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The map label for this gene is lepB [H]

Identifier: 108761714

GI number: 108761714

Start: 4088617

End: 4089873

Strand: Direct

Name: lepB [H]

Synonym: MXAN_3509

Alternate gene names: 108761714

Gene position: 4088617-4089873 (Clockwise)

Preceding gene: 108761403

Following gene: 108761319

Centisome position: 44.73

GC content: 67.7

Gene sequence:

>1257_bases
ATGAACGCGGCCATGCCTTCCGCCACCCCTCCCGCGAAGCTCTCCGAGGCGATGGCGGCCCGCCGCACGCCGGAGATGCT
TCGCGCCCGCAATGTGCTGGTGTGGCGCGAGCGCCTCACCAGCCTCTGGGCTCCGTTGATCATCCTGGCGCTGCTGTACG
TGCCGTACACGGTGATCATCGAGTACTCGCGCGCGTCCGCCGTGTGGGCCCAGCCGGTGATGAAGGGGCTGGGGCTGCTG
CTGGTCCTCTACTTCGTGGCCCTGCTGGTGTGGCGCAACGTCTCCCCCAAGGAGAAGGCGCTGCGCGGCGTGCGCCATGA
TGCGAACGAGCTGCTGGAGGAGAACGAGCGCATCCTCCGCAAGCCCGGCGTGAGCGCGAAGGTGGCGGGGCCGGTGCTGG
ACCGCATCGCCGAGCAGGCGCTGCGCGTGGAGCAGGCCTCCGCCGCGGGTGACGCGGAGCAACTGCGCACCGAGGTGAAG
GGCCTGGAGGCGTTGACCGCGCAGCATCTGGGCGCGTTCCGCAAGCAGTCCGCCATGGACTTCCTGGGCGGGTTCGGCAA
GGCGCTGCTGGTGGCGCTGGTGTTCCGCACCTTCATCGTGGAGCCGTACCGAATCCCCTCCGGCTCCATGCTCCCCACGC
TGGAGATTGGCGACCAGGTCTTCGTCAACAAGTTCATCTACGGCGTGCGCGTCCCGTTCCTCAACTTCGTGCCGTTCGTC
ATCGTCCGGCCGCCGGAGCGTGGAGACGTCATCGTCTTCAACAACCCGGTGAACGAGTCGGTGGACTACATCAAGCGCGT
GGTCGGCGTGCCGGGCGACGTGGTGGAATTCATCAACGGCGTCGTCCACATCAACGGCCAGCCGCAGAAGCGCGAGCTCG
TCTCCAACGAGTTCACCGTCCACAACATCACCGACGACGGGCGCTGGTACGACCAGCAGGAGACCCTCTACGAGGAGAAC
CTGTCCGGCGTGGCGCACGCCGCGTTGCAGACGCTGCCGCGCATGCCGCGCCGGGAAGGCCCCTACGAGGTTCCTCCGGG
CCACGTCTTCGCCGTGGGTGACAACCGGGACAACAGCGCGGACAGCCGCCACGGCCTGGGAGTCACGGGGTACGGCAAGG
CGGAGTACGTCCCCTACGGCCACATCAAGGGCAAGGCCATGGTGGTGTGGCTGTCGCTGGGCTATCACGGGCTGCTGCAC
GGCCTGTTCGGTGGCACCGGCCTCCGCGTGGATCGGTTCTTCGAACCGGTCCGTTGA

Upstream 100 bases:

>100_bases
GGAGAAGCAAAAGGAGGGCAAGAAGCGCATGAAGCAGGTCGGAACGGTGGAGATTCCGCAGGAAGCCTTCCTCGCGGTCC
TCAAGTCGGAGCAGTAGCCC

Downstream 100 bases:

>100_bases
GGCGTTCGCTGAAAGCAGGCAGGCCGCCGCGCCGCGCACGACGCTTGACGTGCCGCACGCCCCGGGGTACGCGGCGCCCC
CGGCCATGAGACACCTGCTT

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MNAAMPSATPPAKLSEAMAARRTPEMLRARNVLVWRERLTSLWAPLIILALLYVPYTVIIEYSRASAVWAQPVMKGLGLL
LVLYFVALLVWRNVSPKEKALRGVRHDANELLEENERILRKPGVSAKVAGPVLDRIAEQALRVEQASAAGDAEQLRTEVK
GLEALTAQHLGAFRKQSAMDFLGGFGKALLVALVFRTFIVEPYRIPSGSMLPTLEIGDQVFVNKFIYGVRVPFLNFVPFV
IVRPPERGDVIVFNNPVNESVDYIKRVVGVPGDVVEFINGVVHINGQPQKRELVSNEFTVHNITDDGRWYDQQETLYEEN
LSGVAHAALQTLPRMPRREGPYEVPPGHVFAVGDNRDNSADSRHGLGVTGYGKAEYVPYGHIKGKAMVVWLSLGYHGLLH
GLFGGTGLRVDRFFEPVR

Sequences:

>Translated_418_residues
MNAAMPSATPPAKLSEAMAARRTPEMLRARNVLVWRERLTSLWAPLIILALLYVPYTVIIEYSRASAVWAQPVMKGLGLL
LVLYFVALLVWRNVSPKEKALRGVRHDANELLEENERILRKPGVSAKVAGPVLDRIAEQALRVEQASAAGDAEQLRTEVK
GLEALTAQHLGAFRKQSAMDFLGGFGKALLVALVFRTFIVEPYRIPSGSMLPTLEIGDQVFVNKFIYGVRVPFLNFVPFV
IVRPPERGDVIVFNNPVNESVDYIKRVVGVPGDVVEFINGVVHINGQPQKRELVSNEFTVHNITDDGRWYDQQETLYEEN
LSGVAHAALQTLPRMPRREGPYEVPPGHVFAVGDNRDNSADSRHGLGVTGYGKAEYVPYGHIKGKAMVVWLSLGYHGLLH
GLFGGTGLRVDRFFEPVR
>Mature_418_residues
MNAAMPSATPPAKLSEAMAARRTPEMLRARNVLVWRERLTSLWAPLIILALLYVPYTVIIEYSRASAVWAQPVMKGLGLL
LVLYFVALLVWRNVSPKEKALRGVRHDANELLEENERILRKPGVSAKVAGPVLDRIAEQALRVEQASAAGDAEQLRTEVK
GLEALTAQHLGAFRKQSAMDFLGGFGKALLVALVFRTFIVEPYRIPSGSMLPTLEIGDQVFVNKFIYGVRVPFLNFVPFV
IVRPPERGDVIVFNNPVNESVDYIKRVVGVPGDVVEFINGVVHINGQPQKRELVSNEFTVHNITDDGRWYDQQETLYEEN
LSGVAHAALQTLPRMPRREGPYEVPPGHVFAVGDNRDNSADSRHGLGVTGYGKAEYVPYGHIKGKAMVVWLSLGYHGLLH
GLFGGTGLRVDRFFEPVR

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=269, Percent_Identity=34.2007434944238, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 46436; Mature: 46436

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS00639 THIOL_PROTEASE_HIS ; PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAAMPSATPPAKLSEAMAARRTPEMLRARNVLVWRERLTSLWAPLIILALLYVPYTVII
CCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEE
EYSRASAVWAQPVMKGLGLLLVLYFVALLVWRNVSPKEKALRGVRHDANELLEENERILR
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KPGVSAKVAGPVLDRIAEQALRVEQASAAGDAEQLRTEVKGLEALTAQHLGAFRKQSAMD
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGGFGKALLVALVFRTFIVEPYRIPSGSMLPTLEIGDQVFVNKFIYGVRVPFLNFVPFV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHCCHHHCCCEE
IVRPPERGDVIVFNNPVNESVDYIKRVVGVPGDVVEFINGVVHINGQPQKRELVSNEFTV
EECCCCCCCEEEECCCCCHHHHHHHHHHCCCHHHHHHHCCEEEECCCCHHHHHHCCCCEE
HNITDDGRWYDQQETLYEENLSGVAHAALQTLPRMPRREGPYEVPPGHVFAVGDNRDNSA
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCC
DSRHGLGVTGYGKAEYVPYGHIKGKAMVVWLSLGYHGLLHGLFGGTGLRVDRFFEPVR
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCHHHHHCCCC
>Mature Secondary Structure
MNAAMPSATPPAKLSEAMAARRTPEMLRARNVLVWRERLTSLWAPLIILALLYVPYTVII
CCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEE
EYSRASAVWAQPVMKGLGLLLVLYFVALLVWRNVSPKEKALRGVRHDANELLEENERILR
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KPGVSAKVAGPVLDRIAEQALRVEQASAAGDAEQLRTEVKGLEALTAQHLGAFRKQSAMD
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGGFGKALLVALVFRTFIVEPYRIPSGSMLPTLEIGDQVFVNKFIYGVRVPFLNFVPFV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHCCHHHCCCEE
IVRPPERGDVIVFNNPVNESVDYIKRVVGVPGDVVEFINGVVHINGQPQKRELVSNEFTV
EECCCCCCCEEEECCCCCHHHHHHHHHHCCCHHHHHHHCCEEEECCCCHHHHHHCCCCEE
HNITDDGRWYDQQETLYEENLSGVAHAALQTLPRMPRREGPYEVPPGHVFAVGDNRDNSA
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCC
DSRHGLGVTGYGKAEYVPYGHIKGKAMVVWLSLGYHGLLHGLFGGTGLRVDRFFEPVR
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]