Click here to switch to the map view.

The map label for this gene is aroE [H]

Identifier: 108563617

GI number: 108563617

Start: 1257265

End: 1258056

Strand: Reverse

Name: aroE [H]

Synonym: HPAG1_1192

Alternate gene names: 108563617

Gene position: 1258056-1257265 (Counterclockwise)

Preceding gene: 108563618

Following gene: 108563616

Centisome position: 78.81

GC content: 40.53

Gene sequence:

>792_bases
ATGAAATTAAAATCTTTTGGGGTTTTGGGAAATCCCATTAAGCATTCCAAATCGCCCTTAATCCATAACGCTTGTTTTTT
AACTTTTCAAAAAAAATTAGGGTTTTTGGGGCATTACCACCCCATATTACTCCCTTTAGAAAGCCATATCAAAAACGAGT
TCTTGCATTTAGGATTGAGTGGGGCTAATGTAACCTTACCCTTTAAAGAAAGGGCGTTTCAAATTTGCGATAAGATCAAA
GGTATCGCACTTGAATGCGGAGCGGTCAATACGCTTGTTTTGGAAGATGATGAGCTTGTGGGTTACAATACCGACGCTTT
AGGTTTCTGGCTCTCTTTGGGAGATGAGGGCTACCAGAGCGCTCTGATTTTAGGCTCTGGGGGGAGCGCTAAGGCTTTAG
CGTGCGAATTGAAAAAACAAGGCTTGAAAGTGAGCGTGTTGAACCGCTCTGCTAGGGGATTGGATTTTTTCCAACGCTTG
GGTTGTGATTGTTTCATGGAGCCTCCTAAAAGCGCTTTTGATTTAATTATTAACGCTACTTCAGCGAGTTTGAATAACGA
ATTGCCTTTGAATAAAGAGGTTTTGAAAGGGTATTTTAAAGAGGGCAAACTCGCTTATGATTTGGCGTATGGGTTTTTAA
CGCCCTTTTTGTCTCTAGCCAAAGAGTTAAAAACCCCTTTTCAAGATGGGAAAGACATGCTCATCTATCAAGCCTCTTTA
AGTTTTGAAAAATTCAGCGCTTCTCAAATCCCTTATTCAAAGGCGTTTGAAGTCATGCGAAGTGTTTTTTGA

Upstream 100 bases:

>100_bases
GTTTTAGAAATCCAAAACGATTGGGCTAAAATTGAATTTTCTAATAAAACAAAGGGCTATGTGTTTTTAAAACTTTTAAA
AAAGGCTGAATGAAAGAATA

Downstream 100 bases:

>100_bases
TGCAAGGGTTTTTAAGAAGCCTGTTTTTTGGGGTTAAAAAGATCCCTAAACCATTCGCTCCTCTAATAGAAAAGGGCGTT
TTAAAAGAAGCGCTTGAATT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MKLKSFGVLGNPIKHSKSPLIHNACFLTFQKKLGFLGHYHPILLPLESHIKNEFLHLGLSGANVTLPFKERAFQICDKIK
GIALECGAVNTLVLEDDELVGYNTDALGFWLSLGDEGYQSALILGSGGSAKALACELKKQGLKVSVLNRSARGLDFFQRL
GCDCFMEPPKSAFDLIINATSASLNNELPLNKEVLKGYFKEGKLAYDLAYGFLTPFLSLAKELKTPFQDGKDMLIYQASL
SFEKFSASQIPYSKAFEVMRSVF

Sequences:

>Translated_263_residues
MKLKSFGVLGNPIKHSKSPLIHNACFLTFQKKLGFLGHYHPILLPLESHIKNEFLHLGLSGANVTLPFKERAFQICDKIK
GIALECGAVNTLVLEDDELVGYNTDALGFWLSLGDEGYQSALILGSGGSAKALACELKKQGLKVSVLNRSARGLDFFQRL
GCDCFMEPPKSAFDLIINATSASLNNELPLNKEVLKGYFKEGKLAYDLAYGFLTPFLSLAKELKTPFQDGKDMLIYQASL
SFEKFSASQIPYSKAFEVMRSVF
>Mature_263_residues
MKLKSFGVLGNPIKHSKSPLIHNACFLTFQKKLGFLGHYHPILLPLESHIKNEFLHLGLSGANVTLPFKERAFQICDKIK
GIALECGAVNTLVLEDDELVGYNTDALGFWLSLGDEGYQSALILGSGGSAKALACELKKQGLKVSVLNRSARGLDFFQRL
GCDCFMEPPKSAFDLIINATSASLNNELPLNKEVLKGYFKEGKLAYDLAYGFLTPFLSLAKELKTPFQDGKDMLIYQASL
SFEKFSASQIPYSKAFEVMRSVF

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789675, Length=257, Percent_Identity=33.852140077821, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787983, Length=287, Percent_Identity=26.8292682926829, Blast_Score=78, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320332, Length=287, Percent_Identity=25.4355400696864, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 29030; Mature: 29030

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKSFGVLGNPIKHSKSPLIHNACFLTFQKKLGFLGHYHPILLPLESHIKNEFLHLGLS
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHEEECC
GANVTLPFKERAFQICDKIKGIALECGAVNTLVLEDDELVGYNTDALGFWLSLGDEGYQS
CCEEEECHHHHHHHHHHHHCCEEEECCCEEEEEEECCCEECCCCHHHEEEEECCCCCCCE
ALILGSGGSAKALACELKKQGLKVSVLNRSARGLDFFQRLGCDCFMEPPKSAFDLIINAT
EEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHCCCCEECCCCCHHHHEEEECC
SASLNNELPLNKEVLKGYFKEGKLAYDLAYGFLTPFLSLAKELKTPFQDGKDMLIYQASL
CCCCCCCCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCHHCCCCCEEEEEECC
SFEKFSASQIPYSKAFEVMRSVF
CHHHHCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKLKSFGVLGNPIKHSKSPLIHNACFLTFQKKLGFLGHYHPILLPLESHIKNEFLHLGLS
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHEEECC
GANVTLPFKERAFQICDKIKGIALECGAVNTLVLEDDELVGYNTDALGFWLSLGDEGYQS
CCEEEECHHHHHHHHHHHHCCEEEECCCEEEEEEECCCEECCCCHHHEEEEECCCCCCCE
ALILGSGGSAKALACELKKQGLKVSVLNRSARGLDFFQRLGCDCFMEPPKSAFDLIINAT
EEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHCCCCEECCCCCHHHHEEEECC
SASLNNELPLNKEVLKGYFKEGKLAYDLAYGFLTPFLSLAKELKTPFQDGKDMLIYQASL
CCCCCCCCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCHHCCCCCEEEEEECC
SFEKFSASQIPYSKAFEVMRSVF
CHHHHCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]