAHQLAELLPDNGQLFVGNSLIVRLIDALGQLPAGYPVYSNRG HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCCCC ASGIDGLLSTAAGVQRATAKPTLAIVGDLSALYDLNALALLRQSSAPMVLLVINNNGGQI CCHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEE FSLLPTPEAERQRFYCMPQDVNFEHAAVMFSLGYARPNSWPQLRELAHQCWLRGGTTLIE EEECCCCCHHCCEEEECCCCCCCHHHHHEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEE VQVPPSQGAETLQQLVQQVTLIPQVAP EECCCCCCHHHHHHHHHHHHHCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA