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The map label for this gene is nuoC [H]

Identifier: 93005405

GI number: 93005405

Start: 685298

End: 687073

Strand: Direct

Name: nuoC [H]

Synonym: Pcryo_0575

Alternate gene names: 93005405

Gene position: 685298-687073 (Clockwise)

Preceding gene: 93005404

Following gene: 93005406

Centisome position: 22.4

GC content: 46.34

Gene sequence:

>1776_bases
ATGGTCACGGTAGTCGAAAACACAGATCCTAAGATCAAGCCTGTCCCAGCGGTTATCAAAGAGCTGGAAGAAAAATATGC
TGGTAAGTTCGTTGTGCAGCACACGGTTGACGACATTCCAACGGTTTGGGTGGCACGCGCTGATTTATTAGACGTTCTCT
TATTCTTACGAAAATTGCCAAAACCTTATGTCATGTTATTTGACTTGTCAGCGATAGATGAGCGTTTACGTCAGCATCGC
CAAGGTTTACCTGACAGTGATTTTACGGTGTTTTATCACTTGATGTCGCTTGAGCGTAATAGTGATGTGCGTATCAAAGT
GGCGCTCAGTGAAGAAGATTTAAACGTCCCAAGTGCGACACAGATTTGGCCCAATGCCAACTGGTATGAGCGCGAAGTGT
GGGACATGTTTGGTATTGTCTTTACTGGTCATCCGCATTTAACGCGTATTTTATTGCCAAAATACTGGGAAGGTCATCCA
CTGCGCAAAGAATATCATGCGCGGGCAACTGAGTTTACTCCGTATTTCTTGAATACCGCCAAACAACAATATGAGCAAGA
AAACCTGCGCTTTGTCCCAGAAGAGTGGGGTATGAAACGCTCGGGTCGCGATGAAGACTTTATGTTCTTGAACATCGGTC
CTAACCATCCATCCGCTCATGGTGCTTTCCGTTTGGTACTACAGCTTGATGGTGAAGAAGTCGTCGATTGTATCCCTGAT
ATTGGCTATCACCATCGCGGCGCCGAAAAAATGGCTGAGCGTCAAACATGGCACTCATTTATTCCTTATACCGACCGTAT
TGATTATCTTGGCGGCGTAATGAATGAGCTACCGTACATCATGTCGGTTGAAAAGCTTGCCGGTATTACTATTCCGCCGC
GTGCTGAAACCATCCGCGTGATGATGAGTGAGTTTTTCCGTATTACCAATAACTTGCTGTTCGTCGGTACCTTTATCCAA
GATGCCGGTGGTATGACGCCGGTATTCTATATGTTTACTGATCGCCAAAAAGCTTATGACGTTATCGAAGCTGTAACCGG
TTATCGTATGCACCCGGCATGGTTCCGTATCGGCGGTACAGCGCACGATTTACCGCGTGGCTGGCAGCGTTTGGTACGTG
AGTTCTTAGATTGGATGCCAAAACGCTTGGATGAGTATGTTAAAGCAGCATTGCAAAACAGTGTGCTTAAAGGTCGTACT
CAAGGCGTTGCCCAATATAATACCAAGCAAGCATTGGCGTGGGGCGTTACTGGCGCAGGTTTGCGTGCAACAGGTTTGGA
TTTTGATTTGCGTAAAGCGCGTCCGTACATGGGATACGAGAATTACGATTTCGAAGTACCAGTCGGCTATAACGGCGATG
CTTATGATCGCTGTATGGTGAAAGTCGAAGAGATGCGCCAGTCGCTACGTATTATCCGTCAATGTATGGATAATATGCCA
CAAGGTCCTTATAAGGCGGATCATCCATTGGCAGTACCGCCGCCAAAAGACCGTACGTTGAACGATATTGAAACCTTGAT
TAATCACTTTATCTCTGTTTCTTGGGGTCCTGTGATGCCAGCGGGTGAGTGCACAACGATTGTAGAAGCGACTAAAGGTC
TAAACAGCTATTACATCACCTCGGATAAAGCGACGATGAGCTATCGTACCCGTATTCGTACGCCGACATTCGCGCATTTG
CAGCAGATGCCATCAGTTATTAATGGCTCATTGGTATCCGATGCCATTATGTATTTGGCATCGATTGATATTGTGATGGC
GGATTGTGACCGTTAG

Upstream 100 bases:

>100_bases
GTTAGAAGTGCGCGTACGCTCATCATAGTTTGGTTATGATTATCATCTTTTATTATGGTTGTCATGGTTCAGTTATGATT
AATGAAGGAAGACATCATTC

Downstream 100 bases:

>100_bases
AGCGTCTGTGGTTATACGTTTATCATTATCGTTTATATATTAAAAGCACGACGCGTTCATTAACATATTATCGCCAAACT
GGCACACCAAAACGCTGTCA

Product: bifunctional NADH:ubiquinone oxidoreductase subunit C/D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit C/D; NDH-1 subunit C/D [H]

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MVTVVENTDPKIKPVPAVIKELEEKYAGKFVVQHTVDDIPTVWVARADLLDVLLFLRKLPKPYVMLFDLSAIDERLRQHR
QGLPDSDFTVFYHLMSLERNSDVRIKVALSEEDLNVPSATQIWPNANWYEREVWDMFGIVFTGHPHLTRILLPKYWEGHP
LRKEYHARATEFTPYFLNTAKQQYEQENLRFVPEEWGMKRSGRDEDFMFLNIGPNHPSAHGAFRLVLQLDGEEVVDCIPD
IGYHHRGAEKMAERQTWHSFIPYTDRIDYLGGVMNELPYIMSVEKLAGITIPPRAETIRVMMSEFFRITNNLLFVGTFIQ
DAGGMTPVFYMFTDRQKAYDVIEAVTGYRMHPAWFRIGGTAHDLPRGWQRLVREFLDWMPKRLDEYVKAALQNSVLKGRT
QGVAQYNTKQALAWGVTGAGLRATGLDFDLRKARPYMGYENYDFEVPVGYNGDAYDRCMVKVEEMRQSLRIIRQCMDNMP
QGPYKADHPLAVPPPKDRTLNDIETLINHFISVSWGPVMPAGECTTIVEATKGLNSYYITSDKATMSYRTRIRTPTFAHL
QQMPSVINGSLVSDAIMYLASIDIVMADCDR

Sequences:

>Translated_591_residues
MVTVVENTDPKIKPVPAVIKELEEKYAGKFVVQHTVDDIPTVWVARADLLDVLLFLRKLPKPYVMLFDLSAIDERLRQHR
QGLPDSDFTVFYHLMSLERNSDVRIKVALSEEDLNVPSATQIWPNANWYEREVWDMFGIVFTGHPHLTRILLPKYWEGHP
LRKEYHARATEFTPYFLNTAKQQYEQENLRFVPEEWGMKRSGRDEDFMFLNIGPNHPSAHGAFRLVLQLDGEEVVDCIPD
IGYHHRGAEKMAERQTWHSFIPYTDRIDYLGGVMNELPYIMSVEKLAGITIPPRAETIRVMMSEFFRITNNLLFVGTFIQ
DAGGMTPVFYMFTDRQKAYDVIEAVTGYRMHPAWFRIGGTAHDLPRGWQRLVREFLDWMPKRLDEYVKAALQNSVLKGRT
QGVAQYNTKQALAWGVTGAGLRATGLDFDLRKARPYMGYENYDFEVPVGYNGDAYDRCMVKVEEMRQSLRIIRQCMDNMP
QGPYKADHPLAVPPPKDRTLNDIETLINHFISVSWGPVMPAGECTTIVEATKGLNSYYITSDKATMSYRTRIRTPTFAHL
QQMPSVINGSLVSDAIMYLASIDIVMADCDR
>Mature_591_residues
MVTVVENTDPKIKPVPAVIKELEEKYAGKFVVQHTVDDIPTVWVARADLLDVLLFLRKLPKPYVMLFDLSAIDERLRQHR
QGLPDSDFTVFYHLMSLERNSDVRIKVALSEEDLNVPSATQIWPNANWYEREVWDMFGIVFTGHPHLTRILLPKYWEGHP
LRKEYHARATEFTPYFLNTAKQQYEQENLRFVPEEWGMKRSGRDEDFMFLNIGPNHPSAHGAFRLVLQLDGEEVVDCIPD
IGYHHRGAEKMAERQTWHSFIPYTDRIDYLGGVMNELPYIMSVEKLAGITIPPRAETIRVMMSEFFRITNNLLFVGTFIQ
DAGGMTPVFYMFTDRQKAYDVIEAVTGYRMHPAWFRIGGTAHDLPRGWQRLVREFLDWMPKRLDEYVKAALQNSVLKGRT
QGVAQYNTKQALAWGVTGAGLRATGLDFDLRKARPYMGYENYDFEVPVGYNGDAYDRCMVKVEEMRQSLRIIRQCMDNMP
QGPYKADHPLAVPPPKDRTLNDIETLINHFISVSWGPVMPAGECTTIVEATKGLNSYYITSDKATMSYRTRIRTPTFAHL
QQMPSVINGSLVSDAIMYLASIDIVMADCDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=382, Percent_Identity=41.6230366492147, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI260898743, Length=376, Percent_Identity=41.4893617021277, Blast_Score=302, Evalue=5e-82,
Organism=Homo sapiens, GI4758788, Length=118, Percent_Identity=42.3728813559322, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI145693162, Length=576, Percent_Identity=69.4444444444444, Blast_Score=884, Evalue=0.0,
Organism=Escherichia coli, GI1789076, Length=507, Percent_Identity=27.2189349112426, Blast_Score=168, Evalue=8e-43,
Organism=Escherichia coli, GI1788832, Length=516, Percent_Identity=26.7441860465116, Blast_Score=152, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17555284, Length=398, Percent_Identity=40.9547738693467, Blast_Score=325, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI17568379, Length=401, Percent_Identity=40.1496259351621, Blast_Score=322, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI71990788, Length=148, Percent_Identity=34.4594594594595, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32563621, Length=148, Percent_Identity=34.4594594594595, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221459469, Length=425, Percent_Identity=39.2941176470588, Blast_Score=327, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24638644, Length=384, Percent_Identity=40.625, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24656494, Length=148, Percent_Identity=37.1621621621622, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR010218
- InterPro:   IPR023062
- InterPro:   IPR001135
- InterPro:   IPR001268
- InterPro:   IPR014029
- InterPro:   IPR022885
- ProDom:   PD001581 [H]

Pfam domain/function: PF00329 Complex1_30kDa; PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 68016; Mature: 68016

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTVVENTDPKIKPVPAVIKELEEKYAGKFVVQHTVDDIPTVWVARADLLDVLLFLRKLP
CEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHCC
KPYVMLFDLSAIDERLRQHRQGLPDSDFTVFYHLMSLERNSDVRIKVALSEEDLNVPSAT
CCEEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCC
QIWPNANWYEREVWDMFGIVFTGHPHLTRILLPKYWEGHPLRKEYHARATEFTPYFLNTA
EECCCCCCHHHHHHHHHHEEEECCCHHHHEECCCCCCCCCCHHHHHCCCCCCCHHHHHHH
KQQYEQENLRFVPEEWGMKRSGRDEDFMFLNIGPNHPSAHGAFRLVLQLDGEEVVDCIPD
HHHHHHHCCCCCCHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHC
IGYHHRGAEKMAERQTWHSFIPYTDRIDYLGGVMNELPYIMSVEKLAGITIPPRAETIRV
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCHHHHHH
MMSEFFRITNNLLFVGTFIQDAGGMTPVFYMFTDRQKAYDVIEAVTGYRMHPAWFRIGGT
HHHHHHHHHCCEEEEEEHHHCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCEEEECCC
AHDLPRGWQRLVREFLDWMPKRLDEYVKAALQNSVLKGRTQGVAQYNTKQALAWGVTGAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHEECCCCCC
LRATGLDFDLRKARPYMGYENYDFEVPVGYNGDAYDRCMVKVEEMRQSLRIIRQCMDNMP
CEECCCCCCHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
QGPYKADHPLAVPPPKDRTLNDIETLINHFISVSWGPVMPAGECTTIVEATKGLNSYYIT
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEEE
SDKATMSYRTRIRTPTFAHLQQMPSVINGSLVSDAIMYLASIDIVMADCDR
CCCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEECCCC
>Mature Secondary Structure
MVTVVENTDPKIKPVPAVIKELEEKYAGKFVVQHTVDDIPTVWVARADLLDVLLFLRKLP
CEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHCC
KPYVMLFDLSAIDERLRQHRQGLPDSDFTVFYHLMSLERNSDVRIKVALSEEDLNVPSAT
CCEEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCC
QIWPNANWYEREVWDMFGIVFTGHPHLTRILLPKYWEGHPLRKEYHARATEFTPYFLNTA
EECCCCCCHHHHHHHHHHEEEECCCHHHHEECCCCCCCCCCHHHHHCCCCCCCHHHHHHH
KQQYEQENLRFVPEEWGMKRSGRDEDFMFLNIGPNHPSAHGAFRLVLQLDGEEVVDCIPD
HHHHHHHCCCCCCHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHC
IGYHHRGAEKMAERQTWHSFIPYTDRIDYLGGVMNELPYIMSVEKLAGITIPPRAETIRV
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCHHHHHH
MMSEFFRITNNLLFVGTFIQDAGGMTPVFYMFTDRQKAYDVIEAVTGYRMHPAWFRIGGT
HHHHHHHHHCCEEEEEEHHHCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCEEEECCC
AHDLPRGWQRLVREFLDWMPKRLDEYVKAALQNSVLKGRTQGVAQYNTKQALAWGVTGAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHEECCCCCC
LRATGLDFDLRKARPYMGYENYDFEVPVGYNGDAYDRCMVKVEEMRQSLRIIRQCMDNMP
CEECCCCCCHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
QGPYKADHPLAVPPPKDRTLNDIETLINHFISVSWGPVMPAGECTTIVEATKGLNSYYIT
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEEE
SDKATMSYRTRIRTPTFAHLQQMPSVINGSLVSDAIMYLASIDIVMADCDR
CCCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA