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The map label for this gene is icd [H]

Identifier: 103487448

GI number: 103487448

Start: 2069542

End: 2070756

Strand: Direct

Name: icd [H]

Synonym: Sala_1964

Alternate gene names: 103487448

Gene position: 2069542-2070756 (Clockwise)

Preceding gene: 103487445

Following gene: 103487449

Centisome position: 61.87

GC content: 61.32

Gene sequence:

>1215_bases
ATGGGCAAGATCAAGGTAGCCAACCCGGTCGTCGAACTCGACGGCGACGAAATGACCCGGATCATCTGGCAATGGATCCG
CGAGCGGCTGATCCTGCCCTATCTCGACATCGACCTGCATTATTACGACCTCGGCATCGAGGAACGCGACCGCACCGACG
ACAAGATCACCGTCGAGGCCGCGAACGCCATCAAGAAATATGGCGTCGGCGTCAAATGCGCGACGATCACCCCCGACGAA
GCCCGCGTCGAGGAGTTCGGCCTCAAGAAGATGTGGAAGTCGCCGAACGGCACGATCCGCAACATCCTGGGCGGCGTGGT
GTTCCGCGAACCGATCGTGATGAAGAATGTGCCGCGGCTGGTCCCCGGCTGGACCGACCCGATCGTCGTCGGACGTCATG
CCTTCGGCGACCAGTACAAGGCGACCGATTTTCGCGTCCCCGGCCCCGGCAAGCTGCGCCTGGTGTTCGAGGGCGAGGAC
GGCACGCTGATCGACGAGGAAGTGTTCCAGTTCCCTTCGTCGGGCGTCGCGATGGGCATGTACAATCTCGACGATTCGAT
CCGCGACTTCGCGCGCGCCAGCCTGAACTATGGCCTTGCGCGCGAATGGCCGGTGTATCTGTCGACCAAGAACACGATCC
TGAAAGCCTATGACGGGCGTTTCAAGGACATCTTCGAGGAAGTGTTCAACGCCGAATTCAAGGTGCAGTTCGACGCGCTC
GGCATCGTCTACGAACATCGCCTGATCGACGACATGGTCGCCTCGGCGCTCAAATGGTCGGGCAAGTTCGTCTGGGCGTG
CAAGAATTACGACGGCGATGTCCAGTCGGACACCGTTGCGCAGGGGTTCGGCTCGCTCGGCCTGATGACCAGCGTGCTGA
TGACCCCCGACGGCAAGACCGTCGAATCCGAAGCCGCGCACGGCACCGTCACGCGCCACTATCGCATGCACCAGCAGGGC
AAGGCGACCTCGACCAACCCGATTGCCTCGATCTTTGCCTGGACCGGCGGGCTCAAACATCGCGGCAAGCTCGACGACAA
TGCCGCGCTGGTGAAGTTCGCCGACGATCTGGAGAAGGTTTGCGTCGCGACGGTCGAAAGCGGCAAGATGACCAAGGATC
TGGCGCTGCTCATCGGTCCCGACCAGAACTGGTTGACGACCGAAGGCTTTTTCGAGGCGATCGTCGAGAATCTCGACAAG
AAGATGGGCGCTTAG

Upstream 100 bases:

>100_bases
GCGCGCGCGACACCGGTTGCGTCGGGGCGGTTGATCAATCGCCCCGCTTTGCCTAAGGCCCGCTGCAACTCCGACTCCCC
AAGGATAAAGGCAGAAACGC

Downstream 100 bases:

>100_bases
TCCTCCGGCCGTCGTCGCGGAACAATGCGGTTGCCATAACCACCCAGAGCGGCTGCTGTATATCTGACCCACCGGGATTG
CGTCAGGAAGCGTCTCGGAC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MGKIKVANPVVELDGDEMTRIIWQWIRERLILPYLDIDLHYYDLGIEERDRTDDKITVEAANAIKKYGVGVKCATITPDE
ARVEEFGLKKMWKSPNGTIRNILGGVVFREPIVMKNVPRLVPGWTDPIVVGRHAFGDQYKATDFRVPGPGKLRLVFEGED
GTLIDEEVFQFPSSGVAMGMYNLDDSIRDFARASLNYGLAREWPVYLSTKNTILKAYDGRFKDIFEEVFNAEFKVQFDAL
GIVYEHRLIDDMVASALKWSGKFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKTVESEAAHGTVTRHYRMHQQG
KATSTNPIASIFAWTGGLKHRGKLDDNAALVKFADDLEKVCVATVESGKMTKDLALLIGPDQNWLTTEGFFEAIVENLDK
KMGA

Sequences:

>Translated_404_residues
MGKIKVANPVVELDGDEMTRIIWQWIRERLILPYLDIDLHYYDLGIEERDRTDDKITVEAANAIKKYGVGVKCATITPDE
ARVEEFGLKKMWKSPNGTIRNILGGVVFREPIVMKNVPRLVPGWTDPIVVGRHAFGDQYKATDFRVPGPGKLRLVFEGED
GTLIDEEVFQFPSSGVAMGMYNLDDSIRDFARASLNYGLAREWPVYLSTKNTILKAYDGRFKDIFEEVFNAEFKVQFDAL
GIVYEHRLIDDMVASALKWSGKFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKTVESEAAHGTVTRHYRMHQQG
KATSTNPIASIFAWTGGLKHRGKLDDNAALVKFADDLEKVCVATVESGKMTKDLALLIGPDQNWLTTEGFFEAIVENLDK
KMGA
>Mature_403_residues
GKIKVANPVVELDGDEMTRIIWQWIRERLILPYLDIDLHYYDLGIEERDRTDDKITVEAANAIKKYGVGVKCATITPDEA
RVEEFGLKKMWKSPNGTIRNILGGVVFREPIVMKNVPRLVPGWTDPIVVGRHAFGDQYKATDFRVPGPGKLRLVFEGEDG
TLIDEEVFQFPSSGVAMGMYNLDDSIRDFARASLNYGLAREWPVYLSTKNTILKAYDGRFKDIFEEVFNAEFKVQFDALG
IVYEHRLIDDMVASALKWSGKFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKTVESEAAHGTVTRHYRMHQQGK
ATSTNPIASIFAWTGGLKHRGKLDDNAALVKFADDLEKVCVATVESGKMTKDLALLIGPDQNWLTTEGFFEAIVENLDKK
MGA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=408, Percent_Identity=67.156862745098, Blast_Score=577, Evalue=1e-165,
Organism=Homo sapiens, GI28178825, Length=410, Percent_Identity=64.1463414634146, Blast_Score=545, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI17540874, Length=402, Percent_Identity=66.6666666666667, Blast_Score=562, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI17550822, Length=408, Percent_Identity=63.9705882352941, Blast_Score=547, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6323203, Length=409, Percent_Identity=64.5476772616137, Blast_Score=539, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6320137, Length=409, Percent_Identity=64.0586797066015, Blast_Score=538, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6324319, Length=407, Percent_Identity=61.9164619164619, Blast_Score=532, Evalue=1e-152,
Organism=Drosophila melanogaster, GI21356561, Length=403, Percent_Identity=67.4937965260546, Blast_Score=569, Evalue=1e-162,
Organism=Drosophila melanogaster, GI221330987, Length=403, Percent_Identity=67.4937965260546, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI221330985, Length=403, Percent_Identity=67.4937965260546, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI28574947, Length=403, Percent_Identity=67.4937965260546, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24660849, Length=403, Percent_Identity=67.4937965260546, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24660856, Length=403, Percent_Identity=67.4937965260546, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24660868, Length=403, Percent_Identity=67.4937965260546, Blast_Score=566, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24660860, Length=403, Percent_Identity=67.4937965260546, Blast_Score=566, Evalue=1e-162,
Organism=Drosophila melanogaster, GI221330983, Length=403, Percent_Identity=67.4937965260546, Blast_Score=566, Evalue=1e-162,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45193; Mature: 45062

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKIKVANPVVELDGDEMTRIIWQWIRERLILPYLDIDLHYYDLGIEERDRTDDKITVEA
CCCEEECCCEEEECCHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCEEEEHH
ANAIKKYGVGVKCATITPDEARVEEFGLKKMWKSPNGTIRNILGGVVFREPIVMKNVPRL
HHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHCCCCC
VPGWTDPIVVGRHAFGDQYKATDFRVPGPGKLRLVFEGEDGTLIDEEVFQFPSSGVAMGM
CCCCCCCEEECCCCCCCCCCCCEEECCCCCEEEEEEECCCCCEECHHHHHCCCCCEEEEE
YNLDDSIRDFARASLNYGLAREWPVYLSTKNTILKAYDGRFKDIFEEVFNAEFKVQFDAL
ECCCHHHHHHHHHHHCCCCCCCCCEEEECCCCEEECCCCHHHHHHHHHHCCEEEEEEEEE
GIVYEHRLIDDMVASALKWSGKFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKT
EHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHCHHHHHHHHEECCCCCC
VESEAAHGTVTRHYRMHQQGKATSTNPIASIFAWTGGLKHRGKLDDNAALVKFADDLEKV
CCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHH
CVATVESGKMTKDLALLIGPDQNWLTTEGFFEAIVENLDKKMGA
HHHHHCCCCCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GKIKVANPVVELDGDEMTRIIWQWIRERLILPYLDIDLHYYDLGIEERDRTDDKITVEA
CCEEECCCEEEECCHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCEEEEHH
ANAIKKYGVGVKCATITPDEARVEEFGLKKMWKSPNGTIRNILGGVVFREPIVMKNVPRL
HHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHCCCCC
VPGWTDPIVVGRHAFGDQYKATDFRVPGPGKLRLVFEGEDGTLIDEEVFQFPSSGVAMGM
CCCCCCCEEECCCCCCCCCCCCEEECCCCCEEEEEEECCCCCEECHHHHHCCCCCEEEEE
YNLDDSIRDFARASLNYGLAREWPVYLSTKNTILKAYDGRFKDIFEEVFNAEFKVQFDAL
ECCCHHHHHHHHHHHCCCCCCCCCEEEECCCCEEECCCCHHHHHHHHHHCCEEEEEEEEE
GIVYEHRLIDDMVASALKWSGKFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKT
EHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHCHHHHHHHHEECCCCCC
VESEAAHGTVTRHYRMHQQGKATSTNPIASIFAWTGGLKHRGKLDDNAALVKFADDLEKV
CCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHH
CVATVESGKMTKDLALLIGPDQNWLTTEGFFEAIVENLDKKMGA
HHHHHCCCCCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]