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The map label for this gene is guaB [H]

Identifier: 108761961

GI number: 108761961

Start: 4497188

End: 4498645

Strand: Reverse

Name: guaB [H]

Synonym: MXAN_3777

Alternate gene names: 108761961

Gene position: 4498645-4497188 (Counterclockwise)

Preceding gene: 108758922

Following gene: 108760981

Centisome position: 49.22

GC content: 68.04

Gene sequence:

>1458_bases
ATGCTCAACCCCGATATCCGGCTCGCCCTCACTTTCGACGACGTCCTGCTGGTCCCGGGCGAGAGCTCGGTCGTCCCCAA
GGACGTCGACCTGACGACCCGGCTCACTCGCAATCTCCGTCTCAACATCCCCCTCCTGTCGGCGGCCATGGACACCGTCA
CGGAGTCCCGGACCGCCATCGCCATGGCCCAGGAGGGCGGCATTGGTGTCATCCACAAGAACATGACGCCCGAGCAGCAG
GCGCTCGAGGTCCTCAAGGTCAAGAAGTTCGAAAGCGGCATGGTGGTGGACCCCGTCACCATCGAACCGGAGGCCCCGCT
GGGCCGCGCGCTGGAGCTGATGCGCCTTCACGGCGTGTCCGGCATCCCGGTGGTGAAGGGCCAGCGACTGGTGGGCATCG
TCACCAGCCGCGACGTGCGCTTCGAGACCAACTTCACCCAGACGGTGGAGTCGATGATGACGCGCAAGCTCGTCACCGGC
CGCGAAGGCATCACGCAGGAAGATGCGCAGAAGCTGCTGCACGAGCACCGCATCGAGAAGCTCCTCGTCGTCAATGACGC
CTTCGAGCTCAAGGGCCTCATCACCATCAAGGACATCGAGAAGCGCCGCACGCACCCCAACGCGGCCAAGGACGGCATGG
GCCGCCTGCTGTGCGCCGCCGCCGTGGGTGTGTCCGCGGACCGCGAGGCCCGCGTGGAGGCGCTCATCAAGGCCGGCGTG
GACGTCATCGTCGTGGACACCGCGCACGGTCACTCCACCGCGGTGCTGGATGGCGTGCGCGACACCCGGAAGAACTTCCA
GGGCTTCGAGCTCATCGCCGGCAACGTCGCCACCGCCGAGGCCACCCGCGCGCTCATCCAGGCCGGCGTGGACGCGGTGA
AGGTGGGCATCGGCCCCGGCTCCATCTGCACCACCCGCGTGGTGGCCGGCGTGGGCGTGCCCCAGGTGACGGCCGTGGAT
GACTGCGTCCGCGAGGCCCAGAAGCACGACGTGCCCATCATCTCCGACGGCGGCATCAAGTACTCGGGCGACATCGTCAA
GGCGCTGGCCGCGGGCGCCAACACGGTGATGGTCGGCTCGCTCTTCGCAGGCACCGAGGAGTCCCCGGGCGACGTCATCC
TGTACCAGGGCCGCAGCTACAAGAGCTACCGCGGCATGGGCAGCCTGGGCGCCATGAAGCAGGGCGCCAAGGACCGCTAC
TTCCAGGCGGACGTGGAGGCCGTGAAGCTGGTGCCCGAGGGCATCGAGGGCCGCGTGCCGTACAAGGGCACCCTGGCGAT
GAACGTCCACCAGATGCTGGGCGGCATCCGCAGCGGCATGGGCTACGTGGGCTGCCGCACCATCGACGAGCTGCGCACCC
AGGCCACCTTCGTCCGCATCACCTCGGCCGGGCTCAAGGAGAGCCACGTGCACGACGTCATCATCACCGAGGAAGCACCG
AACTACCGCGTCGGGTAG

Upstream 100 bases:

>100_bases
TCAGCGCCCTTCTCCGTTGCGCCGGGGCAGCGTACCTCGTATGGAACCGCACCCGCGGGCTGTGGTGCCCCGCGGGCACC
TGCCCACGGGAGCGCCGCTC

Downstream 100 bases:

>100_bases
TCCGGAGGGCGCCAGGAGCGCGGTGGCCCGTCCTCCCGCTCCGCGTCCTGATGCCATGAAAAAGGGCCCGCGCCTCTCGG
CGGGGCCCTGGGTGTCCAGC

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MLNPDIRLALTFDDVLLVPGESSVVPKDVDLTTRLTRNLRLNIPLLSAAMDTVTESRTAIAMAQEGGIGVIHKNMTPEQQ
ALEVLKVKKFESGMVVDPVTIEPEAPLGRALELMRLHGVSGIPVVKGQRLVGIVTSRDVRFETNFTQTVESMMTRKLVTG
REGITQEDAQKLLHEHRIEKLLVVNDAFELKGLITIKDIEKRRTHPNAAKDGMGRLLCAAAVGVSADREARVEALIKAGV
DVIVVDTAHGHSTAVLDGVRDTRKNFQGFELIAGNVATAEATRALIQAGVDAVKVGIGPGSICTTRVVAGVGVPQVTAVD
DCVREAQKHDVPIISDGGIKYSGDIVKALAAGANTVMVGSLFAGTEESPGDVILYQGRSYKSYRGMGSLGAMKQGAKDRY
FQADVEAVKLVPEGIEGRVPYKGTLAMNVHQMLGGIRSGMGYVGCRTIDELRTQATFVRITSAGLKESHVHDVIITEEAP
NYRVG

Sequences:

>Translated_485_residues
MLNPDIRLALTFDDVLLVPGESSVVPKDVDLTTRLTRNLRLNIPLLSAAMDTVTESRTAIAMAQEGGIGVIHKNMTPEQQ
ALEVLKVKKFESGMVVDPVTIEPEAPLGRALELMRLHGVSGIPVVKGQRLVGIVTSRDVRFETNFTQTVESMMTRKLVTG
REGITQEDAQKLLHEHRIEKLLVVNDAFELKGLITIKDIEKRRTHPNAAKDGMGRLLCAAAVGVSADREARVEALIKAGV
DVIVVDTAHGHSTAVLDGVRDTRKNFQGFELIAGNVATAEATRALIQAGVDAVKVGIGPGSICTTRVVAGVGVPQVTAVD
DCVREAQKHDVPIISDGGIKYSGDIVKALAAGANTVMVGSLFAGTEESPGDVILYQGRSYKSYRGMGSLGAMKQGAKDRY
FQADVEAVKLVPEGIEGRVPYKGTLAMNVHQMLGGIRSGMGYVGCRTIDELRTQATFVRITSAGLKESHVHDVIITEEAP
NYRVG
>Mature_485_residues
MLNPDIRLALTFDDVLLVPGESSVVPKDVDLTTRLTRNLRLNIPLLSAAMDTVTESRTAIAMAQEGGIGVIHKNMTPEQQ
ALEVLKVKKFESGMVVDPVTIEPEAPLGRALELMRLHGVSGIPVVKGQRLVGIVTSRDVRFETNFTQTVESMMTRKLVTG
REGITQEDAQKLLHEHRIEKLLVVNDAFELKGLITIKDIEKRRTHPNAAKDGMGRLLCAAAVGVSADREARVEALIKAGV
DVIVVDTAHGHSTAVLDGVRDTRKNFQGFELIAGNVATAEATRALIQAGVDAVKVGIGPGSICTTRVVAGVGVPQVTAVD
DCVREAQKHDVPIISDGGIKYSGDIVKALAAGANTVMVGSLFAGTEESPGDVILYQGRSYKSYRGMGSLGAMKQGAKDRY
FQADVEAVKLVPEGIEGRVPYKGTLAMNVHQMLGGIRSGMGYVGCRTIDELRTQATFVRITSAGLKESHVHDVIITEEAP
NYRVG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=454, Percent_Identity=44.4933920704846, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI34328928, Length=454, Percent_Identity=44.4933920704846, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI34328930, Length=454, Percent_Identity=44.4933920704846, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI156616279, Length=454, Percent_Identity=44.4933920704846, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI217035152, Length=450, Percent_Identity=44.4444444444444, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI217035148, Length=454, Percent_Identity=43.6123348017621, Blast_Score=345, Evalue=6e-95,
Organism=Homo sapiens, GI66933016, Length=479, Percent_Identity=41.1273486430063, Blast_Score=345, Evalue=8e-95,
Organism=Homo sapiens, GI217035150, Length=454, Percent_Identity=40.7488986784141, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI50541954, Length=245, Percent_Identity=40.8163265306122, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI50541952, Length=245, Percent_Identity=40.8163265306122, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI50541948, Length=245, Percent_Identity=40.8163265306122, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI50541956, Length=245, Percent_Identity=41.6326530612245, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI156104880, Length=222, Percent_Identity=41.4414414414414, Blast_Score=161, Evalue=2e-39,
Organism=Escherichia coli, GI1788855, Length=480, Percent_Identity=61.6666666666667, Blast_Score=545, Evalue=1e-156,
Organism=Escherichia coli, GI1786293, Length=238, Percent_Identity=38.2352941176471, Blast_Score=152, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71994385, Length=500, Percent_Identity=37, Blast_Score=298, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI71994389, Length=427, Percent_Identity=40.0468384074941, Blast_Score=282, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17560440, Length=278, Percent_Identity=37.0503597122302, Blast_Score=172, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6322012, Length=490, Percent_Identity=39.1836734693878, Blast_Score=338, Evalue=9e-94,
Organism=Saccharomyces cerevisiae, GI6323585, Length=490, Percent_Identity=38.5714285714286, Blast_Score=327, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6323464, Length=490, Percent_Identity=39.3877551020408, Blast_Score=318, Evalue=8e-88,
Organism=Saccharomyces cerevisiae, GI6319352, Length=346, Percent_Identity=39.0173410404624, Blast_Score=251, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6319353, Length=114, Percent_Identity=40.3508771929825, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24641071, Length=484, Percent_Identity=40.495867768595, Blast_Score=348, Evalue=6e-96,
Organism=Drosophila melanogaster, GI24641073, Length=484, Percent_Identity=40.495867768595, Blast_Score=348, Evalue=6e-96,
Organism=Drosophila melanogaster, GI28571163, Length=444, Percent_Identity=40.5405405405405, Blast_Score=313, Evalue=2e-85,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52015; Mature: 52015

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNPDIRLALTFDDVLLVPGESSVVPKDVDLTTRLTRNLRLNIPLLSAAMDTVTESRTAI
CCCCCEEEEEEECCEEEECCCCCCCCCCCCHHHHHCCCEEECCHHHHHHHHHHHCCCCEE
AMAQEGGIGVIHKNMTPEQQALEVLKVKKFESGMVVDPVTIEPEAPLGRALELMRLHGVS
EEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEECCEEECCCCCHHHHHHHHHHCCCC
GIPVVKGQRLVGIVTSRDVRFETNFTQTVESMMTRKLVTGREGITQEDAQKLLHEHRIEK
CCCEECCCEEEEEEECCCEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCE
LLVVNDAFELKGLITIKDIEKRRTHPNAAKDGMGRLLCAAAVGVSADREARVEALIKAGV
EEEEECCHHHCEEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
DVIVVDTAHGHSTAVLDGVRDTRKNFQGFELIAGNVATAEATRALIQAGVDAVKVGIGPG
CEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCC
SICTTRVVAGVGVPQVTAVDDCVREAQKHDVPIISDGGIKYSGDIVKALAAGANTVMVGS
CHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCCEEEEEE
LFAGTEESPGDVILYQGRSYKSYRGMGSLGAMKQGAKDRYFQADVEAVKLVPEGIEGRVP
EECCCCCCCCCEEEECCCCCCHHCCCCCHHHHHCCCCCCHHHHCCHHEEECCCCCCCCCC
YKGTLAMNVHQMLGGIRSGMGYVGCRTIDELRTQATFVRITSAGLKESHVHDVIITEEAP
CCCEEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHEEEEEEECCCCCCCCCEEEEEECCCC
NYRVG
CCCCC
>Mature Secondary Structure
MLNPDIRLALTFDDVLLVPGESSVVPKDVDLTTRLTRNLRLNIPLLSAAMDTVTESRTAI
CCCCCEEEEEEECCEEEECCCCCCCCCCCCHHHHHCCCEEECCHHHHHHHHHHHCCCCEE
AMAQEGGIGVIHKNMTPEQQALEVLKVKKFESGMVVDPVTIEPEAPLGRALELMRLHGVS
EEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEECCEEECCCCCHHHHHHHHHHCCCC
GIPVVKGQRLVGIVTSRDVRFETNFTQTVESMMTRKLVTGREGITQEDAQKLLHEHRIEK
CCCEECCCEEEEEEECCCEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCE
LLVVNDAFELKGLITIKDIEKRRTHPNAAKDGMGRLLCAAAVGVSADREARVEALIKAGV
EEEEECCHHHCEEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
DVIVVDTAHGHSTAVLDGVRDTRKNFQGFELIAGNVATAEATRALIQAGVDAVKVGIGPG
CEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCC
SICTTRVVAGVGVPQVTAVDDCVREAQKHDVPIISDGGIKYSGDIVKALAAGANTVMVGS
CHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCCEEEEEE
LFAGTEESPGDVILYQGRSYKSYRGMGSLGAMKQGAKDRYFQADVEAVKLVPEGIEGRVP
EECCCCCCCCCEEEECCCCCCHHCCCCCHHHHHCCCCCCHHHHCCHHEEECCCCCCCCCC
YKGTLAMNVHQMLGGIRSGMGYVGCRTIDELRTQATFVRITSAGLKESHVHDVIITEEAP
CCCEEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHEEEEEEECCCCCCCCCEEEEEECCCC
NYRVG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]