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The map label for this gene is serA [H]

Identifier: 93005240

GI number: 93005240

Start: 499010

End: 500236

Strand: Direct

Name: serA [H]

Synonym: Pcryo_0410

Alternate gene names: 93005240

Gene position: 499010-500236 (Clockwise)

Preceding gene: 93005238

Following gene: 93005245

Centisome position: 16.31

GC content: 45.64

Gene sequence:

>1227_bases
ATGGCGTTATCACTCCAAAAAGACAAAATCCGGTTTTTATTGCTTGAAGGTCTGCACGACAATGCTTTAAAAGTATTAAA
AGATGCTGGTTATCAAAACATTGAAAATATCAGTCATGCATTGGATCAAGATGAGCTGATTGAAAAGATTAAAGATGCTC
ATTTTATTGGTATTCGCTCGCGCACGCAGCTGACACGTGAAGTGCTTCAGCATGCACATAAGCTTATCGGCATTGGTTGC
TTTTGTATTGGTACCAACCAAGTAGACCTAGATGCTGCTCGTGAATTCGGTATTCCGGTCTTCAATGCGCCATTCTCGAA
CACCCGTTCGGTCGCTGAGTTGGTACTTGCTGAAGCCATCATGCTCTATCGCGGTATCCCTGAAAAGAGTGCCACTGTAC
ATCGCGGTGGTTGGGGTAAGTCTGCGACTAACTCACATGAAGTACGCGGCAAAACCATCGGTATCGTCGGTTACGGCTCT
ATTGGCTCGCAGCTGTCTGTATTGGCTGAAAGCTTTGGTATGAAAGTTATCTATCATGATGTCTTGACCAAACTGCCACT
AGGTAATGCAGTGCAAGTAGCTAGCTTAGAAGAGCTGTTATCTACTGCTGATATCGTGACTTTGCATGTACCTGATCTGC
CAAGCACACGCTACATGATGGGCGCGGCGCAGTTTGCGCATATGAAAGACGGCAGCTACTTTATCAATGCTGCGCGTGGT
ACTTGTGTCGAGATTGATGACCTTGCTGCCGTGCTTGAATCTGGCAAAATCTTGGGCGCTGCAATTGATGTGTTCCCAAA
AGAGCCAAAATCTGCTGATGAAGAGTTTGAGTCACCACTGCGTAAGTTCGATAATGTTATCTTGACGCCGCATATCGGTG
GCTCAACGCAAGAAGCACAGGCAAATATTGGACTGGAAGTTGCAGATAAATTTGTGCGATATTCTGACCAAGGCGATACA
GCAACGGCGGTCAACTTCCCAGAAGTATCGATTCCGTTTAAAGAAGGCACGCATCGCCTGCTACATATCCACAAAAACGT
ACCAGGCGTCCTGTCACAGATTAACCGTCTGTTTGCTGAAGCAAATATCAATATCTTGGCGCAGAGCTTGATGACGGAAG
GCGATGTCGGCTATCTCGTTATGGATGTCGATTATAACGACTCAACCGCGGCTTTAGATCAGCTAAAAGACGTTCAAGAG
ACAATTCGTGTGCGTATTTTGTTTTAA

Upstream 100 bases:

>100_bases
CCGCCCAATTTTGTGTAAGATATCCAGACTCTTTTCGTTTCATTCATCCAAGCTTATCCCTCAGATGATTTTTATAAGAC
AATTATAGGACAGTTCTCAC

Downstream 100 bases:

>100_bases
GTTTTGTAATAACAGTTTAAATTTATAGTTAGCGCTATAAATAGCGAATAACAAAAAAGAGAGGCTCTATTCATAAGAGC
CTCTCTTTTTTTATCGCATT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MALSLQKDKIRFLLLEGLHDNALKVLKDAGYQNIENISHALDQDELIEKIKDAHFIGIRSRTQLTREVLQHAHKLIGIGC
FCIGTNQVDLDAAREFGIPVFNAPFSNTRSVAELVLAEAIMLYRGIPEKSATVHRGGWGKSATNSHEVRGKTIGIVGYGS
IGSQLSVLAESFGMKVIYHDVLTKLPLGNAVQVASLEELLSTADIVTLHVPDLPSTRYMMGAAQFAHMKDGSYFINAARG
TCVEIDDLAAVLESGKILGAAIDVFPKEPKSADEEFESPLRKFDNVILTPHIGGSTQEAQANIGLEVADKFVRYSDQGDT
ATAVNFPEVSIPFKEGTHRLLHIHKNVPGVLSQINRLFAEANINILAQSLMTEGDVGYLVMDVDYNDSTAALDQLKDVQE
TIRVRILF

Sequences:

>Translated_408_residues
MALSLQKDKIRFLLLEGLHDNALKVLKDAGYQNIENISHALDQDELIEKIKDAHFIGIRSRTQLTREVLQHAHKLIGIGC
FCIGTNQVDLDAAREFGIPVFNAPFSNTRSVAELVLAEAIMLYRGIPEKSATVHRGGWGKSATNSHEVRGKTIGIVGYGS
IGSQLSVLAESFGMKVIYHDVLTKLPLGNAVQVASLEELLSTADIVTLHVPDLPSTRYMMGAAQFAHMKDGSYFINAARG
TCVEIDDLAAVLESGKILGAAIDVFPKEPKSADEEFESPLRKFDNVILTPHIGGSTQEAQANIGLEVADKFVRYSDQGDT
ATAVNFPEVSIPFKEGTHRLLHIHKNVPGVLSQINRLFAEANINILAQSLMTEGDVGYLVMDVDYNDSTAALDQLKDVQE
TIRVRILF
>Mature_407_residues
ALSLQKDKIRFLLLEGLHDNALKVLKDAGYQNIENISHALDQDELIEKIKDAHFIGIRSRTQLTREVLQHAHKLIGIGCF
CIGTNQVDLDAAREFGIPVFNAPFSNTRSVAELVLAEAIMLYRGIPEKSATVHRGGWGKSATNSHEVRGKTIGIVGYGSI
GSQLSVLAESFGMKVIYHDVLTKLPLGNAVQVASLEELLSTADIVTLHVPDLPSTRYMMGAAQFAHMKDGSYFINAARGT
CVEIDDLAAVLESGKILGAAIDVFPKEPKSADEEFESPLRKFDNVILTPHIGGSTQEAQANIGLEVADKFVRYSDQGDTA
TAVNFPEVSIPFKEGTHRLLHIHKNVPGVLSQINRLFAEANINILAQSLMTEGDVGYLVMDVDYNDSTAALDQLKDVQET
IRVRILF

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=304, Percent_Identity=37.171052631579, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI61743967, Length=260, Percent_Identity=29.6153846153846, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4557497, Length=260, Percent_Identity=29.6153846153846, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI145580578, Length=246, Percent_Identity=30.8943089430894, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4557499, Length=246, Percent_Identity=30.8943089430894, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI145580575, Length=246, Percent_Identity=30.8943089430894, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI6912396, Length=241, Percent_Identity=28.2157676348548, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1789279, Length=408, Percent_Identity=58.8235294117647, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI87082289, Length=261, Percent_Identity=31.8007662835249, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1787645, Length=249, Percent_Identity=29.3172690763052, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI87081824, Length=155, Percent_Identity=34.8387096774194, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788660, Length=273, Percent_Identity=29.6703296703297, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=33.5403726708075, Blast_Score=168, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI25147481, Length=245, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=50, Blast_Score=403, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6322116, Length=418, Percent_Identity=49.2822966507177, Blast_Score=399, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6324964, Length=243, Percent_Identity=32.5102880658436, Blast_Score=106, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=230, Percent_Identity=29.1304347826087, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6324980, Length=180, Percent_Identity=31.6666666666667, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=177, Percent_Identity=34.4632768361582, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19921140, Length=316, Percent_Identity=31.0126582278481, Blast_Score=151, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24646446, Length=240, Percent_Identity=32.0833333333333, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646448, Length=240, Percent_Identity=32.0833333333333, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646452, Length=240, Percent_Identity=32.0833333333333, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646450, Length=240, Percent_Identity=32.0833333333333, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574286, Length=270, Percent_Identity=28.1481481481481, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI62472511, Length=240, Percent_Identity=32.0833333333333, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24585516, Length=297, Percent_Identity=27.6094276094276, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28571528, Length=293, Percent_Identity=27.6450511945392, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24585514, Length=284, Percent_Identity=27.112676056338, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574282, Length=284, Percent_Identity=27.112676056338, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45552429, Length=284, Percent_Identity=27.112676056338, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45551003, Length=284, Percent_Identity=27.112676056338, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28574284, Length=284, Percent_Identity=27.112676056338, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44632; Mature: 44500

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSLQKDKIRFLLLEGLHDNALKVLKDAGYQNIENISHALDQDELIEKIKDAHFIGIRS
CCCCCCHHCEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHCCCEEEEECH
RTQLTREVLQHAHKLIGIGCFCIGTNQVDLDAAREFGIPVFNAPFSNTRSVAELVLAEAI
HHHHHHHHHHHHHHHHEEEEEEEECCEECHHHHHHCCCCEECCCCCCHHHHHHHHHHHHH
MLYRGIPEKSATVHRGGWGKSATNSHEVRGKTIGIVGYGSIGSQLSVLAESFGMKVIYHD
HHHCCCCCCCCEEECCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHHH
VLTKLPLGNAVQVASLEELLSTADIVTLHVPDLPSTRYMMGAAQFAHMKDGSYFINAARG
HHHHCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHEECCCCEEEEECCC
TCVEIDDLAAVLESGKILGAAIDVFPKEPKSADEEFESPLRKFDNVILTPHIGGSTQEAQ
CEEEHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCHHH
ANIGLEVADKFVRYSDQGDTATAVNFPEVSIPFKEGTHRLLHIHKNVPGVLSQINRLFAE
HCCCHHHHHHHHHCCCCCCCEEEECCCCEECCHHHCCCEEEEEECCCCHHHHHHHHHHHH
ANINILAQSLMTEGDVGYLVMDVDYNDSTAALDQLKDVQETIRVRILF
CCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHEEEEEC
>Mature Secondary Structure 
ALSLQKDKIRFLLLEGLHDNALKVLKDAGYQNIENISHALDQDELIEKIKDAHFIGIRS
CCCCCHHCEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHCCCEEEEECH
RTQLTREVLQHAHKLIGIGCFCIGTNQVDLDAAREFGIPVFNAPFSNTRSVAELVLAEAI
HHHHHHHHHHHHHHHHEEEEEEEECCEECHHHHHHCCCCEECCCCCCHHHHHHHHHHHHH
MLYRGIPEKSATVHRGGWGKSATNSHEVRGKTIGIVGYGSIGSQLSVLAESFGMKVIYHD
HHHCCCCCCCCEEECCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHHH
VLTKLPLGNAVQVASLEELLSTADIVTLHVPDLPSTRYMMGAAQFAHMKDGSYFINAARG
HHHHCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHEECCCCEEEEECCC
TCVEIDDLAAVLESGKILGAAIDVFPKEPKSADEEFESPLRKFDNVILTPHIGGSTQEAQ
CEEEHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCHHH
ANIGLEVADKFVRYSDQGDTATAVNFPEVSIPFKEGTHRLLHIHKNVPGVLSQINRLFAE
HCCCHHHHHHHHHCCCCCCCEEEECCCCEECCHHHCCCEEEEEECCCCHHHHHHHHHHHH
ANINILAQSLMTEGDVGYLVMDVDYNDSTAALDQLKDVQETIRVRILF
CCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]