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The map label for this gene is prlC [H]

Identifier: 108763137

GI number: 108763137

Start: 1620674

End: 1622635

Strand: Reverse

Name: prlC [H]

Synonym: MXAN_1381

Alternate gene names: 108763137

Gene position: 1622635-1620674 (Counterclockwise)

Preceding gene: 108761090

Following gene: 108756915

Centisome position: 17.75

GC content: 71.41

Gene sequence:

>1962_bases
GTGCCGTCCACGCCGAGCCCCCTGGAGCCTGACGCAGGACGCCAACTGACCGCCACACCCGGGCGGTTCCTGGCGACCTG
CCTGTGCGACGTGCAACGGGCCTCGGCGCGCATCAACGCCCTGCTGTCACTGCCCGAGCCCCGGAACGTGGAGGTGGCCC
TCACCGCCTACGACGACGCCATCGCACTGCTGGACGACGCCAACGGCCGCGCGGGCATCGGTGCCAACACCCACCCGGAC
GCCGCGTTCCGCGCGGCGGCGGCGCGCTGCGCCCAGGCAGCGGATGGCATGCGCACGGACGTGTCGCTCAACCCCCACGT
CTACGCGGCTCTGGCCGCGCTGGACCTGAGCGGGCAGGACACCGCCACCCAGCGATGGGTGGACCTGGTGCTGCGAAACT
TCCGGCGCGCGGGGGTGAACCGGGACGAGGCCACCCGCGCGCGGCTGCGCGAGCTGAACGACGCCCTCACCCGGCTGGGG
CAGGCGTTCAGCCAGCACATCCGCGAAGACGTCCGGCACGTGGACGTGACACCCGAAGCGCTGGAGGGCCTTCCCGACGA
TTACATCCGGGACCATCCGCCCGGGCCCGACGGCCGGGTGCGCGTCACCACCGACGCCTCCGACGCCCTGCCCGTCCTGA
CGTACGCGCGCGACAACGGCGCCCGCGAGGCGCTCTGGCGCGCGGGCCAGCAGCGCGGCCATCCCCGCAACCTGGAGACG
CTGTCACGCCTGCTCCAGACGCGCCACGACCTGGCCACGCTCCTGGGCTATCCGAGCTGGGCCGCCTACGCGTCCGAGGA
CAAGATGGTCCGGCACCAGCACGTGGCCGAGGACTTCATCGAACAGCTCGCCACCGCCACCACCACGCGCGTGCAGGACG
ACTACACCGCGCTGCTGGAGCGCAAGCGGCGCGACGTGCCCGGCGCGTCCCACGTGGAGCCGTGGGAGCAGACGTACCTC
AAGGAACAGGTGCGCGCGGAGCGTTACCGCTTCGACTCGCGCGACCTGCGGCCCTACTTCGAATACACGCGGGTGAAGCA
GGGCGTGCTGGACATCACCTCGCGGCTCTTCGGGCTCACCTACCGCCGCGTCCCGGACGCGCCGGTGTGGCACCCGGACA
TCGAGGCCTGGGACATCTACGAGGGACCCACGCGTCTGGGGCGCTTCTACCTGGACATGCACCCACGCCCGAACAAGTAC
GCCCATCCGGCGCAGTGGGACCTGGCCACCGGCCGCGCGGGCAGGACGCTTCCCGAAGGCGTGCTGACAGGCAACTTCCC
GCGTCCCGGCGCCCACCCCGCGCTGCTCCAGCACTCCCAGGTGCAGACGTTCTTCCACGAGTTCGGCCACCTGCTGCACC
ACGTCCTCGGCGGCCGGACGCGCTGGGCCGGCCTGTCCGGCTCGCGCACGGAGCGTGACTTCGTGGAGGCTCCCGCCCAG
GTGCTGGAGGAGTGGGCCTGGCGCCCGGAGTCACTCCAGACGTTCGCCCGGCACGTCGTCACCGGCGAGTTGCTGCCCAC
GGAGACCATCCTCCGGATGCGGCGCGCGGACGCCTTCGGCAAGGGACTGTGGCTTCGCCAACAGCTCTTCTACGCGGCCG
TCAGCCTCCAGCTCCATGCGAGCGACCCCGCAGGCGTGGACACCACCGCGCGGGTGAACGCGCTCCAGGAGCGCTACATG
CCCTTCCCCGCAGTGGACGACACCTACGCCCATCTCTCCTTCGTCCAGCTCGACGGCTACTACTCCTCCGCGTACTACGC
CTACCTCTGGTCGCTCGTCATCGCCCGGGACCTGCTCACACCGTTCCTGGAGCACGGGCTGATGGACACCTCCACCGCCC
AGCGCTACCGGGACGCCGTGCTGGGGCCGGGCGGCTCCCGTGACGCGGCGGACCTGGTCCGGTCATTCCTGGGCAGGGAC
TACGGCTTCGAGGCGTATACCCGTTGGCTGGACGACGCCTGA

Upstream 100 bases:

>100_bases
GCATTTGCACCGCTTGGTCGTCTTCGTCGTCAGCCTCGCGCTCGCAGGCTGCGCTGGCTCGTCATCCGCCCAGCGCCCTG
CGTCATCCACCGAACATCCG

Downstream 100 bases:

>100_bases
CGCTGCTCGTCAGGGCCTGTAAAAACCAAGGGCCCCGCGATGTGAATCGCGAGGCCCCTTGGGTTGTGAATCCGTCAACC
CGTTGACACTCCGCTCACGC

Product: M3 family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 653; Mature: 652

Protein sequence:

>653_residues
MPSTPSPLEPDAGRQLTATPGRFLATCLCDVQRASARINALLSLPEPRNVEVALTAYDDAIALLDDANGRAGIGANTHPD
AAFRAAAARCAQAADGMRTDVSLNPHVYAALAALDLSGQDTATQRWVDLVLRNFRRAGVNRDEATRARLRELNDALTRLG
QAFSQHIREDVRHVDVTPEALEGLPDDYIRDHPPGPDGRVRVTTDASDALPVLTYARDNGAREALWRAGQQRGHPRNLET
LSRLLQTRHDLATLLGYPSWAAYASEDKMVRHQHVAEDFIEQLATATTTRVQDDYTALLERKRRDVPGASHVEPWEQTYL
KEQVRAERYRFDSRDLRPYFEYTRVKQGVLDITSRLFGLTYRRVPDAPVWHPDIEAWDIYEGPTRLGRFYLDMHPRPNKY
AHPAQWDLATGRAGRTLPEGVLTGNFPRPGAHPALLQHSQVQTFFHEFGHLLHHVLGGRTRWAGLSGSRTERDFVEAPAQ
VLEEWAWRPESLQTFARHVVTGELLPTETILRMRRADAFGKGLWLRQQLFYAAVSLQLHASDPAGVDTTARVNALQERYM
PFPAVDDTYAHLSFVQLDGYYSSAYYAYLWSLVIARDLLTPFLEHGLMDTSTAQRYRDAVLGPGGSRDAADLVRSFLGRD
YGFEAYTRWLDDA

Sequences:

>Translated_653_residues
MPSTPSPLEPDAGRQLTATPGRFLATCLCDVQRASARINALLSLPEPRNVEVALTAYDDAIALLDDANGRAGIGANTHPD
AAFRAAAARCAQAADGMRTDVSLNPHVYAALAALDLSGQDTATQRWVDLVLRNFRRAGVNRDEATRARLRELNDALTRLG
QAFSQHIREDVRHVDVTPEALEGLPDDYIRDHPPGPDGRVRVTTDASDALPVLTYARDNGAREALWRAGQQRGHPRNLET
LSRLLQTRHDLATLLGYPSWAAYASEDKMVRHQHVAEDFIEQLATATTTRVQDDYTALLERKRRDVPGASHVEPWEQTYL
KEQVRAERYRFDSRDLRPYFEYTRVKQGVLDITSRLFGLTYRRVPDAPVWHPDIEAWDIYEGPTRLGRFYLDMHPRPNKY
AHPAQWDLATGRAGRTLPEGVLTGNFPRPGAHPALLQHSQVQTFFHEFGHLLHHVLGGRTRWAGLSGSRTERDFVEAPAQ
VLEEWAWRPESLQTFARHVVTGELLPTETILRMRRADAFGKGLWLRQQLFYAAVSLQLHASDPAGVDTTARVNALQERYM
PFPAVDDTYAHLSFVQLDGYYSSAYYAYLWSLVIARDLLTPFLEHGLMDTSTAQRYRDAVLGPGGSRDAADLVRSFLGRD
YGFEAYTRWLDDA
>Mature_652_residues
PSTPSPLEPDAGRQLTATPGRFLATCLCDVQRASARINALLSLPEPRNVEVALTAYDDAIALLDDANGRAGIGANTHPDA
AFRAAAARCAQAADGMRTDVSLNPHVYAALAALDLSGQDTATQRWVDLVLRNFRRAGVNRDEATRARLRELNDALTRLGQ
AFSQHIREDVRHVDVTPEALEGLPDDYIRDHPPGPDGRVRVTTDASDALPVLTYARDNGAREALWRAGQQRGHPRNLETL
SRLLQTRHDLATLLGYPSWAAYASEDKMVRHQHVAEDFIEQLATATTTRVQDDYTALLERKRRDVPGASHVEPWEQTYLK
EQVRAERYRFDSRDLRPYFEYTRVKQGVLDITSRLFGLTYRRVPDAPVWHPDIEAWDIYEGPTRLGRFYLDMHPRPNKYA
HPAQWDLATGRAGRTLPEGVLTGNFPRPGAHPALLQHSQVQTFFHEFGHLLHHVLGGRTRWAGLSGSRTERDFVEAPAQV
LEEWAWRPESLQTFARHVVTGELLPTETILRMRRADAFGKGLWLRQQLFYAAVSLQLHASDPAGVDTTARVNALQERYMP
FPAVDDTYAHLSFVQLDGYYSSAYYAYLWSLVIARDLLTPFLEHGLMDTSTAQRYRDAVLGPGGSRDAADLVRSFLGRDY
GFEAYTRWLDDA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=580, Percent_Identity=30.3448275862069, Blast_Score=281, Evalue=2e-75,
Organism=Homo sapiens, GI14149738, Length=584, Percent_Identity=26.1986301369863, Blast_Score=229, Evalue=5e-60,
Organism=Homo sapiens, GI156105687, Length=583, Percent_Identity=27.2727272727273, Blast_Score=200, Evalue=3e-51,
Organism=Escherichia coli, GI1789913, Length=553, Percent_Identity=31.1030741410488, Blast_Score=251, Evalue=1e-67,
Organism=Escherichia coli, GI1787819, Length=569, Percent_Identity=30.4042179261863, Blast_Score=225, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI32565901, Length=458, Percent_Identity=20.3056768558952, Blast_Score=87, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319793, Length=610, Percent_Identity=26.7213114754098, Blast_Score=223, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6322715, Length=547, Percent_Identity=24.6800731261426, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI20129717, Length=582, Percent_Identity=27.4914089347079, Blast_Score=185, Evalue=8e-47,
Organism=Drosophila melanogaster, GI21356111, Length=588, Percent_Identity=25.3401360544218, Blast_Score=144, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 73491; Mature: 73360

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSTPSPLEPDAGRQLTATPGRFLATCLCDVQRASARINALLSLPEPRNVEVALTAYDDA
CCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEECCCE
IALLDDANGRAGIGANTHPDAAFRAAAARCAQAADGMRTDVSLNPHVYAALAALDLSGQD
EEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCC
TATQRWVDLVLRNFRRAGVNRDEATRARLRELNDALTRLGQAFSQHIREDVRHVDVTPEA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LEGLPDDYIRDHPPGPDGRVRVTTDASDALPVLTYARDNGAREALWRAGQQRGHPRNLET
HHCCCHHHHCCCCCCCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCHHH
LSRLLQTRHDLATLLGYPSWAAYASEDKMVRHQHVAEDFIEQLATATTTRVQDDYTALLE
HHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKRRDVPGASHVEPWEQTYLKEQVRAERYRFDSRDLRPYFEYTRVKQGVLDITSRLFGLT
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YRRVPDAPVWHPDIEAWDIYEGPTRLGRFYLDMHPRPNKYAHPAQWDLATGRAGRTLPEG
HHCCCCCCCCCCCCCCEECCCCHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
VLTGNFPRPGAHPALLQHSQVQTFFHEFGHLLHHVLGGRTRWAGLSGSRTERDFVEAPAQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHH
VLEEWAWRPESLQTFARHVVTGELLPTETILRMRRADAFGKGLWLRQQLFYAAVSLQLHA
HHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEEEEC
SDPAGVDTTARVNALQERYMPFPAVDDTYAHLSFVQLDGYYSSAYYAYLWSLVIARDLLT
CCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHH
PFLEHGLMDTSTAQRYRDAVLGPGGSRDAADLVRSFLGRDYGFEAYTRWLDDA
HHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
PSTPSPLEPDAGRQLTATPGRFLATCLCDVQRASARINALLSLPEPRNVEVALTAYDDA
CCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEECCCE
IALLDDANGRAGIGANTHPDAAFRAAAARCAQAADGMRTDVSLNPHVYAALAALDLSGQD
EEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCC
TATQRWVDLVLRNFRRAGVNRDEATRARLRELNDALTRLGQAFSQHIREDVRHVDVTPEA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LEGLPDDYIRDHPPGPDGRVRVTTDASDALPVLTYARDNGAREALWRAGQQRGHPRNLET
HHCCCHHHHCCCCCCCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCHHH
LSRLLQTRHDLATLLGYPSWAAYASEDKMVRHQHVAEDFIEQLATATTTRVQDDYTALLE
HHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKRRDVPGASHVEPWEQTYLKEQVRAERYRFDSRDLRPYFEYTRVKQGVLDITSRLFGLT
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YRRVPDAPVWHPDIEAWDIYEGPTRLGRFYLDMHPRPNKYAHPAQWDLATGRAGRTLPEG
HHCCCCCCCCCCCCCCEECCCCHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
VLTGNFPRPGAHPALLQHSQVQTFFHEFGHLLHHVLGGRTRWAGLSGSRTERDFVEAPAQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHH
VLEEWAWRPESLQTFARHVVTGELLPTETILRMRRADAFGKGLWLRQQLFYAAVSLQLHA
HHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEEEEC
SDPAGVDTTARVNALQERYMPFPAVDDTYAHLSFVQLDGYYSSAYYAYLWSLVIARDLLT
CCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHH
PFLEHGLMDTSTAQRYRDAVLGPGGSRDAADLVRSFLGRDYGFEAYTRWLDDA
HHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]