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The map label for this gene is hemG

Identifier: 108763002

GI number: 108763002

Start: 1518704

End: 1520119

Strand: Reverse

Name: hemG

Synonym: MXAN_1293

Alternate gene names: 108763002

Gene position: 1520119-1518704 (Counterclockwise)

Preceding gene: 108758100

Following gene: 108762941

Centisome position: 16.63

GC content: 70.83

Gene sequence:

>1416_bases
ATGCACCACATGCCGAGGACAACTGGAATGAATGTCGCCGTCGTGGGAGGTGGGATTTCGGGGTTGGCCGTCGCGCATCA
TTTGCGCTCGCGCGGTACGGATGCCGTGCTTCTGGAGTCCTCCGCCCGACTTGGCGGCGCGGTGGGCACGCATGCGCTCG
CCGGCTACCTGGTGGAGCAGGGGCCCAACAGCTTCCTGGACCGCGAGCCCGCAACGCGGGCGCTCGCGGCGGCGCTGAAT
CTGGAGGGGCGAATTCGCGCCGCGGACCCGGCGGCGAAGCGTCGCTATGTCTACACGCGGGGCAGACTCCGGTCGGTACC
GGCCTCGCCGCCCGCGTTTCTCGCATCGGACATTCTGCCGCTCGGCGCGCGGTTGCGCGTCGCTGGCGAACTGTTCTCCC
GCCGCGCGCCGGAGGGTGTGGACGAATCGCTGGCCGCCTTCGGCCGCCGCCACCTGGGACACAGGGCGACGCAGGTGCTG
CTCGACGCGGTGCAGACGGGCATCTACGCGGGCGACGTGGAGCAGCTCAGCGTCGCGGCCACCTTCCCCATGCTGGTGAA
GATGGAGCGCGAGCACCGCAGCCTCATCCTGGGCGCCATCCGCGCGCAGAAGGCTCAGCGCCAGGCGGCGCTCCCCGCGG
GAACGGCGCCGAAGTTGAGCGGCGCGCTGAGCACGTTCGACGGCGGATTGCAGGTGCTCATCGACGCGCTCGCCGCATCG
TTGGGTGACGCGGCGCACGTGGGCGCGCGCGTGGAGGGGCTGGCGCGCGAGGACGGCGGTTGGAGGCTCATCATCGAGGA
GCACGGACGCCGCGCGGAACTGTCCGTGGCCCAGGTGGTACTGGCGGCGCCCGCGCATGCCACCGCGAAATTGCTACGCC
CACTGGATGACGCGCTCGCCGCCCTGGTGGCGGGTATCGCCTATGCGCCCATCGCGGTGGTGCACCTGGGCTTCGACGCG
GGGACACTTCCGGCGCCGGATGGCTTTGGGTTCCTGGTGCCAGCGGAGGAGCAGCGGCGGATGCTGGGCGCCATCCACGC
GTCCACCACCTTTCCCTTCCGGGCCGAGGGCGGACGCGTGCTCTATTCCTGCATGGTGGGGGGCGCGCGTCAGCCAGGGC
TGGTGGAACAGGACGAGGATGCATTGGCGGCGCTGGCGCGCGAGGAACTGAAGGCGCTGGCAGGCGTGACGGCGCGCCCC
TCCTTCACGCGGGTGTTCCGCTGGCCGCTTGGCATTCCCCAGTACAACCTGGGACACCTGGAGCGCGTGGCCGCTATCGA
CGCGGCGCTGCAACGCTTGCCCGGCCTGCACCTCATCGGGAATGCGTACAAGGGCGTGGGCCTCAACGACTGCATCCGCA
ACGCGGCGCAACTCGCGGACGCCCTGGTCGCGGGGAACACCTCCCACGCCCCGTAG

Upstream 100 bases:

>100_bases
TCCGGTGATGACGTAGCGCATGCATGGCATTAACGCGCTGAATGCCTTCCGCTGGCAAAACACGCGTGTTGACGACCAGG
GAGTGCACGCTGGTAACCGG

Downstream 100 bases:

>100_bases
GAGCGGGCCTCACCCCGCACGACAACCCGCGCACGCGGCGCCAGCACACATTCGTGGCGCCCTTGCTCCCACCGGCTGAC
CTGGCATGTCAGCCCAAAGC

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MHHMPRTTGMNVAVVGGGISGLAVAHHLRSRGTDAVLLESSARLGGAVGTHALAGYLVEQGPNSFLDREPATRALAAALN
LEGRIRAADPAAKRRYVYTRGRLRSVPASPPAFLASDILPLGARLRVAGELFSRRAPEGVDESLAAFGRRHLGHRATQVL
LDAVQTGIYAGDVEQLSVAATFPMLVKMEREHRSLILGAIRAQKAQRQAALPAGTAPKLSGALSTFDGGLQVLIDALAAS
LGDAAHVGARVEGLAREDGGWRLIIEEHGRRAELSVAQVVLAAPAHATAKLLRPLDDALAALVAGIAYAPIAVVHLGFDA
GTLPAPDGFGFLVPAEEQRRMLGAIHASTTFPFRAEGGRVLYSCMVGGARQPGLVEQDEDALAALAREELKALAGVTARP
SFTRVFRWPLGIPQYNLGHLERVAAIDAALQRLPGLHLIGNAYKGVGLNDCIRNAAQLADALVAGNTSHAP

Sequences:

>Translated_471_residues
MHHMPRTTGMNVAVVGGGISGLAVAHHLRSRGTDAVLLESSARLGGAVGTHALAGYLVEQGPNSFLDREPATRALAAALN
LEGRIRAADPAAKRRYVYTRGRLRSVPASPPAFLASDILPLGARLRVAGELFSRRAPEGVDESLAAFGRRHLGHRATQVL
LDAVQTGIYAGDVEQLSVAATFPMLVKMEREHRSLILGAIRAQKAQRQAALPAGTAPKLSGALSTFDGGLQVLIDALAAS
LGDAAHVGARVEGLAREDGGWRLIIEEHGRRAELSVAQVVLAAPAHATAKLLRPLDDALAALVAGIAYAPIAVVHLGFDA
GTLPAPDGFGFLVPAEEQRRMLGAIHASTTFPFRAEGGRVLYSCMVGGARQPGLVEQDEDALAALAREELKALAGVTARP
SFTRVFRWPLGIPQYNLGHLERVAAIDAALQRLPGLHLIGNAYKGVGLNDCIRNAAQLADALVAGNTSHAP
>Mature_471_residues
MHHMPRTTGMNVAVVGGGISGLAVAHHLRSRGTDAVLLESSARLGGAVGTHALAGYLVEQGPNSFLDREPATRALAAALN
LEGRIRAADPAAKRRYVYTRGRLRSVPASPPAFLASDILPLGARLRVAGELFSRRAPEGVDESLAAFGRRHLGHRATQVL
LDAVQTGIYAGDVEQLSVAATFPMLVKMEREHRSLILGAIRAQKAQRQAALPAGTAPKLSGALSTFDGGLQVLIDALAAS
LGDAAHVGARVEGLAREDGGWRLIIEEHGRRAELSVAQVVLAAPAHATAKLLRPLDDALAALVAGIAYAPIAVVHLGFDA
GTLPAPDGFGFLVPAEEQRRMLGAIHASTTFPFRAEGGRVLYSCMVGGARQPGLVEQDEDALAALAREELKALAGVTARP
SFTRVFRWPLGIPQYNLGHLERVAAIDAALQRLPGLHLIGNAYKGVGLNDCIRNAAQLADALVAGNTSHAP

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. May have an essential extracellular function during development, possibly as a pheromone

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family

Homologues:

Organism=Homo sapiens, GI170650615, Length=494, Percent_Identity=31.7813765182186, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI4506001, Length=494, Percent_Identity=31.7813765182186, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24649745, Length=467, Percent_Identity=29.1220556745182, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPOX_MYXXA (P56601)

Other databases:

- EMBL:   L27429
- EMBL:   AF098938
- PDB:   2IVD
- PDB:   2IVE
- PDBsum:   2IVD
- PDBsum:   2IVE
- ProteinModelPortal:   P56601
- SMR:   P56601
- BRENDA:   1.3.3.4
- GO:   GO:0005737
- GO:   GO:0005488
- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00562

Pfam domain/function: PF01593 Amino_oxidase

EC number: =1.3.3.4

Molecular weight: Translated: 49388; Mature: 49388

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHMPRTTGMNVAVVGGGISGLAVAHHLRSRGTDAVLLESSARLGGAVGTHALAGYLVEQ
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHC
GPNSFLDREPATRALAAALNLEGRIRAADPAAKRRYVYTRGRLRSVPASPPAFLASDILP
CCCHHHCCCHHHHHHHHHHCCCCCEEECCHHHHCCEEEECCCCCCCCCCCHHHHHHHHHC
LGARLRVAGELFSRRAPEGVDESLAAFGRRHLGHRATQVLLDAVQTGIYAGDVEQLSVAA
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
TFPMLVKMEREHRSLILGAIRAQKAQRQAALPAGTAPKLSGALSTFDGGLQVLIDALAAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHH
LGDAAHVGARVEGLAREDGGWRLIIEEHGRRAELSVAQVVLAAPAHATAKLLRPLDDALA
CCCHHHHCHHHHHHEECCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ALVAGIAYAPIAVVHLGFDAGTLPAPDGFGFLVPAEEQRRMLGAIHASTTFPFRAEGGRV
HHHHHHHHHCEEEEEECCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCEECCCCEE
LYSCMVGGARQPGLVEQDEDALAALAREELKALAGVTARPSFTRVFRWPLGIPQYNLGHL
EEEEHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCCCCCCHHHH
ERVAAIDAALQRLPGLHLIGNAYKGVGLNDCIRNAAQLADALVAGNTSHAP
HHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MHHMPRTTGMNVAVVGGGISGLAVAHHLRSRGTDAVLLESSARLGGAVGTHALAGYLVEQ
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHC
GPNSFLDREPATRALAAALNLEGRIRAADPAAKRRYVYTRGRLRSVPASPPAFLASDILP
CCCHHHCCCHHHHHHHHHHCCCCCEEECCHHHHCCEEEECCCCCCCCCCCHHHHHHHHHC
LGARLRVAGELFSRRAPEGVDESLAAFGRRHLGHRATQVLLDAVQTGIYAGDVEQLSVAA
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
TFPMLVKMEREHRSLILGAIRAQKAQRQAALPAGTAPKLSGALSTFDGGLQVLIDALAAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHH
LGDAAHVGARVEGLAREDGGWRLIIEEHGRRAELSVAQVVLAAPAHATAKLLRPLDDALA
CCCHHHHCHHHHHHEECCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ALVAGIAYAPIAVVHLGFDAGTLPAPDGFGFLVPAEEQRRMLGAIHASTTFPFRAEGGRV
HHHHHHHHHCEEEEEECCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCEECCCCEE
LYSCMVGGARQPGLVEQDEDALAALAREELKALAGVTARPSFTRVFRWPLGIPQYNLGHL
EEEEHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCCCCCCHHHH
ERVAAIDAALQRLPGLHLIGNAYKGVGLNDCIRNAAQLADALVAGNTSHAP
HHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1372277; 8621504