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The map label for this gene is ubiE [C]

Identifier: 108797408

GI number: 108797408

Start: 475966

End: 476802

Strand: Direct

Name: ubiE [C]

Synonym: Mmcs_0428

Alternate gene names: 108797408

Gene position: 475966-476802 (Clockwise)

Preceding gene: 108797407

Following gene: 108797409

Centisome position: 8.34

GC content: 66.67

Gene sequence:

>837_bases
ATGAACATCCATGCGCCATCCCAAGACCTGATCCGCGATGCCTGGGATGCCATTGCGCCCAGGTTCGACGAGTTCGTGAC
GCCGGAGAGCATGCAGTACGGCGCTCATGCCCTCCGACAGCTCCACATCGGCAGGGGCACCAGATTTCTGGATGTGGCCT
GCGGTAGTGGGGCATTGAGCCTCCCCGCCGCGCGCCTGGGAGCCGACGTGGTGGCAGTCGACATCTCGCAGGCCATGACC
GAGCGGGTGGCCGCCAGGGCAAGGGCGCAAGGGCTGTCGAACATCTGGTGCCGGGTCATGAACGGTCAGGATTTGGACCT
CGCAGACGACACGTTTGACATAGCCGCCTCCCAGCACGGGGTGTCGTTGTTCCCCGATGTGGACGCCGGGCTGGCCGAGA
TGGTGCGCGTGACCAAGCGCGGCGGGACTGTGCTCGTCATCGCGTTCGGCGCTCTGCCGAAGGCGGAGTTTCTCGCGTTC
TTCGTAGCCGCCATCAAGGCGGCCGTGCCCGGCTTCGCCGTCCTGCCTCTGGACCCGCCGCCGCTGCCATTCCAGCTGGC
CGACCGGGAGCTCTTCCGCAGCAAGCTCATCACGGCCGGGCTGAACGACGTCACCGTCGAGAGGACTGCCTGGGAGATGC
CCTTCCGGTCGGGGGCGCACATGTGCACTATGGTCACCTCCAGCAACCCATTGGGCGCCCAGTTGGTCGCCGGCCTGACC
GCCGCCCAGCGCGCCGACGTGGAACATGTGCTCGACGGGATACTTCGTGAACGCTCGGGCGGCCAACCGGGCGCGGTGCT
GTACGCCGACGTCAACGTCGGTGTCGGCACGAAATGA

Upstream 100 bases:

>100_bases
CGCGCCCCGGCTGACCCATAGAGCAGTGCCGGGCCGCCCAGCGGCGGGCGTTGAGCCGCTACGGAGCTCACTTCGTCGAA
GGCACCAGAGAGGAACTGTC

Downstream 100 bases:

>100_bases
CCCCACTGGTGGGTCGCGGCTGGCTACACGCTCACTGTGCCCGGCGATGCGGGGGGCGCAGCCCAGTACTCACCTGGTAC
TGATCCGCCCGAGCGGCAGC

Product: type 11 methyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MNIHAPSQDLIRDAWDAIAPRFDEFVTPESMQYGAHALRQLHIGRGTRFLDVACGSGALSLPAARLGADVVAVDISQAMT
ERVAARARAQGLSNIWCRVMNGQDLDLADDTFDIAASQHGVSLFPDVDAGLAEMVRVTKRGGTVLVIAFGALPKAEFLAF
FVAAIKAAVPGFAVLPLDPPPLPFQLADRELFRSKLITAGLNDVTVERTAWEMPFRSGAHMCTMVTSSNPLGAQLVAGLT
AAQRADVEHVLDGILRERSGGQPGAVLYADVNVGVGTK

Sequences:

>Translated_278_residues
MNIHAPSQDLIRDAWDAIAPRFDEFVTPESMQYGAHALRQLHIGRGTRFLDVACGSGALSLPAARLGADVVAVDISQAMT
ERVAARARAQGLSNIWCRVMNGQDLDLADDTFDIAASQHGVSLFPDVDAGLAEMVRVTKRGGTVLVIAFGALPKAEFLAF
FVAAIKAAVPGFAVLPLDPPPLPFQLADRELFRSKLITAGLNDVTVERTAWEMPFRSGAHMCTMVTSSNPLGAQLVAGLT
AAQRADVEHVLDGILRERSGGQPGAVLYADVNVGVGTK
>Mature_278_residues
MNIHAPSQDLIRDAWDAIAPRFDEFVTPESMQYGAHALRQLHIGRGTRFLDVACGSGALSLPAARLGADVVAVDISQAMT
ERVAARARAQGLSNIWCRVMNGQDLDLADDTFDIAASQHGVSLFPDVDAGLAEMVRVTKRGGTVLVIAFGALPKAEFLAF
FVAAIKAAVPGFAVLPLDPPPLPFQLADRELFRSKLITAGLNDVTVERTAWEMPFRSGAHMCTMVTSSNPLGAQLVAGLT
AAQRADVEHVLDGILRERSGGQPGAVLYADVNVGVGTK

Specific function: Methyltransferase Required For The Conversion Of Dimethylmenaquinone (Dmkh2) To Menaquinone (Mkh2) And The Conversion Of 2-Polyprenyl-6-Methoxy-1,4-Benzoquinol (Ddmqh2) To 2-Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol (Dmqh2). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To M.tuberculosis Rv1403c [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 29542; Mature: 29542

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIHAPSQDLIRDAWDAIAPRFDEFVTPESMQYGAHALRQLHIGRGTRFLDVACGSGALS
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCC
LPAARLGADVVAVDISQAMTERVAARARAQGLSNIWCRVMNGQDLDLADDTFDIAASQHG
CCHHHHCCCEEEEHHHHHHHHHHHHHHHHCCHHHHHEEECCCCCCCCCCCCHHHHHCCCC
VSLFPDVDAGLAEMVRVTKRGGTVLVIAFGALPKAEFLAFFVAAIKAAVPGFAVLPLDPP
CEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEECCCC
PLPFQLADRELFRSKLITAGLNDVTVERTAWEMPFRSGAHMCTMVTSSNPLGAQLVAGLT
CCCHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHH
AAQRADVEHVLDGILRERSGGQPGAVLYADVNVGVGTK
HHHHCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCC
>Mature Secondary Structure
MNIHAPSQDLIRDAWDAIAPRFDEFVTPESMQYGAHALRQLHIGRGTRFLDVACGSGALS
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCC
LPAARLGADVVAVDISQAMTERVAARARAQGLSNIWCRVMNGQDLDLADDTFDIAASQHG
CCHHHHCCCEEEEHHHHHHHHHHHHHHHHCCHHHHHEEECCCCCCCCCCCCHHHHHCCCC
VSLFPDVDAGLAEMVRVTKRGGTVLVIAFGALPKAEFLAFFVAAIKAAVPGFAVLPLDPP
CEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEECCCC
PLPFQLADRELFRSKLITAGLNDVTVERTAWEMPFRSGAHMCTMVTSSNPLGAQLVAGLT
CCCHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHH
AAQRADVEHVLDGILRERSGGQPGAVLYADVNVGVGTK
HHHHCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]