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The map label for this gene is fadA [H]

Identifier: 103487643

GI number: 103487643

Start: 2273025

End: 2274206

Strand: Direct

Name: fadA [H]

Synonym: Sala_2162

Alternate gene names: 103487643

Gene position: 2273025-2274206 (Clockwise)

Preceding gene: 103487642

Following gene: 103487644

Centisome position: 67.95

GC content: 65.23

Gene sequence:

>1182_bases
ATGCGTGACGCCGTTATCGTTTCCACCGCCCGCACCCCGCTGACCAAGGCGGCGCGCGGCTCGTTCAACAACACGCTCGC
CCCGACGCTGGGTTCTTTCTCGGTCAAGGCCGCGGTCGAGCGCGCCGGTCTGGAGGGCGGCGAGATCGACGACGTCGTGT
TCGGCGCCGCGATGCAGCAGGGGTCGCAGACGATGAACGTCGCGCGGCTGATCGCGCTGCGTTCGGGCCTGCCCGTCACC
GTCCCCGGCATGTCGATCGACCGTCAATGCTCGTCGGGCCTGATGACGATCGCGACCGCCGCGAAGCAGATCATCGTCGA
CCGTCAGGACATCTGCGTCGCCGGCGGCATCGAAAGCATCTCGAAAGTCAGCGGCAGCGGCAAGGTGTTCATCGAGACCG
ACGCCGAGCTGATCGCGATGCACAAGGACACTTATATGCCGATGATCGGCACCGCCGAGGTCGTCGCCAAGCGTTACAAC
ATCGGCCGCGAATATCAGGACGAATATTCGCTCCAGTCGCAGCAGCGCACCGCCGCCGCGCAGGCCGCGGGCAAATATGA
CGACGAGATCGTCGCCTGCAAGGCGACGATGGCGGTGATGGACAAGGAAACCAAGGAAGTCAGCTATAAGGAGGTCGTGG
CCGACAAGGACGAATGCAACCGTCCCGACACGACGCTCGAAGGGCTGGCGAGCCTGAAGCCGGTGATGGGCGAAGGCCAC
ACGATCACCGCGGGCAACGCCAGCCAGCTCGCCGATGGCTCGTCGGCGTGCGTCGTGATGGAAGCCAAGGTTGCCGAAAA
GCGCGGCCTCCAGCCGCTCGGCCGCTATGTCGGCATGGCGGTCGCCGGCACCGAGCCCGACGAAATGGGCATTGGCCCGG
TCTTCGCGATCCCCAAGCTGCTCGAACGCTTCGAATTGAAGATGGACGACATCGGCCTGTGGGAGCTCAACGAAGCCTTT
GCGGTGCAGGTGCTCTATTGCCGCGACAAGCTCGGTATTCCGAACGAGCTGCTCAACGTCAACGGCGGCTCGATCTCGAT
CGGCCACCCCTTCGGCATGACCGGCGCGCGCTGCGTCGGCCACGCGCTGATCGAAGGCAAGCGCCGCGGCGTGAAGTACG
CCGTCGTGACAATGTGCATCGGCGGCGGCCAGGGCGCGGCAGGCCTGTTCGAGGTCTTCTGA

Upstream 100 bases:

>100_bases
GGAAAAGCCCGCCCTGATCGCCGAATGGATCAGCCAGTTTTTCGTTTGAGCGCCCTCCCCGGCAAAGACCCGTTCAAATT
GACCAAGAAGGATTTTCATC

Downstream 100 bases:

>100_bases
TTTGCGCCTAGACCAACCGCGCATCGAGCCGGTCGATCTGGACCGGCTCGATGCCGACCAGCGCACCGCGCTAGACCCCT
TCCTCGCCAGCGATGGCGGC

Product: Acetyl-CoA C-acyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MRDAVIVSTARTPLTKAARGSFNNTLAPTLGSFSVKAAVERAGLEGGEIDDVVFGAAMQQGSQTMNVARLIALRSGLPVT
VPGMSIDRQCSSGLMTIATAAKQIIVDRQDICVAGGIESISKVSGSGKVFIETDAELIAMHKDTYMPMIGTAEVVAKRYN
IGREYQDEYSLQSQQRTAAAQAAGKYDDEIVACKATMAVMDKETKEVSYKEVVADKDECNRPDTTLEGLASLKPVMGEGH
TITAGNASQLADGSSACVVMEAKVAEKRGLQPLGRYVGMAVAGTEPDEMGIGPVFAIPKLLERFELKMDDIGLWELNEAF
AVQVLYCRDKLGIPNELLNVNGGSISIGHPFGMTGARCVGHALIEGKRRGVKYAVVTMCIGGGQGAAGLFEVF

Sequences:

>Translated_393_residues
MRDAVIVSTARTPLTKAARGSFNNTLAPTLGSFSVKAAVERAGLEGGEIDDVVFGAAMQQGSQTMNVARLIALRSGLPVT
VPGMSIDRQCSSGLMTIATAAKQIIVDRQDICVAGGIESISKVSGSGKVFIETDAELIAMHKDTYMPMIGTAEVVAKRYN
IGREYQDEYSLQSQQRTAAAQAAGKYDDEIVACKATMAVMDKETKEVSYKEVVADKDECNRPDTTLEGLASLKPVMGEGH
TITAGNASQLADGSSACVVMEAKVAEKRGLQPLGRYVGMAVAGTEPDEMGIGPVFAIPKLLERFELKMDDIGLWELNEAF
AVQVLYCRDKLGIPNELLNVNGGSISIGHPFGMTGARCVGHALIEGKRRGVKYAVVTMCIGGGQGAAGLFEVF
>Mature_393_residues
MRDAVIVSTARTPLTKAARGSFNNTLAPTLGSFSVKAAVERAGLEGGEIDDVVFGAAMQQGSQTMNVARLIALRSGLPVT
VPGMSIDRQCSSGLMTIATAAKQIIVDRQDICVAGGIESISKVSGSGKVFIETDAELIAMHKDTYMPMIGTAEVVAKRYN
IGREYQDEYSLQSQQRTAAAQAAGKYDDEIVACKATMAVMDKETKEVSYKEVVADKDECNRPDTTLEGLASLKPVMGEGH
TITAGNASQLADGSSACVVMEAKVAEKRGLQPLGRYVGMAVAGTEPDEMGIGPVFAIPKLLERFELKMDDIGLWELNEAF
AVQVLYCRDKLGIPNELLNVNGGSISIGHPFGMTGARCVGHALIEGKRRGVKYAVVTMCIGGGQGAAGLFEVF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=390, Percent_Identity=41.025641025641, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI167614485, Length=403, Percent_Identity=37.468982630273, Blast_Score=245, Evalue=6e-65,
Organism=Homo sapiens, GI4557237, Length=408, Percent_Identity=37.0098039215686, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI148539872, Length=400, Percent_Identity=36.25, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=32.5641025641026, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI4504327, Length=439, Percent_Identity=29.3849658314351, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI1787663, Length=413, Percent_Identity=39.9515738498789, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1788554, Length=410, Percent_Identity=39.5121951219512, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI48994986, Length=397, Percent_Identity=35.7682619647355, Blast_Score=230, Evalue=9e-62,
Organism=Escherichia coli, GI87082165, Length=402, Percent_Identity=36.5671641791045, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI1788683, Length=418, Percent_Identity=29.9043062200957, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI133906874, Length=392, Percent_Identity=37.5, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI25147385, Length=397, Percent_Identity=34.7607052896725, Blast_Score=200, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI17535921, Length=405, Percent_Identity=35.8024691358025, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=445, Percent_Identity=28.5393258426966, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=27.9898218829517, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6322031, Length=401, Percent_Identity=35.6608478802993, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6325229, Length=405, Percent_Identity=29.8765432098765, Blast_Score=152, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24655093, Length=403, Percent_Identity=37.9652605459057, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI17648125, Length=362, Percent_Identity=38.6740331491713, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24640423, Length=404, Percent_Identity=35.8910891089109, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI17137578, Length=438, Percent_Identity=29.9086757990868, Blast_Score=172, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41625; Mature: 41625

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDAVIVSTARTPLTKAARGSFNNTLAPTLGSFSVKAAVERAGLEGGEIDDVVFGAAMQQ
CCCCEEEECCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHC
GSQTMNVARLIALRSGLPVTVPGMSIDRQCSSGLMTIATAAKQIIVDRQDICVAGGIESI
CCHHHHHHHHHHHHCCCCEEECCCCCCHHHHCCHHHHHHHHHHHHCCCCCEEEECCHHHH
SKVSGSGKVFIETDAELIAMHKDTYMPMIGTAEVVAKRYNIGREYQDEYSLQSQQRTAAA
HHCCCCCEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QAAGKYDDEIVACKATMAVMDKETKEVSYKEVVADKDECNRPDTTLEGLASLKPVMGEGH
HHCCCCCCCEEEHHHHHHHHCCHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHCHHCCCCC
TITAGNASQLADGSSACVVMEAKVAEKRGLQPLGRYVGMAVAGTEPDEMGIGPVFAIPKL
EEECCCHHHCCCCCCEEEEEEEHHHHHCCCCHHHHHHCEEEECCCCHHCCCCHHHHHHHH
LERFELKMDDIGLWELNEAFAVQVLYCRDKLGIPNELLNVNGGSISIGHPFGMTGARCVG
HHHHCCCCCCCCEEECCHHHEEEEEEECCCCCCCHHHEECCCCEEEECCCCCCCHHHHHH
HALIEGKRRGVKYAVVTMCIGGGQGAAGLFEVF
HHHHHHHHCCCEEEEEEEEECCCCCCCCHHCCC
>Mature Secondary Structure
MRDAVIVSTARTPLTKAARGSFNNTLAPTLGSFSVKAAVERAGLEGGEIDDVVFGAAMQQ
CCCCEEEECCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHC
GSQTMNVARLIALRSGLPVTVPGMSIDRQCSSGLMTIATAAKQIIVDRQDICVAGGIESI
CCHHHHHHHHHHHHCCCCEEECCCCCCHHHHCCHHHHHHHHHHHHCCCCCEEEECCHHHH
SKVSGSGKVFIETDAELIAMHKDTYMPMIGTAEVVAKRYNIGREYQDEYSLQSQQRTAAA
HHCCCCCEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QAAGKYDDEIVACKATMAVMDKETKEVSYKEVVADKDECNRPDTTLEGLASLKPVMGEGH
HHCCCCCCCEEEHHHHHHHHCCHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHCHHCCCCC
TITAGNASQLADGSSACVVMEAKVAEKRGLQPLGRYVGMAVAGTEPDEMGIGPVFAIPKL
EEECCCHHHCCCCCCEEEEEEEHHHHHCCCCHHHHHHCEEEECCCCHHCCCCHHHHHHHH
LERFELKMDDIGLWELNEAFAVQVLYCRDKLGIPNELLNVNGGSISIGHPFGMTGARCVG
HHHHCCCCCCCCEEECCHHHEEEEEEECCCCCCCHHHEECCCCEEEECCCCCCCHHHHHH
HALIEGKRRGVKYAVVTMCIGGGQGAAGLFEVF
HHHHHHHHCCCEEEEEEEEECCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]