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The map label for this gene is pyrC [H]

Identifier: 108762395

GI number: 108762395

Start: 4090849

End: 4092162

Strand: Direct

Name: pyrC [H]

Synonym: MXAN_3511

Alternate gene names: 108762395

Gene position: 4090849-4092162 (Clockwise)

Preceding gene: 108761319

Following gene: 108762105

Centisome position: 44.76

GC content: 70.24

Gene sequence:

>1314_bases
ATGAGCTCCACGGTGCTCTTCAGGCGGGGGCGTGTCATCGACCCTCGCAACGGGGTGGACGGCGTCCGCGACGTGCTGGT
CCGCGACGGCAAGGTGGTGGAGGTGTCGGTGACCCTGCTGCCAGTGCCCTCCAGCGCCGAGGTGGTGGATGCCACCGGCA
AGTGGGTGCTGCCGGGCTTCATCGACCTGCACGTCCACCTGCGCGAGCCGGGCGAGGAGGGCAAGGAGACGGTCCTCACC
GGCTGCCGCGCCGCCGTGGCGGGTGGTTTCACCGCCGTGGTGGCCATGCCCAACACCAAGGTGGTCAACGACAACGCCAT
GGTGACGGAGCTGGTGCTGAACCGCGCCCGCGCCGCGGGCCTGTGTCATGTCTATCCCGCCGGGGCCATCACCAAGGGCC
TCAAGGGCGAGGAGCTGGCGGAGATGGGCGAGCTGGTGTCCGCCGGCTGCGTGGCCATCACCGATGACGGCCGCCCGGTG
ATGAACGCGTCGCTGATGCGGCGCACGCTCCAATACGCCACCCAGTTCGACGTGCCCGTCATGGTCCACGAGGAGGACCT
GACGCTGTCCGCGGGCGGGGCCATGCATGAAGGCACCACGTCCACGCGGCTGGGCCTGCGCGGCATCCCCGCTTCCGCGG
AGGTGGCCATGGTGGCGCGAGACCTGGTGCTGCTGGAGGAGACGAAGGGCCGGCTGCACGTGGCGCACGTGTCCTGCGAG
GGCAGCGTGCGGCTCATCCGCGAGGCCAAGCGCAGCGGTCTGCGCGTCACCTGCGAGGTGGCGCCACACCACTTCATCCT
GGATGACCGCGCGGTGGGGGACTATGACACCCACGCGAAGATGGCCCCGCCGCTGCGCGCGGACACCGATGTGCAGGCCC
TGCGCGAGGCGCTGGTGGACGGGACGGTGGACGCCATCGCCACGGACCATGCGCCGCACGGGGTGTTGGACAAGCAGGTG
GAGTTCGAGAAGGGCATCAACGGCATCGTGGGGCTGGAGACGGCCCTGGGGCTGACGCTGGAGCTGGTGCATGCGGGCGT
GCTCACCGCGAACCGCGCGGTGGAGCTGCTGACGCACGGGCCCGCGAAGGCGTTCGGCCTGCCGGGCGGTCACCTGGCGC
CTGGGGCGCCAGCGGACGTCACGGTGGTGGATCCGGACGCGGAGTGGACGGTGGACGCCCACCAGTTCCATTCCCGCAGC
CGGAATACACCGTTCCATGGCCGGAAGCAGAAGGGTCGCGTTATCCAGACGTGGGTCGCGGGCCACAAGGTGTTCGACAA
GGGCCAGGTCGGCCAGAGCAAGGAGTCGCGGTGA

Upstream 100 bases:

>100_bases
AGCTGGCGCCGGCGGTGGCGGATGGCGCCCGCAGCGTCATCCTCGAGCAGGTGTCCAACGGCGTCGCCGTGCGGCGGGCC
ATCCTGGAGGTGTGTACGGC

Downstream 100 bases:

>100_bases
TGACGAAGCGGGCAGTGCTCGCCCTGGCGGATGGCACCACGTTCGAAGGCCGTGCGTTTGGCGCGGTGGGCGAAACGGTG
GGTGAAGTGGTGTTCAACAC

Product: dihydroorotase, multifunctional complex type

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MSSTVLFRRGRVIDPRNGVDGVRDVLVRDGKVVEVSVTLLPVPSSAEVVDATGKWVLPGFIDLHVHLREPGEEGKETVLT
GCRAAVAGGFTAVVAMPNTKVVNDNAMVTELVLNRARAAGLCHVYPAGAITKGLKGEELAEMGELVSAGCVAITDDGRPV
MNASLMRRTLQYATQFDVPVMVHEEDLTLSAGGAMHEGTTSTRLGLRGIPASAEVAMVARDLVLLEETKGRLHVAHVSCE
GSVRLIREAKRSGLRVTCEVAPHHFILDDRAVGDYDTHAKMAPPLRADTDVQALREALVDGTVDAIATDHAPHGVLDKQV
EFEKGINGIVGLETALGLTLELVHAGVLTANRAVELLTHGPAKAFGLPGGHLAPGAPADVTVVDPDAEWTVDAHQFHSRS
RNTPFHGRKQKGRVIQTWVAGHKVFDKGQVGQSKESR

Sequences:

>Translated_437_residues
MSSTVLFRRGRVIDPRNGVDGVRDVLVRDGKVVEVSVTLLPVPSSAEVVDATGKWVLPGFIDLHVHLREPGEEGKETVLT
GCRAAVAGGFTAVVAMPNTKVVNDNAMVTELVLNRARAAGLCHVYPAGAITKGLKGEELAEMGELVSAGCVAITDDGRPV
MNASLMRRTLQYATQFDVPVMVHEEDLTLSAGGAMHEGTTSTRLGLRGIPASAEVAMVARDLVLLEETKGRLHVAHVSCE
GSVRLIREAKRSGLRVTCEVAPHHFILDDRAVGDYDTHAKMAPPLRADTDVQALREALVDGTVDAIATDHAPHGVLDKQV
EFEKGINGIVGLETALGLTLELVHAGVLTANRAVELLTHGPAKAFGLPGGHLAPGAPADVTVVDPDAEWTVDAHQFHSRS
RNTPFHGRKQKGRVIQTWVAGHKVFDKGQVGQSKESR
>Mature_436_residues
SSTVLFRRGRVIDPRNGVDGVRDVLVRDGKVVEVSVTLLPVPSSAEVVDATGKWVLPGFIDLHVHLREPGEEGKETVLTG
CRAAVAGGFTAVVAMPNTKVVNDNAMVTELVLNRARAAGLCHVYPAGAITKGLKGEELAEMGELVSAGCVAITDDGRPVM
NASLMRRTLQYATQFDVPVMVHEEDLTLSAGGAMHEGTTSTRLGLRGIPASAEVAMVARDLVLLEETKGRLHVAHVSCEG
SVRLIREAKRSGLRVTCEVAPHHFILDDRAVGDYDTHAKMAPPLRADTDVQALREALVDGTVDAIATDHAPHGVLDKQVE
FEKGINGIVGLETALGLTLELVHAGVLTANRAVELLTHGPAKAFGLPGGHLAPGAPADVTVVDPDAEWTVDAHQFHSRSR
NTPFHGRKQKGRVIQTWVAGHKVFDKGQVGQSKESR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=379, Percent_Identity=34.3007915567282, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI4503375, Length=464, Percent_Identity=26.2931034482759, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI19923821, Length=421, Percent_Identity=26.8408551068884, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI190194363, Length=441, Percent_Identity=24.7165532879819, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1786722, Length=445, Percent_Identity=28.314606741573, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI87082175, Length=447, Percent_Identity=26.6219239373602, Blast_Score=117, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193204318, Length=418, Percent_Identity=29.1866028708134, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI71989490, Length=463, Percent_Identity=27.2138228941685, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17539558, Length=440, Percent_Identity=27.5, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI86575075, Length=427, Percent_Identity=25.2927400468384, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322218, Length=386, Percent_Identity=27.4611398963731, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24642586, Length=380, Percent_Identity=33.1578947368421, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI17137462, Length=430, Percent_Identity=26.2790697674419, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI18859883, Length=449, Percent_Identity=26.0579064587973, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 46553; Mature: 46422

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTVLFRRGRVIDPRNGVDGVRDVLVRDGKVVEVSVTLLPVPSSAEVVDATGKWVLPGF
CCCCEEEECCCEECCCCCHHHHHHHHHCCCEEEEEEEEEEECCCCCCEEECCCCEECCCE
IDLHVHLREPGEEGKETVLTGCRAAVAGGFTAVVAMPNTKVVNDNAMVTELVLNRARAAG
EEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEECCCHHHHHHHHHHHHHCC
LCHVYPAGAITKGLKGEELAEMGELVSAGCVAITDDGRPVMNASLMRRTLQYATQFDVPV
EEEECCCHHHHCCCCHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEE
MVHEEDLTLSAGGAMHEGTTSTRLGLRGIPASAEVAMVARDLVLLEETKGRLHVAHVSCE
EEECCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEEEECCCEEEEEEEECC
GSVRLIREAKRSGLRVTCEVAPHHFILDDRAVGDYDTHAKMAPPLRADTDVQALREALVD
CCHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
GTVDAIATDHAPHGVLDKQVEFEKGINGIVGLETALGLTLELVHAGVLTANRAVELLTHG
CCHHHHCCCCCCCCCCCCCHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCHHEEEEECC
PAKAFGLPGGHLAPGAPADVTVVDPDAEWTVDAHQFHSRSRNTPFHGRKQKGRVIQTWVA
CHHHCCCCCCCCCCCCCCCEEEECCCCCEEECHHHHHHCCCCCCCCCCCCCCCEEEEEHH
GHKVFDKGQVGQSKESR
CCCEECCCCCCCCCCCC
>Mature Secondary Structure 
SSTVLFRRGRVIDPRNGVDGVRDVLVRDGKVVEVSVTLLPVPSSAEVVDATGKWVLPGF
CCCEEEECCCEECCCCCHHHHHHHHHCCCEEEEEEEEEEECCCCCCEEECCCCEECCCE
IDLHVHLREPGEEGKETVLTGCRAAVAGGFTAVVAMPNTKVVNDNAMVTELVLNRARAAG
EEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEECCCHHHHHHHHHHHHHCC
LCHVYPAGAITKGLKGEELAEMGELVSAGCVAITDDGRPVMNASLMRRTLQYATQFDVPV
EEEECCCHHHHCCCCHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEE
MVHEEDLTLSAGGAMHEGTTSTRLGLRGIPASAEVAMVARDLVLLEETKGRLHVAHVSCE
EEECCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEEEECCCEEEEEEEECC
GSVRLIREAKRSGLRVTCEVAPHHFILDDRAVGDYDTHAKMAPPLRADTDVQALREALVD
CCHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
GTVDAIATDHAPHGVLDKQVEFEKGINGIVGLETALGLTLELVHAGVLTANRAVELLTHG
CCHHHHCCCCCCCCCCCCCHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCHHEEEEECC
PAKAFGLPGGHLAPGAPADVTVVDPDAEWTVDAHQFHSRSRNTPFHGRKQKGRVIQTWVA
CHHHCCCCCCCCCCCCCCCEEEECCCCCEEECHHHHHHCCCCCCCCCCCCCCCEEEEEHH
GHKVFDKGQVGQSKESR
CCCEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA