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The map label for this gene is menE [H]

Identifier: 108763899

GI number: 108763899

Start: 4113225

End: 4114673

Strand: Direct

Name: menE [H]

Synonym: MXAN_3532

Alternate gene names: 108763899

Gene position: 4113225-4114673 (Clockwise)

Preceding gene: 108761657

Following gene: 108763094

Centisome position: 45.0

GC content: 71.22

Gene sequence:

>1449_bases
ATGTCGGTCCTGCTGTGTCCCATTCGAGTAGGCGCTCGTCATCACCCCCAGGCAGAGGCCCTGACGTTCGCGGGCCGCTC
CTGGTCCTATGAAGCGCTGGATGCGGAAGTCTCCCGATGGGTTGCCGCACTCGAGGCGGAGGGCGTCGGCGCTTCGGACA
GGGTGGCGTCGCTCGCGACGAACCACGTCGCCTCCGTGTGCCTCTTCTGGGCGCTGGGCCGGCTGGGCGCGGTGTTGGCG
CCGCTCAATGCCCGCCTCACGTCCGTGGAGCTGGCGCCCATGGTGGAGGACATCCAGCCCCGTTTGAGGCTGGCGCTGGG
GGCCCTGGCGGAGCGGCTCCCTGGAGCCCGGCCACTCGAGTCCTTCGCGGAGGCCGTCTCCACGGGGGCTTCCACGTGCC
AGCCCCTGGAGGCATCGTCGCCCCGGGTTGTGCTCTTCACCAGCGGGACCACGGGCCGGCCCAAGGGCGCGGTCCTCACC
GAAGGCAACTTCCGGGCGTCTTCACGAGCGTCGGCGGGCAACCTGGGGGCGCATCCAGCCCCGCGTTGGCTGGGCACATT
GCCGCTTTTCCACGTGGGGGGCATCGCCATGCTCACTCGCACTGCCTACGAGGGAGGCTGCCTCGTCCTGCACGAACGCT
TCGACGCCGATGCGGCCAACCGGGCCATCGACGGGGAGGGCGTGTCCCACGCGAGCCTCGTGGCTACGACGCTGGAGCGA
GTGCTGGAGGCCCGAGGTGACCGGCGCATGCCGGACTCCTTTGCATGGGCGCTGATAGGCGGAGGTCCGGTGCCCGTGCC
CCTCCTCGCACGAGCGAGGGCCGCGGGCCTGCGAGCCCTTCAGACGTACGGCCTGACGGAGGCCTGCTCACAAGTCACGA
CTGAGCGCCCGGACACTGCGGACGGCCGCACCGCTGGTGTCCCGTTGCTGGGTGTCGAGGTGCGCATCGTCGGCGCAGGG
GGCGAAGTCCTCGGTGCTGGGGCGGAGGGCGACATCGAGGTGCGCGCGCCCACGGTGATGGCCGGGTACTGGCAGCGTCC
GGAGGCCACCCAGGAGGCGGTTCGCGACGGCTGGCTGCGCACGAAGGACGTCGGTGTGCTGGATGGTGGGGGGCGGCTCA
CCGTGCTGTCACGCCGCACGGACCTCATCGTCCGAGGTGGGGAGAACATCTACCCGGCGGAGGTGGAAGCGGTGCTCGTC
AACCACCCCGCGGTGCAGGAAGCCTCCGTGGTGGGCTTCCCGGACGACCGCTGGGGCGAACGGCCCGTGGCCTTCGTCGC
GCCGCGCCAGGGGCAACCGCACCCCGGGGATGAGGAACTGGCGGCGTGGTGCCGTCAGTCCCTGGCGGGCTTCAAGACGC
CCGCGCGTTTCGTGTGGGTGGACGCGCTGCCTCGCAACGCCATGGGGAAGGTCGAGCGCACCGTCCTGAGACGGCACGCC
CTCCGCTGA

Upstream 100 bases:

>100_bases
GCACCCCGGGGCTCGGACTGAGCTCCCAGTCCCTGGTGTGACGGCTCGGCGCATGGGAGCCCCCGGCTTGGCCTCCGTTG
ATGAAGCCCAAGGTGACGGA

Downstream 100 bases:

>100_bases
CCCACGGGGGTGGGGCGGGCGCCCTGTCTCAGCACTCCGAGATCGGGTGGCCCCAGGGATTGGTCCGCGGGAACTGCCGC
AGGACGGTGCTCAGCCGGCA

Product: O-succinylbenzoate-CoA ligase

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MSVLLCPIRVGARHHPQAEALTFAGRSWSYEALDAEVSRWVAALEAEGVGASDRVASLATNHVASVCLFWALGRLGAVLA
PLNARLTSVELAPMVEDIQPRLRLALGALAERLPGARPLESFAEAVSTGASTCQPLEASSPRVVLFTSGTTGRPKGAVLT
EGNFRASSRASAGNLGAHPAPRWLGTLPLFHVGGIAMLTRTAYEGGCLVLHERFDADAANRAIDGEGVSHASLVATTLER
VLEARGDRRMPDSFAWALIGGGPVPVPLLARARAAGLRALQTYGLTEACSQVTTERPDTADGRTAGVPLLGVEVRIVGAG
GEVLGAGAEGDIEVRAPTVMAGYWQRPEATQEAVRDGWLRTKDVGVLDGGGRLTVLSRRTDLIVRGGENIYPAEVEAVLV
NHPAVQEASVVGFPDDRWGERPVAFVAPRQGQPHPGDEELAAWCRQSLAGFKTPARFVWVDALPRNAMGKVERTVLRRHA
LR

Sequences:

>Translated_482_residues
MSVLLCPIRVGARHHPQAEALTFAGRSWSYEALDAEVSRWVAALEAEGVGASDRVASLATNHVASVCLFWALGRLGAVLA
PLNARLTSVELAPMVEDIQPRLRLALGALAERLPGARPLESFAEAVSTGASTCQPLEASSPRVVLFTSGTTGRPKGAVLT
EGNFRASSRASAGNLGAHPAPRWLGTLPLFHVGGIAMLTRTAYEGGCLVLHERFDADAANRAIDGEGVSHASLVATTLER
VLEARGDRRMPDSFAWALIGGGPVPVPLLARARAAGLRALQTYGLTEACSQVTTERPDTADGRTAGVPLLGVEVRIVGAG
GEVLGAGAEGDIEVRAPTVMAGYWQRPEATQEAVRDGWLRTKDVGVLDGGGRLTVLSRRTDLIVRGGENIYPAEVEAVLV
NHPAVQEASVVGFPDDRWGERPVAFVAPRQGQPHPGDEELAAWCRQSLAGFKTPARFVWVDALPRNAMGKVERTVLRRHA
LR
>Mature_481_residues
SVLLCPIRVGARHHPQAEALTFAGRSWSYEALDAEVSRWVAALEAEGVGASDRVASLATNHVASVCLFWALGRLGAVLAP
LNARLTSVELAPMVEDIQPRLRLALGALAERLPGARPLESFAEAVSTGASTCQPLEASSPRVVLFTSGTTGRPKGAVLTE
GNFRASSRASAGNLGAHPAPRWLGTLPLFHVGGIAMLTRTAYEGGCLVLHERFDADAANRAIDGEGVSHASLVATTLERV
LEARGDRRMPDSFAWALIGGGPVPVPLLARARAAGLRALQTYGLTEACSQVTTERPDTADGRTAGVPLLGVEVRIVGAGG
EVLGAGAEGDIEVRAPTVMAGYWQRPEATQEAVRDGWLRTKDVGVLDGGGRLTVLSRRTDLIVRGGENIYPAEVEAVLVN
HPAVQEASVVGFPDDRWGERPVAFVAPRQGQPHPGDEELAAWCRQSLAGFKTPARFVWVDALPRNAMGKVERTVLRRHAL
R

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=539, Percent_Identity=29.1280148423006, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI187761345, Length=482, Percent_Identity=29.8755186721992, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI187761343, Length=482, Percent_Identity=29.8755186721992, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI122937307, Length=421, Percent_Identity=28.2660332541568, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI38505220, Length=408, Percent_Identity=26.2254901960784, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI115511026, Length=361, Percent_Identity=27.9778393351801, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI157311624, Length=392, Percent_Identity=25.765306122449, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI157311622, Length=392, Percent_Identity=25.765306122449, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI58082049, Length=393, Percent_Identity=25.6997455470738, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI42544132, Length=376, Percent_Identity=24.7340425531915, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI13375727, Length=520, Percent_Identity=23.4615384615385, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI253970489, Length=382, Percent_Identity=27.2251308900524, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI8923896, Length=382, Percent_Identity=27.2251308900524, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI145693145, Length=497, Percent_Identity=28.3702213279678, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1788107, Length=345, Percent_Identity=32.463768115942, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI221142682, Length=491, Percent_Identity=27.9022403258656, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1788595, Length=354, Percent_Identity=32.7683615819209, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1786810, Length=487, Percent_Identity=27.3100616016427, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1790505, Length=384, Percent_Identity=25.2604166666667, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17558820, Length=477, Percent_Identity=28.7211740041929, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI32563687, Length=465, Percent_Identity=28.6021505376344, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71994690, Length=349, Percent_Identity=30.6590257879656, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71994694, Length=349, Percent_Identity=30.6590257879656, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71994703, Length=349, Percent_Identity=30.6590257879656, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17531443, Length=455, Percent_Identity=25.2747252747253, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17559526, Length=385, Percent_Identity=29.0909090909091, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17538037, Length=508, Percent_Identity=25.7874015748031, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17560308, Length=528, Percent_Identity=25, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17557194, Length=500, Percent_Identity=26.8, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17560140, Length=343, Percent_Identity=25.9475218658892, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI71985884, Length=359, Percent_Identity=27.2980501392758, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17564090, Length=329, Percent_Identity=24.9240121580547, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71983001, Length=556, Percent_Identity=24.2805755395683, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71982997, Length=556, Percent_Identity=24.2805755395683, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319699, Length=339, Percent_Identity=30.6784660766962, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6319264, Length=553, Percent_Identity=24.0506329113924, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323182, Length=398, Percent_Identity=24.3718592964824, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320852, Length=168, Percent_Identity=30.952380952381, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24581924, Length=513, Percent_Identity=27.6803118908382, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI21355181, Length=498, Percent_Identity=25.1004016064257, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI18859661, Length=357, Percent_Identity=31.0924369747899, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI20130357, Length=479, Percent_Identity=22.964509394572, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653035, Length=389, Percent_Identity=24.9357326478149, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24656500, Length=406, Percent_Identity=26.3546798029557, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24648257, Length=347, Percent_Identity=26.5129682997118, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356947, Length=180, Percent_Identity=32.7777777777778, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21358303, Length=225, Percent_Identity=26.6666666666667, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI281365686, Length=348, Percent_Identity=22.9885057471264, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24648253, Length=511, Percent_Identity=23.091976516634, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24648255, Length=511, Percent_Identity=23.2876712328767, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161076582, Length=397, Percent_Identity=23.6775818639798, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI19922652, Length=359, Percent_Identity=24.7910863509749, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356441, Length=302, Percent_Identity=22.8476821192053, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24648260, Length=343, Percent_Identity=24.198250728863, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 51115; Mature: 50984

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLLCPIRVGARHHPQAEALTFAGRSWSYEALDAEVSRWVAALEAEGVGASDRVASLAT
CCEEEEEEECCCCCCCCHHHEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
NHVASVCLFWALGRLGAVLAPLNARLTSVELAPMVEDIQPRLRLALGALAERLPGARPLE
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
SFAEAVSTGASTCQPLEASSPRVVLFTSGTTGRPKGAVLTEGNFRASSRASAGNLGAHPA
HHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCC
PRWLGTLPLFHVGGIAMLTRTAYEGGCLVLHERFDADAANRAIDGEGVSHASLVATTLER
CHHHHCCHHHHHCCHHHHHHHHCCCCEEEEEECCCCCHHCCCCCCCCCCHHHHHHHHHHH
VLEARGDRRMPDSFAWALIGGGPVPVPLLARARAAGLRALQTYGLTEACSQVTTERPDTA
HHHHCCCCCCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
DGRTAGVPLLGVEVRIVGAGGEVLGAGAEGDIEVRAPTVMAGYWQRPEATQEAVRDGWLR
CCCCCCCEEEEEEEEEEECCCCEEECCCCCCEEEECCEEEECCCCCCHHHHHHHHCCCCE
TKDVGVLDGGGRLTVLSRRTDLIVRGGENIYPAEVEAVLVNHPAVQEASVVGFPDDRWGE
ECCCEEEECCCEEEEEECCCEEEEECCCCCCCCCEEEEEECCCCCCCCEEECCCCCCCCC
RPVAFVAPRQGQPHPGDEELAAWCRQSLAGFKTPARFVWVDALPRNAMGKVERTVLRRHA
CCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHC
LR
CC
>Mature Secondary Structure 
SVLLCPIRVGARHHPQAEALTFAGRSWSYEALDAEVSRWVAALEAEGVGASDRVASLAT
CEEEEEEECCCCCCCCHHHEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
NHVASVCLFWALGRLGAVLAPLNARLTSVELAPMVEDIQPRLRLALGALAERLPGARPLE
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
SFAEAVSTGASTCQPLEASSPRVVLFTSGTTGRPKGAVLTEGNFRASSRASAGNLGAHPA
HHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCC
PRWLGTLPLFHVGGIAMLTRTAYEGGCLVLHERFDADAANRAIDGEGVSHASLVATTLER
CHHHHCCHHHHHCCHHHHHHHHCCCCEEEEEECCCCCHHCCCCCCCCCCHHHHHHHHHHH
VLEARGDRRMPDSFAWALIGGGPVPVPLLARARAAGLRALQTYGLTEACSQVTTERPDTA
HHHHCCCCCCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
DGRTAGVPLLGVEVRIVGAGGEVLGAGAEGDIEVRAPTVMAGYWQRPEATQEAVRDGWLR
CCCCCCCEEEEEEEEEEECCCCEEECCCCCCEEEECCEEEECCCCCCHHHHHHHHCCCCE
TKDVGVLDGGGRLTVLSRRTDLIVRGGENIYPAEVEAVLVNHPAVQEASVVGFPDDRWGE
ECCCEEEECCCEEEEEECCCEEEEECCCCCCCCCEEEEEECCCCCCCCEEECCCCCCCCC
RPVAFVAPRQGQPHPGDEELAAWCRQSLAGFKTPARFVWVDALPRNAMGKVERTVLRRHA
CCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHC
LR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA