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The map label for this gene is hutU

Identifier: 103487176

GI number: 103487176

Start: 1780530

End: 1782191

Strand: Direct

Name: hutU

Synonym: Sala_1691

Alternate gene names: 103487176

Gene position: 1780530-1782191 (Clockwise)

Preceding gene: 103487175

Following gene: 103487177

Centisome position: 53.23

GC content: 66.25

Gene sequence:

>1662_bases
ATGACCCGCCTCGATAACAGCCGCGTGATCCGCCCGGCGACCGGCCCGGAGATCAGCGCGAAAAGCTGGCTTACCGAAGC
CCCGATGCGGATGCTGATGAACAACCTCCATCCCGACGTCGCCGAAGCGCCGCACGAGCTGGTCGTCTATGGCGGCATCG
GTCGCGCCGCGCGCGACTGGGAAAGCTATGACCGGATCGTCGAGACGCTCAGACGGCTCGAAGGCGACGAGACATTGCTC
ATCCAGTCGGGCAAGCCCGTGGGCGTATTCCGCACCCACGCGGACGCGCCGCGCGTGCTGCTCGCCAATTCGAACCTCGT
CCCCCAATGGGCGAATTGGGAGCATTTTCACGAGCTCGATAAAAAGGGCCTGATGATGTACGGGCAGATGACCGCGGGCA
GCTGGATCTATATCGGCAGCCAGGGCATCGTGCAGGGAACCTACGAAACCTTCGTCGAAATGGGCCGCCAGCATTATGGC
GGCGACCTTTCGGGTCGCTGGCTGCTGACCGCAGGACTCGGCGGCATGGGCGGCGCGCAGCCGCTCGCGGCGGTGATGGC
GGGCGCGAGCTGTCTCGCGATCGAATGCCAGCCGAGCCGCATCGAGATGCGCCTGCGCACCGGCTATCTCGACAGGCAGG
CGGCGAGCATCGACGAGGCGCTGGCGATGATCGAAGCGAGCCACGCCGAGGACAAGCCGGTCTCGGTCGGCCTGCTCGGC
AACGCCGCCGAAATCCTGCCGGAGATCGTCCGTCGCGGCATCCGCCCCGACCTCCTGACCGACCAGACCTCCGCGCACGA
TCCGGTGAATGGCTACCTCCCCGCGGGCTGGAGCCTCGACCAATGGTTTGCGAAGCGCGAGAGCGATCCGTCCGCAGTCG
CGAAAGCGGCAAAAGCCTCGATGGCGGTGCATGTTCGGGCGATGCTCGACCTGCACGCCGCAGGTGTTCCGACGACCGAT
TATGGCAATAATATCCGCCAGATGGCGAAAGACGAGGGTGTCGAAAATGCCTTCGACTTCCCCGGCTTCGTTCCCGCCTA
TGTCCGCCCGCTCTTCTGTCGCGGTATCGGCCCCTTCCGCTGGGTGGCGCTGTCGGGCGATCCCGAGGACATCTACCGGA
CCGACGCGAGGGTGAAGCAACTGCTCCCCGACAACACCCACCTTCACAACTGGCTCGACATGGCGCGCGAACGCATCCAG
TTCCAGGGCCTGCCTGCGCGCATCTGCTGGGTCGGGCTCGGCGACCGCCACCGCCTCGGCCTCGCCTTTAACGAGATGGT
CGCGTCGGGCGAATTGAAAGCGCCGATCGTGATCGGCCGCGACCATCTCGATTCGGGCTCGGTCGCCTCGCCCAACCGGG
AGACCGAGGCAATGCGCGATGGCAGCGATGCGGTCAGCGACTGGCCGCTGCTCAATGCGCTCCTCAACACCGCATCGGGC
GCGACCTGGGTGTCGCTCCATCACGGCGGCGGGGTCGGCATGGGCTATTCGCAGCACAGCGGCATGGTGATCGTCGCCGA
CGGCACACCCGAAGCGGCGAAGCGGCTCGAGCGCGTGCTGTGGAACGATCCCGGAACCGGGGTCATGCGCCACGCCGACG
CGGGGTATGACATCGCCATCGACTGCGCGCGCGAAAAGGGCCTCGACCTGCCAAGCATCTGA

Upstream 100 bases:

>100_bases
CCCACGCCAACTGGCCCACCCCCCTCGACCCCAACCCGACGATCCGGCCCGTGCTGGAGCAGGTGATCGCCGCCACGCTC
GACTTTGCGAAAGGACGACC

Downstream 100 bases:

>100_bases
CGCTTGTTTCGGTTGCACCAAAACAGCTTCGTATCCTAAGGCTCTCTCCGACGATCAGGGGAGAGCCGAACGCCGATGTC
CGAAGCCGACCAACAAAGCC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase

Number of amino acids: Translated: 553; Mature: 552

Protein sequence:

>553_residues
MTRLDNSRVIRPATGPEISAKSWLTEAPMRMLMNNLHPDVAEAPHELVVYGGIGRAARDWESYDRIVETLRRLEGDETLL
IQSGKPVGVFRTHADAPRVLLANSNLVPQWANWEHFHELDKKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVEMGRQHYG
GDLSGRWLLTAGLGGMGGAQPLAAVMAGASCLAIECQPSRIEMRLRTGYLDRQAASIDEALAMIEASHAEDKPVSVGLLG
NAAEILPEIVRRGIRPDLLTDQTSAHDPVNGYLPAGWSLDQWFAKRESDPSAVAKAAKASMAVHVRAMLDLHAAGVPTTD
YGNNIRQMAKDEGVENAFDFPGFVPAYVRPLFCRGIGPFRWVALSGDPEDIYRTDARVKQLLPDNTHLHNWLDMARERIQ
FQGLPARICWVGLGDRHRLGLAFNEMVASGELKAPIVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTASG
ATWVSLHHGGGVGMGYSQHSGMVIVADGTPEAAKRLERVLWNDPGTGVMRHADAGYDIAIDCAREKGLDLPSI

Sequences:

>Translated_553_residues
MTRLDNSRVIRPATGPEISAKSWLTEAPMRMLMNNLHPDVAEAPHELVVYGGIGRAARDWESYDRIVETLRRLEGDETLL
IQSGKPVGVFRTHADAPRVLLANSNLVPQWANWEHFHELDKKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVEMGRQHYG
GDLSGRWLLTAGLGGMGGAQPLAAVMAGASCLAIECQPSRIEMRLRTGYLDRQAASIDEALAMIEASHAEDKPVSVGLLG
NAAEILPEIVRRGIRPDLLTDQTSAHDPVNGYLPAGWSLDQWFAKRESDPSAVAKAAKASMAVHVRAMLDLHAAGVPTTD
YGNNIRQMAKDEGVENAFDFPGFVPAYVRPLFCRGIGPFRWVALSGDPEDIYRTDARVKQLLPDNTHLHNWLDMARERIQ
FQGLPARICWVGLGDRHRLGLAFNEMVASGELKAPIVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTASG
ATWVSLHHGGGVGMGYSQHSGMVIVADGTPEAAKRLERVLWNDPGTGVMRHADAGYDIAIDCAREKGLDLPSI
>Mature_552_residues
TRLDNSRVIRPATGPEISAKSWLTEAPMRMLMNNLHPDVAEAPHELVVYGGIGRAARDWESYDRIVETLRRLEGDETLLI
QSGKPVGVFRTHADAPRVLLANSNLVPQWANWEHFHELDKKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVEMGRQHYGG
DLSGRWLLTAGLGGMGGAQPLAAVMAGASCLAIECQPSRIEMRLRTGYLDRQAASIDEALAMIEASHAEDKPVSVGLLGN
AAEILPEIVRRGIRPDLLTDQTSAHDPVNGYLPAGWSLDQWFAKRESDPSAVAKAAKASMAVHVRAMLDLHAAGVPTTDY
GNNIRQMAKDEGVENAFDFPGFVPAYVRPLFCRGIGPFRWVALSGDPEDIYRTDARVKQLLPDNTHLHNWLDMARERIQF
QGLPARICWVGLGDRHRLGLAFNEMVASGELKAPIVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTASGA
TWVSLHHGGGVGMGYSQHSGMVIVADGTPEAAKRLERVLWNDPGTGVMRHADAGYDIAIDCAREKGLDLPSI

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family

Homologues:

Organism=Homo sapiens, GI21389467, Length=560, Percent_Identity=33.9285714285714, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI260306182, Length=317, Percent_Identity=33.4384858044164, Blast_Score=153, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71997891, Length=552, Percent_Identity=35.1449275362319, Blast_Score=309, Evalue=2e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTU_SPHAL (Q1GSG8)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616737.1
- ProteinModelPortal:   Q1GSG8
- SMR:   Q1GSG8
- GeneID:   4081094
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1691
- NMPDR:   fig|317655.9.peg.1622
- HOGENOM:   HBG305285
- OMA:   VDCAREQ
- ProtClustDB:   PRK05414
- BioCyc:   SALA317655:SALA_1691-MONOMER
- BRENDA:   4.2.1.49
- GO:   GO:0005737
- HAMAP:   MF_00577
- InterPro:   IPR000193
- PIRSF:   PIRSF001423
- TIGRFAMs:   TIGR01228

Pfam domain/function: PF01175 Urocanase; SSF111326 Urocanase

EC number: =4.2.1.49

Molecular weight: Translated: 60331; Mature: 60200

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS01233 UROCANASE

Important sites: ACT_SITE 409-409

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLDNSRVIRPATGPEISAKSWLTEAPMRMLMNNLHPDVAEAPHELVVYGGIGRAARDW
CCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCCCCHHHHH
ESYDRIVETLRRLEGDETLLIQSGKPVGVFRTHADAPRVLLANSNLVPQWANWEHFHELD
HHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHC
KKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVEMGRQHYGGDLSGRWLLTAGLGGMGGAQ
CCCEEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHH
PLAAVMAGASCLAIECQPSRIEMRLRTGYLDRQAASIDEALAMIEASHAEDKPVSVGLLG
HHHHHHCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECC
NAAEILPEIVRRGIRPDLLTDQTSAHDPVNGYLPAGWSLDQWFAKRESDPSAVAKAAKAS
CHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHH
MAVHVRAMLDLHAAGVPTTDYGNNIRQMAKDEGVENAFDFPGFVPAYVRPLFCRGIGPFR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCEE
WVALSGDPEDIYRTDARVKQLLPDNTHLHNWLDMARERIQFQGLPARICWVGLGDRHRLG
EEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEC
LAFNEMVASGELKAPIVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTASG
HHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCC
ATWVSLHHGGGVGMGYSQHSGMVIVADGTPEAAKRLERVLWNDPGTGVMRHADAGYDIAI
CEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCCEEEE
DCAREKGLDLPSI
EEHHHCCCCCCCC
>Mature Secondary Structure 
TRLDNSRVIRPATGPEISAKSWLTEAPMRMLMNNLHPDVAEAPHELVVYGGIGRAARDW
CCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCCCCHHHHH
ESYDRIVETLRRLEGDETLLIQSGKPVGVFRTHADAPRVLLANSNLVPQWANWEHFHELD
HHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHC
KKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVEMGRQHYGGDLSGRWLLTAGLGGMGGAQ
CCCEEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHH
PLAAVMAGASCLAIECQPSRIEMRLRTGYLDRQAASIDEALAMIEASHAEDKPVSVGLLG
HHHHHHCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECC
NAAEILPEIVRRGIRPDLLTDQTSAHDPVNGYLPAGWSLDQWFAKRESDPSAVAKAAKAS
CHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHH
MAVHVRAMLDLHAAGVPTTDYGNNIRQMAKDEGVENAFDFPGFVPAYVRPLFCRGIGPFR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCEE
WVALSGDPEDIYRTDARVKQLLPDNTHLHNWLDMARERIQFQGLPARICWVGLGDRHRLG
EEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEC
LAFNEMVASGELKAPIVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTASG
HHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCC
ATWVSLHHGGGVGMGYSQHSGMVIVADGTPEAAKRLERVLWNDPGTGVMRHADAGYDIAI
CEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCCEEEE
DCAREKGLDLPSI
EEHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA