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The map label for this gene is guaA [H]

Identifier: 108760981

GI number: 108760981

Start: 4494778

End: 4496331

Strand: Reverse

Name: guaA [H]

Synonym: MXAN_3775

Alternate gene names: 108760981

Gene position: 4496331-4494778 (Counterclockwise)

Preceding gene: 108761961

Following gene: 108763961

Centisome position: 49.2

GC content: 69.5

Gene sequence:

>1554_bases
GTGGACCTGCACGCCGAAAAAATCCTGATCCTCGATTTCGGGAGCCAGTACACCCAGCTCATCGCCCGGCGCGTCCGCGA
GCTGGGCGTCTATTGCGAAATCCACCGCCCGGACCTCCCGGCGGAGGACATCCGCAAGTACGCTCCCCGCGGCATCATCC
TCTCTGGCGGACCGGCGTCCGTGGAGGCCCCGGACTCCCCCCGGTGCGACCCGTTCGTCTTCGAAGCCGGCGTCCCCGTG
CTGGGCATCTGCTACGGCCTCCAGCTCACCGCCAAGCTGCTGGGCGGCAAGATTGACCGGAGCGCCCACCGCGAGTTCGG
CAACGCGGAGGTGGAGGTGCTGGCCCGCCGCGGCCCCTTCGCCGAATTCACCCCCGGGGACAGGGTCCAGGTCTGGATGA
GCCACGGCGACCGGGTGGAGGCGCTGCCCCCCGGCTTCGAGGCCATTGGCCGCAGCGGCAATTCGCCCTTCGCCGCCACC
GCCCACGCGACGAAGCCCTGGTTCGGCGTCCAGTTCCACCCGGAGGTGGTCCACACGCCGCAGGGCAAGGCCATGCTGCG
CGCCTTCGTCTTCAACGAGTGCAAGGTCAGCGGCTCGTGGACGATGAAGGGCTTCATCGACGAGGCCGTGGGCACCATCC
GCCGCCAGGTGGGTGAGCACGGCCGGGTCATCTGCGCGCTGTCGGGCGGCGTGGACAGCTCCGTGGCCGCGCTGCTGCTG
CACCGGGCCATTGGCCCCCGGCTCCAGTGCATCTTCGTGGACAACGGGGTGCTGCGGCAGAACGAGCGCGCCCAGGTGGA
GGCGCTCTTCGTGGACCGCTTCCACGTCCCGCTGAAGACGGTGGATGCCCGCCAGCGCTTCCTGGACAAGCTGGCCGGAG
TGACGGACCCGGAGAAGAAGCGGAAGATCATCGGCCGCGAGTTCATCGCCGTGTTCGAGGAGGCCGCGCGCGACGTGCAG
GACGCGGAGTTCCTGGCCCAGGGCACGCTGTACCCGGACGTCATCGAGTCCGTGTCGTACAAGGGCCCCTCCGTCACCAT
CAAGAGCCACCACAACGTGGGCGGCCTGCCGGAGACGATGAAGCTCAAGCTGGTGGAGCCACTGCGCGAGCTCTTCAAGG
ACGAGGTCCGCGCCCTGGGCCGCGAGCTGGGGCTGCCGGATGAGATGGTGTCCCGCCAGCCGTTCCCCGGCCCGGGTCTG
GCCATCCGCGTCCTGGGCGAAGTCACCGAGCAGCGCCTGGAGCTGGTGCGGCGCGCGGATGCCATCGTCCAGGAGGAGAT
TCGCAGCGCCGGCCTCTACAAGGAGGTCTGGCAGGCCTTCGCGGTGCTGCTGCCGGTGCAGAGCGTGGGCGTCATGGGCG
ACGAGCGCACCTACGAGTCCACCTGCGTGCTGCGCGCCGTCACCAGCGTGGACGGCATGACGGCGGACTGGGCCCGGCTG
CCGTTCCCCGTGCTGGAGCGCATCTCCACGCGCATCACGAACGAGGTGCGCGGCATCAACCGCGTCGCCTACGACATCTC
GTCCAAGCCCCCCGCGACCATCGAATGGGAGTAG

Upstream 100 bases:

>100_bases
CAGGCCTCGAACAATTGAAGGTACTTGGGCGTTGTATTCCGGAAGTTTGTAGCGATAAGGGCCCCCAGCCGTCAACGACG
CCCCTCTTGGAGACTCCCAG

Downstream 100 bases:

>100_bases
GGCGGTAGGGCGTTTGACGCCCTGACGCGAAAGAGGCTGCCCGGGACATGTGCCGGGCAGCCTCTTCGTGTTTCAGGGGC
CCTGGCCGACCGCGCCGGGG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MDLHAEKILILDFGSQYTQLIARRVRELGVYCEIHRPDLPAEDIRKYAPRGIILSGGPASVEAPDSPRCDPFVFEAGVPV
LGICYGLQLTAKLLGGKIDRSAHREFGNAEVEVLARRGPFAEFTPGDRVQVWMSHGDRVEALPPGFEAIGRSGNSPFAAT
AHATKPWFGVQFHPEVVHTPQGKAMLRAFVFNECKVSGSWTMKGFIDEAVGTIRRQVGEHGRVICALSGGVDSSVAALLL
HRAIGPRLQCIFVDNGVLRQNERAQVEALFVDRFHVPLKTVDARQRFLDKLAGVTDPEKKRKIIGREFIAVFEEAARDVQ
DAEFLAQGTLYPDVIESVSYKGPSVTIKSHHNVGGLPETMKLKLVEPLRELFKDEVRALGRELGLPDEMVSRQPFPGPGL
AIRVLGEVTEQRLELVRRADAIVQEEIRSAGLYKEVWQAFAVLLPVQSVGVMGDERTYESTCVLRAVTSVDGMTADWARL
PFPVLERISTRITNEVRGINRVAYDISSKPPATIEWE

Sequences:

>Translated_517_residues
MDLHAEKILILDFGSQYTQLIARRVRELGVYCEIHRPDLPAEDIRKYAPRGIILSGGPASVEAPDSPRCDPFVFEAGVPV
LGICYGLQLTAKLLGGKIDRSAHREFGNAEVEVLARRGPFAEFTPGDRVQVWMSHGDRVEALPPGFEAIGRSGNSPFAAT
AHATKPWFGVQFHPEVVHTPQGKAMLRAFVFNECKVSGSWTMKGFIDEAVGTIRRQVGEHGRVICALSGGVDSSVAALLL
HRAIGPRLQCIFVDNGVLRQNERAQVEALFVDRFHVPLKTVDARQRFLDKLAGVTDPEKKRKIIGREFIAVFEEAARDVQ
DAEFLAQGTLYPDVIESVSYKGPSVTIKSHHNVGGLPETMKLKLVEPLRELFKDEVRALGRELGLPDEMVSRQPFPGPGL
AIRVLGEVTEQRLELVRRADAIVQEEIRSAGLYKEVWQAFAVLLPVQSVGVMGDERTYESTCVLRAVTSVDGMTADWARL
PFPVLERISTRITNEVRGINRVAYDISSKPPATIEWE
>Mature_517_residues
MDLHAEKILILDFGSQYTQLIARRVRELGVYCEIHRPDLPAEDIRKYAPRGIILSGGPASVEAPDSPRCDPFVFEAGVPV
LGICYGLQLTAKLLGGKIDRSAHREFGNAEVEVLARRGPFAEFTPGDRVQVWMSHGDRVEALPPGFEAIGRSGNSPFAAT
AHATKPWFGVQFHPEVVHTPQGKAMLRAFVFNECKVSGSWTMKGFIDEAVGTIRRQVGEHGRVICALSGGVDSSVAALLL
HRAIGPRLQCIFVDNGVLRQNERAQVEALFVDRFHVPLKTVDARQRFLDKLAGVTDPEKKRKIIGREFIAVFEEAARDVQ
DAEFLAQGTLYPDVIESVSYKGPSVTIKSHHNVGGLPETMKLKLVEPLRELFKDEVRALGRELGLPDEMVSRQPFPGPGL
AIRVLGEVTEQRLELVRRADAIVQEEIRSAGLYKEVWQAFAVLLPVQSVGVMGDERTYESTCVLRAVTSVDGMTADWARL
PFPVLERISTRITNEVRGINRVAYDISSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=550, Percent_Identity=37.0909090909091, Blast_Score=305, Evalue=5e-83,
Organism=Escherichia coli, GI1788854, Length=523, Percent_Identity=57.7437858508604, Blast_Score=585, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI71992710, Length=572, Percent_Identity=36.7132867132867, Blast_Score=299, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI71992717, Length=572, Percent_Identity=36.7132867132867, Blast_Score=299, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI133901714, Length=572, Percent_Identity=36.7132867132867, Blast_Score=298, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6323873, Length=520, Percent_Identity=54.0384615384615, Blast_Score=571, Evalue=1e-163,
Organism=Drosophila melanogaster, GI281365319, Length=553, Percent_Identity=37.6130198915009, Blast_Score=294, Evalue=9e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57227; Mature: 57227

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLHAEKILILDFGSQYTQLIARRVRELGVYCEIHRPDLPAEDIRKYAPRGIILSGGPAS
CCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCEEEECCCCC
VEAPDSPRCDPFVFEAGVPVLGICYGLQLTAKLLGGKIDRSAHREFGNAEVEVLARRGPF
CCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEECCCCC
AEFTPGDRVQVWMSHGDRVEALPPGFEAIGRSGNSPFAATAHATKPWFGVQFHPEVVHTP
CCCCCCCCEEEEECCCCEECCCCCCHHHHCCCCCCCEEEECCCCCCEECEEECCCEEECC
QGKAMLRAFVFNECKVSGSWTMKGFIDEAVGTIRRQVGEHGRVICALSGGVDSSVAALLL
CHHHHHHHHHHHHHEECCCEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHH
HRAIGPRLQCIFVDNGVLRQNERAQVEALFVDRFHVPLKTVDARQRFLDKLAGVTDPEKK
HHHCCCCEEEEEECCCCCCCCCHHHEEEEEEHHHCCCHHHHHHHHHHHHHHCCCCCCHHH
RKIIGREFIAVFEEAARDVQDAEFLAQGTLYPDVIESVSYKGPSVTIKSHHNVGGLPETM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEEECCCCCCCCCHHH
KLKLVEPLRELFKDEVRALGRELGLPDEMVSRQPFPGPGLAIRVLGEVTEQRLELVRRAD
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AIVQEEIRSAGLYKEVWQAFAVLLPVQSVGVMGDERTYESTCVLRAVTSVDGMTADWARL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHC
PFPVLERISTRITNEVRGINRVAYDISSKPPATIEWE
CHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEECC
>Mature Secondary Structure
MDLHAEKILILDFGSQYTQLIARRVRELGVYCEIHRPDLPAEDIRKYAPRGIILSGGPAS
CCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCEEEECCCCC
VEAPDSPRCDPFVFEAGVPVLGICYGLQLTAKLLGGKIDRSAHREFGNAEVEVLARRGPF
CCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEECCCCC
AEFTPGDRVQVWMSHGDRVEALPPGFEAIGRSGNSPFAATAHATKPWFGVQFHPEVVHTP
CCCCCCCCEEEEECCCCEECCCCCCHHHHCCCCCCCEEEECCCCCCEECEEECCCEEECC
QGKAMLRAFVFNECKVSGSWTMKGFIDEAVGTIRRQVGEHGRVICALSGGVDSSVAALLL
CHHHHHHHHHHHHHEECCCEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHH
HRAIGPRLQCIFVDNGVLRQNERAQVEALFVDRFHVPLKTVDARQRFLDKLAGVTDPEKK
HHHCCCCEEEEEECCCCCCCCCHHHEEEEEEHHHCCCHHHHHHHHHHHHHHCCCCCCHHH
RKIIGREFIAVFEEAARDVQDAEFLAQGTLYPDVIESVSYKGPSVTIKSHHNVGGLPETM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEEECCCCCCCCCHHH
KLKLVEPLRELFKDEVRALGRELGLPDEMVSRQPFPGPGLAIRVLGEVTEQRLELVRRAD
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AIVQEEIRSAGLYKEVWQAFAVLLPVQSVGVMGDERTYESTCVLRAVTSVDGMTADWARL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHC
PFPVLERISTRITNEVRGINRVAYDISSKPPATIEWE
CHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA