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The map label for this gene is hutH

Identifier: 103487174

GI number: 103487174

Start: 1778201

End: 1779730

Strand: Direct

Name: hutH

Synonym: Sala_1689

Alternate gene names: 103487174

Gene position: 1778201-1779730 (Clockwise)

Preceding gene: 103487173

Following gene: 103487175

Centisome position: 53.16

GC content: 69.48

Gene sequence:

>1530_bases
ATGACGGTTGTGACGATCACCCCCGGCGCGATGAGCTTCGCCGACTGGCGTGCGATTTACGAAGGCGCGAGTGCCGCGCT
GACCGTGGGTGCATGGGATGCGATCGACGCCAGCGCCGCGGCGGTGGCGCGGATCGTCGCCAAGGGCGATCCCGTCTATG
GCATCAACACCGGCTTTGGAAAGCTCGCGAGCGTGCGGATCGCGAGCGACGATCTAGCGACGCTCCAGCGCAACATCGTG
CTCAGCCATGCCGCGGGCACCGGTGCTCCCTCCCCTACCCCTGTCGTCCGACTGATGATGGCGCTCAAGCTCGCGAGCTT
CGGCGTCGGCGCGTCCGGCGTGCGGCGCGAAACGGCGGCGATGCTGGAGGCGATGCTCGCGCGGGGGCTGATCCCGGTCG
TGCCGTCGCAGGGTTCAGTCGGCGCGAGCGGCGACCTTGCGCCGCTGGCGCATATGGCCGCGGCGATGATCGGCGTCGGC
AAGATCGACGTCGGCGGCGCGATCATGCCCGCCGCCGAAGCGCTCGCGCAGGCCGAGCTGACGCCGCTCGAACTTGGCCC
GAAGGAAGGACTCGCGCTGCTCAACGGCACACAGTTTTCGACCGCGAACGCGCTTGCGGGCCTGTTCCGTGCCGAAACCC
TGTTCCGCTCGGCGCTGATCACCGGGGCGCTCTCGACCGAAGCCGCCAAGGGTTCCGACGCGCCCTTCGACCCCCGCATC
CACGCGCTGCGCGGTCATATCGGCCAGCGCGAGGTCGGCGGCGCGCTCCGCACCCTGATGGCGGGGTCGGCGATCCGCGC
CTCGCACGCCATCGACGATCCGCGCGTGCAGGATCCCTATTGCCTGCGCTGCCAGCCGCAGGTGATGGGCGCGGTGCTCG
ACCTGCTGCGTCAGGCGGGGGCGACGCTCGGCGTGGAGGCGAATGGCGTCTCGGACAATCCGCTGATCTTCGCCGATAGC
GACGAAGCCTTGTCGGGCGGCAATTTTCACGCCGAACCGGTGGCTTTCGCCGCCGATATGATCGCGATCGCCTTGTGCGA
AATCGGCTCGATCGCCGAGCGCCGCATCGCGATGCTCGTCGATCCCGCGCTGTCGGGCCTGCCTGCCTTCCTGACGCCGC
GCCCCGGCCTCAACTCGGGCTTCATGATCCCGCAGGTCACCGCTGCGGCGCTGGTCAGCGAAAACAAGCAGCGCGCCTAT
CCCGCCAGCGTCGATTCGATCCCGACCTCGGCGAACCAGGAGGATCATGTGTCGATGGCCGCGCACGGCGCGCGCCGCCT
GCTCGACATGGCCGACAATGCCAGCGCGGTGATCGGCATCGAACTGCTGGCCGCGTGTCAGGGGATCGACTTTCACGCGC
CGCTCAAATCGAGCGACGCGCTCGAGGCGGCGCACCGGCATCTGCGCTCGCACGTCCCGACGCTCGACGACGACCGGCAT
TTCCACCCCGACATGGAAGCCGCGACGGCATTGATCCGTTCGGGCAGCCTCGTCGCCGCGGTGCCGGCCAGCCTGCCGGG
CGTCGGCTGA

Upstream 100 bases:

>100_bases
GCAAGGCCTGCGACCTCGCCATCTGGGACGTCGGCGACCCCGCCGAGCTGGTCTATCGCATCGGCTTCAACCCGCTGCAC
CAACGTATCAAGGACGGACA

Downstream 100 bases:

>100_bases
TGGACTGGCTGCGCGTCCATCGCGGCGACGCGCCGCTCGTCATCGCCTTTCCGCACGGCGGCACCGAGCTTGCGGGGCTC
GACGAGCGGTTCGTGTCGCC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MTVVTITPGAMSFADWRAIYEGASAALTVGAWDAIDASAAAVARIVAKGDPVYGINTGFGKLASVRIASDDLATLQRNIV
LSHAAGTGAPSPTPVVRLMMALKLASFGVGASGVRRETAAMLEAMLARGLIPVVPSQGSVGASGDLAPLAHMAAAMIGVG
KIDVGGAIMPAAEALAQAELTPLELGPKEGLALLNGTQFSTANALAGLFRAETLFRSALITGALSTEAAKGSDAPFDPRI
HALRGHIGQREVGGALRTLMAGSAIRASHAIDDPRVQDPYCLRCQPQVMGAVLDLLRQAGATLGVEANGVSDNPLIFADS
DEALSGGNFHAEPVAFAADMIAIALCEIGSIAERRIAMLVDPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQRAY
PASVDSIPTSANQEDHVSMAAHGARRLLDMADNASAVIGIELLAACQGIDFHAPLKSSDALEAAHRHLRSHVPTLDDDRH
FHPDMEAATALIRSGSLVAAVPASLPGVG

Sequences:

>Translated_509_residues
MTVVTITPGAMSFADWRAIYEGASAALTVGAWDAIDASAAAVARIVAKGDPVYGINTGFGKLASVRIASDDLATLQRNIV
LSHAAGTGAPSPTPVVRLMMALKLASFGVGASGVRRETAAMLEAMLARGLIPVVPSQGSVGASGDLAPLAHMAAAMIGVG
KIDVGGAIMPAAEALAQAELTPLELGPKEGLALLNGTQFSTANALAGLFRAETLFRSALITGALSTEAAKGSDAPFDPRI
HALRGHIGQREVGGALRTLMAGSAIRASHAIDDPRVQDPYCLRCQPQVMGAVLDLLRQAGATLGVEANGVSDNPLIFADS
DEALSGGNFHAEPVAFAADMIAIALCEIGSIAERRIAMLVDPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQRAY
PASVDSIPTSANQEDHVSMAAHGARRLLDMADNASAVIGIELLAACQGIDFHAPLKSSDALEAAHRHLRSHVPTLDDDRH
FHPDMEAATALIRSGSLVAAVPASLPGVG
>Mature_508_residues
TVVTITPGAMSFADWRAIYEGASAALTVGAWDAIDASAAAVARIVAKGDPVYGINTGFGKLASVRIASDDLATLQRNIVL
SHAAGTGAPSPTPVVRLMMALKLASFGVGASGVRRETAAMLEAMLARGLIPVVPSQGSVGASGDLAPLAHMAAAMIGVGK
IDVGGAIMPAAEALAQAELTPLELGPKEGLALLNGTQFSTANALAGLFRAETLFRSALITGALSTEAAKGSDAPFDPRIH
ALRGHIGQREVGGALRTLMAGSAIRASHAIDDPRVQDPYCLRCQPQVMGAVLDLLRQAGATLGVEANGVSDNPLIFADSD
EALSGGNFHAEPVAFAADMIAIALCEIGSIAERRIAMLVDPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQRAYP
ASVDSIPTSANQEDHVSMAAHGARRLLDMADNASAVIGIELLAACQGIDFHAPLKSSDALEAAHRHLRSHVPTLDDDRHF
HPDMEAATALIRSGSLVAAVPASLPGVG

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=471, Percent_Identity=45.0106157112527, Blast_Score=367, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17567831, Length=480, Percent_Identity=43.9583333333333, Blast_Score=361, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_SPHAL (Q1GSH0)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616735.1
- ProteinModelPortal:   Q1GSH0
- SMR:   Q1GSH0
- GeneID:   4081092
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1689
- NMPDR:   fig|317655.9.peg.1620
- HOGENOM:   HBG510887
- OMA:   QKGQIDS
- ProtClustDB:   PRK09367
- BioCyc:   SALA317655:SALA_1689-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 52149; Mature: 52018

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVVTITPGAMSFADWRAIYEGASAALTVGAWDAIDASAAAVARIVAKGDPVYGINTGFG
CEEEEECCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCEEECCCCCC
KLASVRIASDDLATLQRNIVLSHAAGTGAPSPTPVVRLMMALKLASFGVGASGVRRETAA
CEEEEEECCHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHH
MLEAMLARGLIPVVPSQGSVGASGDLAPLAHMAAAMIGVGKIDVGGAIMPAAEALAQAEL
HHHHHHHCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCC
TPLELGPKEGLALLNGTQFSTANALAGLFRAETLFRSALITGALSTEAAKGSDAPFDPRI
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
HALRGHIGQREVGGALRTLMAGSAIRASHAIDDPRVQDPYCLRCQPQVMGAVLDLLRQAG
HHHHCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCC
ATLGVEANGVSDNPLIFADSDEALSGGNFHAEPVAFAADMIAIALCEIGSIAERRIAMLV
CEEEEECCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQRAYPASVDSIPTSANQEDHVSMA
CHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
AHGARRLLDMADNASAVIGIELLAACQGIDFHAPLKSSDALEAAHRHLRSHVPTLDDDRH
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
FHPDMEAATALIRSGSLVAAVPASLPGVG
CCCCHHHHHHHHHCCCEEEECCCCCCCCC
>Mature Secondary Structure 
TVVTITPGAMSFADWRAIYEGASAALTVGAWDAIDASAAAVARIVAKGDPVYGINTGFG
EEEEECCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCEEECCCCCC
KLASVRIASDDLATLQRNIVLSHAAGTGAPSPTPVVRLMMALKLASFGVGASGVRRETAA
CEEEEEECCHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHH
MLEAMLARGLIPVVPSQGSVGASGDLAPLAHMAAAMIGVGKIDVGGAIMPAAEALAQAEL
HHHHHHHCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCC
TPLELGPKEGLALLNGTQFSTANALAGLFRAETLFRSALITGALSTEAAKGSDAPFDPRI
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
HALRGHIGQREVGGALRTLMAGSAIRASHAIDDPRVQDPYCLRCQPQVMGAVLDLLRQAG
HHHHCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCC
ATLGVEANGVSDNPLIFADSDEALSGGNFHAEPVAFAADMIAIALCEIGSIAERRIAMLV
CEEEEECCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQRAYPASVDSIPTSANQEDHVSMA
CHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
AHGARRLLDMADNASAVIGIELLAACQGIDFHAPLKSSDALEAAHRHLRSHVPTLDDDRH
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
FHPDMEAATALIRSGSLVAAVPASLPGVG
CCCCHHHHHHHHHCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA