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The map label for this gene is hutI

Identifier: 103487173

GI number: 103487173

Start: 1776993

End: 1778204

Strand: Direct

Name: hutI

Synonym: Sala_1688

Alternate gene names: 103487173

Gene position: 1776993-1778204 (Clockwise)

Preceding gene: 103487162

Following gene: 103487174

Centisome position: 53.12

GC content: 67.41

Gene sequence:

>1212_bases
ATGACGCATCGGCGCGACACTGTCCAGATGGAGCAACGCTGGACGAACGCCCGACTCGCGACGATGGCCGGTGACGATCT
CGGCCTGATCGACGATGGCGTGGTCGCGGCAAAGGATGGCCGCATCATCTATGCCGGTCCGGCGAAGGACGCGCCTGCGA
CGCAAGGTGCGGTCCATGACTGCGAGGGCCGCCTGATCACGCCCGGCCTGATCGACTGCCACACCCATCTGATACATGGC
GGCAACCGTGCGAACGAATGGGCGATGAGGCTCGAAGGTGCGAGCTATGACGAGATCGCCCGCGCGGGCGGCGGCATCGT
CTCGACGATGCGCGCGACGCGCGACGCGAGCGAAGCCGAACTGGTCGCGAGCGCCCTCCCCCGCCTCGACGCGCTGATCG
CCGAGGGTGTGACGACGATCGAGATCAAGTCAGGCTATGGGCTCTCGACCAACGACGAGTTGAAGATGCTGCGCGCCGCG
CGCGCGCTCGCCAACATCCGCGCGATCCGCGTCGAGCCGACCTTCCTCGGCGCGCACGCGCTGCCTCCCGAATATCAAGG
CGACAGCGACGCCTATATCGACCTCGTCGTGGGCGAGATGATCCCGGCCGTGGCCTCGCTAGCCACCGCGGTCGACGCCT
TTTGCGAAGGCATCGGCTTTTCGCCCGAACAGTGCGCGCGCGTCCTTGCCGCCGCGAAGGCCCATGGGCTCAAGGTCAAG
CTCCACGCCGAACAATTGTCGGCGCTCCACGGCAGCGCGCTCGCCGCGCGGCACGGCGCATTGTCCGCCGACCATCTCGA
ACATGCGACCGACGAGGATGTGCGCGCGATGGCCGAAGCCGGCAGCGTCGCGGTGCTGCTCCCCGGCGCCTATTATTTCA
TGCGCGAAACCAGACTGCCGCCCGTCCAGGCAATGCGCCGCCATGGGACGCGCATCGCGCTGGCGACCGACAACAACCCC
GGAACCTCGCCGACGAGTTCGCTGCTGCTGATGCTCAACATGGGCGCGACCTTGTTCGGGCTGACCGTCATCGAAGCGCT
GCGCGGCGTGACGGTCAACGCCGCCGCCGCGCTCGGCCTGTCGGCGGAGATCGGCACGATTGAGGTCGGCAAGGCCTGCG
ACCTCGCCATCTGGGACGTCGGCGACCCCGCCGAGCTGGTCTATCGCATCGGCTTCAACCCGCTGCACCAACGTATCAAG
GACGGACAATGA

Upstream 100 bases:

>100_bases
GCGATGCGCAGCCGCGCGGCCCTTTCCCAGCGATTGCCGATCCACGCGCGTTCGAACCAGAGCGAAGCCATCATCCGTCC
CCATATTATGTCTAGACATA

Downstream 100 bases:

>100_bases
CGGTTGTGACGATCACCCCCGGCGCGATGAGCTTCGCCGACTGGCGTGCGATTTACGAAGGCGCGAGTGCCGCGCTGACC
GTGGGTGCATGGGATGCGAT

Product: imidazolonepropionase

Products: NA

Alternate protein names: Imidazolone-5-propionate hydrolase

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MTHRRDTVQMEQRWTNARLATMAGDDLGLIDDGVVAAKDGRIIYAGPAKDAPATQGAVHDCEGRLITPGLIDCHTHLIHG
GNRANEWAMRLEGASYDEIARAGGGIVSTMRATRDASEAELVASALPRLDALIAEGVTTIEIKSGYGLSTNDELKMLRAA
RALANIRAIRVEPTFLGAHALPPEYQGDSDAYIDLVVGEMIPAVASLATAVDAFCEGIGFSPEQCARVLAAAKAHGLKVK
LHAEQLSALHGSALAARHGALSADHLEHATDEDVRAMAEAGSVAVLLPGAYYFMRETRLPPVQAMRRHGTRIALATDNNP
GTSPTSSLLLMLNMGATLFGLTVIEALRGVTVNAAAALGLSAEIGTIEVGKACDLAIWDVGDPAELVYRIGFNPLHQRIK
DGQ

Sequences:

>Translated_403_residues
MTHRRDTVQMEQRWTNARLATMAGDDLGLIDDGVVAAKDGRIIYAGPAKDAPATQGAVHDCEGRLITPGLIDCHTHLIHG
GNRANEWAMRLEGASYDEIARAGGGIVSTMRATRDASEAELVASALPRLDALIAEGVTTIEIKSGYGLSTNDELKMLRAA
RALANIRAIRVEPTFLGAHALPPEYQGDSDAYIDLVVGEMIPAVASLATAVDAFCEGIGFSPEQCARVLAAAKAHGLKVK
LHAEQLSALHGSALAARHGALSADHLEHATDEDVRAMAEAGSVAVLLPGAYYFMRETRLPPVQAMRRHGTRIALATDNNP
GTSPTSSLLLMLNMGATLFGLTVIEALRGVTVNAAAALGLSAEIGTIEVGKACDLAIWDVGDPAELVYRIGFNPLHQRIK
DGQ
>Mature_402_residues
THRRDTVQMEQRWTNARLATMAGDDLGLIDDGVVAAKDGRIIYAGPAKDAPATQGAVHDCEGRLITPGLIDCHTHLIHGG
NRANEWAMRLEGASYDEIARAGGGIVSTMRATRDASEAELVASALPRLDALIAEGVTTIEIKSGYGLSTNDELKMLRAAR
ALANIRAIRVEPTFLGAHALPPEYQGDSDAYIDLVVGEMIPAVASLATAVDAFCEGIGFSPEQCARVLAAAKAHGLKVKL
HAEQLSALHGSALAARHGALSADHLEHATDEDVRAMAEAGSVAVLLPGAYYFMRETRLPPVQAMRRHGTRIALATDNNPG
TSPTSSLLLMLNMGATLFGLTVIEALRGVTVNAAAALGLSAEIGTIEVGKACDLAIWDVGDPAELVYRIGFNPLHQRIKD
GQ

Specific function: Unknown

COG id: COG1228

COG function: function code Q; Imidazolonepropionase and related amidohydrolases

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hutI family

Homologues:

Organism=Homo sapiens, GI223972677, Length=370, Percent_Identity=35.9459459459459, Blast_Score=195, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17555004, Length=371, Percent_Identity=32.6145552560647, Blast_Score=186, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTI_SPHAL (Q1GSH1)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616734.1
- ProteinModelPortal:   Q1GSH1
- SMR:   Q1GSH1
- GeneID:   4081091
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1688
- NMPDR:   fig|317655.9.peg.1619
- HOGENOM:   HBG686142
- OMA:   MNMACTL
- BioCyc:   SALA317655:SALA_1688-MONOMER
- BRENDA:   3.5.2.7
- GO:   GO:0005737
- HAMAP:   MF_00372
- InterPro:   IPR006680
- InterPro:   IPR005920
- InterPro:   IPR011059
- TIGRFAMs:   TIGR01224

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.7

Molecular weight: Translated: 42584; Mature: 42453

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00616 HIS_ACID_PHOSPHAT_1

Important sites: BINDING 83-83 BINDING 96-96 BINDING 146-146 BINDING 179-179 BINDING 245-245

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHRRDTVQMEQRWTNARLATMAGDDLGLIDDGVVAAKDGRIIYAGPAKDAPATQGAVHD
CCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCC
CEGRLITPGLIDCHTHLIHGGNRANEWAMRLEGASYDEIARAGGGIVSTMRATRDASEAE
CCCCEECCCHHHHHHHHHCCCCCCCCHHEEECCCCHHHHHHCCCCHHHHHHHHCCCHHHH
LVASALPRLDALIAEGVTTIEIKSGYGLSTNDELKMLRAARALANIRAIRVEPTFLGAHA
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHEEEEEECCCEECCCC
LPPEYQGDSDAYIDLVVGEMIPAVASLATAVDAFCEGIGFSPEQCARVLAAAKAHGLKVK
CCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEE
LHAEQLSALHGSALAARHGALSADHLEHATDEDVRAMAEAGSVAVLLPGAYYFMRETRLP
EEHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHCCCEEEEECCCEEEHHHCCCC
PVQAMRRHGTRIALATDNNPGTSPTSSLLLMLNMGATLFGLTVIEALRGVTVNAAAALGL
HHHHHHHCCCEEEEEECCCCCCCHHHHHEEHHHCCCHHHHHHHHHHHCCCEEEHHHHHCC
SAEIGTIEVGKACDLAIWDVGDPAELVYRIGFNPLHQRIKDGQ
CCCCCEEEECCCCCEEEECCCCHHHHHHHCCCHHHHHHHCCCC
>Mature Secondary Structure 
THRRDTVQMEQRWTNARLATMAGDDLGLIDDGVVAAKDGRIIYAGPAKDAPATQGAVHD
CCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCC
CEGRLITPGLIDCHTHLIHGGNRANEWAMRLEGASYDEIARAGGGIVSTMRATRDASEAE
CCCCEECCCHHHHHHHHHCCCCCCCCHHEEECCCCHHHHHHCCCCHHHHHHHHCCCHHHH
LVASALPRLDALIAEGVTTIEIKSGYGLSTNDELKMLRAARALANIRAIRVEPTFLGAHA
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHEEEEEECCCEECCCC
LPPEYQGDSDAYIDLVVGEMIPAVASLATAVDAFCEGIGFSPEQCARVLAAAKAHGLKVK
CCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEE
LHAEQLSALHGSALAARHGALSADHLEHATDEDVRAMAEAGSVAVLLPGAYYFMRETRLP
EEHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHCCCEEEEECCCEEEHHHCCCC
PVQAMRRHGTRIALATDNNPGTSPTSSLLLMLNMGATLFGLTVIEALRGVTVNAAAALGL
HHHHHHHCCCEEEEEECCCCCCCHHHHHEEHHHCCCHHHHHHHHHHHCCCEEEHHHHHCC
SAEIGTIEVGKACDLAIWDVGDPAELVYRIGFNPLHQRIKDGQ
CCCCCEEEECCCCCEEEECCCCHHHHHHHCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA