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The map label for this gene is hemH [H]

Identifier: 93005245

GI number: 93005245

Start: 505119

End: 506138

Strand: Direct

Name: hemH [H]

Synonym: Pcryo_0415

Alternate gene names: 93005245

Gene position: 505119-506138 (Clockwise)

Preceding gene: 93005240

Following gene: 93005252

Centisome position: 16.51

GC content: 48.43

Gene sequence:

>1020_bases
ATGAAACCTGACCTGCCTCCCCGTATTGCCGTTTTACTTGTCAACCTTGGTACGCCAGATGAACCGACCGCGCCAGCTGT
CCGTCGTTATCTCAAACAGTTTTTGTCCGATCCGCGCGTGATTGAAATCCCAAAATTCTTATGGGCGATTATCCTCAATC
TGTTTGTGCTGCCAAGTCGCCCGAAACGGGTAGCAGAAGCATATGCCAGTATTTGGGATGGCGATTCGCCGATGCGCAAT
ATTCTTAACGCGCAAGTTGAGATGTTAGACAAGCGTTTGGCTGACCGTGCTGCGCCATTTCGCGTGTCTGTTCATGCCGC
GATGAGCTACGGTAATCCGGGTTTGCCTGATGTCATGGATCAATTGCGTAGCGAAGGGGTTGACCATTTCGTCATGTTAC
CCGTGTTTCCGCAGTATTCGGCGACTTCAACAGGTGCGGTTTATGATGCGATTACTAAGTGGTCGCTGAAGCAGCGTAAT
TTGCCCAATATAACGATAGTCAAAGATTACTTTGCTCATCCTTTATATATTAAAGCATTAGCAGATAGCATCCGTCGTTT
TCAAGCGGTACATGGCAAGCCTGAAAAGCTCATGTTTAGCTTTCACGGTATTCCGCAGCCTTATGCTGATAAAGGCGACC
CGTACCCCAAACGCTGTAAATGTACGGCGGCACAAGTGGCTCATGAGCTTGGGCTAAAACCAGATGAATGGATTATCAGT
TTCCAGTCACGCTTTGGTAAGCAAGAATGGATTAAGCCCTATACCGATGTGGTACTCAAAGAGTGGGGCAGCTCAGGTGT
GCGCTCGGTACAAATTCTGAGTCCTGCGTTTTCGGCAGATTGCCTAGAAACCTTGGAAGAATTGGCTATCGAAAACCGCG
AGACTTTCCTGCATGCTGGCGGGCAAGAATACCATTATATTCCAGCGCTCAACGCTGATGAAGCACATATAGACTTGTTA
GAGGCAATGAGTGCACCATTGGTAAAAGGTTGGGCAGGGACTCTGGATGGTTGGGCATAA

Upstream 100 bases:

>100_bases
AAGGGTTAAAATGCTACACTAACGGCGTGCTCATTGAATACTGTCTTAACAATCTTTTGTAGAGCTTCCTTCATCAACTT
AACCATAAAACAGTGCTGCT

Downstream 100 bases:

>100_bases
ACGTTTTTAATATCAAATGAATATTCAAAAAAATACCGAACATCATGTTCGGTATTTTTTTATCAATAATTTTCTAAAAG
TACTATTTAAAAGTCATTGT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MKPDLPPRIAVLLVNLGTPDEPTAPAVRRYLKQFLSDPRVIEIPKFLWAIILNLFVLPSRPKRVAEAYASIWDGDSPMRN
ILNAQVEMLDKRLADRAAPFRVSVHAAMSYGNPGLPDVMDQLRSEGVDHFVMLPVFPQYSATSTGAVYDAITKWSLKQRN
LPNITIVKDYFAHPLYIKALADSIRRFQAVHGKPEKLMFSFHGIPQPYADKGDPYPKRCKCTAAQVAHELGLKPDEWIIS
FQSRFGKQEWIKPYTDVVLKEWGSSGVRSVQILSPAFSADCLETLEELAIENRETFLHAGGQEYHYIPALNADEAHIDLL
EAMSAPLVKGWAGTLDGWA

Sequences:

>Translated_339_residues
MKPDLPPRIAVLLVNLGTPDEPTAPAVRRYLKQFLSDPRVIEIPKFLWAIILNLFVLPSRPKRVAEAYASIWDGDSPMRN
ILNAQVEMLDKRLADRAAPFRVSVHAAMSYGNPGLPDVMDQLRSEGVDHFVMLPVFPQYSATSTGAVYDAITKWSLKQRN
LPNITIVKDYFAHPLYIKALADSIRRFQAVHGKPEKLMFSFHGIPQPYADKGDPYPKRCKCTAAQVAHELGLKPDEWIIS
FQSRFGKQEWIKPYTDVVLKEWGSSGVRSVQILSPAFSADCLETLEELAIENRETFLHAGGQEYHYIPALNADEAHIDLL
EAMSAPLVKGWAGTLDGWA
>Mature_339_residues
MKPDLPPRIAVLLVNLGTPDEPTAPAVRRYLKQFLSDPRVIEIPKFLWAIILNLFVLPSRPKRVAEAYASIWDGDSPMRN
ILNAQVEMLDKRLADRAAPFRVSVHAAMSYGNPGLPDVMDQLRSEGVDHFVMLPVFPQYSATSTGAVYDAITKWSLKQRN
LPNITIVKDYFAHPLYIKALADSIRRFQAVHGKPEKLMFSFHGIPQPYADKGDPYPKRCKCTAAQVAHELGLKPDEWIIS
FQSRFGKQEWIKPYTDVVLKEWGSSGVRSVQILSPAFSADCLETLEELAIENRETFLHAGGQEYHYIPALNADEAHIDLL
EAMSAPLVKGWAGTLDGWA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=308, Percent_Identity=25.974025974026, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI60499021, Length=308, Percent_Identity=25.974025974026, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786681, Length=319, Percent_Identity=46.7084639498433, Blast_Score=307, Evalue=7e-85,
Organism=Saccharomyces cerevisiae, GI6324750, Length=289, Percent_Identity=23.1833910034602, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17864156, Length=294, Percent_Identity=26.1904761904762, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24651774, Length=263, Percent_Identity=25.4752851711027, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45552018, Length=143, Percent_Identity=28.6713286713287, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 38051; Mature: 38051

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPDLPPRIAVLLVNLGTPDEPTAPAVRRYLKQFLSDPRVIEIPKFLWAIILNLFVLPSR
CCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCC
PKRVAEAYASIWDGDSPMRNILNAQVEMLDKRLADRAAPFRVSVHAAMSYGNPGLPDVMD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHH
QLRSEGVDHFVMLPVFPQYSATSTGAVYDAITKWSLKQRNLPNITIVKDYFAHPLYIKAL
HHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCCHHHHHHH
ADSIRRFQAVHGKPEKLMFSFHGIPQPYADKGDPYPKRCKCTAAQVAHELGLKPDEWIIS
HHHHHHHHHHCCCCHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
FQSRFGKQEWIKPYTDVVLKEWGSSGVRSVQILSPAFSADCLETLEELAIENRETFLHAG
HHHHCCHHHHCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHEECC
GQEYHYIPALNADEAHIDLLEAMSAPLVKGWAGTLDGWA
CCCEEEECCCCCCHHHHHHHHHHCCCHHHCCCCCCCCCC
>Mature Secondary Structure
MKPDLPPRIAVLLVNLGTPDEPTAPAVRRYLKQFLSDPRVIEIPKFLWAIILNLFVLPSR
CCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCC
PKRVAEAYASIWDGDSPMRNILNAQVEMLDKRLADRAAPFRVSVHAAMSYGNPGLPDVMD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHH
QLRSEGVDHFVMLPVFPQYSATSTGAVYDAITKWSLKQRNLPNITIVKDYFAHPLYIKAL
HHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCCHHHHHHH
ADSIRRFQAVHGKPEKLMFSFHGIPQPYADKGDPYPKRCKCTAAQVAHELGLKPDEWIIS
HHHHHHHHHHCCCCHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
FQSRFGKQEWIKPYTDVVLKEWGSSGVRSVQILSPAFSADCLETLEELAIENRETFLHAG
HHHHCCHHHHCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHEECC
GQEYHYIPALNADEAHIDLLEAMSAPLVKGWAGTLDGWA
CCCEEEECCCCCCHHHHHHHHHHCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA