Click here to switch to the map view.

The map label for this gene is rsbRA [H]

Identifier: 99080804

GI number: 99080804

Start: 1030665

End: 1031591

Strand: Direct

Name: rsbRA [H]

Synonym: TM1040_0963

Alternate gene names: 99080804

Gene position: 1030665-1031591 (Clockwise)

Preceding gene: 99080803

Following gene: 99080805

Centisome position: 32.2

GC content: 56.53

Gene sequence:

>927_bases
ATGTCGAAATCGCACGCTGTCGTTCACTCCGCTTTGGCTGATGAAGCCAGCCAACATAACAACACCTTGTCCTGGTTTGA
CATTACGCCTGCCGATCAAGAGCGGGTACGATCGCTTGCCCCCATCGCGGACCACGTTGGCGAGGAGATCATTGCAGATT
TCTATGCGCATATTCTGCGGTTTGAGGACGCGGCCCAACAATTTGCGGACGACACGCAAATCGAGCGTGTAAAACGCGGC
CAAAAGAAATATTTTCAAGAGCTGATCAACGCCGAGCTTGACGAGTCCTATGCCGAGGAACGCAAGCGGATCGGTGGCAT
TCACGAACGTGCAGGTATCACGCCCACGCTCTATGTTGGCTCTTACGCCTACTACCTGCAACGACTGAGCCAGTCTATTC
TCGAGAACGGGAAGGAGGATCCGCACAAGCTCTTTGGCCTTGTGCTCTCGATGATGAAGATTGCTCATTACGACATGGCG
CTCGCCCTGGAAACCTACGTCGAGGCGCGCGAAAAGACGATTGAAATCCACGAGCGGCAGATGCGCGAGCTGCCCACGCC
GGTTCTGGAACTGCGCGAGGGCCTGCTGCTGGTGCCCGTTGTTGGTGCGCTGGACAGTCATCGCGCCAGAACGTTGACGA
TGCAACTGTTGGATGGGATTCGGGATACACGAAGTCGCGCGGTGGTGCTCGACATTACAGGTGCCGTTTCCATCGACAGC
AGCGTTGCAAACCATCTGTTTCAGGCCATGACAGCAGCGCGGCTCATGGGCGCAAAGTCCATCCTCGCCGGGATCTCTCC
GACTGTTGCGCAAGAGTTGTTTCGGATCGGCGTTGATACCAAGACCTTTACCACAGCCAGAAACCTGCAGCAGGGGATCG
AGCTCGCGGCCTCCGCGCTTGAGGCGCATTCCAAGCACTCGGTCTAA

Upstream 100 bases:

>100_bases
TCCGCCGTAGGGTCATCTTAACTTTTAAATAGGAATATAATACTTACCTTACGTGATTTGCTGTGGGCGATGTTTGGCCC
AATGATAGGAATGAACACGA

Downstream 100 bases:

>100_bases
TCAGTCGGTTTTCATGTCACCCCCGTCGTCTGAGCGCACGCCCCTTGCGGCCTATTGACGGCCTCGCTTGCCTTGATCCA
TCGCACCTTGCATGGCTGGC

Product: anti-sigma-factor antagonist

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MSKSHAVVHSALADEASQHNNTLSWFDITPADQERVRSLAPIADHVGEEIIADFYAHILRFEDAAQQFADDTQIERVKRG
QKKYFQELINAELDESYAEERKRIGGIHERAGITPTLYVGSYAYYLQRLSQSILENGKEDPHKLFGLVLSMMKIAHYDMA
LALETYVEAREKTIEIHERQMRELPTPVLELREGLLLVPVVGALDSHRARTLTMQLLDGIRDTRSRAVVLDITGAVSIDS
SVANHLFQAMTAARLMGAKSILAGISPTVAQELFRIGVDTKTFTTARNLQQGIELAASALEAHSKHSV

Sequences:

>Translated_308_residues
MSKSHAVVHSALADEASQHNNTLSWFDITPADQERVRSLAPIADHVGEEIIADFYAHILRFEDAAQQFADDTQIERVKRG
QKKYFQELINAELDESYAEERKRIGGIHERAGITPTLYVGSYAYYLQRLSQSILENGKEDPHKLFGLVLSMMKIAHYDMA
LALETYVEAREKTIEIHERQMRELPTPVLELREGLLLVPVVGALDSHRARTLTMQLLDGIRDTRSRAVVLDITGAVSIDS
SVANHLFQAMTAARLMGAKSILAGISPTVAQELFRIGVDTKTFTTARNLQQGIELAASALEAHSKHSV
>Mature_307_residues
SKSHAVVHSALADEASQHNNTLSWFDITPADQERVRSLAPIADHVGEEIIADFYAHILRFEDAAQQFADDTQIERVKRGQ
KKYFQELINAELDESYAEERKRIGGIHERAGITPTLYVGSYAYYLQRLSQSILENGKEDPHKLFGLVLSMMKIAHYDMAL
ALETYVEAREKTIEIHERQMRELPTPVLELREGLLLVPVVGALDSHRARTLTMQLLDGIRDTRSRAVVLDITGAVSIDSS
VANHLFQAMTAARLMGAKSILAGISPTVAQELFRIGVDTKTFTTARNLQQGIELAASALEAHSKHSV

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG1366

COG function: function code T; Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: NA

Molecular weight: Translated: 34331; Mature: 34199

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSHAVVHSALADEASQHNNTLSWFDITPADQERVRSLAPIADHVGEEIIADFYAHILR
CCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FEDAAQQFADDTQIERVKRGQKKYFQELINAELDESYAEERKRIGGIHERAGITPTLYVG
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHH
SYAYYLQRLSQSILENGKEDPHKLFGLVLSMMKIAHYDMALALETYVEAREKTIEIHERQ
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRELPTPVLELREGLLLVPVVGALDSHRARTLTMQLLDGIRDTRSRAVVLDITGAVSIDS
HHHCCCHHHHHHCCEEEEHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHH
SVANHLFQAMTAARLMGAKSILAGISPTVAQELFRIGVDTKTFTTARNLQQGIELAASAL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
EAHSKHSV
HHHHCCCC
>Mature Secondary Structure 
SKSHAVVHSALADEASQHNNTLSWFDITPADQERVRSLAPIADHVGEEIIADFYAHILR
CCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FEDAAQQFADDTQIERVKRGQKKYFQELINAELDESYAEERKRIGGIHERAGITPTLYVG
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHH
SYAYYLQRLSQSILENGKEDPHKLFGLVLSMMKIAHYDMALALETYVEAREKTIEIHERQ
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRELPTPVLELREGLLLVPVVGALDSHRARTLTMQLLDGIRDTRSRAVVLDITGAVSIDS
HHHCCCHHHHHHCCEEEEHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHH
SVANHLFQAMTAARLMGAKSILAGISPTVAQELFRIGVDTKTFTTARNLQQGIELAASAL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
EAHSKHSV
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]