Click here to switch to the map view.

The map label for this gene is ndk [H]

Identifier: 99080798

GI number: 99080798

Start: 1023097

End: 1023519

Strand: Direct

Name: ndk [H]

Synonym: TM1040_0957

Alternate gene names: 99080798

Gene position: 1023097-1023519 (Clockwise)

Preceding gene: 99080797

Following gene: 99080800

Centisome position: 31.96

GC content: 58.87

Gene sequence:

>423_bases
ATGGCACTGGAACGCACCTTTTCGATCATCAAGCCCGATGCAACCCGCCGCAACCTGACTGGCGCAATCAACGCCAAGTT
CGAAGAAGCAGGCCTGCGCATCGTCGCTCAGAAGCGCATCCACATGACCAAGGCACAGGCCGGTAAATTCTACGCCGTGC
ACGCCGAGCGTCCCTTCTATGACGAACTGTGCGAATTCATGTCCTCCGCTCCGGTTGTGGTTCAGGTTCTCGAAGGCGAA
GGCGCCATCGCAAAGAACCGCGAAATCATGGGTGCAACCAACCCCGCTGACGCAGCTCCCGGCACCATCCGTGCCGAGTT
CGCAGAATCCGTGGGTGAGAACTCCGTGCACGGCTCCGACGCACCGGAAACCGCAGCAGAAGAAATCGCCTACTTCTTCT
CCGGTCTCGAACTGGTTGGCTAA

Upstream 100 bases:

>100_bases
GGCGGGCTGTCGTGCTAGGCGGCGCCAGATCGTTGCGGCACCCTGGTTTCGGACGCCGTGACACCTAATCGACCTTAGTA
TTTCTCAAGGAGATCGCCCG

Downstream 100 bases:

>100_bases
GTGCTGCGTCGTCGCAGCTGCGACGACGGGCAGGGGCCTCGAGGGGGCCAGCTGAAAATCAAAAACCGCCACGCTGCATG
CGTGGCGGTTTTCTTTTGAG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MALERTFSIIKPDATRRNLTGAINAKFEEAGLRIVAQKRIHMTKAQAGKFYAVHAERPFYDELCEFMSSAPVVVQVLEGE
GAIAKNREIMGATNPADAAPGTIRAEFAESVGENSVHGSDAPETAAEEIAYFFSGLELVG

Sequences:

>Translated_140_residues
MALERTFSIIKPDATRRNLTGAINAKFEEAGLRIVAQKRIHMTKAQAGKFYAVHAERPFYDELCEFMSSAPVVVQVLEGE
GAIAKNREIMGATNPADAAPGTIRAEFAESVGENSVHGSDAPETAAEEIAYFFSGLELVG
>Mature_139_residues
ALERTFSIIKPDATRRNLTGAINAKFEEAGLRIVAQKRIHMTKAQAGKFYAVHAERPFYDELCEFMSSAPVVVQVLEGEG
AIAKNREIMGATNPADAAPGTIRAEFAESVGENSVHGSDAPETAAEEIAYFFSGLELVG

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=138, Percent_Identity=45.6521739130435, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=43.7956204379562, Blast_Score=125, Evalue=8e-30,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=43.7956204379562, Blast_Score=125, Evalue=8e-30,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=43.7956204379562, Blast_Score=125, Evalue=8e-30,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=43.7956204379562, Blast_Score=125, Evalue=8e-30,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=43.7956204379562, Blast_Score=125, Evalue=9e-30,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=43.3823529411765, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=43.3823529411765, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=38.2352941176471, Blast_Score=106, Evalue=7e-24,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=36.0294117647059, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=31.5789473684211, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=31.5789473684211, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=32.6086956521739, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI30023828, Length=140, Percent_Identity=33.5714285714286, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788866, Length=133, Percent_Identity=57.8947368421053, Blast_Score=166, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=45.1851851851852, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=40.4411764705882, Blast_Score=119, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=47.0588235294118, Blast_Score=131, Evalue=1e-31,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=32.8358208955224, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15089; Mature: 14958

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALERTFSIIKPDATRRNLTGAINAKFEEAGLRIVAQKRIHMTKAQAGKFYAVHAERPFY
CCCCCCHHEECCCCCCCCCCCCCCCEEHHCCEEEEHHHHHHHHHCCCCCEEEEECCCCCH
DELCEFMSSAPVVVQVLEGEGAIAKNREIMGATNPADAAPGTIRAEFAESVGENSVHGSD
HHHHHHHCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCC
APETAAEEIAYFFSGLELVG
CCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALERTFSIIKPDATRRNLTGAINAKFEEAGLRIVAQKRIHMTKAQAGKFYAVHAERPFY
CCCCCHHEECCCCCCCCCCCCCCCEEHHCCEEEEHHHHHHHHHCCCCCEEEEECCCCCH
DELCEFMSSAPVVVQVLEGEGAIAKNREIMGATNPADAAPGTIRAEFAESVGENSVHGSD
HHHHHHHCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCC
APETAAEEIAYFFSGLELVG
CCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA