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The map label for this gene is tlyC [H]

Identifier: 108763307

GI number: 108763307

Start: 1525985

End: 1527352

Strand: Reverse

Name: tlyC [H]

Synonym: MXAN_1301

Alternate gene names: 108763307

Gene position: 1527352-1525985 (Counterclockwise)

Preceding gene: 108758913

Following gene: 108758100

Centisome position: 16.71

GC content: 69.23

Gene sequence:

>1368_bases
ATGCCTACCTGGACCCTCTGGGTCGCCTGCCTGGCGCTGAGTTTCATCAGGGCCCTTGTCGCCGCTTCGGAGTCCGCGCT
CTACGGCGTGTCCGACTTGCGAGCACAGGAACTGGCGAACACGCAGCCGGGCCGGGCGACTCGCCGGGTCCTCCGCCACA
AGACGGACCGCGAGCCCGTGGCCACGGCGCTGCGCCTGGGCATGGTGCTCAGCGGCTTCCAGGCCGCGGCCATTGGCGCC
TTCGTCCCGCCGCGCATGCTGGACTTCAGCCGCTACGGCGAATCCGCGTGGCTGCCGGTGGCCACCGTCGCCGCGGGCGC
GCTGCTGGTGGGCGTGCTGGCCACGCTCATGGAAGTCACCATGCGCGGGCTGGCCAACGGCAGCCCGGAGCGCTGGGCCC
TGCGGCTGTCGGGCTTCACCTCGCTGCTGGTGACGGTGCTCTACCCGCCCATGCGCATGGCCATGGTGGTGCTCAACCTG
ATGGCGCGCACCTTCGGCCGGACGCTGCGCTTCGAGCCGCCGCCCCCTCCGCTGGAGGAGTTGGAGAAGCTGCTGGCCGC
CCAGGCCGCGAAGAACGAGGTCGACAAGAGCGCCCCGCAGCTCATCCGCTCCATCTTCGAGCTGTCCGACAAGCGCTGCC
GCGACGTCATGGTGCCGCGCACGGAAGTGGTGACGGTGGACGTCACCATCACCCCGGACGAGCTGCTGCGCCTGCTGGCG
GAGGAGAACCACTCCCGCATCCCCGTGTACCGGGACGACGTGGACCACGTCATCGGCGTGTTGCACGCGCGCGACATCAT
CCCCCTGCTCCAGCACCCCGAGCTCATCGTCCTGCAGGACATCATCCGCCCGGCGCACTTCGTACCGTGGATGAAGCCCA
TTGGCGACCTGCTCCGGGACATGCAGAAGCAGAAGATCCACATGGCCATCGTCGTCGACGAGTACGGCGGCTTCATGGGT
GTGGTGACGCTGGAGGACATCCTCCGCGAAATCGTCGGCGACATCGGCGACGAGTTCGAGGTGGAGGAGAAGCAGGTGGA
GAAGCTGGCGGACGGCAGCTTCCTGGTGGACGCCGCGCTGGAGGTGGACGCCTTCACGCAGACGTTCGGCTTCCCCCTGC
CCGAAGGCGACTTCGACACGCTGGGCGGCTTCCTCTCCTCCATGGCGGGCCACCTGCCCGACGTGGGCGAGCGCTTCGCC
TACAGCGGCTGGCAGTTCGTCGTGGCGTCCAAGGAAGGCCCCCGCATCGACCGCGTGCGGATGTCGCGCGTGAAGTCTGG
CCTCACCAAGGACGGCAAGGCCGCGGAGTCCCGCGACGGGCTGGGGCGCGAGCACGGCCGCGAGGAACAGGCCTCCGCGA
AGAGCTGA

Upstream 100 bases:

>100_bases
CGAGAAGGGCCAGGAGTGCTCCAACAACGTACATGCGAGCGGACATCAGAGCTCCAGCGCAGTGGTATGGACCCTTAGCA
CGGGATAAGAACAGGGCTCT

Downstream 100 bases:

>100_bases
GGCCCGGAGCGGCACCGGCCCCGCTCCGGGGCCGGCCCCTCCCCCACTACTGGGACCAGTAGCACTCCAGCGTCTCTCGC
GCGGACTTGCCAATCAGCTC

Product: CBS/transporter associated domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MPTWTLWVACLALSFIRALVAASESALYGVSDLRAQELANTQPGRATRRVLRHKTDREPVATALRLGMVLSGFQAAAIGA
FVPPRMLDFSRYGESAWLPVATVAAGALLVGVLATLMEVTMRGLANGSPERWALRLSGFTSLLVTVLYPPMRMAMVVLNL
MARTFGRTLRFEPPPPPLEELEKLLAAQAAKNEVDKSAPQLIRSIFELSDKRCRDVMVPRTEVVTVDVTITPDELLRLLA
EENHSRIPVYRDDVDHVIGVLHARDIIPLLQHPELIVLQDIIRPAHFVPWMKPIGDLLRDMQKQKIHMAIVVDEYGGFMG
VVTLEDILREIVGDIGDEFEVEEKQVEKLADGSFLVDAALEVDAFTQTFGFPLPEGDFDTLGGFLSSMAGHLPDVGERFA
YSGWQFVVASKEGPRIDRVRMSRVKSGLTKDGKAAESRDGLGREHGREEQASAKS

Sequences:

>Translated_455_residues
MPTWTLWVACLALSFIRALVAASESALYGVSDLRAQELANTQPGRATRRVLRHKTDREPVATALRLGMVLSGFQAAAIGA
FVPPRMLDFSRYGESAWLPVATVAAGALLVGVLATLMEVTMRGLANGSPERWALRLSGFTSLLVTVLYPPMRMAMVVLNL
MARTFGRTLRFEPPPPPLEELEKLLAAQAAKNEVDKSAPQLIRSIFELSDKRCRDVMVPRTEVVTVDVTITPDELLRLLA
EENHSRIPVYRDDVDHVIGVLHARDIIPLLQHPELIVLQDIIRPAHFVPWMKPIGDLLRDMQKQKIHMAIVVDEYGGFMG
VVTLEDILREIVGDIGDEFEVEEKQVEKLADGSFLVDAALEVDAFTQTFGFPLPEGDFDTLGGFLSSMAGHLPDVGERFA
YSGWQFVVASKEGPRIDRVRMSRVKSGLTKDGKAAESRDGLGREHGREEQASAKS
>Mature_454_residues
PTWTLWVACLALSFIRALVAASESALYGVSDLRAQELANTQPGRATRRVLRHKTDREPVATALRLGMVLSGFQAAAIGAF
VPPRMLDFSRYGESAWLPVATVAAGALLVGVLATLMEVTMRGLANGSPERWALRLSGFTSLLVTVLYPPMRMAMVVLNLM
ARTFGRTLRFEPPPPPLEELEKLLAAQAAKNEVDKSAPQLIRSIFELSDKRCRDVMVPRTEVVTVDVTITPDELLRLLAE
ENHSRIPVYRDDVDHVIGVLHARDIIPLLQHPELIVLQDIIRPAHFVPWMKPIGDLLRDMQKQKIHMAIVVDEYGGFMGV
VTLEDILREIVGDIGDEFEVEEKQVEKLADGSFLVDAALEVDAFTQTFGFPLPEGDFDTLGGFLSSMAGHLPDVGERFAY
SGWQFVVASKEGPRIDRVRMSRVKSGLTKDGKAAESRDGLGREHGREEQASAKS

Specific function: Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined [H]

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=402, Percent_Identity=24.6268656716418, Blast_Score=136, Evalue=5e-32,
Organism=Escherichia coli, GI1786879, Length=253, Percent_Identity=33.201581027668, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI145693175, Length=415, Percent_Identity=26.7469879518072, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1790664, Length=429, Percent_Identity=24.009324009324, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI87082033, Length=258, Percent_Identity=24.4186046511628, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788119, Length=227, Percent_Identity=27.7533039647577, Blast_Score=80, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC [H]

EC number: NA

Molecular weight: Translated: 50257; Mature: 50126

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTWTLWVACLALSFIRALVAASESALYGVSDLRAQELANTQPGRATRRVLRHKTDREPV
CCHHHHHHHHHHHHHHHHHHHHCCHHHHCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHH
ATALRLGMVLSGFQAAAIGAFVPPRMLDFSRYGESAWLPVATVAAGALLVGVLATLMEVT
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MRGLANGSPERWALRLSGFTSLLVTVLYPPMRMAMVVLNLMARTFGRTLRFEPPPPPLEE
HHHHCCCCCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
LEKLLAAQAAKNEVDKSAPQLIRSIFELSDKRCRDVMVPRTEVVTVDVTITPDELLRLLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECHHHHHHHHH
EENHSRIPVYRDDVDHVIGVLHARDIIPLLQHPELIVLQDIIRPAHFVPWMKPIGDLLRD
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MQKQKIHMAIVVDEYGGFMGVVTLEDILREIVGDIGDEFEVEEKQVEKLADGSFLVDAAL
HHHHHEEEEEEEECCCCEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCEEEHHHH
EVDAFTQTFGFPLPEGDFDTLGGFLSSMAGHLPDVGERFAYSGWQFVVASKEGPRIDRVR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEEECCCCCCHHHHH
MSRVKSGLTKDGKAAESRDGLGREHGREEQASAKS
HHHHHHCCCCCCCCCHHHCCCCHHCCCHHHHCCCC
>Mature Secondary Structure 
PTWTLWVACLALSFIRALVAASESALYGVSDLRAQELANTQPGRATRRVLRHKTDREPV
CHHHHHHHHHHHHHHHHHHHHCCHHHHCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHH
ATALRLGMVLSGFQAAAIGAFVPPRMLDFSRYGESAWLPVATVAAGALLVGVLATLMEVT
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MRGLANGSPERWALRLSGFTSLLVTVLYPPMRMAMVVLNLMARTFGRTLRFEPPPPPLEE
HHHHCCCCCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
LEKLLAAQAAKNEVDKSAPQLIRSIFELSDKRCRDVMVPRTEVVTVDVTITPDELLRLLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECHHHHHHHHH
EENHSRIPVYRDDVDHVIGVLHARDIIPLLQHPELIVLQDIIRPAHFVPWMKPIGDLLRD
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MQKQKIHMAIVVDEYGGFMGVVTLEDILREIVGDIGDEFEVEEKQVEKLADGSFLVDAAL
HHHHHEEEEEEEECCCCEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCEEEHHHH
EVDAFTQTFGFPLPEGDFDTLGGFLSSMAGHLPDVGERFAYSGWQFVVASKEGPRIDRVR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEEECCCCCCHHHHH
MSRVKSGLTKDGKAAESRDGLGREHGREEQASAKS
HHHHHHCCCCCCCCCHHHCCCCHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7968456 [H]