Click here to switch to the map view.

The map label for this gene is pyrB

Identifier: 108761319

GI number: 108761319

Start: 4089959

End: 4090852

Strand: Direct

Name: pyrB

Synonym: MXAN_3510

Alternate gene names: 108761319

Gene position: 4089959-4090852 (Clockwise)

Preceding gene: 108761714

Following gene: 108762395

Centisome position: 44.75

GC content: 69.35

Gene sequence:

>894_bases
ATGAGACACCTGCTTGGAATCGAAGGCTGGCGCCGGGACGAGCTGGAGTCACTGCTCGACCGGGCGAAGGCACACCTCCC
CGGCGGTCCCGACACCACCCACCTGCTTCGCGGCAAGGTGGTGGCGAATCTCTTCTTCGAGGACTCCACCCGGACCCGAA
CGTCGTTCCACATGGCAGCGAAGGGTCTGGGGGCCAGTGTGCTCAACTGGACTCACACCGGCTCCTCGGTGTCCAAGGGT
GAGACGCTGCTGGACACCGCCCGCAACATCGAAGCGACGGGGCCGGTGGCCATCGTCATGCGTCATCGCTCGTCTGGAGC
GCCGCACCTGGTGGCGAAGCACGTGAAGTGCGCCGTCATCAACGCGGGTGATGGCACGCACGAGCACCCCTCCCAGGCGC
TGCTGGACGCCTTCACGCTGCGCCAGCGCTGGGGCTCGCTGGACGGGCGCACGGTGCTCATCGTGGGCGACGTGCTGCAC
AGCCGCGTGGCCCGCTCCAACCTGCACTGCCTCAAGGCGCTGGGCGCCCAGGTGGTGATGTGTGGCCCGCCCACGCTGCT
TCCGCCGGGGCTGGAGTCGCTGGGCGCGGAGGTGACGCACAACCTGGATGCTGCGCTCCCTCGCGCGGACGCGGTGATGT
GCCTGCGCGTCCAACTGGAGCGGCAGGAGCAGGCGTTCCTGCCGTCCACGCGTGAATATGCACGGCTGTTCGGCCTCAAC
GCGGCCCGCGAAGAGCGGATGAAGGCGGGCGCGGTGGTGATGCATCCGGGCCCCATCAACCGGGGCGTGGAGCTGGCGCC
GGCGGTGGCGGATGGCGCCCGCAGCGTCATCCTCGAGCAGGTGTCCAACGGCGTCGCCGTGCGGCGGGCCATCCTGGAGG
TGTGTACGGCATGA

Upstream 100 bases:

>100_bases
GAACCGGTCCGTTGAGGCGTTCGCTGAAAGCAGGCAGGCCGCCGCGCCGCGCACGACGCTTGACGTGCCGCACGCCCCGG
GGTACGCGGCGCCCCCGGCC

Downstream 100 bases:

>100_bases
GCTCCACGGTGCTCTTCAGGCGGGGGCGTGTCATCGACCCTCGCAACGGGGTGGACGGCGTCCGCGACGTGCTGGTCCGC
GACGGCAAGGTGGTGGAGGT

Product: aspartate carbamoyltransferase

Products: NA

Alternate protein names: Aspartate transcarbamylase; ATCase

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MRHLLGIEGWRRDELESLLDRAKAHLPGGPDTTHLLRGKVVANLFFEDSTRTRTSFHMAAKGLGASVLNWTHTGSSVSKG
ETLLDTARNIEATGPVAIVMRHRSSGAPHLVAKHVKCAVINAGDGTHEHPSQALLDAFTLRQRWGSLDGRTVLIVGDVLH
SRVARSNLHCLKALGAQVVMCGPPTLLPPGLESLGAEVTHNLDAALPRADAVMCLRVQLERQEQAFLPSTREYARLFGLN
AAREERMKAGAVVMHPGPINRGVELAPAVADGARSVILEQVSNGVAVRRAILEVCTA

Sequences:

>Translated_297_residues
MRHLLGIEGWRRDELESLLDRAKAHLPGGPDTTHLLRGKVVANLFFEDSTRTRTSFHMAAKGLGASVLNWTHTGSSVSKG
ETLLDTARNIEATGPVAIVMRHRSSGAPHLVAKHVKCAVINAGDGTHEHPSQALLDAFTLRQRWGSLDGRTVLIVGDVLH
SRVARSNLHCLKALGAQVVMCGPPTLLPPGLESLGAEVTHNLDAALPRADAVMCLRVQLERQEQAFLPSTREYARLFGLN
AAREERMKAGAVVMHPGPINRGVELAPAVADGARSVILEQVSNGVAVRRAILEVCTA
>Mature_297_residues
MRHLLGIEGWRRDELESLLDRAKAHLPGGPDTTHLLRGKVVANLFFEDSTRTRTSFHMAAKGLGASVLNWTHTGSSVSKG
ETLLDTARNIEATGPVAIVMRHRSSGAPHLVAKHVKCAVINAGDGTHEHPSQALLDAFTLRQRWGSLDGRTVLIVGDVLH
SRVARSNLHCLKALGAQVVMCGPPTLLPPGLESLGAEVTHNLDAALPRADAVMCLRVQLERQEQAFLPSTREYARLFGLN
AAREERMKAGAVVMHPGPINRGVELAPAVADGARSVILEQVSNGVAVRRAILEVCTA

Specific function: Pyrimidine biosynthesis; second step. [C]

COG id: COG0540

COG function: function code F; Aspartate carbamoyltransferase, catalytic chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI18105007, Length=303, Percent_Identity=35.973597359736, Blast_Score=171, Evalue=8e-43,
Organism=Escherichia coli, GI2367364, Length=305, Percent_Identity=35.0819672131148, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1790703, Length=328, Percent_Identity=24.390243902439, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI193204318, Length=306, Percent_Identity=36.2745098039216, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6322331, Length=307, Percent_Identity=35.5048859934853, Blast_Score=154, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24642586, Length=307, Percent_Identity=31.9218241042345, Blast_Score=140, Evalue=8e-34,

Paralogues:

None

Copy number: 2080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 14328 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): PYRB_MYXXD (Q1D6L9)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_631704.1
- ProteinModelPortal:   Q1D6L9
- STRING:   Q1D6L9
- GeneID:   4102858
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_3510
- TIGR:   MXAN_3510
- eggNOG:   COG0540
- HOGENOM:   HBG579429
- OMA:   MNRGLEI
- BioCyc:   MXAN246197:MXAN_3510-MONOMER
- HAMAP:   MF_00001
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002082
- PRINTS:   PR00100
- PRINTS:   PR00101
- TIGRFAMs:   TIGR00670

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.2

Molecular weight: Translated: 31933; Mature: 31933

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHLLGIEGWRRDELESLLDRAKAHLPGGPDTTHLLRGKVVANLFFEDSTRTRTSFHMAA
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEECCCCCCHHHHHHHH
KGLGASVLNWTHTGSSVSKGETLLDTARNIEATGPVAIVMRHRSSGAPHLVAKHVKCAVI
HCCCHHHHEEECCCCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHCCEEEEE
NAGDGTHEHPSQALLDAFTLRQRWGSLDGRTVLIVGDVLHSRVARSNLHCLKALGAQVVM
ECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEE
CGPPTLLPPGLESLGAEVTHNLDAALPRADAVMCLRVQLERQEQAFLPSTREYARLFGLN
ECCCCCCCCCHHHHHHHHHHCHHHHCCCHHHEEHHHHHHHHHHHHCCCCHHHHHHHHCCC
AAREERMKAGAVVMHPGPINRGVELAPAVADGARSVILEQVSNGVAVRRAILEVCTA
HHHHHHHHCCEEEECCCCCCCCCEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRHLLGIEGWRRDELESLLDRAKAHLPGGPDTTHLLRGKVVANLFFEDSTRTRTSFHMAA
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEECCCCCCHHHHHHHH
KGLGASVLNWTHTGSSVSKGETLLDTARNIEATGPVAIVMRHRSSGAPHLVAKHVKCAVI
HCCCHHHHEEECCCCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHCCEEEEE
NAGDGTHEHPSQALLDAFTLRQRWGSLDGRTVLIVGDVLHSRVARSNLHCLKALGAQVVM
ECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEE
CGPPTLLPPGLESLGAEVTHNLDAALPRADAVMCLRVQLERQEQAFLPSTREYARLFGLN
ECCCCCCCCCHHHHHHHHHHCHHHHCCCHHHEEHHHHHHHHHHHHCCCCHHHHHHHHCCC
AAREERMKAGAVVMHPGPINRGVELAPAVADGARSVILEQVSNGVAVRRAILEVCTA
HHHHHHHHCCEEEECCCCCCCCCEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA