Click here to switch to the map view.

The map label for this gene is pdxH

Identifier: 108758100

GI number: 108758100

Start: 1520897

End: 1521559

Strand: Reverse

Name: pdxH

Synonym: MXAN_1295

Alternate gene names: 108758100

Gene position: 1521559-1520897 (Counterclockwise)

Preceding gene: 108763307

Following gene: 108763002

Centisome position: 16.65

GC content: 69.83

Gene sequence:

>663_bases
GTGCGCACATTGACGTGTGTGCCGGATGAGTCAACCGCGAAGGTGCACACCTGCCGCGCCCCCTTTATGTTGCACCGCGT
GATGATTCCTCCAGACCCCATCCAGCGCTTCGCGGAGCTCTTCGAGCGAGCGAAGCAGGCCATTGCGGTGGACCCCAACG
CCATGGTGGTCGCCACCGTGGGGGATGACGGGCGCCCCAGCGCGCGCGTCGTCCTGCTCAAGGACTTCGATGCGCGCGGC
TTCGTGTTCTACACGAACCACGAAAGCCGGAAGGGCCGCGAGGCCCGCGCGCATCCCTACGCGGCGCTCTGCTTCTACTG
GCAGCCCTTGAATGAACAGGTGCGCGTGGAAGGCCGCGTGGAGCGCGTCACGGACGCGGAGGCGGACGCGTACTTCCAGA
GCCGCGCCCGCGGCAGCCAGGTGGGCGCGTGGGCCAGCCTGCAGAGCCAGCCGCTGGCGACTCGCGAGGAGCTGGAGGCC
CGCGTGGCGGAGGTGGAGCAGAAGTACGCCGGCCAGCCCGTGCCGCGCCCGCCGCACTGGTCCGGCTTCCGCGTGGTGCC
GGACCGCATCGAGTTCTGGCACGCCCAGGAGAGCCGGCTCCACGACCGGCACGTCTACCTGCGCGAGGACGGCGGCTGGC
GCACGCAGATGCTCTACCCATGA

Upstream 100 bases:

>100_bases
CCAGCGAGGCAAGCGCGGCGGGGAGGGCCCCGGCCACGTCCCCCAGGCCCCCCGTCTTGGAGAACGGGGCCACCTCCGAG
GAGATGAAGAGGACATTCAT

Downstream 100 bases:

>100_bases
GGGCACGGCTACCAGGGCACTTCGGTCCCCTGGTAGTCGAAGAACCGGCCGCTGTGCTCCGGGTTCAGCCCGTCGATGAC
CCGCAGCATGCCGCGCACCG

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MRTLTCVPDESTAKVHTCRAPFMLHRVMIPPDPIQRFAELFERAKQAIAVDPNAMVVATVGDDGRPSARVVLLKDFDARG
FVFYTNHESRKGREARAHPYAALCFYWQPLNEQVRVEGRVERVTDAEADAYFQSRARGSQVGAWASLQSQPLATREELEA
RVAEVEQKYAGQPVPRPPHWSGFRVVPDRIEFWHAQESRLHDRHVYLREDGGWRTQMLYP

Sequences:

>Translated_220_residues
MRTLTCVPDESTAKVHTCRAPFMLHRVMIPPDPIQRFAELFERAKQAIAVDPNAMVVATVGDDGRPSARVVLLKDFDARG
FVFYTNHESRKGREARAHPYAALCFYWQPLNEQVRVEGRVERVTDAEADAYFQSRARGSQVGAWASLQSQPLATREELEA
RVAEVEQKYAGQPVPRPPHWSGFRVVPDRIEFWHAQESRLHDRHVYLREDGGWRTQMLYP
>Mature_220_residues
MRTLTCVPDESTAKVHTCRAPFMLHRVMIPPDPIQRFAELFERAKQAIAVDPNAMVVATVGDDGRPSARVVLLKDFDARG
FVFYTNHESRKGREARAHPYAALCFYWQPLNEQVRVEGRVERVTDAEADAYFQSRARGSQVGAWASLQSQPLATREELEA
RVAEVEQKYAGQPVPRPPHWSGFRVVPDRIEFWHAQESRLHDRHVYLREDGGWRTQMLYP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=178, Percent_Identity=49.438202247191, Blast_Score=178, Evalue=3e-45,
Organism=Escherichia coli, GI1787926, Length=197, Percent_Identity=45.1776649746193, Blast_Score=176, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17553712, Length=214, Percent_Identity=38.3177570093458, Blast_Score=150, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6319509, Length=205, Percent_Identity=39.5121951219512, Blast_Score=147, Evalue=1e-36,
Organism=Drosophila melanogaster, GI45551845, Length=187, Percent_Identity=40.6417112299465, Blast_Score=141, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24644901, Length=187, Percent_Identity=40.6417112299465, Blast_Score=141, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24644903, Length=161, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_MYXXA (P21159)

Other databases:

- EMBL:   L27429
- PIR:   S36092
- PIR:   T10126
- ProteinModelPortal:   P21159
- SMR:   P21159
- BRENDA:   1.4.3.5
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 25285; Mature: 25285

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 69-69 BINDING 72-72 BINDING 74-74 BINDING 91-91 BINDING 131-131 BINDING 135-135 BINDING 139-139

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLTCVPDESTAKVHTCRAPFMLHRVMIPPDPIQRFAELFERAKQAIAVDPNAMVVATV
CCEEEECCCCCCCEEEECCCCHHHHEECCCCHHHHHHHHHHHHHHHHEEECCCEEEEEEE
GDDGRPSARVVLLKDFDARGFVFYTNHESRKGREARAHPYAALCFYWQPLNEQVRVEGRV
CCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCEEEEEEEEECCCCEEEECCHH
ERVTDAEADAYFQSRARGSQVGAWASLQSQPLATREELEARVAEVEQKYAGQPVPRPPHW
HHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
SGFRVVPDRIEFWHAQESRLHDRHVYLREDGGWRTQMLYP
CCEEECCCHHHHCCCHHHCCCCEEEEEEECCCEEEEEECC
>Mature Secondary Structure
MRTLTCVPDESTAKVHTCRAPFMLHRVMIPPDPIQRFAELFERAKQAIAVDPNAMVVATV
CCEEEECCCCCCCEEEECCCCHHHHEECCCCHHHHHHHHHHHHHHHHEEECCCEEEEEEE
GDDGRPSARVVLLKDFDARGFVFYTNHESRKGREARAHPYAALCFYWQPLNEQVRVEGRV
CCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCEEEEEEEEECCCCEEEECCHH
ERVTDAEADAYFQSRARGSQVGAWASLQSQPLATREELEARVAEVEQKYAGQPVPRPPHW
HHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
SGFRVVPDRIEFWHAQESRLHDRHVYLREDGGWRTQMLYP
CCEEECCCHHHHCCCHHHCCCCEEEEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2152902