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The map label for this gene is pdxA

Identifier: 99080786

GI number: 99080786

Start: 1007596

End: 1008576

Strand: Reverse

Name: pdxA

Synonym: TM1040_0945

Alternate gene names: 99080786

Gene position: 1008576-1007596 (Counterclockwise)

Preceding gene: 99080787

Following gene: 99080785

Centisome position: 31.51

GC content: 64.32

Gene sequence:

>981_bases
ATGACAGGCGCGCCGCAGGTCATTGCTCTCTCCTGCGGCGAACCTGCCGGGATCGGCCCGGAAATCGCTGTCGCCGCATG
GGATCAACTGCGCGCGGACTGCCCCTTCGTCTGGATCGGCGATCCGCGTCACCTGCCCTCATCCCACCCTTGGCAACCCG
TCTCTGCCCCCGCAGAGGCGTTGCAAGTCAGCGCAGATGCGCTGCCGGTATGGCCCTTGGAATTTGCCGGAAACACCACC
AAGGGCGAGGCCGACCCGCAAAACGCATCAGGTGTGATCCAATCGATCAAGACCGGTGTGGAGCTTGTAACTTCGGGCAA
GGCCGCAGCGCTCTGCACGGCTCCGATCCACAAAAAAGCGCTGATTGATGGCGCCGGCTTTGCCTATCCCGGCCACACCG
AGTTCCTCGCAGCCCTTGGAGGGGTCGACCATGTGGTGATGATGCTGGCCAGCGCCGCTCTTCGGGTGGTGCCAGCCACC
ATCCACATTCCGCTGAGCGCCGTGCCCGAAGTGCTGACACCAGACCACCTGCGCCGCGTCATCACCCTTACAGACCGTGG
CCTGCGCGACCAGTTCGGTCTCACCGCCCCGCGCATCGCCGTCACTGGCCTCAACCCGCATGCAGGCGAAGGCGGGGCCA
TGGGCCAGGAAGAAGGTGACTGGATCGAAGCACTGATCCGCGAGATGCAGACCGAAGGCTACCGGCTCACCGGTCCCCAT
CCGGCAGACACATTGTTTCACGCCGCCGCCCGCGCGCGCTATGACGCGGCCATCGCGATGTATCACGATCAGGCGCTCAT
CCCGATCAAGACGCTCGACTTCGACAAGGGCGTCAATGTCACCCTTGGCCTGCCCTTCATCCGCACATCCCCCGATCACG
GCACCGCGTTCGACATCGCTGGCAAAGGTCTTGCCAATCCCTCCAGCCTCATCGAAGCCCTGCGTCTGGCGCAAACCATG
GCCAAGACCCGCCAGCCCTGA

Upstream 100 bases:

>100_bases
CCCGTGTCGCTGTGGCCAACGCTCTTGTGCAACAGCGCCTGAATGAACTCGCCGAGGCCCATGTCGAACAGCTGAAGGCC
AACGCCCGGATCGATTTCCA

Downstream 100 bases:

>100_bases
TCTCTTCTTCTAACCCCAAATATCCCGGGGTGTTTGAGGGGCAGCGCCCCTCATCCCAAGTCAAACCTGCGCGCAGGGAA
GCCCCTGCGCACCTTTCGGA

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MTGAPQVIALSCGEPAGIGPEIAVAAWDQLRADCPFVWIGDPRHLPSSHPWQPVSAPAEALQVSADALPVWPLEFAGNTT
KGEADPQNASGVIQSIKTGVELVTSGKAAALCTAPIHKKALIDGAGFAYPGHTEFLAALGGVDHVVMMLASAALRVVPAT
IHIPLSAVPEVLTPDHLRRVITLTDRGLRDQFGLTAPRIAVTGLNPHAGEGGAMGQEEGDWIEALIREMQTEGYRLTGPH
PADTLFHAAARARYDAAIAMYHDQALIPIKTLDFDKGVNVTLGLPFIRTSPDHGTAFDIAGKGLANPSSLIEALRLAQTM
AKTRQP

Sequences:

>Translated_326_residues
MTGAPQVIALSCGEPAGIGPEIAVAAWDQLRADCPFVWIGDPRHLPSSHPWQPVSAPAEALQVSADALPVWPLEFAGNTT
KGEADPQNASGVIQSIKTGVELVTSGKAAALCTAPIHKKALIDGAGFAYPGHTEFLAALGGVDHVVMMLASAALRVVPAT
IHIPLSAVPEVLTPDHLRRVITLTDRGLRDQFGLTAPRIAVTGLNPHAGEGGAMGQEEGDWIEALIREMQTEGYRLTGPH
PADTLFHAAARARYDAAIAMYHDQALIPIKTLDFDKGVNVTLGLPFIRTSPDHGTAFDIAGKGLANPSSLIEALRLAQTM
AKTRQP
>Mature_325_residues
TGAPQVIALSCGEPAGIGPEIAVAAWDQLRADCPFVWIGDPRHLPSSHPWQPVSAPAEALQVSADALPVWPLEFAGNTTK
GEADPQNASGVIQSIKTGVELVTSGKAAALCTAPIHKKALIDGAGFAYPGHTEFLAALGGVDHVVMMLASAALRVVPATI
HIPLSAVPEVLTPDHLRRVITLTDRGLRDQFGLTAPRIAVTGLNPHAGEGGAMGQEEGDWIEALIREMQTEGYRLTGPHP
ADTLFHAAARARYDAAIAMYHDQALIPIKTLDFDKGVNVTLGLPFIRTSPDHGTAFDIAGKGLANPSSLIEALRLAQTMA
KTRQP

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=326, Percent_Identity=41.4110429447853, Blast_Score=228, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA_SILST (Q1GI38)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_612940.1
- ProteinModelPortal:   Q1GI38
- SMR:   Q1GI38
- STRING:   Q1GI38
- GeneID:   4077339
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_0945
- NMPDR:   fig|292414.1.peg.3025
- eggNOG:   COG1995
- HOGENOM:   HBG451136
- OMA:   LETAYQM
- PhylomeDB:   Q1GI38
- ProtClustDB:   PRK05312
- BioCyc:   SSP292414:TM1040_0945-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR001804
- InterPro:   IPR005255
- Gene3D:   G3DSA:3.40.718.10
- TIGRFAMs:   TIGR00557

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 34340; Mature: 34208

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: BINDING 132-132 BINDING 133-133 BINDING 270-270 BINDING 279-279 BINDING 288-288

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGAPQVIALSCGEPAGIGPEIAVAAWDQLRADCPFVWIGDPRHLPSSHPWQPVSAPAEA
CCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHH
LQVSADALPVWPLEFAGNTTKGEADPQNASGVIQSIKTGVELVTSGKAAALCTAPIHKKA
HHHCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEEECCCCEEEEECCCHHHH
LIDGAGFAYPGHTEFLAALGGVDHVVMMLASAALRVVPATIHIPLSAVPEVLTPDHLRRV
EECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEECHHHCCCCCCHHHHHHH
ITLTDRGLRDQFGLTAPRIAVTGLNPHAGEGGAMGQEEGDWIEALIREMQTEGYRLTGPH
HHHCCCCCHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEECCCC
PADTLFHAAARARYDAAIAMYHDQALIPIKTLDFDKGVNVTLGLPFIRTSPDHGTAFDIA
CHHHHHHHHHHHHHHEEEEEECCCEEEEEEEECCCCCCEEEEECCEEEECCCCCCEEEEC
GKGLANPSSLIEALRLAQTMAKTRQP
CCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TGAPQVIALSCGEPAGIGPEIAVAAWDQLRADCPFVWIGDPRHLPSSHPWQPVSAPAEA
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHH
LQVSADALPVWPLEFAGNTTKGEADPQNASGVIQSIKTGVELVTSGKAAALCTAPIHKKA
HHHCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEEECCCCEEEEECCCHHHH
LIDGAGFAYPGHTEFLAALGGVDHVVMMLASAALRVVPATIHIPLSAVPEVLTPDHLRRV
EECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEECHHHCCCCCCHHHHHHH
ITLTDRGLRDQFGLTAPRIAVTGLNPHAGEGGAMGQEEGDWIEALIREMQTEGYRLTGPH
HHHCCCCCHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEECCCC
PADTLFHAAARARYDAAIAMYHDQALIPIKTLDFDKGVNVTLGLPFIRTSPDHGTAFDIA
CHHHHHHHHHHHHHHEEEEEECCCEEEEEEEECCCCCCEEEEECCEEEECCCCCCEEEEC
GKGLANPSSLIEALRLAQTMAKTRQP
CCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA