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The map label for this gene is algA [H]

Identifier: 99080800

GI number: 99080800

Start: 1024317

End: 1025639

Strand: Direct

Name: algA [H]

Synonym: TM1040_0959

Alternate gene names: 99080800

Gene position: 1024317-1025639 (Clockwise)

Preceding gene: 99080798

Following gene: 99080802

Centisome position: 32.0

GC content: 62.66

Gene sequence:

>1323_bases
ATGTTGCACCCCATTATCCTCGCAGGAGGCGTCACACAGACCAGCGAATGGTCCACCGGGGTGTGCCATCTGGCACTTGA
AACCGCACCCGGCGTTCCCAGCAGATTTGAGGGCGTGCTTGATGCGATGTCCGGCGATGTGTTTGCCGACCCGGTGGTTG
TGACCACCCGGGACAACATGTCCCTGGTCGAGCGCCAGATCGCAGCACGTCCGGCGGCCCTGATCGTCGAGCCGGAGACC
CACAAGCCAGCCGCCGCCCTCCTGAGCGCCGTTCTCTCGCTGCGCCACATGCCCGGTGCACTTGTGGTGGTTGCGCCTGC
AACCGCAAACCTCGCCGATACACGCAATCTCGACAAGGCCCTGTGCAATGCCATCCCAGCAGCCCAACGCGGCGAGATCG
TGATGTTTGGTCAGCGCACCACCCGCGCCTATGGCGGCTTTGGCATCATGGAGGTGGTTACGCAACCGCATGAAAATGCG
CCCGTCGCCGTCAGCCGGGTGCTCGCCTCAGGGCGAAAGGTGACGCTGTCGCATCTTCTCCATGGCAATCACCAGCTCTG
GGGCACCGGGCTCTATTTAGCACGCGTCGATGTCTTGCTGGCCGCTTTCAAATCCCATGCAAGCCGCCTGTTTCTGCCGG
TGAAGAACGCGCTTTTGCGGGCCGGGACGGTGGATCGCACCACCTTGCTGGACCGGGCCACTTATCGACGTGTAAAGGCG
ATCACCTTTGAAAAGGCCGTTGCCGAAAAGATTGAGAACATCTGCGCTATTCAGCTCGATCCGACCTGGAGCGCGCTGGA
AGAGTGGGATCAGGACGCCGCCGCCGACAGCGCTGTTGCGCAATGGGACGAAGATCTGGCGCAAGAACGTGCGGGTGTCC
TGAACGCGCGCGCCGCCGCGCCATTCCCGCATTCGGCAGACATGATGGCGGTTTATGCCAGCCTGTCGAAAATCTCGGCG
GAGGATGCCCTGTCGGCTCATGCTACCGAATATGACTGGGGCCGTCTCGAAAGCCTCGCCATGGGGCCGGGGTTCACGCT
GCAGCGCATGTCGATCGCTCCGGGTGCGACCCTTGATCTGAACGCCGCGCCCGGCGGGGCGGAACATTGGATCGTCGCGC
AAGGCTCGGTACTGATTACGATTGGCGATCATGTGCGCCTTGTCTGGGAAGGTCATAGCGCCCGCATTCCAGCTGGCCGC
TCCCGCCGGATCGAGAATCCGGGTTCAGGCACGCTGGTTCTGGTTCAGCTGCAGGTCATGCCCCTCTCTGCAACAGGGCA
ACCTCAGAGCGCCGCAAGTTTTTCGCCCGCCGGTGTTGCCTGA

Upstream 100 bases:

>100_bases
ATCCTTTGGCGAGCGGTGCAACACCCGATGGATAGGACGTGCGGCAATGAAAGTTCGAATAGATTTGTGCACAACGGAAT
ACAATTAATCAGAGGTTCAA

Downstream 100 bases:

>100_bases
TCCGATCGCGCCTCCCGCGCGCTGCATCCGAGGCTGACGGTCTGTCTGACAGGCTTTGTGGTCAGACCGTCCAACCGAAC
CCTCGTCTGTGACAATGTCG

Product: mannose-6-phosphate isomerase, type II

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MLHPIILAGGVTQTSEWSTGVCHLALETAPGVPSRFEGVLDAMSGDVFADPVVVTTRDNMSLVERQIAARPAALIVEPET
HKPAAALLSAVLSLRHMPGALVVVAPATANLADTRNLDKALCNAIPAAQRGEIVMFGQRTTRAYGGFGIMEVVTQPHENA
PVAVSRVLASGRKVTLSHLLHGNHQLWGTGLYLARVDVLLAAFKSHASRLFLPVKNALLRAGTVDRTTLLDRATYRRVKA
ITFEKAVAEKIENICAIQLDPTWSALEEWDQDAAADSAVAQWDEDLAQERAGVLNARAAAPFPHSADMMAVYASLSKISA
EDALSAHATEYDWGRLESLAMGPGFTLQRMSIAPGATLDLNAAPGGAEHWIVAQGSVLITIGDHVRLVWEGHSARIPAGR
SRRIENPGSGTLVLVQLQVMPLSATGQPQSAASFSPAGVA

Sequences:

>Translated_440_residues
MLHPIILAGGVTQTSEWSTGVCHLALETAPGVPSRFEGVLDAMSGDVFADPVVVTTRDNMSLVERQIAARPAALIVEPET
HKPAAALLSAVLSLRHMPGALVVVAPATANLADTRNLDKALCNAIPAAQRGEIVMFGQRTTRAYGGFGIMEVVTQPHENA
PVAVSRVLASGRKVTLSHLLHGNHQLWGTGLYLARVDVLLAAFKSHASRLFLPVKNALLRAGTVDRTTLLDRATYRRVKA
ITFEKAVAEKIENICAIQLDPTWSALEEWDQDAAADSAVAQWDEDLAQERAGVLNARAAAPFPHSADMMAVYASLSKISA
EDALSAHATEYDWGRLESLAMGPGFTLQRMSIAPGATLDLNAAPGGAEHWIVAQGSVLITIGDHVRLVWEGHSARIPAGR
SRRIENPGSGTLVLVQLQVMPLSATGQPQSAASFSPAGVA
>Mature_440_residues
MLHPIILAGGVTQTSEWSTGVCHLALETAPGVPSRFEGVLDAMSGDVFADPVVVTTRDNMSLVERQIAARPAALIVEPET
HKPAAALLSAVLSLRHMPGALVVVAPATANLADTRNLDKALCNAIPAAQRGEIVMFGQRTTRAYGGFGIMEVVTQPHENA
PVAVSRVLASGRKVTLSHLLHGNHQLWGTGLYLARVDVLLAAFKSHASRLFLPVKNALLRAGTVDRTTLLDRATYRRVKA
ITFEKAVAEKIENICAIQLDPTWSALEEWDQDAAADSAVAQWDEDLAQERAGVLNARAAAPFPHSADMMAVYASLSKISA
EDALSAHATEYDWGRLESLAMGPGFTLQRMSIAPGATLDLNAAPGGAEHWIVAQGSVLITIGDHVRLVWEGHSARIPAGR
SRRIENPGSGTLVLVQLQVMPLSATGQPQSAASFSPAGVA

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=455, Percent_Identity=21.7582417582418, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 46695; Mature: 46695

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHPIILAGGVTQTSEWSTGVCHLALETAPGVPSRFEGVLDAMSGDVFADPVVVTTRDNM
CCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEECCEEEEECCCH
SLVERQIAARPAALIVEPETHKPAAALLSAVLSLRHMPGALVVVAPATANLADTRNLDKA
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHCCHHHH
LCNAIPAAQRGEIVMFGQRTTRAYGGFGIMEVVTQPHENAPVAVSRVLASGRKVTLSHLL
HHHHCCCCCCCCEEEEECCHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHCCCEEEEHHHH
HGNHQLWGTGLYLARVDVLLAAFKSHASRLFLPVKNALLRAGTVDRTTLLDRATYRRVKA
CCCCEEEECHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ITFEKAVAEKIENICAIQLDPTWSALEEWDQDAAADSAVAQWDEDLAQERAGVLNARAAA
HHHHHHHHHHHCCEEEEEECCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PFPHSADMMAVYASLSKISAEDALSAHATEYDWGRLESLAMGPGFTLQRMSIAPGATLDL
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEEEECCCCEEEE
NAAPGGAEHWIVAQGSVLITIGDHVRLVWEGHSARIPAGRSRRIENPGSGTLVLVQLQVM
CCCCCCCCEEEEECCCEEEEECCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEE
PLSATGQPQSAASFSPAGVA
EECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLHPIILAGGVTQTSEWSTGVCHLALETAPGVPSRFEGVLDAMSGDVFADPVVVTTRDNM
CCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEECCEEEEECCCH
SLVERQIAARPAALIVEPETHKPAAALLSAVLSLRHMPGALVVVAPATANLADTRNLDKA
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHCCHHHH
LCNAIPAAQRGEIVMFGQRTTRAYGGFGIMEVVTQPHENAPVAVSRVLASGRKVTLSHLL
HHHHCCCCCCCCEEEEECCHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHCCCEEEEHHHH
HGNHQLWGTGLYLARVDVLLAAFKSHASRLFLPVKNALLRAGTVDRTTLLDRATYRRVKA
CCCCEEEECHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ITFEKAVAEKIENICAIQLDPTWSALEEWDQDAAADSAVAQWDEDLAQERAGVLNARAAA
HHHHHHHHHHHCCEEEEEECCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PFPHSADMMAVYASLSKISAEDALSAHATEYDWGRLESLAMGPGFTLQRMSIAPGATLDL
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEEEECCCCEEEE
NAAPGGAEHWIVAQGSVLITIGDHVRLVWEGHSARIPAGRSRRIENPGSGTLVLVQLQVM
CCCCCCCCEEEEECCCEEEEECCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEE
PLSATGQPQSAASFSPAGVA
EECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12775688 [H]