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The map label for this gene is yhdN [H]

Identifier: 99081032

GI number: 99081032

Start: 1281161

End: 1282156

Strand: Direct

Name: yhdN [H]

Synonym: TM1040_1191

Alternate gene names: 99081032

Gene position: 1281161-1282156 (Clockwise)

Preceding gene: 99081031

Following gene: 99081033

Centisome position: 40.02

GC content: 60.94

Gene sequence:

>996_bases
ATGTCGCATGAAATGCTGAAACGTGAGATCGGCCGCTCCGGGATCGAGGCTTCGGCCATCGGGCTTGGCACCTGGGCCAT
TGGCGGCTGGATGTGGGGTGGCACGGATGAGGCGCGCTCGATCGCCGCTATTCAGGCCTCGATTGAGGCCGGAGTGAGCC
TCATCGACACCGCGCCCGCCTATGGTCAGGGCGTCGCCGAGGAGATCGTCGGCAAGGCCATCAAGGACCGTCGCGACAAG
GTGGTGCTGGCCACGAAATGCGGGCTCGTCTGGCACACGCAAAAGGGCAATCACTTCTTTGATTACGACGGCGCGCCGGT
GCATCGCTATCTTGGCAAGGATGCGATCATCTATGAGGTCGAACAAAGCCTCACGCGTCTCGGCACCGATTACATCGATC
ACTACATCACCCATTGGCAGGATCCCACGACGCCGATTGCCGAAACGATGGAGGCGCTGGAGCAGCTGAAAACACAGGGC
AAAATCCGCTCGATTGGTGCCAGCAATACCACGCCTTTGGACGTGCGTGCCTATCTCGAGGCGGGACAGCTTGATGCGGT
TCAAGAAGAATATTCGATGGTGAACCGCGCGGTTGAGGCCGAGATGGCGCCGCTCTGTCATGAAAACGGGGTGTCCATCC
TCAGCTATTCCTCGCTCGCGCTGGGGCTTCTGACCGGCAAGATCGGCCCCGACCGGGTGTTTGAAGGCGACGATCAGCGC
AAGGACAACCCACGGTTTTCAATTGCCAATCGCGAAAAAGTGGCCCGCTTGATGGAGGCCATCGCGCACATTGCCGAAGT
ACACGGTGCCACCAAGGCCCAGGTGGTGATCGCCTGGACGCTGCAGCAGCCGGGGATAACCTTCTCGCTCTGCGGGGCGC
GCGATGCGACACAAGCAGTTGAAAACGCCAAGGCGGGTCTGCTGCGTCTCAGCGCGGATGACATTGCCCGGATAAGCGGT
GCCGCCAGCACGCATCTCAGCGACCTCGACGGCTGA

Upstream 100 bases:

>100_bases
CGCCCCATCGAGGCGGCGCTTGAAGGCGGGTTTCTGAGCTCGCTCATCGTTGACGAAGACACGGCCGCAGAAGTGCTGCA
GAAATATGAAGGAACTGAAT

Downstream 100 bases:

>100_bases
TTCACAGGCCCTGACGCCACCACATGACATGCACAAAACGCTGCGACGACCTCGTCAGCGCACGGAGAAGATATGCCCGA
TCAACGAGTGAAAAACTGGC

Product: aldo/keto reductase

Products: NA

Alternate protein names: GSP69; AKR11B [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MSHEMLKREIGRSGIEASAIGLGTWAIGGWMWGGTDEARSIAAIQASIEAGVSLIDTAPAYGQGVAEEIVGKAIKDRRDK
VVLATKCGLVWHTQKGNHFFDYDGAPVHRYLGKDAIIYEVEQSLTRLGTDYIDHYITHWQDPTTPIAETMEALEQLKTQG
KIRSIGASNTTPLDVRAYLEAGQLDAVQEEYSMVNRAVEAEMAPLCHENGVSILSYSSLALGLLTGKIGPDRVFEGDDQR
KDNPRFSIANREKVARLMEAIAHIAEVHGATKAQVVIAWTLQQPGITFSLCGARDATQAVENAKAGLLRLSADDIARISG
AASTHLSDLDG

Sequences:

>Translated_331_residues
MSHEMLKREIGRSGIEASAIGLGTWAIGGWMWGGTDEARSIAAIQASIEAGVSLIDTAPAYGQGVAEEIVGKAIKDRRDK
VVLATKCGLVWHTQKGNHFFDYDGAPVHRYLGKDAIIYEVEQSLTRLGTDYIDHYITHWQDPTTPIAETMEALEQLKTQG
KIRSIGASNTTPLDVRAYLEAGQLDAVQEEYSMVNRAVEAEMAPLCHENGVSILSYSSLALGLLTGKIGPDRVFEGDDQR
KDNPRFSIANREKVARLMEAIAHIAEVHGATKAQVVIAWTLQQPGITFSLCGARDATQAVENAKAGLLRLSADDIARISG
AASTHLSDLDG
>Mature_330_residues
SHEMLKREIGRSGIEASAIGLGTWAIGGWMWGGTDEARSIAAIQASIEAGVSLIDTAPAYGQGVAEEIVGKAIKDRRDKV
VLATKCGLVWHTQKGNHFFDYDGAPVHRYLGKDAIIYEVEQSLTRLGTDYIDHYITHWQDPTTPIAETMEALEQLKTQGK
IRSIGASNTTPLDVRAYLEAGQLDAVQEEYSMVNRAVEAEMAPLCHENGVSILSYSSLALGLLTGKIGPDRVFEGDDQRK
DNPRFSIANREKVARLMEAIAHIAEVHGATKAQVVIAWTLQQPGITFSLCGARDATQAVENAKAGLLRLSADDIARISGA
ASTHLSDLDG

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=331, Percent_Identity=32.6283987915408, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI4504825, Length=328, Percent_Identity=32.6219512195122, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI27436966, Length=320, Percent_Identity=30.3125, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI27436964, Length=320, Percent_Identity=30.3125, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI27436962, Length=317, Percent_Identity=30.2839116719243, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI27436971, Length=334, Percent_Identity=29.6407185628743, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI223718702, Length=220, Percent_Identity=29.0909090909091, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI41152114, Length=234, Percent_Identity=28.2051282051282, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI41327764, Length=234, Percent_Identity=29.4871794871795, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1788070, Length=317, Percent_Identity=41.6403785488959, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI87081735, Length=334, Percent_Identity=32.3353293413174, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI1789199, Length=354, Percent_Identity=29.0960451977401, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1788081, Length=322, Percent_Identity=28.8819875776398, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1789375, Length=334, Percent_Identity=28.1437125748503, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI48994888, Length=329, Percent_Identity=24.3161094224924, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786400, Length=303, Percent_Identity=28.0528052805281, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI212645785, Length=310, Percent_Identity=27.0967741935484, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6325169, Length=298, Percent_Identity=26.510067114094, Blast_Score=92, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6323998, Length=333, Percent_Identity=26.7267267267267, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319958, Length=296, Percent_Identity=26.6891891891892, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319951, Length=294, Percent_Identity=25.8503401360544, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322615, Length=260, Percent_Identity=25, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321052, Length=167, Percent_Identity=31.7365269461078, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24646155, Length=247, Percent_Identity=31.1740890688259, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24640980, Length=323, Percent_Identity=26.3157894736842, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24646159, Length=238, Percent_Identity=30.2521008403361, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45549126, Length=323, Percent_Identity=26.3157894736842, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 35797; Mature: 35666

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHEMLKREIGRSGIEASAIGLGTWAIGGWMWGGTDEARSIAAIQASIEAGVSLIDTAPA
CCHHHHHHHHCCCCCCHHHEECCHHHHCCEECCCCHHHHHHHHHHHHHHHCCCEEECCCC
YGQGVAEEIVGKAIKDRRDKVVLATKCGLVWHTQKGNHFFDYDGAPVHRYLGKDAIIYEV
CCCCHHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCEEECCCCCHHHHHHCCCCEEHHH
EQSLTRLGTDYIDHYITHWQDPTTPIAETMEALEQLKTQGKIRSIGASNTTPLDVRAYLE
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHH
AGQLDAVQEEYSMVNRAVEAEMAPLCHENGVSILSYSSLALGLLTGKIGPDRVFEGDDQR
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCC
KDNPRFSIANREKVARLMEAIAHIAEVHGATKAQVVIAWTLQQPGITFSLCGARDATQAV
CCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCEEEECCCCHHHHHH
ENAKAGLLRLSADDIARISGAASTHLSDLDG
HHHHHCEEEECHHHHHHHCCCHHHCHHCCCC
>Mature Secondary Structure 
SHEMLKREIGRSGIEASAIGLGTWAIGGWMWGGTDEARSIAAIQASIEAGVSLIDTAPA
CHHHHHHHHCCCCCCHHHEECCHHHHCCEECCCCHHHHHHHHHHHHHHHCCCEEECCCC
YGQGVAEEIVGKAIKDRRDKVVLATKCGLVWHTQKGNHFFDYDGAPVHRYLGKDAIIYEV
CCCCHHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCEEECCCCCHHHHHHCCCCEEHHH
EQSLTRLGTDYIDHYITHWQDPTTPIAETMEALEQLKTQGKIRSIGASNTTPLDVRAYLE
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHH
AGQLDAVQEEYSMVNRAVEAEMAPLCHENGVSILSYSSLALGLLTGKIGPDRVFEGDDQR
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCC
KDNPRFSIANREKVARLMEAIAHIAEVHGATKAQVVIAWTLQQPGITFSLCGARDATQAV
CCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCEEEECCCCHHHHHH
ENAKAGLLRLSADDIARISGAASTHLSDLDG
HHHHHCEEEECHHHHHHHCCCHHHCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 9298659 [H]