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The map label for this gene is atsA [H]

Identifier: 103485797

GI number: 103485797

Start: 301155

End: 302786

Strand: Direct

Name: atsA [H]

Synonym: Sala_0302

Alternate gene names: 103485797

Gene position: 301155-302786 (Clockwise)

Preceding gene: 103485794

Following gene: 103485798

Centisome position: 9.0

GC content: 66.97

Gene sequence:

>1632_bases
ATGGCCAATAAATGGGTGGCGCTGGGTGCCATGACGCTGGCGGCGGTCGGTGGCTATTGGGCCTATGACGCGAACAAATA
TCGCATCCCCGGCATCGTGCAGGACTGGCGCGAGCCGGTGCAGCCGAACCGGGCGATCGCGTGGCAGCAAGGGCCGGCGG
CGGCGCCGGAGGGCGCGCGGCCGCCGAACATCATCCTGATCGTCGCCGACGACCTGGGCTATAACGACATCAGCCTGAAC
GGCGGCGGCGTCGCGGGGATCGTCAAGACGCCGAACATCGATGCGCTGGCGCGTGAGGGGGTCCATTTCACCACCGCCTA
TGCCGCCAACGCGACCTGCTCGCCCTCGCGCGCGGCGATGATGACGGGGCGCTATCCGACGCGCTTCGGCTTCGAGTTCA
CCGCGGTGCCGATCGAGTTCGCCGAAAATCTGGCGCATGGCGAGGGTGTCGGGCCGCACCGCGCGATCTTTCACGACGAA
CTGGTGACGCCCGACATCCCGCCCTATCCCCAGATGGGGGTGCCCGCGAGCGAGGTGACAATTGCCGAAGCGGTGAAGGC
GGCGGGCTATCACACGGTTCACATCGGCAAATGGCATCTGGGCGAAGCCCCCGAATTGCAGCCGCACGCCCAGGGCTTCG
ACGAAAGCCTGGCGGTGCTGGCGGGCGCGGCAATGCTGCTGCCCGAGGATGACCCCGACGCAGTCAACGCCAAGCTGCCG
TGGGATCCGATCGACCGCTTCATCTGGGCCAATCTGCGCCACGCAGTGACCTTCAACGGCAGCAAGCGGTTTGCCGCGCA
GGGGCATATGACCGACTATTTCGCCGACGAGGCGATCAAGGCGATCGAAGCGAACCGGAACCGGCCCTTTTTCCTCTATC
TTGCCTTCACCGCGCCGCACACGCCGCTGCAGGCGACGCGCGCCGATTATGACCGGCTCGCGGCGATCAAGGATCACAGG
ACGCGCGTTTATGGCGCGATGATCGCGCAGATGGACCGGCGGATCGGCGACGTGATGGCCAAGCTGAAGGAGGCCGGGAT
CGACGACAATACGCTCGTCATCTTCACCAGCGACAATGGCGGCGCCTGGTACAACGGGATGCCGGGGCTGAATGCGCCGT
TCCGCGGGTGGAAAGCGACCTTTTTCGAAGGCGGCATCCGGGCGCCGCTGTTCATGCGCTGGCCAGCGCGCATCGCGCCG
GGGACCGAGCGCGGCGACGTGACGGGCCATCTCGACCTTTTCGCGACGATTGCCGCCGCGGCGGGCGCGGCGCTGCCCGC
GGACCGGACGATCGACAGCGAGGATATATTGGCCGGTCCCGCCAAGCGTCCGGCGATGTTCTGGCGCTCGGGCGATTATC
GCGCGGTGCGCGCGGGCGACTGGAAATTGCAGGTGACGAAGCGACCCGAAAAGGCGCGCCTCTATAACCTTGCCGCCGAT
CCGACCGAACGGACCGACCTGTCGGCGCGCGAGCCGGCGCGCGTCGCCGAACTCGGCGCGATGATCGAGGCGCAGAACCG
GGGCATGGCGACGCCGATCTGGCCGGGGTTGGTCGAAGGGCCGGTGCGCATCGACGTGCCGCTGAACACGCCGTGGCAGG
ACGGGCAGGATTATATCTATTGGACCAACTGA

Upstream 100 bases:

>100_bases
GCCGCCGACGTCAAACGATCTTGCACTTCGGCGAATATAATGACACATATAGTGCCAATAGTTTTCGGGCAAGCCGAAGC
GGCGGGTGAAGGGAGCGGGC

Downstream 100 bases:

>100_bases
TCGCGTCTGACCGCTTGTGAAACAAGGCCGCCGCACGTTAAGGGGCGGGGATGGCAAAGGGATCGGGGTCCAATGGCGGC
GGCAACGCGCGCCCGACGAT

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MANKWVALGAMTLAAVGGYWAYDANKYRIPGIVQDWREPVQPNRAIAWQQGPAAAPEGARPPNIILIVADDLGYNDISLN
GGGVAGIVKTPNIDALAREGVHFTTAYAANATCSPSRAAMMTGRYPTRFGFEFTAVPIEFAENLAHGEGVGPHRAIFHDE
LVTPDIPPYPQMGVPASEVTIAEAVKAAGYHTVHIGKWHLGEAPELQPHAQGFDESLAVLAGAAMLLPEDDPDAVNAKLP
WDPIDRFIWANLRHAVTFNGSKRFAAQGHMTDYFADEAIKAIEANRNRPFFLYLAFTAPHTPLQATRADYDRLAAIKDHR
TRVYGAMIAQMDRRIGDVMAKLKEAGIDDNTLVIFTSDNGGAWYNGMPGLNAPFRGWKATFFEGGIRAPLFMRWPARIAP
GTERGDVTGHLDLFATIAAAAGAALPADRTIDSEDILAGPAKRPAMFWRSGDYRAVRAGDWKLQVTKRPEKARLYNLAAD
PTERTDLSAREPARVAELGAMIEAQNRGMATPIWPGLVEGPVRIDVPLNTPWQDGQDYIYWTN

Sequences:

>Translated_543_residues
MANKWVALGAMTLAAVGGYWAYDANKYRIPGIVQDWREPVQPNRAIAWQQGPAAAPEGARPPNIILIVADDLGYNDISLN
GGGVAGIVKTPNIDALAREGVHFTTAYAANATCSPSRAAMMTGRYPTRFGFEFTAVPIEFAENLAHGEGVGPHRAIFHDE
LVTPDIPPYPQMGVPASEVTIAEAVKAAGYHTVHIGKWHLGEAPELQPHAQGFDESLAVLAGAAMLLPEDDPDAVNAKLP
WDPIDRFIWANLRHAVTFNGSKRFAAQGHMTDYFADEAIKAIEANRNRPFFLYLAFTAPHTPLQATRADYDRLAAIKDHR
TRVYGAMIAQMDRRIGDVMAKLKEAGIDDNTLVIFTSDNGGAWYNGMPGLNAPFRGWKATFFEGGIRAPLFMRWPARIAP
GTERGDVTGHLDLFATIAAAAGAALPADRTIDSEDILAGPAKRPAMFWRSGDYRAVRAGDWKLQVTKRPEKARLYNLAAD
PTERTDLSAREPARVAELGAMIEAQNRGMATPIWPGLVEGPVRIDVPLNTPWQDGQDYIYWTN
>Mature_542_residues
ANKWVALGAMTLAAVGGYWAYDANKYRIPGIVQDWREPVQPNRAIAWQQGPAAAPEGARPPNIILIVADDLGYNDISLNG
GGVAGIVKTPNIDALAREGVHFTTAYAANATCSPSRAAMMTGRYPTRFGFEFTAVPIEFAENLAHGEGVGPHRAIFHDEL
VTPDIPPYPQMGVPASEVTIAEAVKAAGYHTVHIGKWHLGEAPELQPHAQGFDESLAVLAGAAMLLPEDDPDAVNAKLPW
DPIDRFIWANLRHAVTFNGSKRFAAQGHMTDYFADEAIKAIEANRNRPFFLYLAFTAPHTPLQATRADYDRLAAIKDHRT
RVYGAMIAQMDRRIGDVMAKLKEAGIDDNTLVIFTSDNGGAWYNGMPGLNAPFRGWKATFFEGGIRAPLFMRWPARIAPG
TERGDVTGHLDLFATIAAAAGAALPADRTIDSEDILAGPAKRPAMFWRSGDYRAVRAGDWKLQVTKRPEKARLYNLAADP
TERTDLSAREPARVAELGAMIEAQNRGMATPIWPGLVEGPVRIDVPLNTPWQDGQDYIYWTN

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4503899, Length=425, Percent_Identity=32.9411764705882, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI146229331, Length=475, Percent_Identity=32.2105263157895, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI146229329, Length=475, Percent_Identity=32.2105263157895, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI6005990, Length=475, Percent_Identity=32.2105263157895, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI146229324, Length=475, Percent_Identity=32.2105263157895, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI59797060, Length=506, Percent_Identity=27.4703557312253, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI109389362, Length=513, Percent_Identity=26.7056530214425, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI38569405, Length=524, Percent_Identity=26.9083969465649, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI38569407, Length=393, Percent_Identity=29.5165394402036, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI157266309, Length=456, Percent_Identity=28.0701754385965, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI45430057, Length=400, Percent_Identity=29.75, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI146229327, Length=367, Percent_Identity=31.0626702997275, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI53831991, Length=293, Percent_Identity=29.3515358361775, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI58743319, Length=140, Percent_Identity=40.7142857142857, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI31742482, Length=159, Percent_Identity=37.7358490566038, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI71852586, Length=143, Percent_Identity=37.0629370629371, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI71852584, Length=143, Percent_Identity=37.0629370629371, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI87081924, Length=534, Percent_Identity=25.6554307116105, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1790233, Length=537, Percent_Identity=27.7467411545624, Blast_Score=136, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI115533416, Length=508, Percent_Identity=28.1496062992126, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI115533418, Length=499, Percent_Identity=28.0561122244489, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17559078, Length=281, Percent_Identity=28.8256227758007, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24666175, Length=383, Percent_Identity=29.7650130548303, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI281366397, Length=410, Percent_Identity=30.4878048780488, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI281366395, Length=410, Percent_Identity=30.4878048780488, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24666163, Length=410, Percent_Identity=30.4878048780488, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI281363223, Length=431, Percent_Identity=29.9303944315545, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24666109, Length=442, Percent_Identity=30.7692307692308, Blast_Score=146, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 59299; Mature: 59167

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00523 SULFATASE_1 ; PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANKWVALGAMTLAAVGGYWAYDANKYRIPGIVQDWREPVQPNRAIAWQQGPAAAPEGAR
CCCCEEEHHHHHHHHHCCEEEECCCCEECCCHHHHHHHCCCCCCEEEECCCCCCCCCCCC
PPNIILIVADDLGYNDISLNGGGVAGIVKTPNIDALAREGVHFTTAYAANATCSPSRAAM
CCCEEEEEECCCCCCEEEECCCCEEEEEECCCHHHHHHCCCEEEEEEECCCCCCCCHHEE
MTGRYPTRFGFEFTAVPIEFAENLAHGEGVGPHRAIFHDELVTPDIPPYPQMGVPASEVT
EECCCCCCCCCEEEEECHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHH
IAEAVKAAGYHTVHIGKWHLGEAPELQPHAQGFDESLAVLAGAAMLLPEDDPDAVNAKLP
HHHHHHHCCEEEEEEEEEECCCCCCCCHHHCCHHHHHHHHHCEEEECCCCCCCCEECCCC
WDPIDRFIWANLRHAVTFNGSKRFAAQGHMTDYFADEAIKAIEANRNRPFFLYLAFTAPH
CCHHHHHHHHCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCC
TPLQATRADYDRLAAIKDHRTRVYGAMIAQMDRRIGDVMAKLKEAGIDDNTLVIFTSDNG
CCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
GAWYNGMPGLNAPFRGWKATFFEGGIRAPLFMRWPARIAPGTERGDVTGHLDLFATIAAA
CEEECCCCCCCCCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCCCCEEHHHHHHHHHHH
AGAALPADRTIDSEDILAGPAKRPAMFWRSGDYRAVRAGDWKLQVTKRPEKARLYNLAAD
HCCCCCCCCCCCCCHHCCCCCCCCEEEEECCCEEEEEECCEEEEEECCCCHHEEEEECCC
PTERTDLSAREPARVAELGAMIEAQNRGMATPIWPGLVEGPVRIDVPLNTPWQDGQDYIY
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEE
WTN
ECC
>Mature Secondary Structure 
ANKWVALGAMTLAAVGGYWAYDANKYRIPGIVQDWREPVQPNRAIAWQQGPAAAPEGAR
CCCEEEHHHHHHHHHCCEEEECCCCEECCCHHHHHHHCCCCCCEEEECCCCCCCCCCCC
PPNIILIVADDLGYNDISLNGGGVAGIVKTPNIDALAREGVHFTTAYAANATCSPSRAAM
CCCEEEEEECCCCCCEEEECCCCEEEEEECCCHHHHHHCCCEEEEEEECCCCCCCCHHEE
MTGRYPTRFGFEFTAVPIEFAENLAHGEGVGPHRAIFHDELVTPDIPPYPQMGVPASEVT
EECCCCCCCCCEEEEECHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHH
IAEAVKAAGYHTVHIGKWHLGEAPELQPHAQGFDESLAVLAGAAMLLPEDDPDAVNAKLP
HHHHHHHCCEEEEEEEEEECCCCCCCCHHHCCHHHHHHHHHCEEEECCCCCCCCEECCCC
WDPIDRFIWANLRHAVTFNGSKRFAAQGHMTDYFADEAIKAIEANRNRPFFLYLAFTAPH
CCHHHHHHHHCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCC
TPLQATRADYDRLAAIKDHRTRVYGAMIAQMDRRIGDVMAKLKEAGIDDNTLVIFTSDNG
CCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
GAWYNGMPGLNAPFRGWKATFFEGGIRAPLFMRWPARIAPGTERGDVTGHLDLFATIAAA
CEEECCCCCCCCCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCCCCEEHHHHHHHHHHH
AGAALPADRTIDSEDILAGPAKRPAMFWRSGDYRAVRAGDWKLQVTKRPEKARLYNLAAD
HCCCCCCCCCCCCCHHCCCCCCCCEEEEECCCEEEEEECCEEEEEECCCCHHEEEEECCC
PTERTDLSAREPARVAELGAMIEAQNRGMATPIWPGLVEGPVRIDVPLNTPWQDGQDYIY
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEE
WTN
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7744061; 10984043 [H]