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The map label for this gene is rnr [H]

Identifier: 108563616

GI number: 108563616

Start: 1255331

End: 1257265

Strand: Reverse

Name: rnr [H]

Synonym: HPAG1_1191

Alternate gene names: 108563616

Gene position: 1257265-1255331 (Counterclockwise)

Preceding gene: 108563617

Following gene: 108563615

Centisome position: 78.76

GC content: 38.14

Gene sequence:

>1935_bases
ATGCAAGGGTTTTTAAGAAGCCTGTTTTTTGGGGTTAAAAAGATCCCTAAACCATTCGCTCCTCTAATAGAAAAGGGCGT
TTTAAAAGAAGCGCTTGAATTGAAAAAGGATCGCTATTTTTTAAAAGAAGGCTTTGATATAGGTAGGATTGAATGGGCAG
AAAATAAGGCGTTTTTCGTTTCTTTGGCGAAAAATTACCCTAAAGACCCTTTAATCAAAAACTTACCCCCATCTTTTAAA
ACAGACGCTTTGATTTTATGCCAAATAGAATGTTCTAAAAAACGCCCTAAAGCCTTTTTTAAAGCCGCTCTTTTAAATGC
AGATCACACGATGATAGCTTATTTGGCTAAAAAAAATCACCAGATTGTGGCTATCCCTTTTAAAGAGCCTTTTAAAAAAC
CCATTCTTTTAAAGCACAGCCAAAGATCCTTACTAGAATTGCCTAGGCATTGCGTGGTGAAGATCGATCTTAAAAAGCGT
GAAATCAGCGAAATTTTAGGGCCTTTAGAAGACCCTTTAATAGATGAAAACCTTTCTTTAAGCCTTTTTGACAGGGTTAA
GGATTTTTCAAAAGATTGTTTGAATTTAGCCCAACATTACGCGCAACTCAAAGCGAGCGATTTTAAAGACAGGATCAATT
ATTCTCACATCCCTTTTATCACCATTGACCCCAAAGACGCTAAAGATTTTGACGATGCGATTTTTTATGACCAAGAAAAA
AGGGTTTTGTTTGTGGCGGTTGCTGATGTGAGCGAATTTGTGCCGAAACATTCCAGTTTGGATAAAGAAGCTAGGGTTAG
GGGCTTTAGCGTGTATTTCCCTAATAGCGTCTATCCCATGCTGCCTTTGAGTTTGTCTCAAGGGGCATGCTCATTAAAAG
CGTTTGAAAAACGCCTGGCTTTAGTGTATGAAATCCCTTTAGATAATTTGAAAAACGCCCGATTGTTTCAAGGCGTTATT
GAAGTTAGGGCTAATTGCACTTATGAAGAAATCAATCATTTTTTAAGCACCCAACAAAGCTCTTTAGATAAAGATTTGCA
GCAAAGCCTTTTGGGGTTTTTAGAGGTGGCTTTAAAGTTAAAAAAGGAGCGTTTAAAAAAGGGGTTTAATTTCAATTCCT
TTGAAAACAAGCTGTATTTGAATGAAGAAGGGCGTATAGAAAAAATTGAAACGCAACAAGAAAGCGATGCGCACACCCTT
ATAGAAGAAGCCATGCTCTTAGCCAACCAATCTAGCGCGAGGTTATTAGATGAGCATTTTCACAATAAGGGGATATACCG
CACCCACAAAGAGCCAAGTTTGGAGCAGCAAAAACGCCTCTATGCCAAGTTTTTTGATTATGAGATTGTGCGCCCTAAAA
ACATGGGCTTTTTTCCTTTTTTAGAGCATGCTTTAAAGATAGCCAAAGAAAAGAGTATAGAAAGAGAAGTTTCACGCCTA
ATCATTAAGTCTCAAAATTTAGCCCTTTATAGCCCCATGCAAGAAAGCCATTTTGGTTTGGGGTTTATTAGCTATACGCA
TTTCACTTCGCCCATTAGACGATACAGCGATTTAGCCTTACACAGGCTTTTAAAAGAATTGTTGTTCCATCAAGCTAAAG
GCTGCTCGTATCTGTTAGAAGAAACGCCTGAGTTATGCGCTGAGTTGAACGCTTTACAAAAAAAGGCCGCTTTGATTGAA
AGGGATTTTGTCAAACGCAAGTTCGCTCGCTTAGCTTTAGAACTTTTAGAAAAAGAATTTTTGGGCGTTGTTTTGGAGGT
TAAAGATTGGGTGGTGGTGGGGCTAAAAGAATTTATAGGGCTTAAAGTTTTAGTCAAAACGAACAAGGTTTTTAAGCCTT
TAGAAAAAGTGCGCGTTACAATCACGCATGCGGATTTGATTTTAGGGCAAGTTAGAGGCGAAATCACAGAAAGGATTAAA
GAGCATGTATCGTAA

Upstream 100 bases:

>100_bases
AAGACATGCTCATCTATCAAGCCTCTTTAAGTTTTGAAAAATTCAGCGCTTCTCAAATCCCTTATTCAAAGGCGTTTGAA
GTCATGCGAAGTGTTTTTTG

Downstream 100 bases:

>100_bases
AGATTTGGACCATTATTTAAAACAACGACTCCCTAAAGCGGTGTTTTTGTATGGGGAGTTTGATTTTTTTATCCATTATT
ATATTCAAACGATTAGCGCG

Product: 3'-5' exoribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MQGFLRSLFFGVKKIPKPFAPLIEKGVLKEALELKKDRYFLKEGFDIGRIEWAENKAFFVSLAKNYPKDPLIKNLPPSFK
TDALILCQIECSKKRPKAFFKAALLNADHTMIAYLAKKNHQIVAIPFKEPFKKPILLKHSQRSLLELPRHCVVKIDLKKR
EISEILGPLEDPLIDENLSLSLFDRVKDFSKDCLNLAQHYAQLKASDFKDRINYSHIPFITIDPKDAKDFDDAIFYDQEK
RVLFVAVADVSEFVPKHSSLDKEARVRGFSVYFPNSVYPMLPLSLSQGACSLKAFEKRLALVYEIPLDNLKNARLFQGVI
EVRANCTYEEINHFLSTQQSSLDKDLQQSLLGFLEVALKLKKERLKKGFNFNSFENKLYLNEEGRIEKIETQQESDAHTL
IEEAMLLANQSSARLLDEHFHNKGIYRTHKEPSLEQQKRLYAKFFDYEIVRPKNMGFFPFLEHALKIAKEKSIEREVSRL
IIKSQNLALYSPMQESHFGLGFISYTHFTSPIRRYSDLALHRLLKELLFHQAKGCSYLLEETPELCAELNALQKKAALIE
RDFVKRKFARLALELLEKEFLGVVLEVKDWVVVGLKEFIGLKVLVKTNKVFKPLEKVRVTITHADLILGQVRGEITERIK
EHVS

Sequences:

>Translated_644_residues
MQGFLRSLFFGVKKIPKPFAPLIEKGVLKEALELKKDRYFLKEGFDIGRIEWAENKAFFVSLAKNYPKDPLIKNLPPSFK
TDALILCQIECSKKRPKAFFKAALLNADHTMIAYLAKKNHQIVAIPFKEPFKKPILLKHSQRSLLELPRHCVVKIDLKKR
EISEILGPLEDPLIDENLSLSLFDRVKDFSKDCLNLAQHYAQLKASDFKDRINYSHIPFITIDPKDAKDFDDAIFYDQEK
RVLFVAVADVSEFVPKHSSLDKEARVRGFSVYFPNSVYPMLPLSLSQGACSLKAFEKRLALVYEIPLDNLKNARLFQGVI
EVRANCTYEEINHFLSTQQSSLDKDLQQSLLGFLEVALKLKKERLKKGFNFNSFENKLYLNEEGRIEKIETQQESDAHTL
IEEAMLLANQSSARLLDEHFHNKGIYRTHKEPSLEQQKRLYAKFFDYEIVRPKNMGFFPFLEHALKIAKEKSIEREVSRL
IIKSQNLALYSPMQESHFGLGFISYTHFTSPIRRYSDLALHRLLKELLFHQAKGCSYLLEETPELCAELNALQKKAALIE
RDFVKRKFARLALELLEKEFLGVVLEVKDWVVVGLKEFIGLKVLVKTNKVFKPLEKVRVTITHADLILGQVRGEITERIK
EHVS
>Mature_644_residues
MQGFLRSLFFGVKKIPKPFAPLIEKGVLKEALELKKDRYFLKEGFDIGRIEWAENKAFFVSLAKNYPKDPLIKNLPPSFK
TDALILCQIECSKKRPKAFFKAALLNADHTMIAYLAKKNHQIVAIPFKEPFKKPILLKHSQRSLLELPRHCVVKIDLKKR
EISEILGPLEDPLIDENLSLSLFDRVKDFSKDCLNLAQHYAQLKASDFKDRINYSHIPFITIDPKDAKDFDDAIFYDQEK
RVLFVAVADVSEFVPKHSSLDKEARVRGFSVYFPNSVYPMLPLSLSQGACSLKAFEKRLALVYEIPLDNLKNARLFQGVI
EVRANCTYEEINHFLSTQQSSLDKDLQQSLLGFLEVALKLKKERLKKGFNFNSFENKLYLNEEGRIEKIETQQESDAHTL
IEEAMLLANQSSARLLDEHFHNKGIYRTHKEPSLEQQKRLYAKFFDYEIVRPKNMGFFPFLEHALKIAKEKSIEREVSRL
IIKSQNLALYSPMQESHFGLGFISYTHFTSPIRRYSDLALHRLLKELLFHQAKGCSYLLEETPELCAELNALQKKAALIE
RDFVKRKFARLALELLEKEFLGVVLEVKDWVVVGLKEFIGLKVLVKTNKVFKPLEKVRVTITHADLILGQVRGEITERIK
EHVS

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=390, Percent_Identity=30, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI190014623, Length=390, Percent_Identity=30, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI219521928, Length=379, Percent_Identity=27.9683377308707, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI19115966, Length=379, Percent_Identity=27.9683377308707, Blast_Score=111, Evalue=3e-24,
Organism=Homo sapiens, GI134288890, Length=385, Percent_Identity=26.4935064935065, Blast_Score=110, Evalue=6e-24,
Organism=Escherichia coli, GI87082383, Length=400, Percent_Identity=35.75, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1787542, Length=374, Percent_Identity=27.807486631016, Blast_Score=123, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI212645896, Length=401, Percent_Identity=28.927680798005, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17553506, Length=409, Percent_Identity=28.1173594132029, Blast_Score=118, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324552, Length=434, Percent_Identity=27.1889400921659, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6323943, Length=442, Percent_Identity=25.3393665158371, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24649634, Length=428, Percent_Identity=28.5046728971963, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24654592, Length=424, Percent_Identity=26.4150943396226, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI19922976, Length=424, Percent_Identity=26.4150943396226, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24654597, Length=424, Percent_Identity=26.4150943396226, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR011805 [H]

Pfam domain/function: PF00773 RNB [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 74462; Mature: 74462

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGFLRSLFFGVKKIPKPFAPLIEKGVLKEALELKKDRYFLKEGFDIGRIEWAENKAFFV
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEE
SLAKNYPKDPLIKNLPPSFKTDALILCQIECSKKRPKAFFKAALLNADHTMIAYLAKKNH
EEHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHCCCC
QIVAIPFKEPFKKPILLKHSQRSLLELPRHCVVKIDLKKREISEILGPLEDPLIDENLSL
EEEEEECCCCCCCCCEEECCHHHHHHCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCH
SLFDRVKDFSKDCLNLAQHYAQLKASDFKDRINYSHIPFITIDPKDAKDFDDAIFYDQEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHEECCCC
RVLFVAVADVSEFVPKHSSLDKEARVRGFSVYFPNSVYPMLPLSLSQGACSLKAFEKRLA
CEEEEEEHHHHHHCCCCCCCCHHHHHCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
LVYEIPLDNLKNARLFQGVIEVRANCTYEEINHFLSTQQSSLDKDLQQSLLGFLEVALKL
EEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKERLKKGFNFNSFENKLYLNEEGRIEKIETQQESDAHTLIEEAMLLANQSSARLLDEHF
HHHHHHCCCCCCCCCCEEEECCCCCEEHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
HNKGIYRTHKEPSLEQQKRLYAKFFDYEIVRPKNMGFFPFLEHALKIAKEKSIEREVSRL
CCCCCEECCCCCCHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IIKSQNLALYSPMQESHFGLGFISYTHFTSPIRRYSDLALHRLLKELLFHQAKGCSYLLE
HHHCCCCEEECCCHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
ETPELCAELNALQKKAALIERDFVKRKFARLALELLEKEFLGVVLEVKDWVVVGLKEFIG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LKVLVKTNKVFKPLEKVRVTITHADLILGQVRGEITERIKEHVS
EEEEEECCHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQGFLRSLFFGVKKIPKPFAPLIEKGVLKEALELKKDRYFLKEGFDIGRIEWAENKAFFV
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEE
SLAKNYPKDPLIKNLPPSFKTDALILCQIECSKKRPKAFFKAALLNADHTMIAYLAKKNH
EEHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHCCCC
QIVAIPFKEPFKKPILLKHSQRSLLELPRHCVVKIDLKKREISEILGPLEDPLIDENLSL
EEEEEECCCCCCCCCEEECCHHHHHHCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCH
SLFDRVKDFSKDCLNLAQHYAQLKASDFKDRINYSHIPFITIDPKDAKDFDDAIFYDQEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHEECCCC
RVLFVAVADVSEFVPKHSSLDKEARVRGFSVYFPNSVYPMLPLSLSQGACSLKAFEKRLA
CEEEEEEHHHHHHCCCCCCCCHHHHHCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
LVYEIPLDNLKNARLFQGVIEVRANCTYEEINHFLSTQQSSLDKDLQQSLLGFLEVALKL
EEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKERLKKGFNFNSFENKLYLNEEGRIEKIETQQESDAHTLIEEAMLLANQSSARLLDEHF
HHHHHHCCCCCCCCCCEEEECCCCCEEHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
HNKGIYRTHKEPSLEQQKRLYAKFFDYEIVRPKNMGFFPFLEHALKIAKEKSIEREVSRL
CCCCCEECCCCCCHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IIKSQNLALYSPMQESHFGLGFISYTHFTSPIRRYSDLALHRLLKELLFHQAKGCSYLLE
HHHCCCCEEECCCHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
ETPELCAELNALQKKAALIERDFVKRKFARLALELLEKEFLGVVLEVKDWVVVGLKEFIG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LKVLVKTNKVFKPLEKVRVTITHADLILGQVRGEITERIKEHVS
EEEEEECCHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]