Click here to switch to the map view.

The map label for this gene is rmlA2 [H]

Identifier: 93005455

GI number: 93005455

Start: 744379

End: 745251

Strand: Direct

Name: rmlA2 [H]

Synonym: Pcryo_0625

Alternate gene names: 93005455

Gene position: 744379-745251 (Clockwise)

Preceding gene: 93005454

Following gene: 93005456

Centisome position: 24.33

GC content: 41.47

Gene sequence:

>873_bases
ATGAAAGGTATTATTTTAGCTGGCGGTTCAGGTACACGCCTACATCCTATTACTCGTGGTGTGTCTAAGCAGTTACTACC
AATTTATGATAAGCCGATGATTTATTATCCCTTATCAGTACTGATGCTCGCTGGTATTCGTGAGGTTTTGATTATTTCTA
CACCAGAAGATTTACCTAGCTTCCAAAAATTACTTGGAACGGGTGAAAGCTTCGGTATTGAGTTAAGTTATGCCGAACAG
CCTTCTCCAGACGGTTTAGCACAAGCATTTATTATTGGCGAAGAATTTATTGGTCAAGACAATGTGTGTTTAGTTTTGGG
TGACAATATTTTTTATGGCCATGGCTTTAGTGGTATGTTACAAGAAGTCGCTAAGCGCCCGATAGGTGCTACTGTATTTG
GCTATCATGTAATTGACCCAGAACGTTTTGGTGTCGTTGATTTCGATAGCGATGGCAAAGCGCTATCAATTGAAGAGAAG
CCTCAAAAACCTAAATCGAGCTATGCTGTTACTGGTTTATATTTTTATGATAACGATGTTGTTGAGATTGCAAAGCAGGT
TAAGCCATCGCACCGTGGTGAGTTAGAAATCACAGATATAAACAATGCTTACCTAGAGCGTGGTGATTTACATGTCAGTT
TGTTAGGCCGCGGTTTCGCTTGGTTAGATACAGGTACTCACGATTCCTTAATGGAGGCAGGGCACTTCGTACAAACCATC
GAAGCGCGTCAAGGCTTAAAAGTGGCTTGCTTAGAGGAAATTGCATATCGTCAAGGCTGGTTAACGGCTGAACAGCTTAG
ATTACAAGCTACTGACCTAAGTAAGACAGGCTACGGACAGTATTTGCTGAATCTGTTAGAGCAGGAGAATTGA

Upstream 100 bases:

>100_bases
CCGGTATGCGTAAAACAGTGCAATGGTATTTAGATAATAAAAATTGGTGGCAGCGTGTGCTAAATGGAAGTTACCGCTTA
GAACGATTGGGAGAGTATAA

Downstream 100 bases:

>100_bases
TCATGCAAGTGATTAAAACTAAGTTAGCTGGCGTATTAATTATCGAACCAAAGATTTTTGGTGATTACCGTGGTTTTTTT
AAAGAAACCTTCAATGCTGA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 2; dTDP-glucose pyrophosphorylase 2; dTDP-glucose synthase 2 [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MKGIILAGGSGTRLHPITRGVSKQLLPIYDKPMIYYPLSVLMLAGIREVLIISTPEDLPSFQKLLGTGESFGIELSYAEQ
PSPDGLAQAFIIGEEFIGQDNVCLVLGDNIFYGHGFSGMLQEVAKRPIGATVFGYHVIDPERFGVVDFDSDGKALSIEEK
PQKPKSSYAVTGLYFYDNDVVEIAKQVKPSHRGELEITDINNAYLERGDLHVSLLGRGFAWLDTGTHDSLMEAGHFVQTI
EARQGLKVACLEEIAYRQGWLTAEQLRLQATDLSKTGYGQYLLNLLEQEN

Sequences:

>Translated_290_residues
MKGIILAGGSGTRLHPITRGVSKQLLPIYDKPMIYYPLSVLMLAGIREVLIISTPEDLPSFQKLLGTGESFGIELSYAEQ
PSPDGLAQAFIIGEEFIGQDNVCLVLGDNIFYGHGFSGMLQEVAKRPIGATVFGYHVIDPERFGVVDFDSDGKALSIEEK
PQKPKSSYAVTGLYFYDNDVVEIAKQVKPSHRGELEITDINNAYLERGDLHVSLLGRGFAWLDTGTHDSLMEAGHFVQTI
EARQGLKVACLEEIAYRQGWLTAEQLRLQATDLSKTGYGQYLLNLLEQEN
>Mature_290_residues
MKGIILAGGSGTRLHPITRGVSKQLLPIYDKPMIYYPLSVLMLAGIREVLIISTPEDLPSFQKLLGTGESFGIELSYAEQ
PSPDGLAQAFIIGEEFIGQDNVCLVLGDNIFYGHGFSGMLQEVAKRPIGATVFGYHVIDPERFGVVDFDSDGKALSIEEK
PQKPKSSYAVTGLYFYDNDVVEIAKQVKPSHRGELEITDINNAYLERGDLHVSLLGRGFAWLDTGTHDSLMEAGHFVQTI
EARQGLKVACLEEIAYRQGWLTAEQLRLQATDLSKTGYGQYLLNLLEQEN

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=251, Percent_Identity=25.0996015936255, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI11761621, Length=251, Percent_Identity=25.0996015936255, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1790224, Length=286, Percent_Identity=75.1748251748252, Blast_Score=443, Evalue=1e-126,
Organism=Escherichia coli, GI1788351, Length=289, Percent_Identity=67.4740484429066, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI1788355, Length=242, Percent_Identity=25.6198347107438, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787488, Length=242, Percent_Identity=24.7933884297521, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=230, Percent_Identity=26.5217391304348, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=254, Percent_Identity=24.8031496062992, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355443, Length=218, Percent_Identity=25.2293577981651, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24644084, Length=218, Percent_Identity=25.2293577981651, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32015; Mature: 32015

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLHPITRGVSKQLLPIYDKPMIYYPLSVLMLAGIREVLIISTPEDLPS
CCCEEEECCCCCEECHHHHCCHHCCCCCCCCCEEEHHHHHHHHHCCCEEEEEECCCCCHH
FQKLLGTGESFGIELSYAEQPSPDGLAQAFIIGEEFIGQDNVCLVLGDNIFYGHGFSGML
HHHHHCCCCCCCEEEEECCCCCCCHHHHEEEECHHHCCCCCEEEEEECCEEEECCHHHHH
QEVAKRPIGATVFGYHVIDPERFGVVDFDSDGKALSIEEKPQKPKSSYAVTGLYFYDNDV
HHHHHCCCCCEEEEEEEECCCCCEEEEECCCCCEEEECCCCCCCCCCEEEEEEEEECCHH
VEIAKQVKPSHRGELEITDINNAYLERGDLHVSLLGRGFAWLDTGTHDSLMEAGHFVQTI
HHHHHHCCCCCCCCEEEEECCHHHHHCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHH
EARQGLKVACLEEIAYRQGWLTAEQLRLQATDLSKTGYGQYLLNLLEQEN
HHHCCCCHHHHHHHHHHHCCCCHHHHEEEECCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKGIILAGGSGTRLHPITRGVSKQLLPIYDKPMIYYPLSVLMLAGIREVLIISTPEDLPS
CCCEEEECCCCCEECHHHHCCHHCCCCCCCCCEEEHHHHHHHHHCCCEEEEEECCCCCHH
FQKLLGTGESFGIELSYAEQPSPDGLAQAFIIGEEFIGQDNVCLVLGDNIFYGHGFSGML
HHHHHCCCCCCCEEEEECCCCCCCHHHHEEEECHHHCCCCCEEEEEECCEEEECCHHHHH
QEVAKRPIGATVFGYHVIDPERFGVVDFDSDGKALSIEEKPQKPKSSYAVTGLYFYDNDV
HHHHHCCCCCEEEEEEEECCCCCEEEEECCCCCEEEECCCCCCCCCCEEEEEEEEECCHH
VEIAKQVKPSHRGELEITDINNAYLERGDLHVSLLGRGFAWLDTGTHDSLMEAGHFVQTI
HHHHHHCCCCCCCCEEEEECCHHHHHCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHH
EARQGLKVACLEEIAYRQGWLTAEQLRLQATDLSKTGYGQYLLNLLEQEN
HHHCCCCHHHHHHHHHHHCCCCHHHHEEEECCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503; 7559340 [H]