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The map label for this gene is thrB [H]

Identifier: 108562822

GI number: 108562822

Start: 405517

End: 406398

Strand: Direct

Name: thrB [H]

Synonym: HPAG1_0397

Alternate gene names: 108562822

Gene position: 405517-406398 (Clockwise)

Preceding gene: 108562821

Following gene: 108562823

Centisome position: 25.4

GC content: 41.27

Gene sequence:

>882_bases
TTGGTAGTGAGTGTTCCTGCAACAAGTGCGAATTTAGGCCCCGGTTTTGATTGCTTGGGTTTGAGCTTGAATTTACGCAA
TCATTTTTTTATTGAGCCTAGCAGCTTCCATGCGGTGAAATTGGTTGGGGAGGGTGAGGGGATCCCTAAGTTTTTAACCA
ACAATATTTTCACTAAAGTGTTTTATGAGATTTTAAAAAAGCATGGGAATGACGGATCATTTAAATTTTTATTGCATAAT
AAAGTTCCTATTACAAGGGGCATGGGGTCTAGCTCGGCGATGATTGTGGGGGCGGTCGCTTCAGCGTTTGCGTTTTTAGG
GTTTGATTTTGATAGAGAAAATATTGTCAATACCGCTTTAATTTATGAAAACCACCCGGATAATATCACCCCGGCGGTGT
TTGGGGGGTATAATGCAGCGTTTGTGGAAAAAAAGAAAGTGATAAGTTTAAAAACCAAAATCCCTTCTTTTTTAAAAGCG
GTGATGGTGATCCCTAATAGGGCCATTTCTACCAAGCAATCGCGCCATCTCTTGCCAAAGCGTTACAGCGTGCAAGAAAG
CGTATTTAACCTTTCGCATGCGAGTTTGATGACGATGGCGATTGTGCAGGGGAAGTGGGATTTATTGCGTTGTTGCTCTA
AAGACAGGATGCATCAATATAAGCGCATGCAAACTTACCCCGTGTTGTTTGCGATCCAAAAGATCGCTTTAGAAAATAAC
GCCCTAATGAGCACGCTTTCAGGGAGCGGTTCATCGTTTTTTAACATGTGTTATGAAGAAGACGCCCCTAAATTAAAGCA
GGTTTTGAGCAAGAAATTCCCTAAATTTAGGGTAGCGGTTTTAGATTTTGATAATGATGGGGTTCTTATTGAGAAAGACT
GA

Upstream 100 bases:

>100_bases
AATTCACCCAATTGAACACGCCGTTTTACATTTTGCCTCCTATTTAGTGTATAATGCTAGTTTTAAAAATGAAAGGGTAT
CAACAATAGGGGTTTAAAAT

Downstream 100 bases:

>100_bases
AATTAAAATCCGCATGTGTGTGGCGTGCAGAATGCGCCAACCTCAAAAGGATTTGTTGCGTTTGAAAAGCTTTGAAAATC
AAATCATGGAGTTTGATGGC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MVVSVPATSANLGPGFDCLGLSLNLRNHFFIEPSSFHAVKLVGEGEGIPKFLTNNIFTKVFYEILKKHGNDGSFKFLLHN
KVPITRGMGSSSAMIVGAVASAFAFLGFDFDRENIVNTALIYENHPDNITPAVFGGYNAAFVEKKKVISLKTKIPSFLKA
VMVIPNRAISTKQSRHLLPKRYSVQESVFNLSHASLMTMAIVQGKWDLLRCCSKDRMHQYKRMQTYPVLFAIQKIALENN
ALMSTLSGSGSSFFNMCYEEDAPKLKQVLSKKFPKFRVAVLDFDNDGVLIEKD

Sequences:

>Translated_293_residues
MVVSVPATSANLGPGFDCLGLSLNLRNHFFIEPSSFHAVKLVGEGEGIPKFLTNNIFTKVFYEILKKHGNDGSFKFLLHN
KVPITRGMGSSSAMIVGAVASAFAFLGFDFDRENIVNTALIYENHPDNITPAVFGGYNAAFVEKKKVISLKTKIPSFLKA
VMVIPNRAISTKQSRHLLPKRYSVQESVFNLSHASLMTMAIVQGKWDLLRCCSKDRMHQYKRMQTYPVLFAIQKIALENN
ALMSTLSGSGSSFFNMCYEEDAPKLKQVLSKKFPKFRVAVLDFDNDGVLIEKD
>Mature_293_residues
MVVSVPATSANLGPGFDCLGLSLNLRNHFFIEPSSFHAVKLVGEGEGIPKFLTNNIFTKVFYEILKKHGNDGSFKFLLHN
KVPITRGMGSSSAMIVGAVASAFAFLGFDFDRENIVNTALIYENHPDNITPAVFGGYNAAFVEKKKVISLKTKIPSFLKA
VMVIPNRAISTKQSRHLLPKRYSVQESVFNLSHASLMTMAIVQGKWDLLRCCSKDRMHQYKRMQTYPVLFAIQKIALENN
ALMSTLSGSGSSFFNMCYEEDAPKLKQVLSKKFPKFRVAVLDFDNDGVLIEKD

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=287, Percent_Identity=24.0418118466899, Blast_Score=82, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321814, Length=351, Percent_Identity=26.4957264957265, Blast_Score=108, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 32644; Mature: 32644

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS00627 GHMP_KINASES_ATP ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVSVPATSANLGPGFDCLGLSLNLRNHFFIEPSSFHAVKLVGEGEGIPKFLTNNIFTKV
CEEECCCCCCCCCCCCEEEEEEEECCCEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHH
FYEILKKHGNDGSFKFLLHNKVPITRGMGSSSAMIVGAVASAFAFLGFDFDRENIVNTAL
HHHHHHHHCCCCCEEEEEECCCCEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCEEEE
IYENHPDNITPAVFGGYNAAFVEKKKVISLKTKIPSFLKAVMVIPNRAISTKQSRHLLPK
EEECCCCCCCCCEECCCCEEEECHHHEEEHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCC
RYSVQESVFNLSHASLMTMAIVQGKWDLLRCCSKDRMHQYKRMQTYPVLFAIQKIALENN
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
ALMSTLSGSGSSFFNMCYEEDAPKLKQVLSKKFPKFRVAVLDFDNDGVLIEKD
HHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCCCEEEECC
>Mature Secondary Structure
MVVSVPATSANLGPGFDCLGLSLNLRNHFFIEPSSFHAVKLVGEGEGIPKFLTNNIFTKV
CEEECCCCCCCCCCCCEEEEEEEECCCEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHH
FYEILKKHGNDGSFKFLLHNKVPITRGMGSSSAMIVGAVASAFAFLGFDFDRENIVNTAL
HHHHHHHHCCCCCEEEEEECCCCEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCEEEE
IYENHPDNITPAVFGGYNAAFVEKKKVISLKTKIPSFLKAVMVIPNRAISTKQSRHLLPK
EEECCCCCCCCCEECCCCEEEECHHHEEEHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCC
RYSVQESVFNLSHASLMTMAIVQGKWDLLRCCSKDRMHQYKRMQTYPVLFAIQKIALENN
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
ALMSTLSGSGSSFFNMCYEEDAPKLKQVLSKKFPKFRVAVLDFDNDGVLIEKD
HHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]