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The map label for this gene is lgrC [H]

Identifier: 108760891

GI number: 108760891

Start: 5755833

End: 5760380

Strand: Direct

Name: lgrC [H]

Synonym: MXAN_4598

Alternate gene names: 108760891

Gene position: 5755833-5760380 (Clockwise)

Preceding gene: 108763990

Following gene: 108759753

Centisome position: 62.98

GC content: 68.58

Gene sequence:

>4548_bases
TTGAGCATCGAAGCGTATCGGCTCTCTCCTCAGCAGCTCCGTCTGTGGCGGTTGCACGGCAAGCACCAGACGCTCCGGGT
CCAGGCATTGATGCGGCTCGAGGGCTCCCCTCAACCCGGTGCCCTCGAGCACGCGGTGGCGCGGCTTGTCGCGCGACATG
AGCCGCTCCGAACCCGCTTCCCGAGCCTGCCGGGACTGGACGCCCCCGTGCAGGAGGTGACGGCGAGCGGAGAGGTGGAG
TGGGACCGGGTGGATTTCCGCGCGTTCCCCGCCACCACGCGCGAGGAACGCGCCCTCGCCCACTTCCAACAGGTGAGCCA
GCGCCCTTTCGAGCTCGGCACCGGCCCCGTCCTCCGCGTGAGCCTGATGACGTTGGACACCGGGCAGCACCTGCTGGGGC
TGGTGGCGCCAGCCCTGTGCGCCGACGCCGCCACCCTGCGGCGCTTCTGCTCGGAGCTGCAACGAGACCTTGCAGGGCAA
GCCCAGGAACAGGATCAGGACGGAGAGCCTGCCTCTCACCTCTCTTTCTCTGAATGGCAGAACGAGCTGCGCGAGGAGCT
GACGGAGCGAGACCACCCCGCGGCCACCTTTTGGGAGAAGCACGGGACCACCGCGGGCGCGGCGGTGACACTGCCCTTTG
AAAGGCCCGCGAACGCGGCGCAGGTGTTCGACCCGGCGTCGCTCGAGTTGACGCTGAGAGGCGAGCGGCTGTCGCGGCTC
GACGCGGCGGCGCGCGAGCTGGGGTGCTCCCTCGATGCACTGCTGATCGCCACCTGGAGCGCGGAGCTCTGGAAGCTGAC
CGGCCAGACGGACCTCGTGCTGGGCCTTCAGTGCGACGGACGCGAGCACGAGGAACTGTCGGAAGTGGTCGGCCCCCTCT
CCCGCTGGGTACCGCTCCGCGTCCGCCTCGACGCGGACCAGCCGCTGGGGGAGCTGGCCCTCCAGCTCCAGCAGGAGCAG
CGCGAGGCGCTGGAGTGGCAACGGTACTACGTCTGGCCTGCCGCGGATGGCGAGCGCGTCCCCGGCCGGGACTTCCCCGC
CATCGGCTTCCGCTGGGAGGACTTGCCGGAGACGCCGCACGAGGGCGCGGGTGTGCTCCGACTCGAATCGGCGCGCGCCT
ACGCTGATCAATCCAAGCTGTGCCTCTGCTGCATGCGGACGCGGTCCGCGCTCACGCTCGAACTTCAGTACGATCGAAGC
CTCTTCCCACTCGCTGCTGCTGAACAAGTGCTTGGGCAGCTCGAGGCGCTCCTGGAGCAGATCGCCGGCTCACCGCGGGC
GCGGTTGGATGGCTTGGATGCGGTGAGCCCACGCGAGCGGGCACGGTTGCTGGTGGACTTCAACGCCACGGACCGGGAGC
ACCCGGCGCGCTGCGTCCACACTTGGATGGAAGAACAGGCCTCACGCCATCCGGACCGGGTGGCACTCGTCTACGAGGAG
TGCACGCTCACCTACGCGCAGCTCGACGCGAGGGCCAACCGGGTGGCGCACGCACTCCGCCGCCGGGGCGTGGGTCCGGA
GATGCGTGTGGGGCTGTACCTCAACCGCTCGCTCGAAATCATGGTGGGAATCCTGGCCGTCCTGAAGTCTGGCGCGGCCT
ACGTCCCGCTCGATCCGGGCCAACCCAGGCAACGGCTCGCCGGGTTGCTCGACGACATCCAGGCGAAGGTCCTCCTCACC
CAGAGACGGTTGCGCGAAACCGTCCCCGAGGCCGAGGACCGCGAGGTGCTGTGCCTCGACGAAGAGTCCACGTTCGCCGG
AGAACCCACCAGTGCCCCGCACTGCGGAGCCCTTCCGGAGCACCCCGCGTACGTCCTCTTCACCTCCGGCTCCACCGGCC
GGCCCAAGGGCGTCGTCGTCGAGCACCGGCAACTCCACAACTATGTTGCGAGCGTGATGGAGCGGCTGGACCTGCCCGAA
GGCGCTGCCTACGCCACCGTCTCCACCTTCTCGGCGGACCTCGGCAATACCGTCATCTTCCCCGCGCTCTGTCTCGGCGG
AACCCTGCACGTCATCTCCGCCGAGCGCGTGTCGGATCCGGCGGCCTTCGTGGAGTACCTCCAGCGCAACCCGATTGACG
TGCTCAAGATTGTGCCCAGCCACCTGCGCGCGCTCGCGAGCGCTGGCACGGCCGGGGCGCTTCTCCCGCGGCAGCGGCTC
ATCCTTGGCGGCGAGGCGACGCCCCTCGCGTGGGCCGAAGAACTGCAAGCCCAGGCGCCCGGGTGCCGTATCTACAACCA
CTACGGGCCCACGGAGACGACGGTGGGCGTGATGACGTTCCGGCTGGAGCCGTCGCGGCCCTTCGCCGCGAACAACACCC
TCCCGCTCGAGCGCCCCATCGACAACACCCAGGTCTACGTGCTCGACGCAAGGCTGCGGCCAGTGGCGGTGGGCATGACC
GGCGAACTCTACGTCGGTGGTGCCGCGCTCGCCCGAGGGTACCTGAACCGTCCAGACCTGACCGCGCAGTCCTTCCTCCC
CAATCCCTTCAGCACCACGCCTGGCGCGAGGATGTACCGAACAGGGGATCTCGCCCGCCACCTGCCCGACGGCACCCTGG
AGCACCTCGGCCGGGCGGACAACCAGGTGAAGTACCACGGCTACCGCATCGAGCTGAACGAGCTGCGCCACGCGCTCAAT
CAGCACCCTCAGGTGCGCGACAGCGTGATGATGCTGAAACGGGACACGAACGGTAACGAGGTGCTCGTCGCCTACTACGT
CTCGCGCCAGGAGCAGGAGCACGCTCAACTCCGAGCCTTCCTCGCGGAGCGGCTCATCGAGGAGGTGCTCCCGAACGTCT
ACGTCCATCTGAAGAAGCTGCCGCTCACCCTGAATGGGAAGGTCAACCACGAGGCCCTCCCTTCCCTGGACGAGGCGCGG
CGGAGGCAACGCAGCCAACTCGTCGCCCCCCGGACGCCCGTGGAAGCCACCCTGGCGGACATCTGGTGCCAGGTCCTGAA
CCTGAAGGAGGTGTCGGTCACCGACAACTTCTTCAGCGTCGGCGGGGACTCGATCCTGGGGATCCTCGTCGTTTCGAAAG
CCGACCAGGCGGGGCTCAAGCTGACCCCGCGGCAGCTCTTCAAGCACCAGACAATCGCCGAGCTGGCCAGCGTCGCGGCC
CAGGCACCTGCCTCTCCCGACGCCGAGGGGCCGGTGACCGGCCCCCTGCCGCTGACCCAGATCCAGCGCTGGTTCCTGGA
GCAGGAAGTGCCGGACCTGGATGGCTGGGGCATTGTCGTACCACTCGAAGCGCGGCAACCCCTGGACCCGTCCAGGCTCC
AGCAGGCATTGACCGCGCTGCTGAATCACCACGACGTGCTCAGGCTCCGGGTGACGCGCAATGGCTCCGGCTGGGAAGCC
CTCGTGGCCCCGCCTGGCGCACCGATGCCGTTCACTCGGATTGACCTCGCATCGGTCCCTGACGCCTTGCTCAAGGAGCG
ATTCCAAGCGCTCGGGCATGAACTCCAGGCGAAGCTCCGGTTGGACGGGGGCCCCGTGGTGACGACCGCCCTGCTCGAAC
TGGGCCCCCACCGCCCAAGCCGGCTGATGATCGCCGCGCACCGGCTCGTGGTGGACGGCGTTTCCTGGCGCGTCCTCTTC
GAACAGCTCCAGCTCGCCTATGAGCAGCTCGGAGGAGGCGGCGAATGCAAGCTGCCGCCCAGGACCACCTCGGTCCGCGC
ATGGCTCGAGCGCCTCCAGGGCTACGCGGAATCGCCCCGGCTGCGGGAGGAACTCGCGCACTGGACCGCTCAGGGAAAAG
AGCAACCCCGGCCGCTTCCAGTGGAGCGCCCGGGGCCCCTGGTTCCCACGAGCCTGGAGCGAGAACTCACACACGCCCTG
TCGTCTGAAGAGAGTCGGCTCCTGCTCAACGAGCTGCCCGAGGCGTACCGGTGTGAAATTGGTGAGCTGCTGATCGCCAC
CCTGGCCTGGACCCTGCACGAGTGGACGGGTCATCCGGAAGTGCTGCTCGACATCGAAGGGCACGGGCGCGAGGACGTCT
TCGAGGACGTCGATCTCTCCCGGACGGTGGGCTGGCTCACCTCGCTGTACCCGGTACGGCTCACGCCGGAACGGGTGGGG
CCCAGCGCCACCGTGCGGACGGTGAAGGAGCAGCTCCGGTCCGTGCCGAACCGGGGCCTGGGCTACGGGGTGCTGCGCTA
CCTCTCACCCGACGCGGAGCTTCGCGCCCGGTTGGCGCGAGCGCCCCAGGCCGAGGTGCTCTTCCGGTACGTGGGGCAGT
ACCACCTCGCGGGTCCGTGGTTCACCGTGCTGGACCACCCGGAGCAACGGGCGCCCACGCGCCAGCACAAGCTGGCGGTG
ATTGCCCGCGTGGCGGACGGTCAGCTCCATGTCACCTGGTACTTCAGCAGCGACATGCATGAGACCGCCACCGTGGATCG
GCTCTCTGCTCGGTACCTGGACACGCTCCGGACGTTGCTCGCGGAGCGAGGGGTTCCCGAGCGGCAGGTCCTCGCGCCTT
CAGACTTCCCACTGGCCGGGTTGGACCAGTCGAAGTTGGACAAGCTCCTGGGCAAGCTCAAGAAGTAG

Upstream 100 bases:

>100_bases
CAGCAGCGGAACTACGTGGGGCAGATGGAAGCGCTGGTGCGTCAATGGAACGGCGCATCCTCCCAAGCGGTGCTGGCCGG
AAGATGATGGGAGTTCGCAA

Downstream 100 bases:

>100_bases
CGCCGGGTGGTGTACCTCTTCCGGAGGACTCGCCCTCCGGAACGCGTTGCCGGAAGCATCCTTTCCGGTGGCGCGGTGAA
CTCTTAAACTCGCGTGGGCA

Product: non-ribosomal peptide synthase

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: ATP-dependent valine adenylase; ValA; Valine activase; ATP-dependent D-valine adenylase; D-ValA; D-valine activase; Valine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent D-leucine adenylase; D-LeuA; D-leucine activase; Leucine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan/phenylalanine/tyrosine adenylase; Trp/Phe/TyrA; Tryptophan/phenylalanine/tyrosine activase; ATP-dependent D-leucine adenylase; D-LeuA; D-leucine activase; Leucine racemase [ATP-hydrolyzing] [H]

Number of amino acids: Translated: 1515; Mature: 1514

Protein sequence:

>1515_residues
MSIEAYRLSPQQLRLWRLHGKHQTLRVQALMRLEGSPQPGALEHAVARLVARHEPLRTRFPSLPGLDAPVQEVTASGEVE
WDRVDFRAFPATTREERALAHFQQVSQRPFELGTGPVLRVSLMTLDTGQHLLGLVAPALCADAATLRRFCSELQRDLAGQ
AQEQDQDGEPASHLSFSEWQNELREELTERDHPAATFWEKHGTTAGAAVTLPFERPANAAQVFDPASLELTLRGERLSRL
DAAARELGCSLDALLIATWSAELWKLTGQTDLVLGLQCDGREHEELSEVVGPLSRWVPLRVRLDADQPLGELALQLQQEQ
REALEWQRYYVWPAADGERVPGRDFPAIGFRWEDLPETPHEGAGVLRLESARAYADQSKLCLCCMRTRSALTLELQYDRS
LFPLAAAEQVLGQLEALLEQIAGSPRARLDGLDAVSPRERARLLVDFNATDREHPARCVHTWMEEQASRHPDRVALVYEE
CTLTYAQLDARANRVAHALRRRGVGPEMRVGLYLNRSLEIMVGILAVLKSGAAYVPLDPGQPRQRLAGLLDDIQAKVLLT
QRRLRETVPEAEDREVLCLDEESTFAGEPTSAPHCGALPEHPAYVLFTSGSTGRPKGVVVEHRQLHNYVASVMERLDLPE
GAAYATVSTFSADLGNTVIFPALCLGGTLHVISAERVSDPAAFVEYLQRNPIDVLKIVPSHLRALASAGTAGALLPRQRL
ILGGEATPLAWAEELQAQAPGCRIYNHYGPTETTVGVMTFRLEPSRPFAANNTLPLERPIDNTQVYVLDARLRPVAVGMT
GELYVGGAALARGYLNRPDLTAQSFLPNPFSTTPGARMYRTGDLARHLPDGTLEHLGRADNQVKYHGYRIELNELRHALN
QHPQVRDSVMMLKRDTNGNEVLVAYYVSRQEQEHAQLRAFLAERLIEEVLPNVYVHLKKLPLTLNGKVNHEALPSLDEAR
RRQRSQLVAPRTPVEATLADIWCQVLNLKEVSVTDNFFSVGGDSILGILVVSKADQAGLKLTPRQLFKHQTIAELASVAA
QAPASPDAEGPVTGPLPLTQIQRWFLEQEVPDLDGWGIVVPLEARQPLDPSRLQQALTALLNHHDVLRLRVTRNGSGWEA
LVAPPGAPMPFTRIDLASVPDALLKERFQALGHELQAKLRLDGGPVVTTALLELGPHRPSRLMIAAHRLVVDGVSWRVLF
EQLQLAYEQLGGGGECKLPPRTTSVRAWLERLQGYAESPRLREELAHWTAQGKEQPRPLPVERPGPLVPTSLERELTHAL
SSEESRLLLNELPEAYRCEIGELLIATLAWTLHEWTGHPEVLLDIEGHGREDVFEDVDLSRTVGWLTSLYPVRLTPERVG
PSATVRTVKEQLRSVPNRGLGYGVLRYLSPDAELRARLARAPQAEVLFRYVGQYHLAGPWFTVLDHPEQRAPTRQHKLAV
IARVADGQLHVTWYFSSDMHETATVDRLSARYLDTLRTLLAERGVPERQVLAPSDFPLAGLDQSKLDKLLGKLKK

Sequences:

>Translated_1515_residues
MSIEAYRLSPQQLRLWRLHGKHQTLRVQALMRLEGSPQPGALEHAVARLVARHEPLRTRFPSLPGLDAPVQEVTASGEVE
WDRVDFRAFPATTREERALAHFQQVSQRPFELGTGPVLRVSLMTLDTGQHLLGLVAPALCADAATLRRFCSELQRDLAGQ
AQEQDQDGEPASHLSFSEWQNELREELTERDHPAATFWEKHGTTAGAAVTLPFERPANAAQVFDPASLELTLRGERLSRL
DAAARELGCSLDALLIATWSAELWKLTGQTDLVLGLQCDGREHEELSEVVGPLSRWVPLRVRLDADQPLGELALQLQQEQ
REALEWQRYYVWPAADGERVPGRDFPAIGFRWEDLPETPHEGAGVLRLESARAYADQSKLCLCCMRTRSALTLELQYDRS
LFPLAAAEQVLGQLEALLEQIAGSPRARLDGLDAVSPRERARLLVDFNATDREHPARCVHTWMEEQASRHPDRVALVYEE
CTLTYAQLDARANRVAHALRRRGVGPEMRVGLYLNRSLEIMVGILAVLKSGAAYVPLDPGQPRQRLAGLLDDIQAKVLLT
QRRLRETVPEAEDREVLCLDEESTFAGEPTSAPHCGALPEHPAYVLFTSGSTGRPKGVVVEHRQLHNYVASVMERLDLPE
GAAYATVSTFSADLGNTVIFPALCLGGTLHVISAERVSDPAAFVEYLQRNPIDVLKIVPSHLRALASAGTAGALLPRQRL
ILGGEATPLAWAEELQAQAPGCRIYNHYGPTETTVGVMTFRLEPSRPFAANNTLPLERPIDNTQVYVLDARLRPVAVGMT
GELYVGGAALARGYLNRPDLTAQSFLPNPFSTTPGARMYRTGDLARHLPDGTLEHLGRADNQVKYHGYRIELNELRHALN
QHPQVRDSVMMLKRDTNGNEVLVAYYVSRQEQEHAQLRAFLAERLIEEVLPNVYVHLKKLPLTLNGKVNHEALPSLDEAR
RRQRSQLVAPRTPVEATLADIWCQVLNLKEVSVTDNFFSVGGDSILGILVVSKADQAGLKLTPRQLFKHQTIAELASVAA
QAPASPDAEGPVTGPLPLTQIQRWFLEQEVPDLDGWGIVVPLEARQPLDPSRLQQALTALLNHHDVLRLRVTRNGSGWEA
LVAPPGAPMPFTRIDLASVPDALLKERFQALGHELQAKLRLDGGPVVTTALLELGPHRPSRLMIAAHRLVVDGVSWRVLF
EQLQLAYEQLGGGGECKLPPRTTSVRAWLERLQGYAESPRLREELAHWTAQGKEQPRPLPVERPGPLVPTSLERELTHAL
SSEESRLLLNELPEAYRCEIGELLIATLAWTLHEWTGHPEVLLDIEGHGREDVFEDVDLSRTVGWLTSLYPVRLTPERVG
PSATVRTVKEQLRSVPNRGLGYGVLRYLSPDAELRARLARAPQAEVLFRYVGQYHLAGPWFTVLDHPEQRAPTRQHKLAV
IARVADGQLHVTWYFSSDMHETATVDRLSARYLDTLRTLLAERGVPERQVLAPSDFPLAGLDQSKLDKLLGKLKK
>Mature_1514_residues
SIEAYRLSPQQLRLWRLHGKHQTLRVQALMRLEGSPQPGALEHAVARLVARHEPLRTRFPSLPGLDAPVQEVTASGEVEW
DRVDFRAFPATTREERALAHFQQVSQRPFELGTGPVLRVSLMTLDTGQHLLGLVAPALCADAATLRRFCSELQRDLAGQA
QEQDQDGEPASHLSFSEWQNELREELTERDHPAATFWEKHGTTAGAAVTLPFERPANAAQVFDPASLELTLRGERLSRLD
AAARELGCSLDALLIATWSAELWKLTGQTDLVLGLQCDGREHEELSEVVGPLSRWVPLRVRLDADQPLGELALQLQQEQR
EALEWQRYYVWPAADGERVPGRDFPAIGFRWEDLPETPHEGAGVLRLESARAYADQSKLCLCCMRTRSALTLELQYDRSL
FPLAAAEQVLGQLEALLEQIAGSPRARLDGLDAVSPRERARLLVDFNATDREHPARCVHTWMEEQASRHPDRVALVYEEC
TLTYAQLDARANRVAHALRRRGVGPEMRVGLYLNRSLEIMVGILAVLKSGAAYVPLDPGQPRQRLAGLLDDIQAKVLLTQ
RRLRETVPEAEDREVLCLDEESTFAGEPTSAPHCGALPEHPAYVLFTSGSTGRPKGVVVEHRQLHNYVASVMERLDLPEG
AAYATVSTFSADLGNTVIFPALCLGGTLHVISAERVSDPAAFVEYLQRNPIDVLKIVPSHLRALASAGTAGALLPRQRLI
LGGEATPLAWAEELQAQAPGCRIYNHYGPTETTVGVMTFRLEPSRPFAANNTLPLERPIDNTQVYVLDARLRPVAVGMTG
ELYVGGAALARGYLNRPDLTAQSFLPNPFSTTPGARMYRTGDLARHLPDGTLEHLGRADNQVKYHGYRIELNELRHALNQ
HPQVRDSVMMLKRDTNGNEVLVAYYVSRQEQEHAQLRAFLAERLIEEVLPNVYVHLKKLPLTLNGKVNHEALPSLDEARR
RQRSQLVAPRTPVEATLADIWCQVLNLKEVSVTDNFFSVGGDSILGILVVSKADQAGLKLTPRQLFKHQTIAELASVAAQ
APASPDAEGPVTGPLPLTQIQRWFLEQEVPDLDGWGIVVPLEARQPLDPSRLQQALTALLNHHDVLRLRVTRNGSGWEAL
VAPPGAPMPFTRIDLASVPDALLKERFQALGHELQAKLRLDGGPVVTTALLELGPHRPSRLMIAAHRLVVDGVSWRVLFE
QLQLAYEQLGGGGECKLPPRTTSVRAWLERLQGYAESPRLREELAHWTAQGKEQPRPLPVERPGPLVPTSLERELTHALS
SEESRLLLNELPEAYRCEIGELLIATLAWTLHEWTGHPEVLLDIEGHGREDVFEDVDLSRTVGWLTSLYPVRLTPERVGP
SATVRTVKEQLRSVPNRGLGYGVLRYLSPDAELRARLARAPQAEVLFRYVGQYHLAGPWFTVLDHPEQRAPTRQHKLAVI
ARVADGQLHVTWYFSSDMHETATVDRLSARYLDTLRTLLAERGVPERQVLAPSDFPLAGLDQSKLDKLLGKLKK

Specific function: Activates the 7th to 12th amino acids (Val, D-Val, Trp, D-Leu, Xaa and D-Leu) in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 8th (D-Val), the 10th (D- Leu) an

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 6 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=618, Percent_Identity=24.5954692556634, Blast_Score=115, Evalue=3e-25,
Organism=Homo sapiens, GI28416953, Length=542, Percent_Identity=25.0922509225092, Blast_Score=105, Evalue=5e-22,
Organism=Homo sapiens, GI42544132, Length=527, Percent_Identity=23.9089184060721, Blast_Score=89, Evalue=4e-17,
Organism=Homo sapiens, GI38505220, Length=504, Percent_Identity=25.1984126984127, Blast_Score=88, Evalue=8e-17,
Organism=Escherichia coli, GI1786801, Length=806, Percent_Identity=30.3970223325062, Blast_Score=277, Evalue=4e-75,
Organism=Escherichia coli, GI1786810, Length=524, Percent_Identity=25.9541984732824, Blast_Score=109, Evalue=1e-24,
Organism=Escherichia coli, GI145693145, Length=525, Percent_Identity=23.6190476190476, Blast_Score=104, Evalue=5e-23,
Organism=Escherichia coli, GI221142682, Length=499, Percent_Identity=23.8476953907816, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17556356, Length=533, Percent_Identity=24.202626641651, Blast_Score=122, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17550940, Length=589, Percent_Identity=22.7504244482173, Blast_Score=109, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319591, Length=911, Percent_Identity=25.3567508232711, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24648676, Length=732, Percent_Identity=27.1857923497268, Blast_Score=199, Evalue=1e-50,
Organism=Drosophila melanogaster, GI62472339, Length=548, Percent_Identity=22.8102189781022, Blast_Score=91, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24667955, Length=547, Percent_Identity=22.8519195612431, Blast_Score=91, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24581924, Length=582, Percent_Identity=23.7113402061856, Blast_Score=89, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24667959, Length=409, Percent_Identity=24.2053789731051, Blast_Score=77, Evalue=1e-13,
Organism=Drosophila melanogaster, GI18859661, Length=357, Percent_Identity=24.0896358543417, Blast_Score=71, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR023213
- InterPro:   IPR001242
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 168450; Mature: 168319

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIEAYRLSPQQLRLWRLHGKHQTLRVQALMRLEGSPQPGALEHAVARLVARHEPLRTRF
CCCCCEECCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHC
PSLPGLDAPVQEVTASGEVEWDRVDFRAFPATTREERALAHFQQVSQRPFELGTGPVLRV
CCCCCCCCCHHHHHCCCCCEEEEECEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEE
SLMTLDTGQHLLGLVAPALCADAATLRRFCSELQRDLAGQAQEQDQDGEPASHLSFSEWQ
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCHHCCCHHHHH
NELREELTERDHPAATFWEKHGTTAGAAVTLPFERPANAAQVFDPASLELTLRGERLSRL
HHHHHHHHHCCCCCHHHHHHCCCCCCCEEEECCCCCCCHHHCCCCCCEEEEECCHHHHHH
DAAARELGCSLDALLIATWSAELWKLTGQTDLVLGLQCDGREHEELSEVVGPLSRWVPLR
HHHHHHHCCCHHHHHHEECCHHHHEECCCCEEEEEEECCCCCHHHHHHHHHHHHHCEEEE
VRLDADQPLGELALQLQQEQREALEWQRYYVWPAADGERVPGRDFPAIGFRWEDLPETPH
EEECCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
EGAGVLRLESARAYADQSKLCLCCMRTRSALTLELQYDRSLFPLAAAEQVLGQLEALLEQ
CCCCEEEEECHHHHCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
IAGSPRARLDGLDAVSPRERARLLVDFNATDREHPARCVHTWMEEQASRHPDRVALVYEE
HCCCCCHHCCCCCCCCCHHHCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEHH
CTLTYAQLDARANRVAHALRRRGVGPEMRVGLYLNRSLEIMVGILAVLKSGAAYVPLDPG
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEECCCC
QPRQRLAGLLDDIQAKVLLTQRRLRETVPEAEDREVLCLDEESTFAGEPTSAPHCGALPE
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCC
HPAYVLFTSGSTGRPKGVVVEHRQLHNYVASVMERLDLPEGAAYATVSTFSADLGNTVIF
CCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHCCCHHHH
PALCLGGTLHVISAERVSDPAAFVEYLQRNPIDVLKIVPSHLRALASAGTAGALLPRQRL
HHHHHCCEEEEEEHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
ILGGEATPLAWAEELQAQAPGCRIYNHYGPTETTVGVMTFRLEPSRPFAANNTLPLERPI
EECCCCCCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCC
DNTQVYVLDARLRPVAVGMTGELYVGGAALARGYLNRPDLTAQSFLPNPFSTTPGARMYR
CCCEEEEEECCCCEEEECCCCCEEECHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCEEE
TGDLARHLPDGTLEHLGRADNQVKYHGYRIELNELRHALNQHPQVRDSVMMLKRDTNGNE
CCHHHHHCCCHHHHHCCCCCCCEEEEEEEEEHHHHHHHHHCCCCHHHHHHEEEECCCCCE
VLVAYYVSRQEQEHAQLRAFLAERLIEEVLPNVYVHLKKLPLTLNGKVNHEALPSLDEAR
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHEEHHHCCEEECCCCCHHHCCCHHHHH
RRQRSQLVAPRTPVEATLADIWCQVLNLKEVSVTDNFFSVGGDSILGILVVSKADQAGLK
HHHHHCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCHHHCCCCCEEEEEEEECCCCCCCE
LTPRQLFKHQTIAELASVAAQAPASPDAEGPVTGPLPLTQIQRWFLEQEVPDLDGWGIVV
ECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEE
PLEARQPLDPSRLQQALTALLNHHDVLRLRVTRNGSGWEALVAPPGAPMPFTRIDLASVP
EECCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCCCCCCCCCHHHCC
DALLKERFQALGHELQAKLRLDGGPVVTTALLELGPHRPSRLMIAAHRLVVDGVSWRVLF
HHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHH
EQLQLAYEQLGGGGECKLPPRTTSVRAWLERLQGYAESPRLREELAHWTAQGKEQPRPLP
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCC
VERPGPLVPTSLERELTHALSSEESRLLLNELPEAYRCEIGELLIATLAWTLHEWTGHPE
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
VLLDIEGHGREDVFEDVDLSRTVGWLTSLYPVRLTPERVGPSATVRTVKEQLRSVPNRGL
EEEEECCCCCHHHHHHCCHHHHHHHHHHCCCEEECHHHCCCHHHHHHHHHHHHHCCCCCC
GYGVLRYLSPDAELRARLARAPQAEVLFRYVGQYHLAGPWFTVLDHPEQRAPTRQHKLAV
CHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEECCCCHHCCCCHHHHEEE
IARVADGQLHVTWYFSSDMHETATVDRLSARYLDTLRTLLAERGVPERQVLAPSDFPLAG
EEEECCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCC
LDQSKLDKLLGKLKK
CCHHHHHHHHHHHCC
>Mature Secondary Structure 
SIEAYRLSPQQLRLWRLHGKHQTLRVQALMRLEGSPQPGALEHAVARLVARHEPLRTRF
CCCCEECCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHC
PSLPGLDAPVQEVTASGEVEWDRVDFRAFPATTREERALAHFQQVSQRPFELGTGPVLRV
CCCCCCCCCHHHHHCCCCCEEEEECEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEE
SLMTLDTGQHLLGLVAPALCADAATLRRFCSELQRDLAGQAQEQDQDGEPASHLSFSEWQ
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCHHCCCHHHHH
NELREELTERDHPAATFWEKHGTTAGAAVTLPFERPANAAQVFDPASLELTLRGERLSRL
HHHHHHHHHCCCCCHHHHHHCCCCCCCEEEECCCCCCCHHHCCCCCCEEEEECCHHHHHH
DAAARELGCSLDALLIATWSAELWKLTGQTDLVLGLQCDGREHEELSEVVGPLSRWVPLR
HHHHHHHCCCHHHHHHEECCHHHHEECCCCEEEEEEECCCCCHHHHHHHHHHHHHCEEEE
VRLDADQPLGELALQLQQEQREALEWQRYYVWPAADGERVPGRDFPAIGFRWEDLPETPH
EEECCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
EGAGVLRLESARAYADQSKLCLCCMRTRSALTLELQYDRSLFPLAAAEQVLGQLEALLEQ
CCCCEEEEECHHHHCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
IAGSPRARLDGLDAVSPRERARLLVDFNATDREHPARCVHTWMEEQASRHPDRVALVYEE
HCCCCCHHCCCCCCCCCHHHCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEHH
CTLTYAQLDARANRVAHALRRRGVGPEMRVGLYLNRSLEIMVGILAVLKSGAAYVPLDPG
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEECCCC
QPRQRLAGLLDDIQAKVLLTQRRLRETVPEAEDREVLCLDEESTFAGEPTSAPHCGALPE
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCC
HPAYVLFTSGSTGRPKGVVVEHRQLHNYVASVMERLDLPEGAAYATVSTFSADLGNTVIF
CCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHCCCHHHH
PALCLGGTLHVISAERVSDPAAFVEYLQRNPIDVLKIVPSHLRALASAGTAGALLPRQRL
HHHHHCCEEEEEEHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
ILGGEATPLAWAEELQAQAPGCRIYNHYGPTETTVGVMTFRLEPSRPFAANNTLPLERPI
EECCCCCCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCC
DNTQVYVLDARLRPVAVGMTGELYVGGAALARGYLNRPDLTAQSFLPNPFSTTPGARMYR
CCCEEEEEECCCCEEEECCCCCEEECHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCEEE
TGDLARHLPDGTLEHLGRADNQVKYHGYRIELNELRHALNQHPQVRDSVMMLKRDTNGNE
CCHHHHHCCCHHHHHCCCCCCCEEEEEEEEEHHHHHHHHHCCCCHHHHHHEEEECCCCCE
VLVAYYVSRQEQEHAQLRAFLAERLIEEVLPNVYVHLKKLPLTLNGKVNHEALPSLDEAR
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHEEHHHCCEEECCCCCHHHCCCHHHHH
RRQRSQLVAPRTPVEATLADIWCQVLNLKEVSVTDNFFSVGGDSILGILVVSKADQAGLK
HHHHHCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCHHHCCCCCEEEEEEEECCCCCCCE
LTPRQLFKHQTIAELASVAAQAPASPDAEGPVTGPLPLTQIQRWFLEQEVPDLDGWGIVV
ECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEE
PLEARQPLDPSRLQQALTALLNHHDVLRLRVTRNGSGWEALVAPPGAPMPFTRIDLASVP
EECCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCCCCCCCCCHHHCC
DALLKERFQALGHELQAKLRLDGGPVVTTALLELGPHRPSRLMIAAHRLVVDGVSWRVLF
HHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHH
EQLQLAYEQLGGGGECKLPPRTTSVRAWLERLQGYAESPRLREELAHWTAQGKEQPRPLP
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCC
VERPGPLVPTSLERELTHALSSEESRLLLNELPEAYRCEIGELLIATLAWTLHEWTGHPE
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
VLLDIEGHGREDVFEDVDLSRTVGWLTSLYPVRLTPERVGPSATVRTVKEQLRSVPNRGL
EEEEECCCCCHHHHHHCCHHHHHHHHHHCCCEEECHHHCCCHHHHHHHHHHHHHCCCCCC
GYGVLRYLSPDAELRARLARAPQAEVLFRYVGQYHLAGPWFTVLDHPEQRAPTRQHKLAV
CHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEECCCCHHCCCCHHHHEEE
IARVADGQLHVTWYFSSDMHETATVDRLSARYLDTLRTLLAERGVPERQVLAPSDFPLAG
EEEECCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCC
LDQSKLDKLLGKLKK
CCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA