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The map label for this gene is kefB [H]

Identifier: 103487449

GI number: 103487449

Start: 2071104

End: 2072888

Strand: Direct

Name: kefB [H]

Synonym: Sala_1965

Alternate gene names: 103487449

Gene position: 2071104-2072888 (Clockwise)

Preceding gene: 103487448

Following gene: 103487451

Centisome position: 61.91

GC content: 66.5

Gene sequence:

>1785_bases
ATGGTATCAGAGACAGAAACCTCCGCCATCGGCAATGCGCTGGTGGTGCTGGGCGCGGCGGGCATCGTGATCCCCGCCTT
TGCGCGCTTTCGCCTGCCGCCGGTCATCGGTTTCATCCTCGTCGGGCTGCTCGTCGGCCCATCGGGGCTGGGCGCGCTTG
CCGCCGATTATCCGTGGCTGCGACATGTCACGATCGGATCGACCGAGGACATCGCGCTCTTTGCCGAGTTCGGTATCATC
CTGCTGCTTTTCTCGATCGGGCTCGAATTGTCGTTCCGCCGCCTGTGGCAGCTCAGGAAGCTGGTGTTCGGCATCGGCGC
CGCAGAGTTGTTGTTCGGCGGCGCGATCCTTGGCGGCGCGCTGATGCTCTTCACCGATCACGCGACGCCCGCTGCCTTCG
GTCTCGGCATCGCGCTCGCGCTGTCCTCGACCGCGCTCGTGCTGCCGATCGCCGGCACCAAATCGGCGGTGGGCCGCGCT
TCCTTTTCGATGCTGTTGTTCGAGGATCTGGCAATCGTCCCGATCATCTTCATCCTTGGCGCCTTCGCACCCACCGCCAG
CGGTGACAGCACCCAATTGCTGTTCGCAACGCTGTGGCAGGGCGGGCTCGTCATTGCCGCGCTTGCGATTGGCGGCTGGT
TCCTGCTGCCGCGCATCTTTGCCCAGGCCGCGCGCGCCAAGGATCCCGAACTTTTCCTCGCCGCCAGCCTGCTGGTCGTC
ATCGTCGCGGCGCTTGCAACGGCCGCGGTTGGCCTGTCGCCGATCGTCGGCGCGTTGCTCGCGGGGCTGATGATCGCCGA
AACCGAATATCATGGCGAAGTCGAAGCGATCACCGCGCCGTTCAAGGGGCTCGCGCTCGGCGTCTTTCTGATCAGCGTCG
GCATGGGACTCAACCTCCGCACGATCGTCGAGCAATGGCCCGAACTGATGGTTGCCGTGGGCGGGGTCATCACGATCAAG
GCGCTGGTCACCGCCGCGCTGCTACGCTTTTCGGGTTTTGCACGCCGCGGGACCGCGGCCGAGGTCGGGCTGTTGATGGC
GAGCCCGTCGGAAACCACGCTGATCGTGCTCGCCGCCGCATTGCAGGCGCAGCTCATCACCAGCAGCACCGCCGAGTTCT
GGCAACTCGTCACCGCAATCGGCCTGACGATCACTCCGCTTCTTGCGCGCGTCGGCCACGACGTTGCCCGGCAAATCGAA
ATGCGCAGCGGCGATGCCGACGATGACGAGACGCCCGAGGGTCGCACCGTCATCGTCGGCTTCGGGCGCGTCGGCCGCAC
CGTCGCCGAGTTGCTTCGCGAACATGACCGGCCCTATATCGCGGTCGATGCCGACATCGACACGGTGGCGGCGGCCCGGC
GCGACGGCTTTATCGTCCGCTACGCCGACGTCGCGCGGCCCGGCAGCCTCGACAGGCTGGGCATCGAAAATGCCCAGGCT
ATCGTCCTGACGATGGACGACCCGGTCCAGCAGCTGCGCATGACGCGGCGGCTGCGGCAGAAATATCCCGACCTGCCGAT
CATCAGCCGCGCGCGCGACGCCGACCATGCCGCTGCGCTCTATCAGGCGGGCGCCAGCGACGCCGTGCCCGAAACGCTCG
AAAGCTCGCTGCAACTCGCCGAGGCCGTGCTCATCGACCTGGGCGTCGCCATGGGACCGGTGATCGCGTCGATCCACGAC
GTGCGCGCCAGAATGCGCCACGACATCATGACAAAGGGCAGGCTCGATCACGAACCCCGCGTCCACCGACCCCAGATCGG
CGCTCGCAGCGGCGAAAGCGGTTAG

Upstream 100 bases:

>100_bases
TCTCTTCTCGCGCTGGGCCAAATCGGCTCCGTCTCGGTGAATCAGATATACGGCACGCCGCTCTAGCCAATCGGGGCCGG
CCTGCATAAGGTCGGCCCTT

Downstream 100 bases:

>100_bases
AGCGGCGTGCTCTAACGTCCGCCAACCGCGGCATCGAGACGGGTCGACATCGCACCATTCAGTGCCGACGCATCGGCGAG
CGTCATGCCCTCGGGCAGGA

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter; NEM-activatable K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 594; Mature: 594

Protein sequence:

>594_residues
MVSETETSAIGNALVVLGAAGIVIPAFARFRLPPVIGFILVGLLVGPSGLGALAADYPWLRHVTIGSTEDIALFAEFGII
LLLFSIGLELSFRRLWQLRKLVFGIGAAELLFGGAILGGALMLFTDHATPAAFGLGIALALSSTALVLPIAGTKSAVGRA
SFSMLLFEDLAIVPIIFILGAFAPTASGDSTQLLFATLWQGGLVIAALAIGGWFLLPRIFAQAARAKDPELFLAASLLVV
IVAALATAAVGLSPIVGALLAGLMIAETEYHGEVEAITAPFKGLALGVFLISVGMGLNLRTIVEQWPELMVAVGGVITIK
ALVTAALLRFSGFARRGTAAEVGLLMASPSETTLIVLAAALQAQLITSSTAEFWQLVTAIGLTITPLLARVGHDVARQIE
MRSGDADDDETPEGRTVIVGFGRVGRTVAELLREHDRPYIAVDADIDTVAAARRDGFIVRYADVARPGSLDRLGIENAQA
IVLTMDDPVQQLRMTRRLRQKYPDLPIISRARDADHAAALYQAGASDAVPETLESSLQLAEAVLIDLGVAMGPVIASIHD
VRARMRHDIMTKGRLDHEPRVHRPQIGARSGESG

Sequences:

>Translated_594_residues
MVSETETSAIGNALVVLGAAGIVIPAFARFRLPPVIGFILVGLLVGPSGLGALAADYPWLRHVTIGSTEDIALFAEFGII
LLLFSIGLELSFRRLWQLRKLVFGIGAAELLFGGAILGGALMLFTDHATPAAFGLGIALALSSTALVLPIAGTKSAVGRA
SFSMLLFEDLAIVPIIFILGAFAPTASGDSTQLLFATLWQGGLVIAALAIGGWFLLPRIFAQAARAKDPELFLAASLLVV
IVAALATAAVGLSPIVGALLAGLMIAETEYHGEVEAITAPFKGLALGVFLISVGMGLNLRTIVEQWPELMVAVGGVITIK
ALVTAALLRFSGFARRGTAAEVGLLMASPSETTLIVLAAALQAQLITSSTAEFWQLVTAIGLTITPLLARVGHDVARQIE
MRSGDADDDETPEGRTVIVGFGRVGRTVAELLREHDRPYIAVDADIDTVAAARRDGFIVRYADVARPGSLDRLGIENAQA
IVLTMDDPVQQLRMTRRLRQKYPDLPIISRARDADHAAALYQAGASDAVPETLESSLQLAEAVLIDLGVAMGPVIASIHD
VRARMRHDIMTKGRLDHEPRVHRPQIGARSGESG
>Mature_594_residues
MVSETETSAIGNALVVLGAAGIVIPAFARFRLPPVIGFILVGLLVGPSGLGALAADYPWLRHVTIGSTEDIALFAEFGII
LLLFSIGLELSFRRLWQLRKLVFGIGAAELLFGGAILGGALMLFTDHATPAAFGLGIALALSSTALVLPIAGTKSAVGRA
SFSMLLFEDLAIVPIIFILGAFAPTASGDSTQLLFATLWQGGLVIAALAIGGWFLLPRIFAQAARAKDPELFLAASLLVV
IVAALATAAVGLSPIVGALLAGLMIAETEYHGEVEAITAPFKGLALGVFLISVGMGLNLRTIVEQWPELMVAVGGVITIK
ALVTAALLRFSGFARRGTAAEVGLLMASPSETTLIVLAAALQAQLITSSTAEFWQLVTAIGLTITPLLARVGHDVARQIE
MRSGDADDDETPEGRTVIVGFGRVGRTVAELLREHDRPYIAVDADIDTVAAARRDGFIVRYADVARPGSLDRLGIENAQA
IVLTMDDPVQQLRMTRRLRQKYPDLPIISRARDADHAAALYQAGASDAVPETLESSLQLAEAVLIDLGVAMGPVIASIHD
VRARMRHDIMTKGRLDHEPRVHRPQIGARSGESG

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI1786232, Length=578, Percent_Identity=32.8719723183391, Blast_Score=254, Evalue=2e-68,
Organism=Escherichia coli, GI1789749, Length=568, Percent_Identity=34.1549295774648, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1786685, Length=525, Percent_Identity=24.5714285714286, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR020884
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 62617; Mature: 62617

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSETETSAIGNALVVLGAAGIVIPAFARFRLPPVIGFILVGLLVGPSGLGALAADYPWL
CCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHCCCCCC
RHVTIGSTEDIALFAEFGIILLLFSIGLELSFRRLWQLRKLVFGIGAAELLFGGAILGGA
EEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
LMLFTDHATPAAFGLGIALALSSTALVLPIAGTKSAVGRASFSMLLFEDLAIVPIIFILG
CEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AFAPTASGDSTQLLFATLWQGGLVIAALAIGGWFLLPRIFAQAARAKDPELFLAASLLVV
CCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
IVAALATAAVGLSPIVGALLAGLMIAETEYHGEVEAITAPFKGLALGVFLISVGMGLNLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCCHH
TIVEQWPELMVAVGGVITIKALVTAALLRFSGFARRGTAAEVGLLMASPSETTLIVLAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEECCCCCHHHHHHHH
LQAQLITSSTAEFWQLVTAIGLTITPLLARVGHDVARQIEMRSGDADDDETPEGRTVIVG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
FGRVGRTVAELLREHDRPYIAVDADIDTVAAARRDGFIVRYADVARPGSLDRLGIENAQA
CCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCE
IVLTMDDPVQQLRMTRRLRQKYPDLPIISRARDADHAAALYQAGASDAVPETLESSLQLA
EEEECCCHHHHHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
EAVLIDLGVAMGPVIASIHDVRARMRHDIMTKGRLDHEPRVHRPQIGARSGESG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVSETETSAIGNALVVLGAAGIVIPAFARFRLPPVIGFILVGLLVGPSGLGALAADYPWL
CCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHCCCCCC
RHVTIGSTEDIALFAEFGIILLLFSIGLELSFRRLWQLRKLVFGIGAAELLFGGAILGGA
EEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
LMLFTDHATPAAFGLGIALALSSTALVLPIAGTKSAVGRASFSMLLFEDLAIVPIIFILG
CEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AFAPTASGDSTQLLFATLWQGGLVIAALAIGGWFLLPRIFAQAARAKDPELFLAASLLVV
CCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
IVAALATAAVGLSPIVGALLAGLMIAETEYHGEVEAITAPFKGLALGVFLISVGMGLNLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCCHH
TIVEQWPELMVAVGGVITIKALVTAALLRFSGFARRGTAAEVGLLMASPSETTLIVLAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEECCCCCHHHHHHHH
LQAQLITSSTAEFWQLVTAIGLTITPLLARVGHDVARQIEMRSGDADDDETPEGRTVIVG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
FGRVGRTVAELLREHDRPYIAVDADIDTVAAARRDGFIVRYADVARPGSLDRLGIENAQA
CCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCE
IVLTMDDPVQQLRMTRRLRQKYPDLPIISRARDADHAAALYQAGASDAVPETLESSLQLA
EEEECCCHHHHHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
EAVLIDLGVAMGPVIASIHDVRARMRHDIMTKGRLDHEPRVHRPQIGARSGESG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA