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The map label for this gene is degU [H]

Identifier: 108798029

GI number: 108798029

Start: 1152948

End: 1153607

Strand: Reverse

Name: degU [H]

Synonym: Mmcs_1056

Alternate gene names: 108798029

Gene position: 1153607-1152948 (Counterclockwise)

Preceding gene: 108798035

Following gene: 108798028

Centisome position: 20.22

GC content: 69.55

Gene sequence:

>660_bases
ATGACCGGCGGGCCAGTGCGGATCGTCCTGGTCGACGACCACGAGATGGTCATCGAGGGGCTCAAGGCCATGCTCGCGAC
GTACGCCGACCGGGTCGCGGTGGTGGGACAGGCGGTGGGCGCCGAACGCGCGATCGGCGTGGTCGCCGACCTGCGACCGG
ACATCGTGCTGTGCGACGTCCGGATGCAGGGGGCCAGCGGTCTGGACCTGTGCCTGGAGCTGCGCGGGCGCGACCCGGAC
CAGAAGGTGGTGATGCTCTCGGTGTACGACGACGAGCAGTACCTGTTCCAGGCGCTGCGGGTGGGTGCGTCGGGCTACCT
GCTCAAGAGCATCAGCAGTGACGAGCTGGTCCGCCAGCTCGAGTTGGCCCACCGCGGCCAGACCGCCATCGATCCGGGCA
TGGCGGCCAGGGCGGTCGACACCGCCGCCCGGCTGCAGCGGGACGAGTTCTGGCCCGGGGCCCGCCAGGGCCTCACCCAG
CGCGAGAGCGAGATCCTGTCGTTCGTCGTGACCGGGCTGTCGAACCGGGGTATCGCCAACAAACTGGTGATCGGCGAGGA
GACCGTGAAGACCCATCTGCGGTCGATCTACCGCAAACTCGGCGTCGGTGACCGCGCCGGTGCGGTGGCGACGGCGCTGC
GCGAGGGGATTTACCAGTGA

Upstream 100 bases:

>100_bases
CCTTTGGGGGATTCGACGTGGCGAAGTTGCCCAGCCGTCTGCCGCCGCGCCTCTAAGGTGATGCCATGACCGCCCAGCGA
GAAGCGAAGCGGCATCGCGC

Downstream 100 bases:

>100_bases
CAACGCGAGCGCTGCTGACCGCCGACCGCGAACTGGCCCTGCTGCGCGAGCTCATCCAGGCGGCCTCGAGCGGGCCGGGG
GTGGAGCCGCTCGCGGCCGC

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MTGGPVRIVLVDDHEMVIEGLKAMLATYADRVAVVGQAVGAERAIGVVADLRPDIVLCDVRMQGASGLDLCLELRGRDPD
QKVVMLSVYDDEQYLFQALRVGASGYLLKSISSDELVRQLELAHRGQTAIDPGMAARAVDTAARLQRDEFWPGARQGLTQ
RESEILSFVVTGLSNRGIANKLVIGEETVKTHLRSIYRKLGVGDRAGAVATALREGIYQ

Sequences:

>Translated_219_residues
MTGGPVRIVLVDDHEMVIEGLKAMLATYADRVAVVGQAVGAERAIGVVADLRPDIVLCDVRMQGASGLDLCLELRGRDPD
QKVVMLSVYDDEQYLFQALRVGASGYLLKSISSDELVRQLELAHRGQTAIDPGMAARAVDTAARLQRDEFWPGARQGLTQ
RESEILSFVVTGLSNRGIANKLVIGEETVKTHLRSIYRKLGVGDRAGAVATALREGIYQ
>Mature_218_residues
TGGPVRIVLVDDHEMVIEGLKAMLATYADRVAVVGQAVGAERAIGVVADLRPDIVLCDVRMQGASGLDLCLELRGRDPDQ
KVVMLSVYDDEQYLFQALRVGASGYLLKSISSDELVRQLELAHRGQTAIDPGMAARAVDTAARLQRDEFWPGARQGLTQR
ESEILSFVVTGLSNRGIANKLVIGEETVKTHLRSIYRKLGVGDRAGAVATALREGIYQ

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787473, Length=218, Percent_Identity=33.9449541284404, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788521, Length=215, Percent_Identity=32.093023255814, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1788222, Length=216, Percent_Identity=26.3888888888889, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1790102, Length=199, Percent_Identity=28.643216080402, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788712, Length=192, Percent_Identity=23.9583333333333, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI87082052, Length=117, Percent_Identity=32.4786324786325, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23761; Mature: 23629

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGGPVRIVLVDDHEMVIEGLKAMLATYADRVAVVGQAVGAERAIGVVADLRPDIVLCDV
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCEEEEEE
RMQGASGLDLCLELRGRDPDQKVVMLSVYDDEQYLFQALRVGASGYLLKSISSDELVRQL
EECCCCCHHHHHEECCCCCCCEEEEEEEECCHHHHHHHHHHCCCCHHHHHCCHHHHHHHH
ELAHRGQTAIDPGMAARAVDTAARLQRDEFWPGARQGLTQRESEILSFVVTGLSNRGIAN
HHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
KLVIGEETVKTHLRSIYRKLGVGDRAGAVATALREGIYQ
EEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TGGPVRIVLVDDHEMVIEGLKAMLATYADRVAVVGQAVGAERAIGVVADLRPDIVLCDV
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCEEEEEE
RMQGASGLDLCLELRGRDPDQKVVMLSVYDDEQYLFQALRVGASGYLLKSISSDELVRQL
EECCCCCHHHHHEECCCCCCCEEEEEEEECCHHHHHHHHHHCCCCHHHHHCCHHHHHHHH
ELAHRGQTAIDPGMAARAVDTAARLQRDEFWPGARQGLTQRESEILSFVVTGLSNRGIAN
HHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
KLVIGEETVKTHLRSIYRKLGVGDRAGAVATALREGIYQ
EEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]