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The map label for this gene is merA [H]

Identifier: 103488178

GI number: 103488178

Start: 2842851

End: 2845004

Strand: Reverse

Name: merA [H]

Synonym: Sala_2701

Alternate gene names: 103488178

Gene position: 2845004-2842851 (Counterclockwise)

Preceding gene: 103488179

Following gene: 103488177

Centisome position: 85.05

GC content: 64.9

Gene sequence:

>2154_bases
ATGAACAAACGTCTCATCCTGCTGCTGCTTGTCGCGCTGGCATTTGGTGCATGGGTGTATTTCGACCTCGGCGACTGGCT
GACCCTCGAGGCGCTGAAATCGCAGCAGGCGGCGATCGACGGCTATTTTCGCGCCAATCCGCTGCTCGTGGCGGGACTGT
TTTTCGTCGTCTATGTGGTGTTGACGGCGCTCTCGGTTCCCGGCGCGGCGATATTGACGCTCGCGGCGGGGGCGATCTTC
GGCCTCTACTGGGGAACGCTGATCGTCTCCTTTGCCTCGACGATCGGCGCGACCTTCGCGTTCCTCGCCTCGCGCTATCT
CTTCCGCGACGCCGTGCAGGCGCGCTTCGGCGACCGGTTGCGGCGCGTCAATGATGGCATCGCGCGCGACGGTGCCTTCT
ATCTGTTCTCGCTGCGGCTCGTTCCGGTATTTCCTTTCTTCGCGGTCAATCTGCTGATGGGGCTGACGCCGATCCGCACC
GTCACCTATTTCTGGGTCAGCCAGCTCGGCATGTTCCTCGGGACCGTCATCTATGTGAATGCAGGCACCCAGCTTGCGCG
CATCGATGCGCTGTCCGACATCGCTTCGCCGGGGCTGCTCGCTTCCTTCGCCGCGCTCGGCCTGCTGCCCTGGCTCGGCA
AATGGATCATGGCGGCGATCAAGCGCCGCCGTGTATATGGGCGTTTCCGCCGCCCGCGCCGCTACGATCGCAATCTCGTC
GTGATCGGCGCCGGGGCGGCGGGACTGGTATCCTCCTATATCGCCGCGACGGTGAAGGCGAAGGTGACGCTCGTCGAGGC
CTCGAAAATGGGCGGCGATTGCCTCAACTATGGCTGCGTGCCGTCAAAGGCGCTGATCAAGTCGGCCCGCATTGCGGAGC
AGATGCGACATGCGGATCGCTACGGACTTGTCGCCGCATCGCCCCAGATTCGCTTCCGCTCGGTGATGCAGCGCATCCAC
GACATCATCGCCGCGATCGAGCCGCACGACAGCGTCGAGCGCTATACCGAGCTTGGGGTCGATGTGGTGCAAGGCTATGC
CCGTATCGTCGATCCCTGGACGGTCGAAATCGCGCGCAACGACGGCGAAGTCCAGCGGCTCACGACCCGCGCGATCGTCG
TCGCGGCGGGCGCCGAGCCGGTCGTCCCCGACCTGCCGGGGCTAGCGGAGTCGGGGTATCTGACCAGCGATACGCTGTGG
GAGGCATTTGCGGCGCGCGACACGATGCCGCAGCGCATCGTCATCCTGGGCGGCGGACCGATCGGATCGGAACTGTCGCA
GGCTTTCGCGCGGCTCGGTGCCGATGTCGCGCAGATCGAACGCGGTGATCGCCTGCTGCCACGCGAGGATGATGAGGTGT
CCGAACTGGCGCGCGATGCGCTGGAAAACGCCGGAGTCGAAGTCCTGACCGGGCACGAAGCGCTGCGCGTGGAAGGGATC
GAGGCTGACCGGCGGCTGATTGTCCGCCACGCCGGCGGCGAGCGCGCGATCGCCTTCGACGCGCTGATCGTCGCGGTCGG
GCGCAAGGCACGCCTGACCGGCTATGGGCTCGAGGATCTTGGCATCGAAACGCAGCGCACGGTCGTGACCGACGAATATC
TCGCAACCGTTTATCCCAATATCTATGCTGCGGGCGACGTCGCCGGACCCTATCAGTTCACGCACAGCGCGGCGCACCAG
GCCTGGTATGCCAGCGTCAACGCGCTCTTCGGCCAGTTCCGACGTTTCAAGGCCGACTATCGTGTGATCCCCTGGACAAC
TTTCATCGACCCAGAGGTCGCGCGGGTCGGGCTCAGCGAGGCCGAGGCGGTCGAGAAGGGCGTGGCGTTCGAGGTCACGC
GCTACCCGCTCCACGACCTCGACCGTGCGATTGCGGACTCGGCGACGACGGGCTTCGTCAAGGTCCTGACCCCGCCCGGC
AAGGACCGCATCCTCGGCGTGACGATCGTCGGCGAACATGCCGGCGAACTGCTCGCCGAATATGTGCTTGCCATGAAGCA
TGGTCTCGGTCTCGGAAAGATCCTCGGCACCATCCACACCTATCCGACGATGGCCGAGGCGAACAAATATGCCGCAGGCG
AATGGAAGCGGGCGCATGCGCCCGAACGCCTGCTCAAGCTGGTCGGGCGTTATCACGACTGGCGACGCGGATAA

Upstream 100 bases:

>100_bases
CGCGAAGCGCCTCGCGGCGAAAGAGGACGGTCATGGCGTGTAAGCTTTTGCCGTCTCGCGCGACCAATCTCGCTAAAGGC
CTCCCGCCGGAAGGAAGTTC

Downstream 100 bases:

>100_bases
GGCAATTTGCCGGCCGTTTATTGTAACCAACGGGTGCATTGCCGCGAATCCACCTGTTCAATCAGCATTTCAGGGAGTCC
AGATATGAAGGCGCAGTCGC

Product: pyridine nucleotide-disulphide oxidoreductase dimerisation region

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 717; Mature: 717

Protein sequence:

>717_residues
MNKRLILLLLVALAFGAWVYFDLGDWLTLEALKSQQAAIDGYFRANPLLVAGLFFVVYVVLTALSVPGAAILTLAAGAIF
GLYWGTLIVSFASTIGATFAFLASRYLFRDAVQARFGDRLRRVNDGIARDGAFYLFSLRLVPVFPFFAVNLLMGLTPIRT
VTYFWVSQLGMFLGTVIYVNAGTQLARIDALSDIASPGLLASFAALGLLPWLGKWIMAAIKRRRVYGRFRRPRRYDRNLV
VIGAGAAGLVSSYIAATVKAKVTLVEASKMGGDCLNYGCVPSKALIKSARIAEQMRHADRYGLVAASPQIRFRSVMQRIH
DIIAAIEPHDSVERYTELGVDVVQGYARIVDPWTVEIARNDGEVQRLTTRAIVVAAGAEPVVPDLPGLAESGYLTSDTLW
EAFAARDTMPQRIVILGGGPIGSELSQAFARLGADVAQIERGDRLLPREDDEVSELARDALENAGVEVLTGHEALRVEGI
EADRRLIVRHAGGERAIAFDALIVAVGRKARLTGYGLEDLGIETQRTVVTDEYLATVYPNIYAAGDVAGPYQFTHSAAHQ
AWYASVNALFGQFRRFKADYRVIPWTTFIDPEVARVGLSEAEAVEKGVAFEVTRYPLHDLDRAIADSATTGFVKVLTPPG
KDRILGVTIVGEHAGELLAEYVLAMKHGLGLGKILGTIHTYPTMAEANKYAAGEWKRAHAPERLLKLVGRYHDWRRG

Sequences:

>Translated_717_residues
MNKRLILLLLVALAFGAWVYFDLGDWLTLEALKSQQAAIDGYFRANPLLVAGLFFVVYVVLTALSVPGAAILTLAAGAIF
GLYWGTLIVSFASTIGATFAFLASRYLFRDAVQARFGDRLRRVNDGIARDGAFYLFSLRLVPVFPFFAVNLLMGLTPIRT
VTYFWVSQLGMFLGTVIYVNAGTQLARIDALSDIASPGLLASFAALGLLPWLGKWIMAAIKRRRVYGRFRRPRRYDRNLV
VIGAGAAGLVSSYIAATVKAKVTLVEASKMGGDCLNYGCVPSKALIKSARIAEQMRHADRYGLVAASPQIRFRSVMQRIH
DIIAAIEPHDSVERYTELGVDVVQGYARIVDPWTVEIARNDGEVQRLTTRAIVVAAGAEPVVPDLPGLAESGYLTSDTLW
EAFAARDTMPQRIVILGGGPIGSELSQAFARLGADVAQIERGDRLLPREDDEVSELARDALENAGVEVLTGHEALRVEGI
EADRRLIVRHAGGERAIAFDALIVAVGRKARLTGYGLEDLGIETQRTVVTDEYLATVYPNIYAAGDVAGPYQFTHSAAHQ
AWYASVNALFGQFRRFKADYRVIPWTTFIDPEVARVGLSEAEAVEKGVAFEVTRYPLHDLDRAIADSATTGFVKVLTPPG
KDRILGVTIVGEHAGELLAEYVLAMKHGLGLGKILGTIHTYPTMAEANKYAAGEWKRAHAPERLLKLVGRYHDWRRG
>Mature_717_residues
MNKRLILLLLVALAFGAWVYFDLGDWLTLEALKSQQAAIDGYFRANPLLVAGLFFVVYVVLTALSVPGAAILTLAAGAIF
GLYWGTLIVSFASTIGATFAFLASRYLFRDAVQARFGDRLRRVNDGIARDGAFYLFSLRLVPVFPFFAVNLLMGLTPIRT
VTYFWVSQLGMFLGTVIYVNAGTQLARIDALSDIASPGLLASFAALGLLPWLGKWIMAAIKRRRVYGRFRRPRRYDRNLV
VIGAGAAGLVSSYIAATVKAKVTLVEASKMGGDCLNYGCVPSKALIKSARIAEQMRHADRYGLVAASPQIRFRSVMQRIH
DIIAAIEPHDSVERYTELGVDVVQGYARIVDPWTVEIARNDGEVQRLTTRAIVVAAGAEPVVPDLPGLAESGYLTSDTLW
EAFAARDTMPQRIVILGGGPIGSELSQAFARLGADVAQIERGDRLLPREDDEVSELARDALENAGVEVLTGHEALRVEGI
EADRRLIVRHAGGERAIAFDALIVAVGRKARLTGYGLEDLGIETQRTVVTDEYLATVYPNIYAAGDVAGPYQFTHSAAHQ
AWYASVNALFGQFRRFKADYRVIPWTTFIDPEVARVGLSEAEAVEKGVAFEVTRYPLHDLDRAIADSATTGFVKVLTPPG
KDRILGVTIVGEHAGELLAEYVLAMKHGLGLGKILGTIHTYPTMAEANKYAAGEWKRAHAPERLLKLVGRYHDWRRG

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=466, Percent_Identity=30.2575107296137, Blast_Score=187, Evalue=3e-47,
Organism=Homo sapiens, GI50301238, Length=468, Percent_Identity=28.8461538461538, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI33519430, Length=439, Percent_Identity=24.6013667425968, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI33519428, Length=439, Percent_Identity=24.6013667425968, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI33519426, Length=439, Percent_Identity=24.6013667425968, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI148277065, Length=439, Percent_Identity=24.6013667425968, Blast_Score=109, Evalue=9e-24,
Organism=Homo sapiens, GI22035672, Length=434, Percent_Identity=26.4976958525346, Blast_Score=109, Evalue=9e-24,
Organism=Homo sapiens, GI148277071, Length=439, Percent_Identity=24.6013667425968, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI291045266, Length=436, Percent_Identity=25.2293577981651, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI291045268, Length=433, Percent_Identity=22.6327944572748, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1786307, Length=468, Percent_Identity=29.2735042735043, Blast_Score=178, Evalue=9e-46,
Organism=Escherichia coli, GI87081717, Length=452, Percent_Identity=27.4336283185841, Blast_Score=162, Evalue=9e-41,
Organism=Escherichia coli, GI87082354, Length=471, Percent_Identity=27.3885350318471, Blast_Score=147, Evalue=3e-36,
Organism=Escherichia coli, GI1789915, Length=446, Percent_Identity=28.2511210762332, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI87081964, Length=234, Percent_Identity=31.6239316239316, Blast_Score=77, Evalue=6e-15,
Organism=Escherichia coli, GI1789065, Length=178, Percent_Identity=32.5842696629214, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=463, Percent_Identity=30.8855291576674, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17557007, Length=493, Percent_Identity=25.7606490872211, Blast_Score=146, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71983419, Length=433, Percent_Identity=28.4064665127021, Blast_Score=116, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71983429, Length=433, Percent_Identity=28.4064665127021, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI71982272, Length=443, Percent_Identity=23.2505643340858, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17532687, Length=193, Percent_Identity=27.4611398963731, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325166, Length=473, Percent_Identity=30.4439746300211, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6321091, Length=500, Percent_Identity=28.8, Blast_Score=157, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6325240, Length=487, Percent_Identity=24.2299794661191, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21358499, Length=462, Percent_Identity=31.8181818181818, Blast_Score=207, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24640553, Length=475, Percent_Identity=28, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24640549, Length=475, Percent_Identity=28.2105263157895, Blast_Score=143, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24640551, Length=475, Percent_Identity=28.2105263157895, Blast_Score=142, Evalue=8e-34,
Organism=Drosophila melanogaster, GI17737741, Length=489, Percent_Identity=28.0163599182004, Blast_Score=140, Evalue=4e-33,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 78428; Mature: 78428

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKRLILLLLVALAFGAWVYFDLGDWLTLEALKSQQAAIDGYFRANPLLVAGLFFVVYVV
CCCHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHH
LTALSVPGAAILTLAAGAIFGLYWGTLIVSFASTIGATFAFLASRYLFRDAVQARFGDRL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRVNDGIARDGAFYLFSLRLVPVFPFFAVNLLMGLTPIRTVTYFWVSQLGMFLGTVIYVN
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEEEE
AGTQLARIDALSDIASPGLLASFAALGLLPWLGKWIMAAIKRRRVYGRFRRPRRYDRNLV
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCEE
VIGAGAAGLVSSYIAATVKAKVTLVEASKMGGDCLNYGCVPSKALIKSARIAEQMRHADR
EEECCHHHHHHHHHHHHHHHEEEEEEHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHH
YGLVAASPQIRFRSVMQRIHDIIAAIEPHDSVERYTELGVDVVQGYARIVDPWTVEIARN
CCEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
DGEVQRLTTRAIVVAAGAEPVVPDLPGLAESGYLTSDTLWEAFAARDTMPQRIVILGGGP
CCHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCC
IGSELSQAFARLGADVAQIERGDRLLPREDDEVSELARDALENAGVEVLTGHEALRVEGI
CCHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCEEEEECC
EADRRLIVRHAGGERAIAFDALIVAVGRKARLTGYGLEDLGIETQRTVVTDEYLATVYPN
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEECCCHHHCCCCCCCEEEHHHHHHHHCCC
IYAAGDVAGPYQFTHSAAHQAWYASVNALFGQFRRFKADYRVIPWTTFIDPEVARVGLSE
CEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECEEECCCHHHHHCCCHH
AEAVEKGVAFEVTRYPLHDLDRAIADSATTGFVKVLTPPGKDRILGVTIVGEHAGELLAE
HHHHHCCCEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEECHHHHHHHHH
YVLAMKHGLGLGKILGTIHTYPTMAEANKYAAGEWKRAHAPERLLKLVGRYHDWRRG
HHHHHHHCCCHHHHHHHHHCCCCHHHCCCCCCCCCHHCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNKRLILLLLVALAFGAWVYFDLGDWLTLEALKSQQAAIDGYFRANPLLVAGLFFVVYVV
CCCHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHH
LTALSVPGAAILTLAAGAIFGLYWGTLIVSFASTIGATFAFLASRYLFRDAVQARFGDRL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRVNDGIARDGAFYLFSLRLVPVFPFFAVNLLMGLTPIRTVTYFWVSQLGMFLGTVIYVN
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEEEE
AGTQLARIDALSDIASPGLLASFAALGLLPWLGKWIMAAIKRRRVYGRFRRPRRYDRNLV
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCEE
VIGAGAAGLVSSYIAATVKAKVTLVEASKMGGDCLNYGCVPSKALIKSARIAEQMRHADR
EEECCHHHHHHHHHHHHHHHEEEEEEHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHH
YGLVAASPQIRFRSVMQRIHDIIAAIEPHDSVERYTELGVDVVQGYARIVDPWTVEIARN
CCEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
DGEVQRLTTRAIVVAAGAEPVVPDLPGLAESGYLTSDTLWEAFAARDTMPQRIVILGGGP
CCHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCC
IGSELSQAFARLGADVAQIERGDRLLPREDDEVSELARDALENAGVEVLTGHEALRVEGI
CCHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCEEEEECC
EADRRLIVRHAGGERAIAFDALIVAVGRKARLTGYGLEDLGIETQRTVVTDEYLATVYPN
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEECCCHHHCCCCCCCEEEHHHHHHHHCCC
IYAAGDVAGPYQFTHSAAHQAWYASVNALFGQFRRFKADYRVIPWTTFIDPEVARVGLSE
CEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECEEECCCHHHHHCCCHH
AEAVEKGVAFEVTRYPLHDLDRAIADSATTGFVKVLTPPGKDRILGVTIVGEHAGELLAE
HHHHHCCCEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEECHHHHHHHHH
YVLAMKHGLGLGKILGTIHTYPTMAEANKYAAGEWKRAHAPERLLKLVGRYHDWRRG
HHHHHHHCCCHHHHHHHHHCCCCHHHCCCCCCCCCHHCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2067577 [H]