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The map label for this gene is mmsB [H]

Identifier: 108798035

GI number: 108798035

Start: 1157822

End: 1158694

Strand: Reverse

Name: mmsB [H]

Synonym: Mmcs_1062

Alternate gene names: 108798035

Gene position: 1158694-1157822 (Counterclockwise)

Preceding gene: 108798036

Following gene: 108798029

Centisome position: 20.31

GC content: 69.3

Gene sequence:

>873_bases
GTGACGACGATTGCGTTCTTCGGCCTGGGCCACATGGGCGGTCCGATGGCGGCCAACCTGGCCAAGGCGGGGCACACCGT
GCGGGGTTTCGACCCGGTGCCCGCGCTGCGGACCGCCGCCGAGGACAACGGTATCTCCACGTTCGAAAGCGGTACTGAAG
CGGTGGCCGGCGCCGAGGTGGTGATCACCTCGCTGCCCAACGGCGCGATCGTCAAGAGCGTGTACGACGAGGTGCTGCCC
GCCGCGGCGGACGGCACGCTGTTCATCGACACCTCGACCATCTCGGTGGACGACGCGCGCGAGGTCAACGCCGCGGCCGC
GGCGAAGGGTTTCGCCCAGCTCGACGCGCCGGTCTCCGGCGGGGTCAAGGGCGCCACCGCGGGAACGTTGGCGTTCATGG
TGGGTGGTGATGACGCGGCCGTCGAGCGGGCGCGTCCGGTGCTGGAACCCATGGCGGGCAAGGTCGTCCACTGCGGCGCC
TCGGGCACCGGCCAGGCCGCCAAACTGTGCAACAACATGGTGCTCGCCGTCCAGCAGATCGCGATCGGTGAGGCGTTCGT
CCTGGCCGAGAAGCTCGGGCTGTCGGCTCAGTCGCTGTTCGACGTCATCACCGGCGCGACCGGCAACTGCTGGGCGGTGC
ACACGAACTGCCCTGTGCCGGGACCGGTTCCGACCTCTCCGGCCAATAACGACTTCAAACCGGGGTTCGCGACGGCGTTG
ATGAACAAGGACCTCGGCCTGGCCATGGCCGCGGTGTCGTCGACGGGTGCGTCGGCGCCGCTGGGCAGCCACGCCGCCGA
GCTGTACCAGACATTCGCCGAGGACCACGCCGACAAGGACTTCAGCGCGATCATCGAGACCCTGCGGGGCTGA

Upstream 100 bases:

>100_bases
GGTCCACCGGATCCTCGAGGGCAGCAACGAGATCATGCGCGTGGTCATCGGGCGGGCAGCCGCTGCGAGGGCGCGGACAT
CGGCTTAAGGAGTTCAGACA

Downstream 100 bases:

>100_bases
TTCAGGCCGCGAGCCGGTTCACCACACCGGCGAACACGGCGGGCAGTGCCTGCGCTGCGGGCACGATGCGCGGCCGGATC
GACGGCGTCGCCCCGGCCCG

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MTTIAFFGLGHMGGPMAANLAKAGHTVRGFDPVPALRTAAEDNGISTFESGTEAVAGAEVVITSLPNGAIVKSVYDEVLP
AAADGTLFIDTSTISVDDAREVNAAAAAKGFAQLDAPVSGGVKGATAGTLAFMVGGDDAAVERARPVLEPMAGKVVHCGA
SGTGQAAKLCNNMVLAVQQIAIGEAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFATAL
MNKDLGLAMAAVSSTGASAPLGSHAAELYQTFAEDHADKDFSAIIETLRG

Sequences:

>Translated_290_residues
MTTIAFFGLGHMGGPMAANLAKAGHTVRGFDPVPALRTAAEDNGISTFESGTEAVAGAEVVITSLPNGAIVKSVYDEVLP
AAADGTLFIDTSTISVDDAREVNAAAAAKGFAQLDAPVSGGVKGATAGTLAFMVGGDDAAVERARPVLEPMAGKVVHCGA
SGTGQAAKLCNNMVLAVQQIAIGEAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFATAL
MNKDLGLAMAAVSSTGASAPLGSHAAELYQTFAEDHADKDFSAIIETLRG
>Mature_289_residues
TTIAFFGLGHMGGPMAANLAKAGHTVRGFDPVPALRTAAEDNGISTFESGTEAVAGAEVVITSLPNGAIVKSVYDEVLPA
AADGTLFIDTSTISVDDAREVNAAAAAKGFAQLDAPVSGGVKGATAGTLAFMVGGDDAAVERARPVLEPMAGKVVHCGAS
GTGQAAKLCNNMVLAVQQIAIGEAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFATALM
NKDLGLAMAAVSSTGASAPLGSHAAELYQTFAEDHADKDFSAIIETLRG

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=292, Percent_Identity=39.3835616438356, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI40556376, Length=292, Percent_Identity=26.7123287671233, Blast_Score=92, Evalue=5e-19,
Organism=Escherichia coli, GI145693186, Length=275, Percent_Identity=35.2727272727273, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1790315, Length=294, Percent_Identity=34.6938775510204, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1786719, Length=295, Percent_Identity=30.1694915254237, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1789092, Length=293, Percent_Identity=30.7167235494881, Blast_Score=92, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17557316, Length=295, Percent_Identity=38.9830508474576, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24655230, Length=292, Percent_Identity=44.1780821917808, Blast_Score=238, Evalue=3e-63,
Organism=Drosophila melanogaster, GI19922568, Length=292, Percent_Identity=44.1780821917808, Blast_Score=238, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 29157; Mature: 29026

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIAFFGLGHMGGPMAANLAKAGHTVRGFDPVPALRTAAEDNGISTFESGTEAVAGAEV
CCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCHHHCCCHHHCCCEE
VITSLPNGAIVKSVYDEVLPAAADGTLFIDTSTISVDDAREVNAAAAAKGFAQLDAPVSG
EEEECCCCHHHHHHHHHHCCCCCCCEEEEEECEECCCCHHHHHHHHHHHHHHHCCCCCCC
GVKGATAGTLAFMVGGDDAAVERARPVLEPMAGKVVHCGASGTGQAAKLCNNMVLAVQQI
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHH
AIGEAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFATAL
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHH
MNKDLGLAMAAVSSTGASAPLGSHAAELYQTFAEDHADKDFSAIIETLRG
HCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TTIAFFGLGHMGGPMAANLAKAGHTVRGFDPVPALRTAAEDNGISTFESGTEAVAGAEV
CEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCHHHCCCHHHCCCEE
VITSLPNGAIVKSVYDEVLPAAADGTLFIDTSTISVDDAREVNAAAAAKGFAQLDAPVSG
EEEECCCCHHHHHHHHHHCCCCCCCEEEEEECEECCCCHHHHHHHHHHHHHHHCCCCCCC
GVKGATAGTLAFMVGGDDAAVERARPVLEPMAGKVVHCGASGTGQAAKLCNNMVLAVQQI
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHH
AIGEAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFATAL
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHH
MNKDLGLAMAAVSSTGASAPLGSHAAELYQTFAEDHADKDFSAIIETLRG
HCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]